LLPS-Caj-0864
TERF1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Telomeric repeat-binding factor |
| Gene Name: | TERF1 |
| Ensembl Gene: | ENSCJAG00000047203.1 |
| Ensembl Protein: | ENSCJAP00000062491.1 |
| Organism: | Callithrix jacchus |
| Taxa ID: | 9483 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCJAT00000083194.1 | ENSCJAP00000062491.1 |
| Ensembl | ENSCJAT00000080621.1 | ENSCJAP00000054298.1 |
| UniProt | F7IQX6, F7IQX6_CALJA | |
| GeneBank | GAMR01001649, GAMS01004211, GAMT01002511 | JAB18925.1, JAB32283.1, JAB09350.1 |
| RefSeq | XM_002758992.3 | XP_002759038.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEDASSAAP SPRGCADGRD ADATEERIAE TERNDEEQFE CQELLECQMQ LGASEEEEED 60 61 AGFVAEAEAV AAGWMLDFLC LSLCRAFRDG RSEDFRQTRD SAEAIIHGLS SLTAYQLRTV 120 121 YICQFLTRIA AGKNLDAQFE NDERITPLES ALMIWGSIEK EHDKLHEEIQ NLIEVQAIAV 180 181 CMENGNFKEA EEVFERIFGD PNSCAPLKRK LLMIISQKDT YHSVFQHFSY NHMMEKVKSY 240 241 VNDVLSEKSS TFLMKAAAKV VESKRARTTT SQDKPNGNDV EMETEANLDT RKSVSDKQSA 300 301 VTESSEGTVS LLRSHKNLFL SKLKHGTQQR ELNKERRVGT LQSAKRKKES RRATKSRIPV 360 361 SESQPVTPEK QRARKRQAWL WEEDKNLRSG VRKFGEGNWS KILLHYKFNN RTSVMLKDRW 420 421 RTMKKLKLIC SDSED 435 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGAGG ACGCCTCCTC AGCGGCTCCG AGCCCACGGG GCTGTGCGGA TGGTAGGGAT 60 61 GCCGACGCTA CCGAGGAGCG GATAGCAGAA ACGGAGAGGA ACGACGAGGA GCAGTTCGAG 120 121 TGCCAGGAAC TGCTCGAGTG CCAGATGCAG TTGGGGGCTT CCGAGGAGGA GGAGGAGGAT 180 181 GCGGGCTTTG TGGCCGAGGC CGAGGCTGTG GCTGCCGGCT GGATGCTCGA TTTCCTCTGC 240 241 CTCTCTCTTT GCCGAGCTTT CCGCGACGGC CGCTCCGAGG ACTTTCGCCA GACCCGCGAC 300 301 AGCGCCGAGG CTATTATTCA TGGACTATCC AGTCTAACAG CTTATCAGTT GAGAACTGTA 360 361 TACATATGTC AGTTTTTGAC AAGAATTGCA GCAGGAAAAA ACCTTGATGC ACAGTTTGAA 420 421 AATGATGAAC GAATTACACC CTTAGAATCA GCCCTGATGA TTTGGGGTTC AATTGAAAAG 480 481 GAACATGACA AACTTCACGA AGAAATACAG AATTTAATTG AAGTTCAGGC TATAGCTGTT 540 541 TGTATGGAAA ATGGCAACTT TAAGGAAGCA GAAGAAGTCT TTGAAAGAAT ATTTGGTGAT 600 601 CCAAATTCTT GCGCGCCTTT AAAAAGGAAA TTGCTTATGA TAATCTCTCA GAAAGATACA 660 661 TACCATTCTG TATTTCAACA CTTCAGTTAC AACCACATGA TGGAGAAAGT TAAGAGTTAT 720 721 GTGAATGATG TGCTAAGTGA AAAATCATCA ACCTTTCTAA TGAAGGCAGC AGCAAAAGTA 780 781 GTAGAAAGTA AAAGAGCAAG AACAACAACT TCTCAAGATA AACCTAATGG TAATGATGTT 840 841 GAAATGGAAA CTGAAGCTAA CTTGGATACA AGAAAAAGGT CTCACAAGAA TCTTTTCCTA 900 901 TCTAAATTGA AACATGGAAC CCAGCAACGA GAACTTAATA AAGAAAGAAG AGTAGGAACT 960 961 CTTCAAAGTG CAAAAAGGAA AAAAGAAAGC AGAAGAGCCA CCAAAAGTAG AATACCTGTT 1020 1021 TCGGAGAGTC AACCGGTGAC TCCTGAAAAA CAACGAGCTA GAAAAAGACA GGCATGGCTT 1080 1081 TGGGAAGAAG ACAAGAATTT GAGATCTGGC GTTAGGAAAT TTGGAGAGGG AAACTGGTCT 1140 1141 AAAATACTGT TGCATTATAA ATTCAACAAC CGGACAAGTG TCATGTTAAA AGATAGATGG 1200 1201 AGGACCATGA AGAAACTAAA ACTCATTTGC TCAGACAGTG AAGACTGA 1248 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Fibrillar center | |
Cellular Component | Nuclear body | |
Cellular Component | Shelterin complex | |
Molecular Function | Ankyrin repeat binding | |
Molecular Function | DNA binding, bending | |
Molecular Function | Double-stranded telomeric DNA binding | |
Molecular Function | G-rich strand telomeric DNA binding | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Telomerase activity | |
Biological Process | Meiotic telomere clustering | |
Biological Process | Negative regulation of DNA replication | |
Biological Process | Negative regulation of establishment of protein localization to telomere | |
Biological Process | Negative regulation of establishment of RNA localization to telomere | |
Biological Process | Negative regulation of exonuclease activity | |
Biological Process | Negative regulation of telomerase activity | |
Biological Process | Negative regulation of telomere maintenance via telomerase | |
Biological Process | Negative regulation of telomeric D-loop disassembly | |
Biological Process | Positive regulation of shelterin complex assembly | |
Biological Process | Telomere maintenance via telomerase | |
Biological Process | Telomeric D-loop disassembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aon-4108 | Aotus nancymaae | 93.56 | 0.0 | 781 |
| LLPS-Poa-0194 | Pongo abelii | 91.06 | 0.0 | 738 |
| LLPS-Cea-2335 | Cercocebus atys | 90.62 | 0.0 | 751 |
| LLPS-Maf-0913 | Macaca fascicularis | 89.5 | 0.0 | 747 |
| LLPS-Mal-1035 | Mandrillus leucophaeus | 89.5 | 0.0 | 747 |
| LLPS-Man-0341 | Macaca nemestrina | 89.5 | 0.0 | 747 |
| LLPS-Mam-3907 | Macaca mulatta | 89.5 | 0.0 | 747 |
| LLPS-Paa-2013 | Papio anubis | 89.04 | 0.0 | 746 |
| LLPS-Gog-2124 | Gorilla gorilla | 88.3 | 0.0 | 740 |
| LLPS-Pat-1334 | Pan troglodytes | 88.15 | 0.0 | 741 |
| LLPS-Hos-2224 | Homo sapiens | 88.15 | 0.0 | 735 |
| LLPS-Pap-3265 | Pan paniscus | 87.95 | 0.0 | 734 |
| LLPS-Chs-1524 | Chlorocebus sabaeus | 87.5 | 0.0 | 741 |
| LLPS-Nol-2971 | Nomascus leucogenys | 83.79 | 0.0 | 672 |
| LLPS-Eqc-1377 | Equus caballus | 82.15 | 0.0 | 668 |
| LLPS-Cas-0181 | Carlito syrichta | 81.77 | 0.0 | 581 |
| LLPS-Ova-2556 | Ovis aries | 81.58 | 0.0 | 565 |
| LLPS-Rhb-0704 | Rhinopithecus bieti | 80.65 | 0.0 | 611 |
| LLPS-Sus-3280 | Sus scrofa | 79.45 | 0.0 | 643 |
| LLPS-Loa-3164 | Loxodonta africana | 79.03 | 0.0 | 617 |
| LLPS-Bot-2441 | Bos taurus | 78.49 | 0.0 | 652 |
| LLPS-Fec-3274 | Felis catus | 77.35 | 0.0 | 631 |
| LLPS-Orc-3824 | Oryctolagus cuniculus | 76.94 | 0.0 | 613 |
| LLPS-Caf-2735 | Canis familiaris | 75.45 | 0.0 | 619 |
| LLPS-Aim-0831 | Ailuropoda melanoleuca | 73.24 | 0.0 | 610 |
| LLPS-Tut-0812 | Tursiops truncatus | 73.0 | 0.0 | 547 |
| LLPS-Fud-3086 | Fukomys damarensis | 70.57 | 0.0 | 563 |
| LLPS-Mea-2661 | Mesocricetus auratus | 70.39 | 1e-169 | 489 |
| LLPS-Mup-3116 | Mustela putorius furo | 70.36 | 0.0 | 561 |
| LLPS-Urm-2238 | Ursus maritimus | 70.32 | 3e-141 | 412 |
| LLPS-Myl-3646 | Myotis lucifugus | 70.27 | 0.0 | 573 |
| LLPS-Mum-0500 | Mus musculus | 69.83 | 2e-177 | 510 |
| LLPS-Cap-2836 | Cavia porcellus | 69.43 | 0.0 | 530 |
| LLPS-Otg-2298 | Otolemur garnettii | 68.25 | 0.0 | 546 |
| LLPS-Dio-1132 | Dipodomys ordii | 67.13 | 1e-161 | 469 |
| LLPS-Scm-1891 | Scophthalmus maximus | 66.67 | 8e-14 | 77.8 |
| LLPS-Ran-0345 | Rattus norvegicus | 62.88 | 2e-173 | 500 |
| LLPS-Tar-1491 | Takifugu rubripes | 61.7 | 9e-13 | 70.9 |
| LLPS-Leo-1296 | Lepisosteus oculatus | 60.78 | 1e-13 | 77.0 |
| LLPS-Xim-2156 | Xiphophorus maculatus | 59.26 | 1e-12 | 74.3 |
| LLPS-Pes-3155 | Pelodiscus sinensis | 59.26 | 5e-13 | 75.1 |
| LLPS-Anc-0835 | Anolis carolinensis | 59.26 | 3e-13 | 75.9 |
| LLPS-Orn-3340 | Oreochromis niloticus | 58.82 | 4e-12 | 72.0 |
| LLPS-Lac-0283 | Latimeria chalumnae | 58.18 | 2e-11 | 69.7 |
| LLPS-Xet-1615 | Xenopus tropicalis | 58.18 | 2e-13 | 76.3 |
| LLPS-Ora-0747 | Ornithorhynchus anatinus | 57.41 | 3e-12 | 71.6 |
| LLPS-Scf-2015 | Scleropages formosus | 57.41 | 7e-12 | 71.2 |
| LLPS-Ict-3331 | Ictidomys tridecemlineatus | 57.41 | 6e-13 | 74.7 |
| LLPS-Cii-1470 | Ciona intestinalis | 56.9 | 5e-13 | 74.3 |
| LLPS-Fia-1087 | Ficedula albicollis | 56.36 | 1e-13 | 77.0 |
| LLPS-Cis-1702 | Ciona savignyi | 55.17 | 5e-13 | 71.6 |
| LLPS-Tag-0551 | Taeniopygia guttata | 54.55 | 3e-13 | 75.9 |
| LLPS-Sah-2088 | Sarcophilus harrisii | 53.7 | 2e-12 | 73.2 |
| LLPS-Meg-1370 | Meleagris gallopavo | 53.7 | 1e-10 | 67.4 |
| LLPS-Gaga-0102 | Gallus gallus | 53.7 | 3e-11 | 69.3 |
| LLPS-Mod-3482 | Monodelphis domestica | 52.83 | 1e-11 | 70.5 |
| LLPS-Anp-1253 | Anas platyrhynchos | 52.73 | 1e-12 | 73.9 |
| LLPS-Gaa-0255 | Gasterosteus aculeatus | 51.85 | 1e-11 | 70.9 |
| LLPS-Orl-1567 | Oryzias latipes | 51.67 | 3e-12 | 72.4 |
| LLPS-Asm-1327 | Astyanax mexicanus | 50.88 | 2e-09 | 63.5 |
| LLPS-Sob-1393 | Sorghum bicolor | 47.46 | 3e-06 | 53.1 |
| LLPS-Glm-2452 | Glycine max | 46.43 | 4e-07 | 56.2 |
| LLPS-Via-1043 | Vigna angularis | 46.43 | 2e-07 | 57.0 |
| LLPS-Brn-1191 | Brassica napus | 45.31 | 4e-07 | 56.6 |
| LLPS-Bro-1005 | Brassica oleracea | 45.31 | 4e-07 | 56.6 |
| LLPS-Dar-0854 | Danio rerio | 45.16 | 3e-08 | 60.1 |
| LLPS-Icp-2675 | Ictalurus punctatus | 43.64 | 4e-08 | 59.7 |
| LLPS-Sei-1941 | Setaria italica | 42.25 | 2e-06 | 54.3 |
| LLPS-Dac-1409 | Daucus carota | 42.17 | 2e-08 | 60.1 |
| LLPS-Met-2045 | Medicago truncatula | 41.11 | 5e-09 | 62.0 |
| LLPS-Lep-2240 | Leersia perrieri | 40.0 | 7e-07 | 55.1 |
| LLPS-Zem-2593 | Zea mays | 39.36 | 4e-08 | 59.7 |
| LLPS-Prp-1301 | Prunus persica | 38.96 | 1e-06 | 55.5 |
| LLPS-Hea-0113 | Helianthus annuus | 38.37 | 1e-07 | 58.2 |
| LLPS-Pof-2341 | Poecilia formosa | 31.85 | 1e-12 | 73.6 |
| LLPS-Sem-0878 | Selaginella moellendorffii | 29.49 | 7e-06 | 52.8 |