• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pap-4181
SDHA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene Name: SDHA
Ensembl Gene: ENSPPAG00000035300.1
Ensembl Protein: ENSPPAP00000024489.1
Organism: Pan paniscus
Taxa ID: 9597
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

▼ SEQUENCE

Protein Sequence (FASTA)
1     ASRVHAILRL  SLLSSWDYRH  LPSCPWPAVL  QTGTRGFHFT  VDGNKRASAK  VSDSISAQYP  60
61    VVDHEFDAVV  VGAGGAGLRA  AFGLSEAGFN  TACVTKLFPT  RSHTVAAQGG  INAALGNMEE  120
121   DNWRWHFYDT  VKGSDWLGDQ  DAIHYMTEQA  PAAVVELENY  GMPFSRTEDG  KIYQRAFGGQ  180
181   SLKFGKGGQA  HRCCCVADRT  GHSLLHTLYG  RSLRYDTSYF  VEYFALDLLM  ENGECRGVIA  240
241   LCIEDGSIHR  IRAKNTVVAT  GGYGRTYFSC  TSAHTSTGDG  TAMITRAGLP  CQDLEFVQFH  300
301   PTGIYGAGCL  ITEGCRGEGG  ILINSQGERF  MERYAPVAKD  LASRDVVSRS  MTLEIREGRG  360
361   CGPEKDHVYL  QLHHLPPEQL  ATRLPGISET  AMIFAGVDVT  KEPIPVLPTV  HYNMGGIPTN  420
421   YKGQVLRHVN  GQDQIVPGLY  ACGEAACASV  HGANRLGANS  LLDLVVFGRA  CALSIEESCR  480
481   PGDKVPPIKP  NAGEESVMNL  DKLRFADGSI  RTSELRLSMQ  KSMQNHAAVF  RVGSVLQEGC  540
541   GKISKLYGDL  KHLKTFDRGM  VWNTDLVETL  ELQNLMLCAL  QTIYGAEARK  ESRGAHARED  600
601   YKVRIDEYDY  SKPIQGQQKK  PFEEHWRKHT  LSYVDVGTGK  VTLEYRPVID  KTLNEADCAT  660
661   VPPAIRSY  668
Nucleotide CDS Sequence (FASTA)
1     TGGCCAGCAG  TGTTGCAAAC  AGGAACCCGA  GGTTTTCACT  TCACTGTTGA  TGGGAACAAG  60
61    AGGGCATCTG  CTAAAGTTTC  AGATTCCATT  TCTGCTCAGT  ATCCAGTAGT  GGATCATGAA  120
121   TTTGATGCAG  TGGTGGTAGG  CGCTGGAGGG  GCAGGCTTGC  GAGCTGCATT  TGGCCTTTCT  180
181   GAGGCAGGGT  TTAATACAGC  ATGTGTTACC  AAGCTGTTTC  CTACCAGGTC  ACACACTGTT  240
241   GCAGCGCAGG  GAGGAATCAA  TGCTGCTCTG  GGGAACATGG  AGGAGGACAA  CTGGAGGTGG  300
301   CATTTCTACG  ACACCGTGAA  GGGCTCCGAC  TGGCTGGGGG  ACCAGGATGC  CATCCACTAC  360
361   ATGACGGAGC  AGGCCCCCGC  CGCCGTGGTC  GAGCTAGAAA  ATTATGGCAT  GCCGTTTAGC  420
421   AGAACTGAAG  ATGGGAAGAT  TTATCAGCGT  GCATTTGGTG  GACAGAGCCT  CAAGTTTGGA  480
481   AAGGGCGGGC  AGGCCCATCG  GTGCTGCTGT  GTGGCTGATC  GGACTGGCCA  CTCGCTATTG  540
541   CACACCTTAT  ATGGAAGGTC  TCTGCGATAT  GATACCAGCT  ATTTTGTGGA  GTATTTTGCC  600
601   TTGGATCTCC  TGATGGAGAA  CGGGGAGTGC  CGTGGTGTCA  TCGCACTGTG  CATAGAGGAC  660
661   GGGTCCATCC  ATCGCATAAG  AGCAAAGAAC  ACTGTTGTTG  CCACAGGAGG  CTACGGGCGC  720
721   ACCTACTTCA  GCTGCACGTC  TGCCCACACC  AGCACTGGCG  ACGGCACGGC  CATGATCACC  780
781   AGGGCAGGCC  TTCCTTGCCA  GGACCTCGAG  TTTGTTCAGT  TCCACCCCAC  AGGCATATAT  840
841   GGTGCTGGTT  GTCTCATTAC  GGAAGGATGT  CGTGGAGAGG  GAGGCATTCT  CATTAACAGT  900
901   CAAGGCGAAA  GGTTTATGGA  GCGATACGCC  CCTGTCGCGA  AGGACCTGGC  GTCTAGAGAT  960
961   GTGGTGTCTC  GGTCGATGAC  TCTGGAGATT  CGAGAAGGAA  GAGGCTGTGG  CCCTGAGAAA  1020
1021  GATCACGTCT  ACCTGCAGCT  GCACCACCTA  CCTCCAGAGC  AGCTGGCCAC  GCGCCTGCCT  1080
1081  GGCATTTCAG  AGACAGCCAT  GATCTTCGCT  GGCGTGGACG  TCACGAAGGA  GCCGATCCCT  1140
1141  GTCCTCCCCA  CCGTGCATTA  TAACATGGGC  GGCATTCCCA  CCAACTACAA  GGGGCAGGTC  1200
1201  CTGAGGCACG  TGAATGGCCA  GGATCAGATT  GTGCCTGGCC  TGTACGCCTG  TGGGGAGGCC  1260
1261  GCCTGTGCCT  CGGTACATGG  TGCCAACCGC  CTTGGGGCAA  ACTCGCTCTT  GGACCTGGTT  1320
1321  GTCTTTGGTC  GGGCATGTGC  CCTGAGCATC  GAAGAGTCAT  GCAGGCCTGG  AGATAAAGTC  1380
1381  CCTCCAATTA  AACCAAACGC  TGGGGAAGAA  TCTGTCATGA  ATCTTGACAA  ATTGAGATTT  1440
1441  GCTGATGGAA  GCATAAGAAC  ATCGGAACTG  CGACTCAGCA  TGCAGAAGGT  GCGGATTGAT  1500
1501  GAGTACGATT  ACTCCAAGCC  CATCCAGGGG  CAACAGAAGA  AGCCCTTTGA  GGAGCACTGG  1560
1561  AGAAAGCACA  CCCTGTCGTA  TGTGGACGTT  GGCACTGGGA  AGGTCACTCT  GGAATATAGA  1620
1621  CCCGTAATCG  ACAAAACTTT  GAACGAGGCT  GACTGTGCCA  CCGTCCCGCC  AGCCATTCGC  1680
1681  TCCTACTGA  1689

▼ KEYWORD

ID
Family
Complete proteome
Electron transport
FAD
Flavoprotein
Membrane
Oxidoreductase
Reference proteome
Transit peptide
Transport
Tricarboxylic acid cycle

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Nucleolus
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
Succinate dehydrogenase (ubiquinone) activity
Biological Process
Nervous system development
Biological Process
Respiratory electron transport chain
Biological Process
Succinate metabolic process
Biological Process
Tricarboxylic acid cycle

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-4087Homo sapiens99.840.01305
LLPS-Poa-2207Pongo abelii99.820.01168
LLPS-Pat-1044Pan troglodytes99.690.01294
LLPS-Mam-1257Macaca mulatta99.530.01302
LLPS-Aon-0734Aotus nancymaae98.440.01291
LLPS-Orc-1339Oryctolagus cuniculus98.240.01048
LLPS-Urm-1962Ursus maritimus97.650.01266
LLPS-Otg-4106Otolemur garnettii97.510.01269
LLPS-Mup-1893Mustela putorius furo97.460.01129
LLPS-Mal-1109Mandrillus leucophaeus97.119e-157 459
LLPS-Caj-3812Callithrix jacchus96.830.01293
LLPS-Aim-2528Ailuropoda melanoleuca96.60.01275
LLPS-Mea-2951Mesocricetus auratus96.40.01256
LLPS-Fec-3903Felis catus95.990.01271
LLPS-Caf-1091Canis familiaris95.990.01274
LLPS-Ict-4068Ictidomys tridecemlineatus95.960.01254
LLPS-Mum-3932Mus musculus95.960.01260
LLPS-Rhb-1638Rhinopithecus bieti95.832e-115 352
LLPS-Ran-2990Rattus norvegicus95.750.01247
LLPS-Dio-3917Dipodomys ordii95.750.01241
LLPS-Bot-4736Bos taurus95.710.01135
LLPS-Sus-0787Sus scrofa95.480.01253
LLPS-Myl-1328Myotis lucifugus95.430.01243
LLPS-Cap-2413Cavia porcellus95.330.01258
LLPS-Eqc-1712Equus caballus95.130.01263
LLPS-Paa-3263Papio anubis95.090.0 843
LLPS-Tut-0157Tursiops truncatus94.860.01244
LLPS-Loa-1764Loxodonta africana94.70.01243
LLPS-Ora-3364Ornithorhynchus anatinus94.090.01242
LLPS-Ova-0484Ovis aries93.610.01223
LLPS-Sah-3756Sarcophilus harrisii93.310.01233
LLPS-Mod-3506Monodelphis domestica92.850.01230
LLPS-Pes-1080Pelodiscus sinensis91.962e-178 516
LLPS-Fia-3058Ficedula albicollis91.380.01202
LLPS-Tag-0573Taeniopygia guttata91.290.01212
LLPS-Anc-1169Anolis carolinensis91.110.01197
LLPS-Gaga-3798Gallus gallus90.980.01213
LLPS-Maf-1168Macaca fascicularis90.00.01172
LLPS-Gog-4025Gorilla gorilla88.810.0 734
LLPS-Anp-0248Anas platyrhynchos88.550.01206
LLPS-Asm-3918Astyanax mexicanus87.660.01130
LLPS-Meg-3352Meleagris gallopavo87.560.01150
LLPS-Icp-0244Ictalurus punctatus86.750.01133
LLPS-Xim-2114Xiphophorus maculatus86.140.01147
LLPS-Tar-3095Takifugu rubripes86.070.01152
LLPS-Pof-3913Poecilia formosa86.020.01149
LLPS-Cis-1891Ciona savignyi85.916e-173 504
LLPS-Lac-1320Latimeria chalumnae85.850.01117
LLPS-Scm-0550Scophthalmus maximus85.830.01134
LLPS-Orn-3153Oreochromis niloticus85.510.01139
LLPS-Gaa-3819Gasterosteus aculeatus85.20.01129
LLPS-Dar-3303Danio rerio84.890.01119
LLPS-Scf-4072Scleropages formosus84.770.01133
LLPS-Ten-0393Tetraodon nigroviridis84.750.01140
LLPS-Orl-0189Oryzias latipes83.870.01138
LLPS-Cea-3440Cercocebus atys81.350.0 679
LLPS-Man-2863Macaca nemestrina80.990.0 988
LLPS-Leo-3513Lepisosteus oculatus79.111e-165 494
LLPS-Vir-1979Vigna radiata78.150.0 661
LLPS-Drm-1816Drosophila melanogaster76.380.0 988
LLPS-Cii-2338Ciona intestinalis76.310.0 841
LLPS-Cae-0808Caenorhabditis elegans73.030.0 926
LLPS-Usm-1070Ustilago maydis70.10.0 858
LLPS-Abg-0717Absidia glauca70.10.0 878
LLPS-Nef-1124Neosartorya fischeri70.080.0 849
LLPS-Asfu-0063Aspergillus fumigatus69.920.0 850
LLPS-Scc-1207Schizosaccharomyces cryophilus69.770.0 855
LLPS-Mao-0513Magnaporthe oryzae69.590.0 870
LLPS-Coc-2095Corchorus capsularis69.540.0 845
LLPS-Map-0688Magnaporthe poae69.450.0 853
LLPS-Scj-0025Schizosaccharomyces japonicus69.380.0 853
LLPS-Pytr-1453Pyrenophora triticirepentis69.330.0 865
LLPS-Pyt-0302Pyrenophora teres69.330.0 865
LLPS-Nec-0816Neurospora crassa69.290.0 861
LLPS-Asc-0458Aspergillus clavatus69.270.0 838
LLPS-Orbr-1879Oryza brachyantha69.180.0 837
LLPS-Brd-1086Brachypodium distachyon69.170.0 843
LLPS-Pug-1004Puccinia graminis69.120.0 848
LLPS-Crn-0769Cryptococcus neoformans69.120.0 849
LLPS-Sei-1712Setaria italica69.120.0 852
LLPS-Tru-0996Triticum urartu69.110.0 838
LLPS-Beb-0486Beauveria bassiana68.970.0 841
LLPS-Mua-0191Musa acuminata68.940.0 841
LLPS-Gor-1775Gossypium raimondii68.840.0 831
LLPS-Pot-2711Populus trichocarpa68.780.0 832
LLPS-Gas-1321Galdieria sulphuraria68.760.0 852
LLPS-Lem-0658Leptosphaeria maculans68.740.0 858
LLPS-Miv-1589Microbotryum violaceum68.70.0 849
LLPS-Gag-1202Gaeumannomyces graminis68.650.0 846
LLPS-Asni-1345Aspergillus niger68.630.0 847
LLPS-Php-2517Physcomitrella patens68.620.0 842
LLPS-Viv-1303Vitis vinifera68.560.0 837
LLPS-Sem-1847Selaginella moellendorffii68.560.0 845
LLPS-Scp-0948Schizosaccharomyces pombe68.490.0 855
LLPS-Mae-2474Manihot esculenta68.40.0 832
LLPS-Cus-0848Cucumis sativus68.40.0 832
LLPS-Zem-0924Zea mays68.370.0 852
LLPS-Arl-2707Arabidopsis lyrata68.340.0 835
LLPS-Tum-1234Tuber melanosporum68.30.0 764
LLPS-Chr-1243Chlamydomonas reinhardtii68.270.0 853
LLPS-Amt-2007Amborella trichopoda68.190.0 822
LLPS-Fuv-0067Fusarium verticillioides68.130.0 857
LLPS-Ors-1619Oryza sativa68.120.0 842
LLPS-Orr-1524Oryza rufipogon68.120.0 842
LLPS-Orni-0995Oryza nivara68.120.0 842
LLPS-Ori-2287Oryza indica68.120.0 842
LLPS-Orgl-1280Oryza glumaepatula68.120.0 842
LLPS-Sob-2124Sorghum bicolor68.10.0 848
LLPS-Coo-1357Colletotrichum orbiculare68.10.0 838
LLPS-Tra-2726Triticum aestivum68.10.0 847
LLPS-Art-0648Arabidopsis thaliana68.060.0 833
LLPS-Orm-1021Oryza meridionalis68.060.0 838
LLPS-Thc-1555Theobroma cacao68.060.0 834
LLPS-Met-1965Medicago truncatula68.020.0 828
LLPS-Cogr-1569Colletotrichum graminicola68.010.0 837
LLPS-Phn-1091Phaeosphaeria nodorum67.980.0 842
LLPS-Via-1662Vigna angularis67.970.0 817
LLPS-Osl-1057Ostreococcus lucimarinus67.920.0 818
LLPS-Prp-0627Prunus persica67.920.0 828
LLPS-Dos-1554Dothistroma septosporum67.850.0 846
LLPS-Mel-0652Melampsora laricipopulina67.750.0 848
LLPS-Dac-2221Daucus carota67.750.0 823
LLPS-Bro-1010Brassica oleracea67.730.0 832
LLPS-Spr-1410Sporisorium reilianum67.650.0 856
LLPS-Put-1035Puccinia triticina67.610.0 724
LLPS-Trv-1605Trichoderma virens67.560.0 852
LLPS-Yal-0932Yarrowia lipolytica67.480.0 830
LLPS-Sol-1154Solanum lycopersicum67.40.0 838
LLPS-Phv-0726Phaseolus vulgaris67.370.0 832
LLPS-Lep-0579Leersia perrieri67.310.0 827
LLPS-Hov-2121Hordeum vulgare67.140.0 782
LLPS-Sot-1828Solanum tuberosum67.090.0 838
LLPS-Brn-0204Brassica napus66.930.0 831
LLPS-Zyt-1286Zymoseptoria tritici66.930.0 853
LLPS-Blg-1119Blumeria graminis66.930.0 850
LLPS-Glm-2850Glycine max66.880.0 822
LLPS-Brr-2931Brassica rapa66.610.0 828
LLPS-Cym-0357Cyanidioschyzon merolae66.560.0 840
LLPS-Orp-1165Oryza punctata66.460.0 845
LLPS-Cog-0639Colletotrichum gloeosporioides66.40.0 823
LLPS-Hea-0159Helianthus annuus66.360.0 836
LLPS-Org-0766Oryza glaberrima66.310.0 847
LLPS-Trr-0211Trichoderma reesei66.220.0 858
LLPS-Orb-2386Oryza barthii66.150.0 846
LLPS-Ast-0888Aspergillus terreus66.120.0 845
LLPS-Fuo-1183Fusarium oxysporum66.070.0 860
LLPS-Asn-1155Aspergillus nidulans66.070.0 848
LLPS-Sac-1428Saccharomyces cerevisiae65.810.0 838
LLPS-Asf-1276Aspergillus flavus65.770.0 848
LLPS-Aso-1357Aspergillus oryzae65.770.0 848
LLPS-Chc-0519Chondrus crispus65.620.0 818
LLPS-Ved-0165Verticillium dahliae65.020.0 844
LLPS-Asg-0871Ashbya gossypii64.260.0 824
LLPS-Kop-0421Komagataella pastoris62.290.0 806