LLPS-Ran-0345
Terf1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Telomeric repeat-binding factor
Gene Name: Terf1, rCG_30535
Ensembl Gene: ENSRNOG00000007291.5
Ensembl Protein: ENSRNOP00000043160.2
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGTVTSAAP  GARSNAGGTS  ADSPEKEAAR  DDAELFDCRV  QLGPPREEEN  AELVAEAEAV  60
61    AAGWMLDFLC  LSLCRAFRDG  RCEDFRQTRD  SAEAIIHGLP  SLTAYQLKTV  YICQFLTRVA  120
121   AGKSLDAQFE  VDERITPLES  ALMIWDSIEK  EHDKLHEEIQ  NLIKIQAVAV  CMEMGSFKEA  180
181   EEVFERIFGD  PEFYTPLERK  LLKIISQKDV  FHVLFQRFSY  NLMMEKIQSY  VECVLNEKSS  240
241   TFLMKAATKV  VENEKARTVA  SEDKAKATNT  GTETEVNSNK  GESVNGQQSV  ETESLVDTGS  300
301   SVRSHKNALS  PLKSRRLQPD  FNRNEARTGT  LQCEIATKRN  RRTSGGNRLR  ISKNQPDTNE  360
361   KHGRRKKQTW  LWEEDRSLKC  GVRKYGEGNW  AKILSHYKFN  NRTSVMLKDR  WRTMRRLRLI  420
421   S  421
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGGGA  CTGTCACCTC  AGCAGCTCCG  GGCGCGCGGA  GCAATGCGGG  CGGGACAAGC  60
61    GCGGATTCTC  CAGAGAAGGA  GGCGGCGAGA  GACGACGCAG  AGTTGTTCGA  CTGCCGGGTG  120
121   CAGCTGGGGC  CCCCGAGAGA  GGAGGAGAAC  GCGGAGCTTG  TGGCCGAGGC  GGAGGCCGTG  180
181   GCTGCGGGCT  GGATGCTCGA  CTTCCTCTGC  CTGTCTCTGT  GCCGAGCCTT  TCGCGACGGC  240
241   CGCTGCGAGG  ACTTTCGCCA  GACTCGTGAC  AGCGCCGAGG  CTATTATTCA  TGGACTACCC  300
301   AGTCTTACAG  CTTACCAGTT  GAAAACTGTA  TATATATGTC  AGTTTTTGAC  AAGAGTTGCA  360
361   GCAGGAAAGT  CTCTTGATGC  ACAGTTTGAA  GTTGATGAGC  GGATTACACC  CTTGGAATCA  420
421   GCCCTGATGA  TTTGGGACTC  AATTGAAAAA  GAACATGACA  AACTTCATGA  AGAAATACAG  480
481   AATTTAATTA  AAATTCAGGC  TGTAGCTGTG  TGTATGGAAA  TGGGCAGCTT  TAAGGAAGCA  540
541   GAAGAAGTGT  TTGAAAGAAT  ATTTGGTGAC  CCAGAATTTT  ACACGCCTTT  AGAAAGAAAA  600
601   TTACTTAAGA  TAATCTCTCA  AAAAGACGTC  TTCCACGTCC  TTTTTCAACG  CTTCAGTTAT  660
661   AACCTCATGA  TGGAGAAAAT  TCAGAGTTAT  GTGGAGTGTG  TGTTAAATGA  GAAATCATCA  720
721   ACTTTCCTAA  TGAAGGCAGC  AACAAAAGTA  GTGGAAAATG  AAAAAGCAAG  GACAGTAGCT  780
781   TCGGAGGATA  AAGCAAAGGC  CACCAACACT  GGAACAGAAA  CGGAAGTTAA  CTCGAATAAA  840
841   GGAGAAAGTG  TTAATGGCCA  ACAGTCTGTA  GAAACTGAAT  CCTTGGTGGA  TACAGGATCC  900
901   TCAGTAAGGT  CTCACAAGAA  TGCCTTATCT  CCGTTGAAAA  GCAGACGTCT  TCAGCCAGAT  960
961   TTCAATAGGA  ATGAAGCAAG  AACAGGAACT  CTTCAGTGTG  AAATAGCAAC  AAAACGAAAC  1020
1021  AGAAGAACCA  GTGGAGGGAA  TAGATTACGT  ATTTCAAAGA  ATCAGCCGGA  CACTAATGAA  1080
1081  AAACATGGGC  GCAGGAAAAA  ACAGACATGG  CTTTGGGAAG  AAGACAGAAG  TTTGAAGTGT  1140
1141  GGTGTAAGGA  AATATGGAGA  GGGAAATTGG  GCTAAAATAC  TATCCCATTA  TAAGTTCAAC  1200
1201  AACCGAACAA  GTGTCATGTT  AAAGGATCGG  TGGAGAACGA  TGAGGAGGCT  AAGGCTCATT  1260
1261  AGCTGA  1266

▼ KEYWORD

ID
Family
Cell cycle
Chromosome
Complete proteome
DNA-binding
Nucleus
Reference proteome
Telomere

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Fibrillar center
Cellular Component
Nuclear body
Cellular Component
Nucleus
Cellular Component
Shelterin complex
Molecular Function
Ankyrin repeat binding
Molecular Function
DNA binding, bending
Molecular Function
Double-stranded telomeric DNA binding
Molecular Function
G-rich strand telomeric DNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
Telomerase activity
Biological Process
Meiotic telomere clustering
Biological Process
Negative regulation of DNA replication
Biological Process
Negative regulation of establishment of protein localization to telomere
Biological Process
Negative regulation of establishment of RNA localization to telomere
Biological Process
Negative regulation of exonuclease activity
Biological Process
Negative regulation of telomerase activity
Biological Process
Negative regulation of telomere maintenance via telomerase
Biological Process
Negative regulation of telomeric D-loop disassembly
Biological Process
Positive regulation of shelterin complex assembly
Biological Process
Response to drug
Biological Process
Telomere maintenance via telomerase
Biological Process
Telomeric D-loop disassembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-0500Mus musculus82.190.0 679
LLPS-Mea-2661Mesocricetus auratus80.780.0 575
LLPS-Lac-1115Latimeria chalumnae71.936e-2299.8
LLPS-Sus-3280Sus scrofa69.610.0 556
LLPS-Orc-3824Oryctolagus cuniculus68.60.0 520
LLPS-Ova-2556Ovis aries68.154e-157 454
LLPS-Eqc-1377Equus caballus67.670.0 535
LLPS-Aon-4108Aotus nancymaae67.670.0 541
LLPS-Cea-2335Cercocebus atys66.90.0 535
LLPS-Bot-2441Bos taurus66.740.0 539
LLPS-Gog-2124Gorilla gorilla66.510.0 535
LLPS-Loa-3164Loxodonta africana66.280.0 521
LLPS-Pat-1334Pan troglodytes66.130.0 529
LLPS-Pap-3265Pan paniscus66.130.0 534
LLPS-Poa-0194Pongo abelii66.050.0 528
LLPS-Mam-3907Macaca mulatta65.820.0 533
LLPS-Man-0341Macaca nemestrina65.820.0 533
LLPS-Paa-2013Papio anubis65.820.0 533
LLPS-Mal-1035Mandrillus leucophaeus65.820.0 533
LLPS-Maf-0913Macaca fascicularis65.820.0 533
LLPS-Caj-0864Callithrix jacchus65.660.0 519
LLPS-Hos-2224Homo sapiens65.520.0 526
LLPS-Chs-1524Chlorocebus sabaeus65.520.0 532
LLPS-Cas-0181Carlito syrichta65.516e-155 451
LLPS-Fec-3274Felis catus64.734e-178 512
LLPS-Caf-2735Canis familiaris63.846e-172 496
LLPS-Nol-4453Nomascus leucogenys63.796e-166 479
LLPS-Tut-0812Tursiops truncatus63.597e-158 459
LLPS-Cap-2836Cavia porcellus62.792e-165 478
LLPS-Fud-3086Fukomys damarensis62.652e-164 476
LLPS-Aim-0831Ailuropoda melanoleuca62.162e-173 500
LLPS-Myl-3646Myotis lucifugus61.783e-167 484
LLPS-Dio-1132Dipodomys ordii59.717e-149 436
LLPS-Rhb-0704Rhinopithecus bieti59.132e-142 419
LLPS-Urm-2238Ursus maritimus58.932e-103 315
LLPS-Mup-3116Mustela putorius furo58.852e-157 459
LLPS-Mod-3482Monodelphis domestica58.821e-1273.2
LLPS-Cii-1470Ciona intestinalis58.822e-1169.3
LLPS-Otg-2298Otolemur garnettii58.311e-158 462
LLPS-Xet-1615Xenopus tropicalis58.182e-1375.9
LLPS-Anp-1253Anas platyrhynchos58.181e-1376.6
LLPS-Gaga-0102Gallus gallus57.692e-1169.7
LLPS-Meg-1370Meleagris gallopavo57.691e-1067.4
LLPS-Ora-0747Ornithorhynchus anatinus57.693e-1271.6
LLPS-Pes-3155Pelodiscus sinensis57.413e-1272.8
LLPS-Cis-1702Ciona savignyi56.363e-1268.9
LLPS-Anc-0835Anolis carolinensis55.775e-1272.0
LLPS-Leo-1296Lepisosteus oculatus54.92e-1273.2
LLPS-Tag-0551Taeniopygia guttata54.553e-1272.4
LLPS-Met-2045Medicago truncatula53.333e-0756.6
LLPS-Tar-1491Takifugu rubripes53.198e-1165.1
LLPS-Orn-3340Oreochromis niloticus52.946e-1168.2
LLPS-Sah-2088Sarcophilus harrisii52.381e-1376.6
LLPS-Prp-1301Prunus persica50.913e-0860.1
LLPS-Hea-0113Helianthus annuus50.914e-0859.3
LLPS-Fia-1087Ficedula albicollis50.791e-1273.9
LLPS-Scm-1891Scophthalmus maximus50.773e-1272.8
LLPS-Mae-2641Manihot esculenta50.02e-0860.5
LLPS-Asm-1327Astyanax mexicanus50.07e-0962.0
LLPS-Dac-1409Daucus carota49.284e-0962.4
LLPS-Orl-1567Oryzias latipes49.216e-1271.6
LLPS-Zem-2593Zea mays49.064e-0756.2
LLPS-Nia-2607Nicotiana attenuata49.065e-0652.8
LLPS-Glm-2452Glycine max48.283e-0859.7
LLPS-Via-1043Vigna angularis46.555e-0858.9
LLPS-Scf-0867Scleropages formosus46.483e-1373.9
LLPS-Dar-0854Danio rerio46.35e-0859.3
LLPS-Sob-1393Sorghum bicolor45.764e-0756.2
LLPS-Lep-2240Leersia perrieri43.663e-0755.8
LLPS-Orp-0875Oryza punctata42.253e-0653.1
LLPS-Pof-2341Poecilia formosa41.257e-1168.2
LLPS-Gaa-0255Gasterosteus aculeatus41.189e-1064.7
LLPS-Icp-2675Ictalurus punctatus40.855e-0859.3
LLPS-Xim-2156Xiphophorus maculatus36.138e-1168.2
LLPS-Sei-1941Setaria italica28.962e-0757.0
LLPS-Ict-3331Ictidomys tridecemlineatus27.485e-35 140