• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-0888
DPYD

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name: DPYD
Ensembl Gene: ENSBTAG00000031358.4
Ensembl Protein: ENSBTAP00000070230.1
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAPVLSKDVA  DIESILALNP  RTQSRATLRS  TLAKKLDKKH  WKRNPDKNCF  NCEKLENNFD  60
61    DIKHTTLGER  GALREAMRCL  KCADAPCQKS  CPTNLDIKSF  ITSISNKNYY  GAAKMIFSDN  120
121   PLGLTCGMVC  PTSDLCVGGC  NLYATEEGPI  NIGGLQQYAT  EVFKAMNIPQ  IRNPSLPPPE  180
181   KMPEAYSAKI  VLLGAGPASI  SCASFLARLG  YNDITIFEKQ  EYVGGLSTSE  IPQFRLPHDV  240
241   VNFEIELMKD  LGVKIICGKS  LSVNDITLST  LKEEGYKAAF  IGIGLPEPKK  DHIFQGLTQD  300
301   QGFYTSKDFL  PLVAKSSKAG  MCACHSPLLS  IRGTVIVLGA  GDTAFDCATS  ALRCGARRVF  360
361   IVFRKGFVNI  RAVPEEVELA  REEKCEFLPF  LSPRKVIVKG  GRIVAMQFVR  TEQDETGKWN  420
421   EDEDQIVCLK  ADVVISAFGS  VLSDPKVKEA  LSPIKFNRWD  LPEVDPETMQ  TSEPWVFAGG  480
481   DVVGIANTTV  EAVNDGKQAS  WYIHRYIQSQ  YGASVSAKPE  LPLFYTPIDL  VDISVEMAGL  540
541   KFTNPFGLAS  ATPTTSSSMI  RRAFEAGWAF  ALTKTFSLDK  DIVTNVSPRI  IRGTTSGPMY  600
601   GPGQSSFLNI  ELISEKTAAY  WCQSVTELKA  DFPDNIVIAS  IMCSYNRNDW  MELSRKAEAS  660
661   GADALELNLS  CPHGMGERGM  GLACGQDPEL  VRNICRWVRQ  AVRIPFFAKL  TPNVTDIVSI  720
721   ARAAKEGGAN  GVTATNTVSG  LMGLKADGTP  WPAVGREKRT  TYGGVSGTAI  RPIALRAVTT  780
781   IARALPEFPI  LATGGIDSAE  SGLQFLHGGA  SVLQVCSAIQ  NQDFTIIQDY  CTGLKALLYL  840
841   KSIEELQDWD  GQSPATKSHQ  KGKPVPCIAE  LVGKKLPSFG  PYLEKRKKII  AEEKLRLKKE  900
901   NVTVLPLERN  HFIPKKPIPS  VKDVIGKALQ  YLGTYGELNN  TEQVVAVIDE  EMCINCGKCY  960
961   MTCNDSGYQA  IQFDPETHLP  TVTDTCTGCT  LCLSVCPIID  CIKMVSRTTP  YEPKRGLPLA  1020
1021  VNPVS  1025
Nucleotide CDS Sequence (FASTA)
1     ATGGCCCCTG  TGCTAAGCAA  GGACGTGGCG  GATATCGAGA  GTATCCTGGC  TTTAAATCCT  60
61    CGAACACAGT  CTCGTGCAAC  TCTGCGTTCC  ACTTTGGCCA  AGAAATTAGA  CAAGAAACAT  120
121   TGGAAAAGAA  ATCCTGATAA  GAACTGCTTT  AATTGCGAGA  AGCTGGAGAA  TAATTTTGAT  180
181   GACATCAAGC  ACACGACTCT  TGGTGAGCGA  GGAGCTCTCC  GAGAAGCAAT  GAGATGCCTG  240
241   AAATGTGCAG  ATGCCCCCTG  TCAGAAGAGC  TGTCCAACAA  ATCTAGATAT  CAAATCGTTC  300
301   ATCACAAGTA  TCTCAAACAA  GAACTATTAT  GGAGCTGCTA  AGATGATATT  TTCTGACAAC  360
361   CCACTTGGTC  TGACCTGTGG  AATGGTATGC  CCCACCTCTG  ATCTTTGTGT  AGGTGGATGT  420
421   AATTTGTATG  CCACTGAAGA  GGGACCAATT  AATATTGGTG  GATTGCAGCA  ATATGCTACT  480
481   GAGGTATTCA  AAGCAATGAA  TATCCCACAA  ATCAGGAATC  CTTCTCTGCC  TCCCCCAGAA  540
541   AAAATGCCTG  AAGCCTATTC  TGCAAAGATT  GTTCTTTTGG  GTGCTGGGCC  TGCAAGTATA  600
601   AGTTGTGCTT  CGTTCTTGGC  TCGATTAGGC  TACAATGACA  TCACTATATT  TGAAAAACAA  660
661   GAATACGTTG  GTGGTTTAAG  TACTTCTGAA  ATCCCTCAGT  TCCGGCTGCC  ACATGATGTA  720
721   GTAAATTTTG  AGATTGAGCT  TATGAAGGAC  CTTGGTGTAA  AGATAATTTG  TGGTAAAAGC  780
781   CTTTCAGTGA  ATGACATTAC  TCTTAGTACT  TTGAAAGAAG  AAGGGTACAA  AGCTGCTTTC  840
841   ATTGGGATAG  GTTTGCCAGA  ACCCAAGAAG  GATCACATCT  TCCAAGGCCT  GACACAGGAC  900
901   CAGGGGTTTT  ACACTTCCAA  AGACTTTCTG  CCTCTTGTAG  CCAAAAGCAG  TAAAGCAGGA  960
961   ATGTGCGCCT  GTCACTCTCC  ATTGCTGTCG  ATACGGGGAA  CCGTGATTGT  ACTCGGAGCT  1020
1021  GGAGACACAG  CTTTCGACTG  TGCAACATCC  GCTTTACGTT  GTGGAGCCCG  CCGAGTGTTC  1080
1081  ATCGTCTTCA  GAAAAGGCTT  TGTTAATATA  AGAGCTGTCC  CTGAGGAGGT  GGAGCTTGCT  1140
1141  AGAGAAGAAA  AATGTGAATT  TTTGCCTTTC  TTGTCTCCAC  GGAAGGTTAT  AGTAAAAGGT  1200
1201  GGGAGAATTG  TTGCCATGCA  ATTTGTTCGG  ACAGAGCAAG  ATGAAACTGG  AAAATGGAAT  1260
1261  GAAGATGAAG  ATCAGATAGT  CTGTCTGAAA  GCCGATGTGG  TCATCAGTGC  CTTTGGCTCA  1320
1321  GTTCTGAGTG  ATCCTAAAGT  AAAAGAAGCC  TTGAGCCCTA  TAAAATTTAA  CAGATGGGAT  1380
1381  CTCCCAGAAG  TAGATCCAGA  AACTATGCAA  ACCAGTGAGC  CATGGGTGTT  TGCAGGTGGT  1440
1441  GATGTGGTTG  GTATAGCCAA  CACTACAGTG  GAAGCCGTGA  ATGATGGAAA  GCAAGCCTCT  1500
1501  TGGTACATTC  ACAGATATAT  ACAGTCACAA  TATGGAGCTT  CAGTTTCTGC  TAAGCCCGAA  1560
1561  CTCCCCCTGT  TTTATACTCC  CATTGATCTG  GTGGACATTA  GTGTGGAAAT  GGCTGGATTG  1620
1621  AAGTTTACAA  ATCCTTTTGG  TCTTGCCAGT  GCAACTCCAA  CTACCAGTTC  GTCAATGATT  1680
1681  CGAAGAGCTT  TTGAAGCTGG  ATGGGCCTTT  GCTCTGACCA  AAACTTTCTC  TCTTGATAAG  1740
1741  GATATAGTGA  CAAATGTTTC  ACCCAGAATC  ATCCGGGGGA  CCACCTCTGG  CCCCATGTAT  1800
1801  GGCCCTGGAC  AAAGCTCTTT  CCTGAATATT  GAGCTCATCA  GTGAAAAAAC  GGCTGCATAT  1860
1861  TGGTGTCAAA  GTGTCACTGA  ACTAAAAGCC  GACTTTCCAG  ACAATATTGT  GATTGCTAGC  1920
1921  ATCATGTGCA  GTTACAACAG  AAATGACTGG  ATGGAACTCT  CCAGAAAGGC  TGAGGCTTCT  1980
1981  GGAGCAGACG  CCCTGGAGTT  AAATTTATCG  TGTCCGCATG  GCATGGGAGA  AAGAGGAATG  2040
2041  GGTCTGGCTT  GTGGACAGGA  TCCAGAGCTG  GTGCGGAACA  TCTGTCGCTG  GGTTAGGCAA  2100
2101  GCTGTTCGGA  TTCCTTTTTT  TGCCAAGTTG  ACCCCAAATG  TCACTGATAT  TGTAAGCATA  2160
2161  GCCAGAGCTG  CAAAGGAAGG  TGGGGCAAAT  GGTGTTACAG  CTACCAACAC  TGTCTCAGGT  2220
2221  CTCATGGGAT  TAAAAGCTGA  TGGCACACCC  TGGCCAGCAG  TGGGCCGTGA  GAAGCGGACT  2280
2281  ACATACGGCG  GAGTGTCCGG  CACAGCCATC  AGACCTATTG  CTTTGAGAGC  TGTGACCACC  2340
2341  ATTGCTCGTG  CTTTGCCTGA  ATTTCCCATT  TTGGCCACTG  GTGGAATTGA  CTCAGCTGAA  2400
2401  AGTGGTCTTC  AGTTTCTCCA  CGGTGGTGCT  TCGGTGCTCC  AGGTATGCAG  TGCTATTCAA  2460
2461  AATCAGGATT  TCACTATCAT  CCAAGACTAC  TGCACTGGCC  TCAAAGCCTT  GCTTTATCTG  2520
2521  AAAAGCATTG  AAGAACTACA  GGACTGGGAT  GGGCAGAGTC  CAGCCACGAA  GAGTCACCAG  2580
2581  AAAGGGAAAC  CAGTCCCTTG  TATTGCTGAA  CTTGTGGGAA  AGAAACTGCC  AAGCTTTGGA  2640
2641  CCTTATCTTG  AGAAGCGCAA  GAAAATCATA  GCAGAGGAAA  AGTTGAGACT  GAAAAAAGAA  2700
2701  AATGTGACCG  TTCTACCACT  TGAAAGAAAC  CATTTTATCC  CAAAAAAACC  TATTCCTTCT  2760
2761  GTTAAGGATG  TGATTGGAAA  AGCTCTGCAG  TACCTTGGAA  CATATGGTGA  ACTGAACAAC  2820
2821  ACAGAGCAGG  TTGTGGCTGT  GATCGATGAA  GAGATGTGTA  TCAACTGTGG  CAAATGCTAC  2880
2881  ATGACCTGTA  ATGACTCTGG  CTACCAGGCT  ATCCAGTTTG  ATCCTGAAAC  CCACCTGCCC  2940
2941  ACCGTTACTG  ACACTTGTAC  AGGCTGTACC  CTGTGTCTCT  CCGTCTGCCC  TATTATCGAC  3000
3001  TGCATCAAAA  TGGTTTCCAG  GACAACACCT  TATGAACCAA  AGAGAGGCTT  GCCCTTGGCT  3060
3061  GTGAATCCTG  TGTCTTAA  3078

▼ KEYWORD


ID
Family
4Fe-4S
Complete proteome
FAD
Flavoprotein
FMN
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
Dihydropyrimidine dehydrogenase (NADP+) activity
Molecular Function
Dihydrouracil dehydrogenase (NAD+) activity
Molecular Function
Iron-sulfur cluster binding
Molecular Function
NADH dehydrogenase activity
Molecular Function
NADP binding
Molecular Function
Protein homodimerization activity
Molecular Function
Uracil binding
Biological Process
Beta-alanine biosynthetic process
Biological Process
Purine nucleobase catabolic process
Biological Process
Thymidine catabolic process
Biological Process
Thymine catabolic process
Biological Process
Uracil catabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-2094Ovis aries97.560.02070
LLPS-Sus-0161Sus scrofa93.360.01989
LLPS-Hos-4848Homo sapiens92.680.01981
LLPS-Pap-0360Pan paniscus92.580.01979
LLPS-Pat-1807Pan troglodytes92.580.01980
LLPS-Myl-3381Myotis lucifugus92.570.0 725
LLPS-Nol-1133Nomascus leucogenys92.480.01979
LLPS-Otg-0938Otolemur garnettii92.190.01974
LLPS-Man-1020Macaca nemestrina92.190.01975
LLPS-Mal-1964Mandrillus leucophaeus92.190.01974
LLPS-Cea-0330Cercocebus atys92.180.01947
LLPS-Paa-3063Papio anubis92.090.01971
LLPS-Maf-1497Macaca fascicularis92.080.01944
LLPS-Aon-2945Aotus nancymaae91.990.01965
LLPS-Orc-3304Oryctolagus cuniculus91.980.01973
LLPS-Eqc-2118Equus caballus91.890.01966
LLPS-Chs-1530Chlorocebus sabaeus91.890.01971
LLPS-Loa-3812Loxodonta africana91.80.01966
LLPS-Poa-0031Pongo abelii91.80.01956
LLPS-Caj-2280Callithrix jacchus91.70.01960
LLPS-Mam-1552Macaca mulatta91.660.01952
LLPS-Fud-0320Fukomys damarensis91.510.01938
LLPS-Fec-0417Felis catus91.10.01945
LLPS-Aim-0448Ailuropoda melanoleuca91.10.01949
LLPS-Urm-0650Ursus maritimus91.010.01801
LLPS-Caf-2363Canis familiaris90.980.01894
LLPS-Mup-2522Mustela putorius furo90.510.01937
LLPS-Cap-1759Cavia porcellus90.330.01940
LLPS-Rhb-3246Rhinopithecus bieti88.880.01868
LLPS-Dio-1819Dipodomys ordii88.870.01913
LLPS-Cas-2764Carlito syrichta88.280.01413
LLPS-Mum-3963Mus musculus88.090.01894
LLPS-Mod-1001Monodelphis domestica87.010.01880
LLPS-Sah-0144Sarcophilus harrisii86.820.01885
LLPS-Pes-0979Pelodiscus sinensis86.080.01695
LLPS-Ict-0960Ictidomys tridecemlineatus85.940.01800
LLPS-Ora-2969Ornithorhynchus anatinus85.380.0 695
LLPS-Anp-2814Anas platyrhynchos85.210.01426
LLPS-Ran-1002Rattus norvegicus84.580.01670
LLPS-Gaga-2618Gallus gallus84.080.01811
LLPS-Anc-1406Anolis carolinensis83.980.01807
LLPS-Tag-2394Taeniopygia guttata83.860.01635
LLPS-Fia-2457Ficedula albicollis83.850.01795
LLPS-Gog-0902Gorilla gorilla82.240.0 775
LLPS-Meg-1623Meleagris gallopavo81.430.01352
LLPS-Mea-3291Mesocricetus auratus81.350.01694
LLPS-Leo-2552Lepisosteus oculatus79.040.01719
LLPS-Asm-4146Astyanax mexicanus78.480.01693
LLPS-Icp-3763Ictalurus punctatus77.140.01677
LLPS-Pof-1590Poecilia formosa76.420.01627
LLPS-Xim-0774Xiphophorus maculatus76.230.01619
LLPS-Scf-1444Scleropages formosus75.940.01651
LLPS-Dar-3357Danio rerio75.890.01140
LLPS-Orl-0025Oryzias latipes75.760.01627
LLPS-Gaa-1859Gasterosteus aculeatus75.560.01644
LLPS-Xet-1923Xenopus tropicalis75.110.01469
LLPS-Ten-3236Tetraodon nigroviridis74.850.01607
LLPS-Orn-2463Oreochromis niloticus74.80.01608
LLPS-Scm-2954Scophthalmus maximus74.710.01609
LLPS-Tar-3380Takifugu rubripes73.020.01556
LLPS-Cii-0550Ciona intestinalis71.180.01517
LLPS-Cis-0387Ciona savignyi69.080.01498
LLPS-Drm-1160Drosophila melanogaster65.150.01340
LLPS-Cae-0370Caenorhabditis elegans65.020.01362
LLPS-Sem-1430Selaginella moellendorffii39.092e-67 237
LLPS-Php-0862Physcomitrella patens39.01e-68 241
LLPS-Brd-0924Brachypodium distachyon38.763e-65 231
LLPS-Amt-1887Amborella trichopoda38.511e-68 241
LLPS-Lep-0482Leersia perrieri38.426e-69 241
LLPS-Prp-0679Prunus persica38.218e-66 233
LLPS-Dac-0184Daucus carota38.182e-66 235
LLPS-Ors-1153Oryza sativa38.123e-68 239
LLPS-Org-0933Oryza glaberrima38.123e-68 239
LLPS-Orr-1555Oryza rufipogon38.123e-68 239
LLPS-Orni-1263Oryza nivara38.123e-68 239
LLPS-Orb-0563Oryza barthii38.126e-68 239
LLPS-Ori-0506Oryza indica38.123e-68 239
LLPS-Hov-1887Hordeum vulgare38.122e-67 237
LLPS-Tra-2019Triticum aestivum38.122e-67 237
LLPS-Orgl-0943Oryza glumaepatula38.126e-68 239
LLPS-Orbr-0091Oryza brachyantha38.025e-68 239
LLPS-Sol-0515Solanum lycopersicum37.911e-66 235
LLPS-Sot-1545Solanum tuberosum37.918e-67 236
LLPS-Phv-0703Phaseolus vulgaris37.611e-64 229
LLPS-Thc-2302Theobroma cacao37.614e-65 231
LLPS-Mua-0779Musa acuminata37.615e-66 233
LLPS-Glm-2450Glycine max37.581e-64 229
LLPS-Nia-0575Nicotiana attenuata37.316e-66 233
LLPS-Gor-0996Gossypium raimondii37.311e-64 229
LLPS-Pot-0039Populus trichocarpa37.311e-65 232
LLPS-Vir-1626Vigna radiata37.312e-64 229
LLPS-Via-0342Vigna angularis37.313e-63 228
LLPS-Sei-2043Setaria italica37.242e-65 232
LLPS-Art-0073Arabidopsis thaliana37.161e-62 224
LLPS-Arl-0047Arabidopsis lyrata37.165e-62 222
LLPS-Viv-0767Vitis vinifera37.135e-65 230
LLPS-Coc-1353Corchorus capsularis37.139e-61 231
LLPS-Brr-2844Brassica rapa37.058e-63 224
LLPS-Met-0796Medicago truncatula37.019e-64 227
LLPS-Zem-0251Zea mays36.953e-65 231
LLPS-Bro-2723Brassica oleracea36.861e-61 221
LLPS-Cus-0885Cucumis sativus36.841e-64 229
LLPS-Brn-3266Brassica napus36.751e-61 221
LLPS-Mae-2030Manihot esculenta36.721e-64 229
LLPS-Orp-0561Oryza punctata36.542e-63 228
LLPS-Tru-0240Triticum urartu36.425e-57 206
LLPS-Hea-2190Helianthus annuus36.423e-62 223
LLPS-Sob-1046Sorghum bicolor35.421e-65 232
LLPS-Chr-0862Chlamydomonas reinhardtii34.694e-60 217
LLPS-Yal-1490Yarrowia lipolytica30.112e-0862.0
LLPS-Spr-0911Sporisorium reilianum28.14e-0861.6
LLPS-Miv-0843Microbotryum violaceum27.59e-0653.9
LLPS-Usm-0266Ustilago maydis26.473e-0758.9
LLPS-Put-0384Puccinia triticina26.091e-1689.7
LLPS-Mel-1452Melampsora laricipopulina25.688e-1687.4
LLPS-Sac-0200Saccharomyces cerevisiae25.326e-1168.9
LLPS-Pytr-0506Pyrenophora triticirepentis24.373e-1792.0
LLPS-Pyt-0098Pyrenophora teres24.374e-1791.3
LLPS-Scc-1481Schizosaccharomyces cryophilus24.122e-1792.4
LLPS-Cogr-0822Colletotrichum graminicola24.12e-1792.4
LLPS-Coo-0885Colletotrichum orbiculare24.083e-1895.1
LLPS-Crn-0733Cryptococcus neoformans23.983e-1585.5
LLPS-Trr-0498Trichoderma reesei23.681e-1586.7
LLPS-Asn-0855Aspergillus nidulans23.671e-1793.2
LLPS-Ved-0786Verticillium dahliae23.632e-1482.4
LLPS-Phn-0026Phaeosphaeria nodorum23.622e-1792.4
LLPS-Lem-1603Leptosphaeria maculans23.62e-1689.7
LLPS-Asni-0785Aspergillus niger23.542e-1792.8
LLPS-Asfu-0686Aspergillus fumigatus23.53e-1585.5
LLPS-Mao-1255Magnaporthe oryzae23.476e-1687.8
LLPS-Scp-1090Schizosaccharomyces pombe23.332e-1999.0
LLPS-Aso-1296Aspergillus oryzae23.331e-1483.6
LLPS-Map-0122Magnaporthe poae23.261e-1483.2
LLPS-Pug-1387Puccinia graminis23.244e-1688.2
LLPS-Scj-1496Schizosaccharomyces japonicus23.141e-0862.8
LLPS-Zyt-0934Zymoseptoria tritici23.099e-1893.6
LLPS-Nef-1149Neosartorya fischeri23.031e-1483.2
LLPS-Ast-1041Aspergillus terreus22.936e-1584.3
LLPS-Trv-1012Trichoderma virens22.857e-1584.3
LLPS-Asc-1491Aspergillus clavatus22.552e-1689.0
LLPS-Beb-1469Beauveria bassiana22.431e-1380.1
LLPS-Dos-1297Dothistroma septosporum21.572e-1379.7
LLPS-Orm-1277Oryza meridionalis21.275e-1584.7