• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pat-4006
RRM1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribonucleoside-diphosphate reductase
Gene Name: RRM1, CK820_G0053213
Ensembl Gene: ENSPTRG00000003207.3
Ensembl Protein: ENSPTRP00000005668.2
Organism: Pan troglodytes
Taxa ID: 9598
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHVIKRDGRQ  ERVMFDKITS  RIQKLCYGLN  MDFVDPAQIT  MKVIQGLYSG  VTTVELDTLA  60
61    AETAATLTTK  HPDYAILAAR  IAVSNLHKET  KKVFSDVMED  LYNYINPHNG  KHSPMVAKST  120
121   LDIVLANKDR  LNSAIIYDRD  FSYNYFGFKT  LERSYLLKIN  GKVAERPQHM  LMRVSVGIHK  180
181   EDIDAAIETY  NLLSERWFTH  ASPTLFNAGT  NRPQLSSCFL  LSMKDDSIEG  IYDTLKQCAL  240
241   ISKSAGGIGV  AVSCIRATGS  YIAGTNGNSN  GLVPMLRVYN  NTARYVDQGG  NKRPGAFAIY  300
301   LEPWHLDIFE  FLDLKKNTGK  EEQRARDLFF  ALWIPDLFMK  RVETNQDWSL  MCPNECPGLD  360
361   EVWGEEFEKL  YASYEKQGRV  RKVVKAQQLW  YAIIESQTET  GTPYMLYKDS  CNRKSNQQNL  420
421   GTIKCSNLCT  EIVEYTSKDE  VAVCNLASLA  LNMYVTSEHT  YDFKKLAEVT  KVVVRNLNKI  480
481   IDINYYPVPE  ACLSNKRHRP  IGIGVQGLAD  AFILMRYPFE  SAEAQLLNKQ  IFETIYYGAL  540
541   EASCDLAKEQ  GPYETYEGSP  VSKGILQYDM  WNVTPTDLWD  WKLLKEKIAK  YGIRNSLLIA  600
601   PMPTASTAQI  LGNNESIEPY  TSNIYTRRVL  SGEFQIVNPH  LLKDLTERGL  WHEEMKNQII  660
661   ACNGSIQSIP  EIPDDLKQLY  KTVWEISQKT  VLKMAAERGA  FIDQSQSLNI  HIAEPNYGKL  720
721   TSMHFYGWKQ  GLKTGMYYLR  TRPAANPIQF  TLNKEKLKDK  EKVSKEEEEK  ERNTAAMVCS  780
781   LENRDECLMC  GS  792
Nucleotide CDS Sequence (FASTA)
1     ATGCATGTGA  TCAAGCGAGA  TGGCCGCCAA  GAACGAGTCA  TGTTTGACAA  AATTACATCT  60
61    CGAATCCAGA  AGCTTTGTTA  TGGACTTAAT  ATGGATTTTG  TTGATCCTGC  TCAGATCACC  120
121   ATGAAAGTAA  TCCAAGGCTT  GTACAGTGGG  GTCACCACAG  TGGAACTAGA  TACTCTGGCT  180
181   GCTGAAACAG  CTGCAACCTT  GACTACTAAG  CACCCTGACT  ATGCTATCCT  GGCAGCCAGG  240
241   ATCGCTGTCT  CTAACTTGCA  CAAAGAAACA  AAGAAAGTGT  TCAGTGATGT  GATGGAAGAC  300
301   CTCTATAACT  ACATAAATCC  ACATAATGGC  AAGCACTCTC  CCATGGTGGC  CAAGTCAACA  360
361   TTGGATATTG  TTCTGGCCAA  TAAAGATCGC  CTGAATTCTG  CTATTATCTA  TGACCGAGAT  420
421   TTCTCTTACA  ATTACTTCGG  CTTTAAGACG  CTAGAGCGGT  CTTATTTGTT  GAAGATCAAT  480
481   GGAAAAGTGG  CTGAAAGACC  ACAACATATG  TTGATGAGAG  TATCTGTTGG  GATCCACAAA  540
541   GAAGACATTG  ATGCAGCAAT  TGAAACATAT  AATCTTCTTT  CTGAGAGGTG  GTTTACTCAT  600
601   GCTTCGCCCA  CTCTCTTCAA  TGCTGGTACC  AACCGCCCAC  AACTTTCTAG  CTGTTTTCTT  660
661   CTGAGTATGA  AAGATGACAG  CATTGAAGGC  ATTTATGACA  CTCTAAAGCA  ATGTGCATTG  720
721   ATTTCTAAGT  CTGCTGGAGG  AATTGGTGTT  GCTGTGAGTT  GTATTCGGGC  TACTGGCAGC  780
781   TACATTGCTG  GGACTAATGG  CAATTCCAAT  GGTCTTGTAC  CGATGCTGAG  AGTATATAAC  840
841   AACACAGCTC  GATATGTGGA  TCAAGGTGGG  AACAAGCGTC  CTGGGGCATT  TGCTATTTAC  900
901   CTGGAGCCTT  GGCATTTAGA  CATCTTTGAA  TTCCTTGATT  TAAAGAAGAA  CACAGGAAAG  960
961   GAAGAGCAGC  GTGCCAGAGA  TCTTTTCTTT  GCTCTTTGGA  TTCCGGATCT  CTTCATGAAA  1020
1021  CGAGTGGAGA  CTAATCAGGA  CTGGTCTTTG  ATGTGTCCAA  ATGAGTGTCC  TGGTCTGGAT  1080
1081  GAGGTTTGGG  GAGAGGAATT  TGAGAAACTA  TATGCAAGTT  ATGAGAAACA  AGGTCGTGTC  1140
1141  CGCAAAGTTG  TAAAAGCTCA  GCAGCTTTGG  TATGCCATCA  TTGAGTCTCA  GACGGAAACA  1200
1201  GGCACCCCGT  ATATGCTCTA  CAAAGATTCC  TGTAATCGAA  AGAGCAACCA  GCAGAACCTG  1260
1261  GGAACCATCA  AATGCAGCAA  CCTGTGCACA  GAAATAGTGG  AGTACACCAG  CAAAGATGAG  1320
1321  GTTGCTGTTT  GTAATTTGGC  TTCCCTGGCC  CTGAATATGT  ATGTCACATC  AGAACACACA  1380
1381  TACGACTTTA  AGAAGTTGGC  TGAAGTCACT  AAAGTCGTTG  TCCGAAACTT  GAATAAAATT  1440
1441  ATTGATATAA  ACTACTATCC  TGTACCAGAG  GCATGCCTAT  CAAATAAACG  CCATCGCCCC  1500
1501  ATTGGAATTG  GGGTACAAGG  TCTGGCAGAT  GCTTTTATCC  TGATGAGATA  CCCTTTTGAG  1560
1561  AGTGCAGAAG  CCCAGTTACT  GAATAAGCAG  ATCTTTGAAA  CTATTTATTA  TGGTGCTCTG  1620
1621  GAAGCCAGCT  GTGACCTTGC  CAAGGAGCAG  GGCCCATACG  AAACCTATGA  GGGCTCTCCA  1680
1681  GTTAGCAAAG  GAATTCTTCA  GTATGATATG  TGGAATGTTA  CTCCTACAGA  CCTATGGGAC  1740
1741  TGGAAGCTTC  TCAAGGAGAA  GATTGCAAAG  TATGGTATAA  GAAACAGTTT  ACTTATTGCC  1800
1801  CCGATGCCTA  CAGCTTCCAC  TGCTCAGATC  CTGGGGAATA  ATGAGTCCAT  TGAACCTTAC  1860
1861  ACCAGCAACA  TCTATACTCG  CAGAGTCTTG  TCAGGAGAAT  TTCAGATTGT  AAATCCTCAC  1920
1921  TTATTGAAAG  ATCTTACTGA  GCGGGGCCTA  TGGCATGAAG  AGATGAAAAA  CCAGATTATT  1980
1981  GCATGCAATG  GCTCTATTCA  GAGCATACCA  GAAATTCCTG  ATGACCTGAA  GCAACTTTAT  2040
2041  AAAACTGTGT  GGGAAATCTC  TCAGAAAACT  GTTCTCAAGA  TGGCAGCTGA  GAGAGGTGCT  2100
2101  TTCATTGATC  AAAGCCAATC  TTTGAACATC  CACATTGCTG  AGCCTAACTA  TGGCAAACTC  2160
2161  ACTAGTATGC  ACTTCTACGG  CTGGAAGCAG  GGTTTGAAGA  CTGGGATGTA  TTATTTAAGG  2220
2221  ACAAGACCAG  CGGCTAATCC  AATCCAGTTC  ACTCTAAATA  AGGAGAAGCT  AAAAGACAAA  2280
2281  GAAAAGGTAT  CAAAAGAGGA  AGAAGAGAAG  GAGAGGAACA  CAGCAGCCAT  GGTGTGCTCT  2340
2341  TTGGAGAATA  GAGATGAATG  TCTGATGTGT  GGATCCTGA  2379

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
DNA replication
Nucleotide-binding
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Ribonucleoside-diphosphate reductase complex
Molecular Function
ATP binding
Molecular Function
Disordered domain specific binding
Molecular Function
Identical protein binding
Molecular Function
Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Process
Deoxyribonucleotide biosynthetic process
Biological Process
DNA replication
Biological Process
Protein heterotetramerization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-0394Gorilla gorilla100.00.01573
LLPS-Poa-1028Pongo abelii100.00.01573
LLPS-Pap-0215Pan paniscus100.00.01573
LLPS-Nol-1189Nomascus leucogenys99.870.01572
LLPS-Hos-0396Homo sapiens99.870.01572
LLPS-Rhb-3940Rhinopithecus bieti99.650.01149
LLPS-Mal-0197Mandrillus leucophaeus99.620.01568
LLPS-Paa-2849Papio anubis99.620.01568
LLPS-Cea-0640Cercocebus atys99.620.01568
LLPS-Chs-0056Chlorocebus sabaeus99.620.01568
LLPS-Maf-0219Macaca fascicularis99.490.01568
LLPS-Mam-1882Macaca mulatta99.490.01554
LLPS-Man-0975Macaca nemestrina99.490.01568
LLPS-Ict-1734Ictidomys tridecemlineatus98.990.01556
LLPS-Orc-1961Oryctolagus cuniculus98.610.01555
LLPS-Fec-2350Felis catus98.480.01555
LLPS-Myl-2322Myotis lucifugus98.360.01550
LLPS-Dio-1786Dipodomys ordii98.230.01551
LLPS-Caf-1790Canis familiaris98.110.01552
LLPS-Mup-0397Mustela putorius furo98.070.01033
LLPS-Loa-1547Loxodonta africana97.980.01546
LLPS-Fud-0039Fukomys damarensis97.860.01536
LLPS-Otg-0341Otolemur garnettii97.850.01537
LLPS-Aim-1490Ailuropoda melanoleuca97.80.0 993
LLPS-Ran-2689Rattus norvegicus97.60.01541
LLPS-Mum-3781Mus musculus97.60.01540
LLPS-Cap-1701Cavia porcellus97.60.01534
LLPS-Mea-0066Mesocricetus auratus97.470.01543
LLPS-Eqc-2018Equus caballus97.110.01470
LLPS-Ova-0748Ovis aries96.720.01544
LLPS-Cas-3251Carlito syrichta96.590.01530
LLPS-Bot-3557Bos taurus96.460.01539
LLPS-Ora-2690Ornithorhynchus anatinus96.210.01529
LLPS-Tut-1312Tursiops truncatus95.830.01529
LLPS-Aon-4192Aotus nancymaae95.480.01487
LLPS-Caj-3740Callithrix jacchus95.350.01491
LLPS-Sus-0095Sus scrofa95.170.01498
LLPS-Tag-1934Taeniopygia guttata94.960.0 804
LLPS-Sah-1131Sarcophilus harrisii94.70.01515
LLPS-Gaga-1111Gallus gallus93.690.01504
LLPS-Pes-1606Pelodiscus sinensis93.640.01481
LLPS-Fia-3000Ficedula albicollis93.310.01492
LLPS-Mod-2068Monodelphis domestica90.660.01432
LLPS-Dar-0410Danio rerio90.180.01456
LLPS-Icp-1092Ictalurus punctatus89.960.01437
LLPS-Orn-0710Oreochromis niloticus89.790.01439
LLPS-Leo-0083Lepisosteus oculatus89.770.01452
LLPS-Xim-0263Xiphophorus maculatus89.530.01449
LLPS-Pof-0428Poecilia formosa89.530.01444
LLPS-Xet-2053Xenopus tropicalis89.470.01420
LLPS-Asm-0768Astyanax mexicanus89.410.01436
LLPS-Scm-1172Scophthalmus maximus88.650.01432
LLPS-Lac-0253Latimeria chalumnae88.630.01385
LLPS-Scf-1455Scleropages formosus88.580.01378
LLPS-Orl-1602Oryzias latipes88.520.01431
LLPS-Anc-1195Anolis carolinensis88.470.01415
LLPS-Ten-1168Tetraodon nigroviridis88.410.01426
LLPS-Gaa-2825Gasterosteus aculeatus88.010.01419
LLPS-Anp-0289Anas platyrhynchos87.910.01346
LLPS-Tar-3115Takifugu rubripes86.650.01378
LLPS-Meg-0334Meleagris gallopavo80.430.01232
LLPS-Cii-0533Ciona intestinalis76.041e-92 295
LLPS-Abg-0007Absidia glauca74.680.01221
LLPS-Lem-0078Leptosphaeria maculans74.540.01183
LLPS-Fuo-1268Fusarium oxysporum74.320.0 788
LLPS-Drm-0660Drosophila melanogaster74.280.01242
LLPS-Pyt-0593Pyrenophora teres74.270.01172
LLPS-Nec-0887Neurospora crassa74.140.01174
LLPS-Asf-0219Aspergillus flavus74.010.01162
LLPS-Cae-0251Caenorhabditis elegans73.920.01202
LLPS-Asfu-0249Aspergillus fumigatus73.870.01169
LLPS-Ved-1342Verticillium dahliae73.870.01165
LLPS-Mao-1183Magnaporthe oryzae73.740.01164
LLPS-Map-0472Magnaporthe poae73.740.01168
LLPS-Coo-0064Colletotrichum orbiculare73.740.01164
LLPS-Cogr-1211Colletotrichum graminicola73.740.01164
LLPS-Nef-0761Neosartorya fischeri73.740.01169
LLPS-Asc-0241Aspergillus clavatus73.610.01161
LLPS-Ast-0605Aspergillus terreus73.540.01156
LLPS-Fuv-1027Fusarium verticillioides73.470.01162
LLPS-Asn-0959Aspergillus nidulans73.260.01154
LLPS-Phn-0557Phaeosphaeria nodorum73.210.01160
LLPS-Dos-0469Dothistroma septosporum73.210.01158
LLPS-Spr-0372Sporisorium reilianum73.210.01176
LLPS-Scc-0602Schizosaccharomyces cryophilus73.170.01155
LLPS-Asni-1076Aspergillus niger73.080.01156
LLPS-Cog-0042Colletotrichum gloeosporioides73.080.01155
LLPS-Tum-1231Tuber melanosporum72.980.01147
LLPS-Pug-0516Puccinia graminis72.970.01148
LLPS-Usm-1209Ustilago maydis72.940.01169
LLPS-Scp-0347Schizosaccharomyces pombe72.910.01157
LLPS-Trv-1088Trichoderma virens72.810.01157
LLPS-Gag-0489Gaeumannomyces graminis72.680.01153
LLPS-Scj-0125Schizosaccharomyces japonicus72.640.01148
LLPS-Yal-0520Yarrowia lipolytica72.490.01147
LLPS-Mel-0824Melampsora laricipopulina72.440.01138
LLPS-Beb-0628Beauveria bassiana72.410.01155
LLPS-Fus-0220Fusarium solani72.20.01146
LLPS-Zyt-0984Zymoseptoria tritici72.150.01131
LLPS-Crn-1223Cryptococcus neoformans72.150.01137
LLPS-Aso-0344Aspergillus oryzae72.10.01176
LLPS-Pytr-0520Pyrenophora triticirepentis71.880.01176
LLPS-Miv-0756Microbotryum violaceum71.580.01135
LLPS-Trr-0172Trichoderma reesei71.110.01139
LLPS-Cis-0728Ciona savignyi70.920.01232
LLPS-Blg-0395Blumeria graminis70.690.01147
LLPS-Kop-1310Komagataella pastoris69.970.01113
LLPS-Asg-0184Ashbya gossypii69.260.01118
LLPS-Coc-2005Corchorus capsularis68.290.01065
LLPS-Sot-0048Solanum tuberosum67.940.01125
LLPS-Nia-0254Nicotiana attenuata67.940.01123
LLPS-Brn-2230Brassica napus67.730.01127
LLPS-Brr-0945Brassica rapa67.730.01127
LLPS-Sol-1026Solanum lycopersicum67.690.01124
LLPS-Gor-1987Gossypium raimondii67.690.01122
LLPS-Bro-1004Brassica oleracea67.610.01126
LLPS-Sei-1274Setaria italica67.530.01123
LLPS-Chr-1485Chlamydomonas reinhardtii67.480.01102
LLPS-Thc-1803Theobroma cacao67.450.01129
LLPS-Sem-0113Selaginella moellendorffii67.450.01119
LLPS-Via-0643Vigna angularis67.320.01118
LLPS-Ori-1737Oryza indica67.320.01127
LLPS-Org-0079Oryza glaberrima67.320.01127
LLPS-Sac-1126Saccharomyces cerevisiae67.280.01083
LLPS-Orni-1516Oryza nivara67.280.01125
LLPS-Zem-1719Zea mays67.240.01123
LLPS-Sob-0579Sorghum bicolor67.240.01121
LLPS-Mae-0871Manihot esculenta67.20.01127
LLPS-Ors-0214Oryza sativa67.20.01123
LLPS-Hea-0884Helianthus annuus67.160.01129
LLPS-Orp-0975Oryza punctata67.160.01125
LLPS-Lep-0404Leersia perrieri67.080.01122
LLPS-Arl-1422Arabidopsis lyrata67.070.01120
LLPS-Art-0549Arabidopsis thaliana67.030.01120
LLPS-Amt-1028Amborella trichopoda66.950.01125
LLPS-Viv-0425Vitis vinifera66.950.01124
LLPS-Glm-0576Glycine max66.830.01116
LLPS-Pot-2009Populus trichocarpa66.590.01110
LLPS-Prp-0770Prunus persica66.580.01117
LLPS-Phv-0337Phaseolus vulgaris66.580.01116
LLPS-Met-0771Medicago truncatula66.50.01114
LLPS-Tra-1712Triticum aestivum66.380.01100
LLPS-Hov-0544Hordeum vulgare66.380.01098
LLPS-Brd-1045Brachypodium distachyon66.340.01113
LLPS-Chc-0069Chondrus crispus66.170.01082
LLPS-Cus-0213Cucumis sativus66.090.01120
LLPS-Orgl-0764Oryza glumaepatula66.090.01106
LLPS-Mua-1498Musa acuminata66.090.01115
LLPS-Orb-0351Oryza barthii66.090.01105
LLPS-Cym-0486Cyanidioschyzon merolae65.970.01102
LLPS-Orr-1420Oryza rufipogon65.970.01104
LLPS-Orm-1186Oryza meridionalis65.970.01103
LLPS-Gas-0207Galdieria sulphuraria65.890.01096
LLPS-Vir-0503Vigna radiata65.770.01100
LLPS-Php-1743Physcomitrella patens65.440.01106
LLPS-Orbr-0080Oryza brachyantha64.780.01099
LLPS-Osl-0526Ostreococcus lucimarinus64.630.01086
LLPS-Tru-0431Triticum urartu63.870.01091
LLPS-Put-0270Puccinia triticina63.380.0 978
LLPS-Dac-0141Daucus carota61.040.0 975