• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Orl-0025
dpyd

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name: dpyd
Ensembl Gene: ENSORLG00000013626.2
Ensembl Protein: ENSORLP00000037756.1
Organism: Oryzias latipes
Taxa ID: 8090
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MLSKDLPDIE  SILALNPRVK  THAQITSTAS  KKKEKKHWKR  NPEKNCDFCV  KLENNFDDIK  60
61    HTTLSERGAL  REAYRCLKCA  DAPCQKSCPT  NLDIKAFITS  IANKNYYGAA  RVILSDNPLG  120
121   LTCGMVCPTS  ELCVGGCNLY  ASEEGPINIG  GLQQFATEVF  SQMGIPQIRS  PELPPPNEMP  180
181   ESYHSPVAMI  GCGPASISCA  SFLARLGYDN  ITIFEKQQYI  GGLSTSEIPQ  FRLPYEVVQF  240
241   EIELMKDLGV  KVVCEKGLGV  NGMTLTSLKK  EGFKAVFIGI  GLPQANRAKI  FQGLTGDQGF  300
301   FTSKDFLPLV  ASASKKGMCQ  CRSALPELRG  AVIVLGAGDT  AFDCATSALR  CGARRVYVCF  360
361   RKGFTNIRAV  PEEMELAKEE  KCEFLPFLSP  REVIMKNGRV  AGLQFCRTEQ  TEEGDWVEDE  420
421   EQVVKLKADY  IISAFGSILN  DPKVTEAMAP  VKLSHWGTPE  VNTETMQTSE  PWVFAGGDVA  480
481   GLANTTVESV  NDGKQASWHI  HRYIQSLYGQ  TVETAPKLPL  FYSAIDQVDI  SVEMCGIKFP  540
541   NPFGLASAPP  TTSTAMIRRA  FEQGWGFALT  KTFGLDKDLV  TNVSPRIVRG  TTSGPLYGPG  600
601   LGSFLNIELI  SEKTAAYWCQ  SVAELKKDFP  KNVVISSIMC  AYNKDDWTVL  AKMAEASGAD  660
661   ALELNLSCPH  GMGERGMGLA  CGQDPVLVRN  ICRWVRAAVS  IPFFAKLTPN  VTNIVDIAKA  720
721   AHEGGADGVT  ATNTVSGLMG  LKADSSPWPG  VGAAKRTTYG  GVSGNAIRPI  ALKAVSAIAK  780
781   AIPGFPILAT  GGIDSAETGL  QFLHAGASVL  QVCSAIQNQD  FTVIEDYCLG  LKALLYLKSL  840
841   ELKDWDGQSP  PTQKHQKGKS  VPKVQELVGK  GLPSFGPYLQ  QKTEAIAKYK  KKLRDAGETD  900
901   VKQPNISRIN  TPPKPVPAVK  DVIARALRHI  GAYQELDNME  QVQALIDEDM  CINCGKCYMT  960
961   CNDSGYQAIQ  FDPETHLPFV  TDSCTGCTLC  LTVCPIIDCI  QMVTRKTPHI  PQRGIPINPV  1020
1021  C  1021
Nucleotide CDS Sequence (FASTA)
1     ATGCTGAGTA  AAGATCTTCC  AGACATTGAG  AGTATTCTGG  CTCTCAATCC  CAGAGTAAAG  60
61    ACACACGCAC  AGATCACATC  TACAGCCAGC  AAGAAGAAGG  AAAAGAAACA  CTGGAAGAGA  120
121   AACCCTGAAA  AGAATTGTGA  TTTCTGTGTA  AAGTTGGAGA  ACAACTTTGA  TGACATTAAG  180
181   CACACAACAC  TGAGTGAGAG  GGGAGCTCTA  CGAGAAGCGT  ACAGGTGTCT  GAAATGTGCC  240
241   GATGCTCCCT  GTCAGAAGAG  CTGTCCGACC  AACCTGGACA  TCAAAGCTTT  TATAACAAGC  300
301   ATCGCCAACA  AGAATTACTA  TGGGGCAGCA  CGAGTCATTC  TGTCTGACAA  TCCTCTGGGT  360
361   TTGACCTGTG  GGATGGTTTG  TCCCACATCC  GAGCTGTGTG  TCGGGGGCTG  CAACCTCTAT  420
421   GCTTCAGAGG  AAGGACCCAT  AAACATCGGA  GGACTGCAGC  AGTTTGCCAC  TGAGGTATTC  480
481   AGTCAAATGG  GAATCCCTCA  GATCAGGAGT  CCTGAACTCC  CACCACCCAA  TGAAATGCCA  540
541   GAATCGTATC  ACTCACCTGT  TGCTATGATT  GGCTGTGGCC  CAGCATCGAT  CAGCTGTGCT  600
601   TCTTTCCTAG  CTCGCCTTGG  CTATGACAAC  ATCACTATTT  TTGAGAAACA  GCAGTACATC  660
661   GGAGGGCTCA  GCACTTCAGA  AATCCCTCAG  TTTCGTCTTC  CTTATGAGGT  AGTCCAGTTT  720
721   GAAATAGAGT  TAATGAAGGA  TCTGGGAGTC  AAGGTAGTTT  GCGAGAAAGG  TTTAGGAGTG  780
781   AATGGAATGA  CTCTGACATC  GCTGAAGAAG  GAGGGATTTA  AAGCTGTTTT  CATTGGAATT  840
841   GGTCTCCCCC  AGGCCAACAG  AGCAAAAATC  TTTCAGGGTT  TAACTGGGGA  TCAAGGCTTC  900
901   TTCACTTCCA  AAGACTTCCT  TCCTTTGGTG  GCTTCTGCAA  GCAAGAAAGG  CATGTGCCAG  960
961   TGCCGCTCTG  CTCTGCCGGA  GTTGAGAGGA  GCGGTGATTG  TTTTAGGGGC  CGGTGACACT  1020
1021  GCGTTTGATT  GTGCCACCTC  AGCTCTTCGC  TGTGGAGCCA  GAAGGGTGTA  TGTCTGCTTC  1080
1081  AGGAAAGGAT  TCACCAACAT  CAGAGCAGTT  CCTGAGGAGA  TGGAGCTGGC  GAAGGAGGAG  1140
1141  AAGTGCGAGT  TCCTGCCTTT  CCTGTCTCCT  CGTGAAGTCA  TCATGAAGAA  TGGAAGGGTT  1200
1201  GCCGGGTTAC  AGTTCTGCCG  CACTGAGCAG  ACGGAGGAAG  GGGACTGGGT  GGAGGATGAA  1260
1261  GAGCAAGTTG  TTAAGCTGAA  GGCTGATTAC  ATCATTAGCG  CTTTTGGGTC  AATTCTGAAC  1320
1321  GATCCAAAAG  TGACTGAAGC  CATGGCTCCT  GTGAAGCTGT  CTCACTGGGG  GACTCCAGAA  1380
1381  GTGAACACTG  AGACCATGCA  GACCAGTGAG  CCATGGGTGT  TTGCAGGCGG  AGACGTTGCA  1440
1441  GGTTTGGCAA  ACACCACTGT  GGAGTCTGTG  AACGATGGCA  AACAAGCCTC  GTGGCACATC  1500
1501  CACAGATACA  TACAGTCTCT  TTATGGACAG  ACAGTAGAAA  CAGCCCCAAA  GCTGCCGTTG  1560
1561  TTCTACAGTG  CAATAGACCA  GGTGGACATC  AGTGTTGAGA  TGTGTGGGAT  AAAATTCCCA  1620
1621  AATCCGTTCG  GCCTTGCTTC  TGCTCCTCCA  ACCACCAGCA  CGGCTATGAT  TAGAAGAGCT  1680
1681  TTCGAACAAG  GTTGGGGCTT  CGCTCTGACC  AAGACATTTG  GACTGGATAA  GGACCTGGTG  1740
1741  ACAAACGTGT  CTCCTCGAAT  CGTACGTGGA  ACCACCTCAG  GTCCTCTGTA  TGGACCAGGT  1800
1801  CTGGGCTCCT  TCCTCAACAT  TGAGCTCATC  AGTGAGAAAA  CTGCAGCATA  CTGGTGTCAG  1860
1861  TCTGTCGCAG  AACTCAAGAA  AGACTTCCCT  AAAAATGTGG  TGATCTCCAG  TATTATGTGT  1920
1921  GCTTACAACA  AGGATGACTG  GACAGTCCTG  GCAAAGATGG  CAGAGGCCTC  AGGAGCAGAT  1980
1981  GCTCTGGAGC  TGAACCTGTC  GTGTCCCCAT  GGGATGGGGG  AGAGGGGCAT  GGGGTTGGCC  2040
2041  TGTGGTCAGG  ACCCTGTGTT  GGTGCGAAAC  ATATGCCGGT  GGGTGCGAGC  TGCGGTTTCC  2100
2101  ATTCCGTTTT  TTGCCAAACT  GACACCAAAT  GTGACCAATA  TTGTTGACAT  CGCCAAAGCT  2160
2161  GCCCATGAAG  GCGGCGCAGA  TGGAGTCACG  GCCACCAACA  CGGTCTCAGG  CTTGATGGGA  2220
2221  CTGAAGGCTG  ACAGCTCTCC  CTGGCCGGGT  GTTGGTGCAG  CCAAGCGCAC  CACATATGGA  2280
2281  GGGGTGTCGG  GTAATGCCAT  TAGACCGATC  GCTCTCAAAG  CAGTGTCAGC  CATTGCTAAA  2340
2341  GCAATCCCAG  GTTTCCCTAT  TCTGGCCACC  GGAGGGATTG  ACTCTGCAGA  AACTGGGCTG  2400
2401  CAGTTTCTTC  ATGCAGGGGC  GTCTGTGCTG  CAGGTTTGCA  GTGCAATCCA  GAACCAGGAC  2460
2461  TTCACAGTGA  TTGAAGATTA  CTGTTTGGGG  CTGAAGGCCT  TGTTGTACCT  GAAGAGCCTG  2520
2521  GAACTGAAGG  ACTGGGATGG  TCAGTCTCCT  CCAACTCAGA  AGCATCAGAA  AGGAAAATCT  2580
2581  GTTCCCAAAG  TACAAGAGCT  AGTTGGCAAG  GGACTCCCCA  GCTTTGGCCC  ATACCTCCAG  2640
2641  CAAAAGACCG  AAGCTATTGC  AAAGTACAAG  AAAAAGCTCA  GAGATGCTGG  TGAAACAGAT  2700
2701  GTAAAGCAGC  CCAACATCAG  CAGAATCAAC  ACCCCCCCAA  AGCCTGTTCC  TGCAGTCAAG  2760
2761  GATGTGATAG  CCAGAGCATT  ACGCCACATT  GGAGCATACC  AGGAACTTGA  CAACATGGAG  2820
2821  CAGGTCCAGG  CTTTGATAGA  TGAAGATATG  TGCATCAACT  GTGGTAAATG  TTATATGACC  2880
2881  TGCAATGACT  CTGGATACCA  GGCTATACAG  TTCGACCCAG  AGACCCACCT  TCCTTTTGTG  2940
2941  ACTGACAGCT  GCACAGGTTG  CACTTTGTGC  CTCACTGTGT  GTCCAATCAT  AGACTGCATC  3000
3001  CAGATGGTTA  CCAGGAAGAC  ACCTCACATA  CCACAGAGGG  GTATACCGAT  AAATCCTGTC  3060
3061  TGCTGA  3066

▼ KEYWORD


ID
Family
4Fe-4S
Coiled coil
Complete proteome
FAD
Flavoprotein
FMN
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
Dihydropyrimidine dehydrogenase (NADP+) activity
Molecular Function
Dihydrouracil dehydrogenase (NAD+) activity
Molecular Function
Iron-sulfur cluster binding
Molecular Function
NADH dehydrogenase activity
Molecular Function
NADP binding
Molecular Function
Protein homodimerization activity
Molecular Function
Uracil binding
Biological Process
Beta-alanine biosynthetic process
Biological Process
Thymine catabolic process
Biological Process
Uracil catabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-1590Poecilia formosa90.780.01870
LLPS-Xim-0774Xiphophorus maculatus90.390.01864
LLPS-Orn-2463Oreochromis niloticus89.710.01853
LLPS-Gaa-1859Gasterosteus aculeatus88.830.01859
LLPS-Scm-2954Scophthalmus maximus88.440.01832
LLPS-Ten-3236Tetraodon nigroviridis85.740.01792
LLPS-Tar-3380Takifugu rubripes84.040.01714
LLPS-Icp-3763Ictalurus punctatus83.110.01739
LLPS-Asm-4146Astyanax mexicanus82.460.01732
LLPS-Myl-3381Myotis lucifugus79.780.0 627
LLPS-Scf-1444Scleropages formosus78.820.01665
LLPS-Anp-2814Anas platyrhynchos78.20.01279
LLPS-Leo-2552Lepisosteus oculatus78.120.01657
LLPS-Dar-3357Danio rerio77.870.01117
LLPS-Cas-2764Carlito syrichta77.60.01235
LLPS-Ora-2969Ornithorhynchus anatinus76.680.0 594
LLPS-Pes-0979Pelodiscus sinensis76.320.01477
LLPS-Otg-0938Otolemur garnettii76.270.01618
LLPS-Orc-3304Oryctolagus cuniculus75.980.01611
LLPS-Maf-1497Macaca fascicularis75.910.01596
LLPS-Nol-1133Nomascus leucogenys75.880.01608
LLPS-Eqc-2118Equus caballus75.880.01611
LLPS-Cea-0330Cercocebus atys75.810.01594
LLPS-Chs-1530Chlorocebus sabaeus75.780.01613
LLPS-Mal-1964Mandrillus leucophaeus75.780.01611
LLPS-Man-1020Macaca nemestrina75.780.01611
LLPS-Mam-1552Macaca mulatta75.730.01601
LLPS-Sus-0161Sus scrofa75.710.01593
LLPS-Ova-2094Ovis aries75.710.01610
LLPS-Paa-3063Papio anubis75.680.01608
LLPS-Hos-4848Homo sapiens75.680.01611
LLPS-Loa-3812Loxodonta africana75.680.01611
LLPS-Poa-0031Pongo abelii75.680.01597
LLPS-Fia-2457Ficedula albicollis75.620.01581
LLPS-Pat-1807Pan troglodytes75.590.01611
LLPS-Pap-0360Pan paniscus75.590.01610
LLPS-Tag-2394Taeniopygia guttata75.520.01428
LLPS-Caj-2280Callithrix jacchus75.390.01604
LLPS-Gaga-2618Gallus gallus75.390.01603
LLPS-Aon-2945Aotus nancymaae75.20.01602
LLPS-Cap-1759Cavia porcellus75.20.01595
LLPS-Mum-3963Mus musculus75.10.01603
LLPS-Dio-1819Dipodomys ordii75.10.01601
LLPS-Anc-1406Anolis carolinensis75.10.01594
LLPS-Bot-0888Bos taurus74.880.01593
LLPS-Aim-0448Ailuropoda melanoleuca74.680.01589
LLPS-Caf-2363Canis familiaris74.60.01548
LLPS-Meg-1623Meleagris gallopavo74.530.01219
LLPS-Sah-0144Sarcophilus harrisii74.510.01598
LLPS-Urm-0650Ursus maritimus74.470.01474
LLPS-Fec-0417Felis catus74.340.01588
LLPS-Mod-1001Monodelphis domestica74.290.01579
LLPS-Mup-2522Mustela putorius furo74.240.01586
LLPS-Fud-0320Fukomys damarensis74.220.01580
LLPS-Rhb-3246Rhinopithecus bieti74.090.01525
LLPS-Ran-1002Rattus norvegicus71.890.01423
LLPS-Cii-0550Ciona intestinalis70.590.01469
LLPS-Ict-0960Ictidomys tridecemlineatus69.660.01442
LLPS-Mea-3291Mesocricetus auratus69.050.01416
LLPS-Cis-0387Ciona savignyi68.840.01456
LLPS-Xet-1923Xenopus tropicalis68.650.01328
LLPS-Gog-0902Gorilla gorilla67.020.0 642
LLPS-Cae-0370Caenorhabditis elegans65.010.01316
LLPS-Drm-1160Drosophila melanogaster64.460.01304
LLPS-Mua-0779Musa acuminata39.816e-64 228
LLPS-Sem-1430Selaginella moellendorffii38.963e-64 228
LLPS-Phv-0703Phaseolus vulgaris38.514e-63 225
LLPS-Prp-0679Prunus persica38.514e-62 222
LLPS-Php-0862Physcomitrella patens38.362e-64 229
LLPS-Glm-2657Glycine max38.192e-62 223
LLPS-Sot-1545Solanum tuberosum38.193e-62 223
LLPS-Gor-0996Gossypium raimondii38.197e-62 221
LLPS-Thc-2302Theobroma cacao37.862e-61 220
LLPS-Via-0342Vigna angularis37.864e-61 222
LLPS-Amt-1887Amborella trichopoda37.861e-63 227
LLPS-Dac-0184Daucus carota37.742e-61 220
LLPS-Brr-2844Brassica rapa37.749e-60 216
LLPS-Vir-1626Vigna radiata37.542e-61 221
LLPS-Mae-2030Manihot esculenta37.541e-61 221
LLPS-Bro-2723Brassica oleracea37.543e-58 211
LLPS-Viv-0767Vitis vinifera37.184e-61 219
LLPS-Coc-1353Corchorus capsularis37.184e-58 223
LLPS-Sol-0515Solanum lycopersicum37.132e-62 224
LLPS-Pot-0039Populus trichocarpa37.065e-62 222
LLPS-Art-0073Arabidopsis thaliana36.999e-61 218
LLPS-Brn-2235Brassica napus36.895e-60 217
LLPS-Hea-2190Helianthus annuus36.651e-59 215
LLPS-Nia-0575Nicotiana attenuata36.58e-62 222
LLPS-Lep-0482Leersia perrieri34.881e-66 235
LLPS-Orbr-0091Oryza brachyantha34.612e-66 234
LLPS-Met-0796Medicago truncatula34.562e-62 223
LLPS-Sei-2043Setaria italica34.464e-64 228
LLPS-Brd-0924Brachypodium distachyon34.461e-61 221
LLPS-Orni-1263Oryza nivara34.376e-65 230
LLPS-Ori-0506Oryza indica34.376e-65 230
LLPS-Ors-1153Oryza sativa34.376e-65 230
LLPS-Org-0933Oryza glaberrima34.376e-65 230
LLPS-Orr-1555Oryza rufipogon34.376e-65 230
LLPS-Cus-0885Cucumis sativus34.229e-62 221
LLPS-Arl-0047Arabidopsis lyrata34.221e-61 221
LLPS-Sob-1046Sorghum bicolor34.195e-64 228
LLPS-Orb-0563Oryza barthii34.112e-64 230
LLPS-Hov-1887Hordeum vulgare34.112e-63 226
LLPS-Tra-2019Triticum aestivum34.119e-64 227
LLPS-Orgl-0943Oryza glumaepatula34.112e-64 230
LLPS-Chr-0862Chlamydomonas reinhardtii34.044e-58 211
LLPS-Zem-0251Zea mays33.512e-63 226
LLPS-Orp-0561Oryza punctata33.085e-60 218
LLPS-Tru-0240Triticum urartu32.162e-51 190
LLPS-Asfu-0686Aspergillus fumigatus28.337e-1790.9
LLPS-Spr-0911Sporisorium reilianum28.162e-0965.5
LLPS-Asc-1491Aspergillus clavatus27.916e-1894.4
LLPS-Pug-1387Puccinia graminis27.542e-1585.9
LLPS-Put-0384Puccinia triticina27.545e-1688.2
LLPS-Mel-1452Melampsora laricipopulina27.135e-1894.7
LLPS-Usm-0266Ustilago maydis27.011e-0863.5
LLPS-Beb-1469Beauveria bassiana26.851e-1380.1
LLPS-Asn-0855Aspergillus nidulans26.462e-1999.4
LLPS-Sac-0233Saccharomyces cerevisiae26.424e-1378.2
LLPS-Pyt-0098Pyrenophora teres26.423e-1585.5
LLPS-Pytr-0506Pyrenophora triticirepentis26.422e-1586.3
LLPS-Asg-1161Ashbya gossypii26.068e-1584.0
LLPS-Ast-1041Aspergillus terreus26.043e-1791.7
LLPS-Nef-1149Neosartorya fischeri25.971e-1690.1
LLPS-Scp-1090Schizosaccharomyces pombe25.894e-1998.2
LLPS-Map-0122Magnaporthe poae25.758e-1170.9
LLPS-Tut-1747Tursiops truncatus25.743e-0758.2
LLPS-Asni-0785Aspergillus niger25.737e-1894.0
LLPS-Coo-0885Colletotrichum orbiculare25.323e-1585.5
LLPS-Nec-0845Neurospora crassa25.326e-1687.8
LLPS-Cogr-0822Colletotrichum graminicola25.317e-1377.8
LLPS-Kop-1010Komagataella pastoris25.171e-1070.1
LLPS-Yal-1255Yarrowia lipolytica25.144e-1585.1
LLPS-Abg-1912Absidia glauca25.052e-1482.4
LLPS-Blg-1429Blumeria graminis25.051e-1483.6
LLPS-Ved-0786Verticillium dahliae25.05e-1481.3
LLPS-Fuv-0783Fusarium verticillioides24.772e-1586.3
LLPS-Fus-1124Fusarium solani24.771e-1483.2
LLPS-Fuo-1587Fusarium oxysporum24.683e-1585.5
LLPS-Aso-1296Aspergillus oryzae24.652e-1689.4
LLPS-Scc-1481Schizosaccharomyces cryophilus24.616e-1687.8
LLPS-Mao-1255Magnaporthe oryzae24.532e-1276.3
LLPS-Trr-0498Trichoderma reesei24.436e-1687.4
LLPS-Lem-1603Leptosphaeria maculans24.323e-1585.5
LLPS-Phn-0026Phaeosphaeria nodorum24.272e-1792.4
LLPS-Trv-1012Trichoderma virens24.173e-1585.5
LLPS-Gag-0955Gaeumannomyces graminis23.945e-1171.6
LLPS-Miv-1519Microbotryum violaceum23.948e-1274.3
LLPS-Dos-1297Dothistroma septosporum23.761e-1380.5
LLPS-Crn-0733Cryptococcus neoformans23.733e-1585.5
LLPS-Asf-1546Aspergillus flavus23.644e-1172.0
LLPS-Zyt-0934Zymoseptoria tritici22.92e-1586.3
LLPS-Scj-0219Schizosaccharomyces japonicus22.037e-1584.0
LLPS-Orm-1277Oryza meridionalis21.962e-1172.8