• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Pes-0979
DPYD

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name: DPYD
Ensembl Gene: ENSPSIG00000007676.1
Ensembl Protein: ENSPSIP00000008689.1
Organism: Pelodiscus sinensis
Taxa ID: 13735
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MRCLKCADAP  CQKSCPTNLD  IKSFITNIAN  KNYYGAAKMI  LSDNPLGLTC  GMVCPTSDLC  60
61    VGGCNLYATE  EGPINIGGLQ  QFATEVFKAM  NIPQIRSPFL  FPSEDIPEAY  HAKIALLGAG  120
121   PASISCASFL  ARLGYSDITI  FEKQEYFGGL  STSEIPQFRL  PYEAVNFEVE  LMKDLGVKIV  180
181   CGKGLGIEGM  TLSTLKEDGY  TAVFIGIGLP  EPKKDGIFQG  LKMDQGFYTS  KDFLPLVAMA  240
241   SKPGMCACHS  PLPLIQGTVI  VLGAGDTAFD  CATSALRCGA  RRVFVVFRKG  FTNIRAVPEE  300
301   VELAKEEKCE  FLPFLSPRKV  VVKGKKIVAV  EFVRTEQVEA  GNWIEDEDQV  VRLKADVVIS  360
361   AFGSVLGDLK  VKEAMNPIKF  NRWGLPEVDP  ETMQTSEPWV  FLGGDIGGLA  NTTVESVNDG  420
421   KQASWYMHKY  VQSLYGAAVP  TTPKLPLFYT  PIDLVDISVE  VAGLKFSNPF  GLASATPTTS  480
481   SPMIRRAFEA  GWGFALTKTF  SLDKDIVTNV  SPRIIRGITS  GPIYGPGQGS  FLNIELISEK  540
541   TAEYWCKSIT  ELKADFPNQI  VIASIMCSYN  KDDWTELSKM  AEASGADALE  LNLSCPHGMG  600
601   ERGMGLACGQ  NPELVRNICR  WVRQAVQIPF  FAKLTPNVTD  IVNIAVAAQE  GGADGVTATN  660
661   TVSGLMGLKA  DGTPWPAVGG  EKKTTYGGVS  GSAIRPIALR  AVSAIAHALP  GFPILATGGI  720
721   DSAESGLQFL  HSGASVLQVC  SAIQNQDFTV  IEDYCTGLRA  LLYLKSIEEL  QDWDGQSPAT  780
781   MCHQKGKPVP  KIADLIGKKL  PSFGPYLEQR  KKIMAENKIK  LKQQTTTVVL  PEKKHFIPKK  840
841   PIPAVKDVIG  KALQFIGTYG  ELNNTEQVVA  LIDKEMCINC  GKCYMTCNDS  GYQAIQFDPE  900
901   THLPTVTDSC  TGCNLCLSVC  PIIDCIRMVS  RTTPYEPKRG  LPLAVNSVC  949
Nucleotide CDS Sequence (FASTA)
1     ATGAGGTGCT  TAAAGTGTGC  AGATGCTCCT  TGTCAGAAGA  GCTGCCCAAC  TAATCTAGAC  60
61    ATCAAGTCAT  TTATCACAAA  TATTGCAAAT  AAGAACTATT  ATGGAGCTGC  CAAAATGATT  120
121   CTTTCTGACA  ACCCACTGGG  CCTGACATGT  GGAATGGTAT  GTCCAACCTC  AGACCTTTGT  180
181   GTAGGAGGAT  GCAATTTATA  TGCTACGGAG  GAGGGACCAA  TTAATATTGG  TGGATTGCAG  240
241   CAGTTTGCTA  CTGAGGTGTT  CAAAGCTATG  AATATTCCTC  AGATTAGAAG  CCCTTTCTTA  300
301   TTTCCCTCAG  AAGACATACC  TGAAGCATAC  CATGCGAAGA  TAGCTCTCCT  TGGTGCTGGG  360
361   CCTGCAAGTA  TCAGTTGTGC  TTCTTTTTTG  GCTCGATTAG  GTTACTCAGA  CATCACCATA  420
421   TTTGAAAAAC  AGGAATACTT  TGGTGGCTTA  AGTACATCTG  AAATCCCTCA  ATTCCGGTTG  480
481   CCATATGAAG  CAGTGAATTT  TGAAGTTGAG  CTTATGAAGG  ACCTTGGAGT  GAAGATAGTT  540
541   TGTGGGAAAG  GCCTTGGAAT  AGAAGGAATG  ACACTCAGTA  CCTTGAAGGA  AGATGGTTAC  600
601   ACAGCAGTCT  TTATTGGAAT  AGGTTTACCA  GAGCCAAAGA  AAGATGGTAT  ATTCCAAGGA  660
661   CTGAAAATGG  ATCAAGGTTT  CTACACATCT  AAAGACTTCC  TACCACTGGT  AGCAATGGCA  720
721   AGTAAACCAG  GAATGTGTGC  CTGTCACTCT  CCATTGCCAT  TGATACAGGG  AACTGTGATA  780
781   GTACTTGGAG  CAGGAGACAC  TGCTTTTGAT  TGTGCAACAT  CTGCTTTACG  CTGTGGAGCT  840
841   CGCCGTGTAT  TTGTGGTCTT  CAGAAAGGGA  TTCACTAATA  TCAGGGCTGT  TCCTGAGGAG  900
901   GTGGAACTTG  CAAAAGAAGA  AAAGTGTGAA  TTTTTGCCTT  TCCTCTCACC  TCGTAAGGTT  960
961   GTAGTGAAAG  GTAAAAAAAT  TGTTGCTGTG  GAATTTGTTC  GAACTGAACA  AGTTGAAGCT  1020
1021  GGAAACTGGA  TTGAAGATGA  GGATCAGGTT  GTCCGTTTGA  AGGCAGATGT  GGTGATCAGT  1080
1081  GCCTTTGGTT  CAGTTTTAGG  TGATCTTAAA  GTAAAGGAAG  CCATGAATCC  TATCAAGTTT  1140
1141  AATAGATGGG  GTCTTCCTGA  AGTGGACCCA  GAGACCATGC  AAACCAGTGA  ACCGTGGGTT  1200
1201  TTTTTAGGTG  GTGACATTGG  AGGTCTAGCT  AATACTACAG  TGGAATCTGT  GAATGATGGA  1260
1261  AAACAAGCTT  CCTGGTATAT  GCACAAATAC  GTACAGTCTT  TATATGGTGC  TGCAGTTCCT  1320
1321  ACTACTCCAA  AATTACCTCT  CTTCTATACT  CCTATTGATT  TGGTTGACAT  CAGTGTAGAA  1380
1381  GTGGCTGGAC  TGAAATTTTC  AAATCCCTTT  GGTCTTGCCA  GTGCAACTCC  AACTACTAGT  1440
1441  TCTCCAATGA  TTCGAAGAGC  ATTTGAAGCA  GGATGGGGAT  TTGCTCTGAC  CAAAACATTC  1500
1501  TCCCTCGATA  AGGACATTGT  AACCAATGTT  TCTCCAAGAA  TTATACGTGG  AATTACATCG  1560
1561  GGCCCCATAT  ATGGCCCAGG  TCAAGGCTCT  TTCTTAAACA  TTGAGCTCAT  CAGTGAGAAA  1620
1621  ACTGCAGAAT  ATTGGTGTAA  AAGTATCACT  GAACTGAAGG  CTGACTTTCC  CAACCAGATT  1680
1681  GTAATTGCCA  GTATCATGTG  CAGCTACAAC  AAGGATGACT  GGACTGAACT  TTCAAAAATG  1740
1741  GCTGAGGCTT  CTGGCGCAGA  TGCCCTGGAG  TTAAATTTAT  CATGTCCTCA  TGGCATGGGG  1800
1801  GAGAGAGGCA  TGGGCCTGGC  CTGTGGGCAG  AATCCAGAGC  TAGTCCGTAA  CATCTGTCGC  1860
1861  TGGGTTAGAC  AAGCTGTTCA  GATTCCTTTC  TTTGCCAAGC  TGACCCCAAA  TGTCACTGAT  1920
1921  ATTGTGAATA  TTGCAGTGGC  TGCTCAAGAA  GGTGGTGCAG  ATGGTGTGAC  AGCCACAAAC  1980
1981  ACAGTGTCAG  GACTGATGGG  ACTAAAAGCA  GATGGCACAC  CTTGGCCTGC  AGTTGGTGGA  2040
2041  GAAAAGAAGA  CCACATATGG  CGGTGTGTCT  GGAAGTGCTA  TTAGGCCCAT  AGCCCTGCGA  2100
2101  GCAGTATCTG  CTATAGCTCA  TGCTCTTCCA  GGATTTCCCA  TTTTAGCAAC  AGGAGGAATT  2160
2161  GATTCAGCTG  AGAGTGGGCT  GCAATTTCTT  CACAGTGGTG  CTTCAGTTCT  ACAGGTGTGT  2220
2221  AGTGCCATAC  AGAATCAAGA  TTTCACAGTG  ATTGAGGACT  ACTGCACTGG  TCTGAGAGCC  2280
2281  CTACTTTATC  TGAAAAGCAT  TGAGGAACTT  CAAGACTGGG  ATGGACAGAG  CCCTGCAACC  2340
2341  ATGTGCCATC  AGAAAGGAAA  GCCAGTACCC  AAAATTGCTG  ATCTGATTGG  AAAGAAACTG  2400
2401  CCTAGTTTTG  GACCTTACCT  TGAGCAGCGT  AAAAAGATAA  TGGCTGAGAA  CAAGATTAAA  2460
2461  CTGAAGCAAC  AAACCACAAC  TGTTGTACTT  CCTGAGAAAA  AGCATTTTAT  TCCCAAGAAG  2520
2521  CCCATTCCAG  CTGTCAAGGA  TGTAATTGGA  AAAGCACTGC  AGTTCATTGG  AACATATGGT  2580
2581  GAGCTTAACA  ACACAGAGCA  AGTTGTGGCT  CTGATTGACA  AGGAAATGTG  CATCAACTGT  2640
2641  GGCAAATGCT  ACATGACCTG  TAATGATTCT  GGCTACCAGG  CTATACAGTT  TGATCCAGAA  2700
2701  ACCCACCTGC  CCACTGTTAC  TGACAGTTGT  ACAGGCTGCA  ATCTGTGTCT  CAGTGTCTGC  2760
2761  CCTATTATTG  ACTGCATCAG  AATGGTTTCC  AGGACAACAC  CTTATGAACC  AAAGAGAGGT  2820
2821  CTGCCCTTAG  CTGTGAACTC  AGTGTGTTGA  2850

▼ KEYWORD


ID
Family
4Fe-4S
Complete proteome
FAD
Flavoprotein
FMN
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
Dihydropyrimidine dehydrogenase (NADP+) activity
Molecular Function
Protein homodimerization activity
Biological Process
Beta-alanine biosynthetic process
Biological Process
Purine nucleobase catabolic process
Biological Process
Thymidine catabolic process
Biological Process
Thymine catabolic process
Biological Process
Uracil catabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-2618Gallus gallus88.940.01710
LLPS-Anp-2814Anas platyrhynchos88.850.01421
LLPS-Ora-2969Ornithorhynchus anatinus88.80.0 716
LLPS-Fia-2457Ficedula albicollis87.820.01693
LLPS-Myl-3381Myotis lucifugus87.82e-178 530
LLPS-Tag-2394Taeniopygia guttata87.550.01633
LLPS-Anc-1406Anolis carolinensis87.140.01676
LLPS-Cas-2764Carlito syrichta86.870.01280
LLPS-Orc-3304Oryctolagus cuniculus86.620.01666
LLPS-Eqc-2118Equus caballus86.30.01660
LLPS-Otg-0938Otolemur garnettii86.20.01651
LLPS-Mod-1001Monodelphis domestica86.180.01659
LLPS-Bot-0888Bos taurus86.080.01661
LLPS-Ova-2094Ovis aries85.990.01658
LLPS-Sus-0161Sus scrofa85.880.01647
LLPS-Hos-4848Homo sapiens85.880.01654
LLPS-Pat-1807Pan troglodytes85.770.01653
LLPS-Pap-0360Pan paniscus85.770.01654
LLPS-Caf-2363Canis familiaris85.760.01647
LLPS-Chs-1530Chlorocebus sabaeus85.560.01654
LLPS-Loa-3812Loxodonta africana85.560.01647
LLPS-Nol-1133Nomascus leucogenys85.560.01650
LLPS-Aim-0448Ailuropoda melanoleuca85.520.01646
LLPS-Aon-2945Aotus nancymaae85.350.01650
LLPS-Sah-0144Sarcophilus harrisii85.350.01654
LLPS-Cea-0330Cercocebus atys85.350.01649
LLPS-Mal-1964Mandrillus leucophaeus85.350.01650
LLPS-Man-1020Macaca nemestrina85.350.01649
LLPS-Urm-0650Ursus maritimus85.340.01645
LLPS-Maf-1497Macaca fascicularis85.250.01646
LLPS-Paa-3063Papio anubis85.250.01648
LLPS-Mam-1552Macaca mulatta85.250.01649
LLPS-Cap-1759Cavia porcellus85.140.01637
LLPS-Fec-0417Felis catus85.130.01641
LLPS-Meg-1623Meleagris gallopavo85.070.01344
LLPS-Poa-0031Pongo abelii85.040.01634
LLPS-Caj-2280Callithrix jacchus84.930.01640
LLPS-Fud-0320Fukomys damarensis84.830.01632
LLPS-Dio-1819Dipodomys ordii84.620.01640
LLPS-Mup-2522Mustela putorius furo84.60.01636
LLPS-Gog-0902Gorilla gorilla84.388e-108 348
LLPS-Mum-3963Mus musculus84.190.01634
LLPS-Rhb-3246Rhinopithecus bieti82.510.01570
LLPS-Ran-1002Rattus norvegicus81.330.01585
LLPS-Leo-2552Lepisosteus oculatus81.070.01576
LLPS-Ict-0960Ictidomys tridecemlineatus79.450.01495
LLPS-Asm-4146Astyanax mexicanus79.050.01546
LLPS-Icp-3763Ictalurus punctatus78.440.01528
LLPS-Mea-3291Mesocricetus auratus77.920.01449
LLPS-Pof-1590Poecilia formosa77.590.01504
LLPS-Scf-1444Scleropages formosus77.50.01518
LLPS-Orl-0025Oryzias latipes77.160.01498
LLPS-Gaa-1859Gasterosteus aculeatus76.830.01492
LLPS-Dar-3357Danio rerio76.770.01091
LLPS-Xim-0774Xiphophorus maculatus76.740.01493
LLPS-Orn-2463Oreochromis niloticus75.790.01487
LLPS-Ten-3236Tetraodon nigroviridis75.790.01462
LLPS-Scm-2954Scophthalmus maximus75.260.01469
LLPS-Xet-1923Xenopus tropicalis75.130.01451
LLPS-Tar-3380Takifugu rubripes74.340.01417
LLPS-Cii-0550Ciona intestinalis71.850.01384
LLPS-Cis-0387Ciona savignyi70.060.01359
LLPS-Drm-1160Drosophila melanogaster66.560.01222
LLPS-Cae-0370Caenorhabditis elegans66.250.01248
LLPS-Sem-1430Selaginella moellendorffii40.01e-67 237
LLPS-Php-0862Physcomitrella patens39.272e-67 237
LLPS-Amt-1887Amborella trichopoda38.978e-69 241
LLPS-Lep-0482Leersia perrieri38.928e-68 238
LLPS-Prp-0679Prunus persica38.817e-65 229
LLPS-Sol-0515Solanum lycopersicum38.672e-65 231
LLPS-Sot-1545Solanum tuberosum38.672e-65 232
LLPS-Orb-0563Oryza barthii38.628e-67 236
LLPS-Ori-0506Oryza indica38.624e-67 236
LLPS-Orni-1263Oryza nivara38.624e-67 236
LLPS-Orgl-0943Oryza glumaepatula38.628e-67 236
LLPS-Brd-0924Brachypodium distachyon38.625e-64 227
LLPS-Ors-1153Oryza sativa38.624e-67 236
LLPS-Orbr-0091Oryza brachyantha38.625e-67 236
LLPS-Orr-1555Oryza rufipogon38.624e-67 236
LLPS-Org-0933Oryza glaberrima38.624e-67 236
LLPS-Nia-0575Nicotiana attenuata38.372e-65 231
LLPS-Glm-2657Glycine max38.214e-64 228
LLPS-Phv-0703Phaseolus vulgaris38.215e-64 227
LLPS-Sei-2043Setaria italica38.188e-65 229
LLPS-Hov-1887Hordeum vulgare38.022e-65 231
LLPS-Tra-2019Triticum aestivum38.022e-65 231
LLPS-Thc-2302Theobroma cacao37.912e-63 226
LLPS-Gor-0996Gossypium raimondii37.911e-63 226
LLPS-Pot-0039Populus trichocarpa37.911e-64 229
LLPS-Dac-0184Daucus carota37.881e-64 229
LLPS-Sob-1046Sorghum bicolor37.882e-64 228
LLPS-Zem-0251Zea mays37.882e-64 228
LLPS-Mua-0779Musa acuminata37.765e-65 230
LLPS-Viv-0767Vitis vinifera37.723e-64 228
LLPS-Via-0342Vigna angularis37.615e-62 224
LLPS-Vir-1626Vigna radiata37.613e-63 225
LLPS-Mae-2030Manihot esculenta37.612e-64 228
LLPS-Arl-0047Arabidopsis lyrata37.53e-61 219
LLPS-Coc-1353Corchorus capsularis37.431e-59 226
LLPS-Brr-2844Brassica rapa37.053e-62 222
LLPS-Orp-0561Oryza punctata36.993e-62 224
LLPS-Art-0073Arabidopsis thaliana36.865e-61 219
LLPS-Bro-2723Brassica oleracea36.868e-61 218
LLPS-Brn-3266Brassica napus36.755e-61 219
LLPS-Hea-2190Helianthus annuus36.722e-61 220
LLPS-Cus-0885Cucumis sativus36.561e-64 229
LLPS-Chr-0862Chlamydomonas reinhardtii36.543e-63 225
LLPS-Tru-0240Triticum urartu35.965e-55 199
LLPS-Met-0796Medicago truncatula34.641e-63 226
LLPS-Yal-1490Yarrowia lipolytica28.887e-0860.5
LLPS-Miv-0843Microbotryum violaceum28.126e-0654.7
LLPS-Fus-1124Fusarium solani27.783e-1482.0
LLPS-Pytr-0506Pyrenophora triticirepentis27.742e-1585.9
LLPS-Pyt-0098Pyrenophora teres27.48e-1584.0
LLPS-Asni-0785Aspergillus niger27.372e-1482.4
LLPS-Asn-0855Aspergillus nidulans27.376e-1584.3
LLPS-Ved-0786Verticillium dahliae27.371e-1379.7
LLPS-Coo-0885Colletotrichum orbiculare27.277e-1377.4
LLPS-Kop-1010Komagataella pastoris27.121e-1173.6
LLPS-Spr-1497Sporisorium reilianum27.052e-1276.3
LLPS-Lem-1603Leptosphaeria maculans27.036e-1584.3
LLPS-Trr-0498Trichoderma reesei27.022e-1585.9
LLPS-Scc-1481Schizosaccharomyces cryophilus26.928e-1377.4
LLPS-Aso-1296Aspergillus oryzae26.924e-1378.6
LLPS-Nef-1149Neosartorya fischeri26.922e-1379.3
LLPS-Cogr-0822Colletotrichum graminicola26.921e-1379.7
LLPS-Asg-1161Ashbya gossypii26.912e-1379.3
LLPS-Beb-1469Beauveria bassiana26.93e-1585.1
LLPS-Crn-0733Cryptococcus neoformans26.711e-1276.6
LLPS-Scp-1090Schizosaccharomyces pombe26.621e-1379.7
LLPS-Fuv-0783Fusarium verticillioides26.573e-1379.0
LLPS-Asfu-0686Aspergillus fumigatus26.572e-1379.3
LLPS-Phn-0026Phaeosphaeria nodorum26.463e-1482.0
LLPS-Usm-1479Ustilago maydis26.373e-1172.0
LLPS-Sac-0233Saccharomyces cerevisiae26.281e-1276.6
LLPS-Ast-1041Aspergillus terreus26.283e-1275.1
LLPS-Zyt-0934Zymoseptoria tritici26.224e-1481.6
LLPS-Fuo-1587Fusarium oxysporum26.228e-1377.4
LLPS-Nec-0845Neurospora crassa26.212e-1276.3
LLPS-Trv-1012Trichoderma virens26.212e-1482.8
LLPS-Pug-1387Puccinia graminis26.068e-1584.0
LLPS-Blg-1429Blumeria graminis25.957e-1377.4
LLPS-Gag-0955Gaeumannomyces graminis25.861e-1173.6
LLPS-Mao-1255Magnaporthe oryzae25.775e-1274.7
LLPS-Mel-1452Melampsora laricipopulina25.76e-1584.3
LLPS-Put-0384Puccinia triticina25.74e-1584.7
LLPS-Map-0122Magnaporthe poae25.523e-1172.4
LLPS-Dos-1297Dothistroma septosporum25.175e-1274.7
LLPS-Tum-1418Tuber melanosporum24.98e-1789.0
LLPS-Abg-1912Absidia glauca24.314e-1172.0
LLPS-Scj-1496Schizosaccharomyces japonicus24.225e-1067.0
LLPS-Tut-1747Tursiops truncatus24.045e-0860.5
LLPS-Gas-0530Galdieria sulphuraria22.164e-0757.8