• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ova-2273
KPNA1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit alpha
Gene Name: KPNA1
Ensembl Gene: ENSOARG00000020139.1
Ensembl Protein: ENSOARP00000021625.1
Organism: Ovis aries
Taxa ID: 9940
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear pore complex, Nucleolus, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOART00000021927.1ENSOARP00000021625.1
UniProtW5QFX7, W5QFX7_SHEEP
GeneBankAMGL01008661, AMGL01008660

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTAPGKENFR  LKSYKNKSLN  PDEMRRRREE  EGLQLRKQKR  EEQLFKRRNV  ATAEEETEEE  60
61    VMSDGGFHEA  QINNMEMAPG  GVITSDMIEM  IFSNSPEQQL  SATQKFRKLL  SKVYGETEPN  120
121   PPIDEVISTP  GVVARFVEFL  KRKENCTLQF  ESAWVLTNIA  SGNSLQTRIV  IQAGAVPIFI  180
181   ELLSSEFEDV  QEQAVWALGN  IAGDSTMCRD  YVLDCNILPP  LLQLFSKQNR  LTMTRNAVWA  240
241   LSNLCRGKSP  PPEFAKVSPC  LNVLSWLLFV  SDTDVLADAC  WALSYLSDGP  NDKIQAVIDA  300
301   GVCRRLVELL  MHNDYKVVSP  ALRAVGNIVT  GDDIQTQVIL  NCSALQSLLH  LLSSPKESIK  360
361   KEACWTISNI  TAGNRAQIQT  VIDANIFPAL  ISILQTAEFR  TRKEAAWAIT  NATSGGSAEQ  420
421   IKYLVELGCI  KPLCDLLTVM  DSKIVQVALN  GLENILRLGE  QEAKRNGTGI  NPYCALIEEA  480
481   YGLDKIEFLQ  SHENQEIYQK  AFDLIEHYFG  TEDEDSSIAP  QVDLNQQQYI  FQQCEAPMEG  540
541   FQL  543
Nucleotide CDS Sequence (FASTA)
1     ATGACTGCCC  CAGGAAAAGA  GAACTTTCGC  CTGAAAAGTT  ACAAAAATAA  GTCCCTGAAT  60
61    CCTGATGAGA  TGCGCAGAAG  GAGGGAGGAA  GAAGGACTAC  AGTTACGTAA  GCAGAAAAGA  120
121   GAAGAGCAGT  TATTCAAGAG  AAGAAATGTT  GCTACAGCAG  AAGAAGAAAC  AGAAGAAGAA  180
181   GTTATGTCAG  ATGGAGGCTT  CCATGAGGCT  CAGATTAATA  ACATGGAGAT  GGCACCAGGT  240
241   GGTGTTATTA  CTTCTGACAT  GATTGAAATG  ATATTTTCCA  ATAGCCCAGA  GCAACAGCTT  300
301   TCAGCAACAC  AGAAATTCAG  AAAACTGCTT  TCAAAAGTTT  ATGGGGAGAC  AGAACCTAAT  360
361   CCTCCTATTG  ATGAAGTCAT  CAGCACACCA  GGAGTAGTGG  CCAGGTTTGT  GGAGTTCCTC  420
421   AAACGAAAAG  AGAATTGTAC  ACTGCAGTTT  GAATCAGCTT  GGGTACTGAC  AAATATTGCT  480
481   TCAGGAAATT  CTCTTCAGAC  CCGGATTGTG  ATTCAGGCAG  GAGCTGTGCC  TATCTTCATA  540
541   GAGTTGCTCA  GCTCAGAGTT  TGAAGATGTC  CAGGAACAGG  CAGTCTGGGC  TCTTGGCAAC  600
601   ATTGCTGGAG  ATAGTACCAT  GTGCAGGGAC  TATGTCTTAG  ACTGCAATAT  TCTTCCCCCT  660
661   CTTCTGCAGT  TATTTTCAAA  GCAGAACCGC  CTGACTATGA  CCCGGAATGC  AGTATGGGCT  720
721   TTGTCTAATC  TCTGTAGAGG  GAAAAGTCCA  CCTCCAGAAT  TTGCAAAGGT  TTCCCCTTGT  780
781   CTGAATGTGC  TGTCCTGGCT  GCTGTTTGTC  AGTGACACTG  ATGTACTGGC  TGATGCCTGC  840
841   TGGGCCCTCT  CATATCTATC  AGATGGACCC  AACGATAAAA  TTCAAGCAGT  CATTGATGCA  900
901   GGAGTATGTA  GGAGACTTGT  GGAGCTGTTG  ATGCATAATG  ATTATAAAGT  GGTTTCTCCT  960
961   GCTTTGCGGG  CTGTTGGAAA  CATTGTCACA  GGAGATGATA  TTCAGACACA  GGTAATTTTG  1020
1021  AATTGCTCAG  CTCTGCAGAG  TTTGTTGCAT  TTGCTGAGTA  GCCCAAAGGA  GTCTATCAAA  1080
1081  AAGGAGGCAT  GTTGGACAAT  ATCTAATATC  ACAGCTGGAA  ATAGGGCACA  GATCCAGACT  1140
1141  GTGATAGATG  CCAACATTTT  CCCAGCCCTC  ATTAGTATAC  TACAGACTGC  TGAGTTTCGG  1200
1201  ACAAGGAAAG  AAGCTGCCTG  GGCCATCACA  AATGCAACTT  CTGGAGGATC  AGCTGAACAG  1260
1261  ATCAAGTACC  TCGTAGAACT  GGGCTGTATC  AAGCCACTCT  GTGATCTCCT  CACAGTCATG  1320
1321  GACTCTAAGA  TCGTACAGGT  TGCCCTAAAT  GGCTTGGAAA  ATATCCTGAG  GCTTGGAGAA  1380
1381  CAAGAAGCCA  AAAGGAATGG  CACTGGCATT  AATCCTTACT  GTGCTTTGAT  TGAAGAAGCT  1440
1441  TATGGCCTGG  ATAAAATTGA  ATTCTTACAG  AGTCATGAAA  ACCAAGAGAT  CTACCAGAAG  1500
1501  GCCTTTGATC  TTATTGAGCA  TTACTTTGGG  ACGGAGGATG  AGGACAGCAG  CATCGCACCC  1560
1561  CAGGTTGACC  TCAACCAGCA  GCAGTACATC  TTCCAGCAGT  GTGAGGCACC  TATGGAAGGT  1620
1621  TTCCAGCTTT  GA  1632

▼ KEYWORD

ID
Family
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Glutamatergic synapse
Cellular Component
Nucleoplasm
Cellular Component
Postsynaptic density
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Protein transporter activity
Biological Process
Postsynapse to nucleus signaling pathway
Biological Process
Protein import into nucleus

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Myl-0461Myotis lucifugus99.080.01026
LLPS-Otg-0471Otolemur garnettii98.920.0 904
LLPS-Caj-3495Callithrix jacchus98.90.01014
LLPS-Caf-0369Canis familiaris98.710.01013
LLPS-Poa-0362Pongo abelii98.710.01013
LLPS-Mam-0241Macaca mulatta98.710.01013
LLPS-Fec-1678Felis catus98.710.01013
LLPS-Pap-2276Pan paniscus98.710.01013
LLPS-Pat-3638Pan troglodytes98.710.01013
LLPS-Man-1350Macaca nemestrina98.710.01013
LLPS-Rhb-3243Rhinopithecus bieti98.710.01013
LLPS-Mup-2014Mustela putorius furo98.710.01013
LLPS-Paa-1520Papio anubis98.710.01013
LLPS-Mal-0858Mandrillus leucophaeus98.710.01013
LLPS-Chs-3622Chlorocebus sabaeus98.710.01013
LLPS-Maf-1297Macaca fascicularis98.710.01013
LLPS-Sus-3757Sus scrofa98.710.01014
LLPS-Aon-0472Aotus nancymaae98.710.01013
LLPS-Cea-3714Cercocebus atys98.710.01013
LLPS-Gog-0220Gorilla gorilla98.710.01013
LLPS-Nol-3937Nomascus leucogenys98.530.01010
LLPS-Ict-3526Ictidomys tridecemlineatus98.530.01014
LLPS-Hos-1902Homo sapiens98.530.01011
LLPS-Urm-2350Ursus maritimus98.530.01013
LLPS-Bot-1209Bos taurus98.530.01013
LLPS-Cap-1446Cavia porcellus98.340.01013
LLPS-Eqc-2620Equus caballus98.340.01008
LLPS-Tut-0504Tursiops truncatus98.340.01011
LLPS-Orc-0068Oryctolagus cuniculus98.160.01008
LLPS-Dio-0991Dipodomys ordii98.160.01013
LLPS-Fud-0941Fukomys damarensis98.160.01009
LLPS-Ran-0968Rattus norvegicus97.610.01005
LLPS-Mum-1374Mus musculus97.050.0 999
LLPS-Aim-1103Ailuropoda melanoleuca96.50.0 981
LLPS-Sah-1208Sarcophilus harrisii96.340.01000
LLPS-Mod-1780Monodelphis domestica96.320.0 990
LLPS-Loa-2915Loxodonta africana95.950.0 984
LLPS-Anp-1309Anas platyrhynchos95.210.0 981
LLPS-Tag-2350Taeniopygia guttata95.030.0 983
LLPS-Meg-0948Meleagris gallopavo94.850.0 979
LLPS-Gaga-2207Gallus gallus94.840.0 977
LLPS-Anc-0805Anolis carolinensis94.840.0 979
LLPS-Fia-0460Ficedula albicollis94.840.0 979
LLPS-Pes-1833Pelodiscus sinensis93.740.0 968
LLPS-Xet-0060Xenopus tropicalis92.080.0 937
LLPS-Lac-2517Latimeria chalumnae90.790.0 940
LLPS-Leo-2162Lepisosteus oculatus85.580.0 865
LLPS-Pof-1010Poecilia formosa84.470.0 852
LLPS-Xim-2803Xiphophorus maculatus84.290.0 849
LLPS-Icp-2493Ictalurus punctatus84.10.0 853
LLPS-Orn-0339Oreochromis niloticus83.920.0 851
LLPS-Asm-1726Astyanax mexicanus83.920.0 853
LLPS-Scm-1671Scophthalmus maximus83.730.0 844
LLPS-Gaa-0108Gasterosteus aculeatus83.520.0 838
LLPS-Orl-2373Oryzias latipes82.990.0 838
LLPS-Tar-3376Takifugu rubripes82.810.0 838
LLPS-Ten-3535Tetraodon nigroviridis82.620.0 832
LLPS-Scf-0245Scleropages formosus81.850.0 836
LLPS-Ora-3345Ornithorhynchus anatinus80.150.0 776
LLPS-Cas-1312Carlito syrichta80.040.0 799
LLPS-Dar-4244Danio rerio79.110.0 823
LLPS-Mea-3152Mesocricetus auratus78.490.0 788
LLPS-Cii-1094Ciona intestinalis63.10.0 615
LLPS-Drm-1601Drosophila melanogaster60.470.0 609
LLPS-Phn-1333Phaeosphaeria nodorum60.045e-172 502
LLPS-Beb-0176Beauveria bassiana57.786e-177 518
LLPS-Ved-1391Verticillium dahliae57.288e-172 505
LLPS-Cog-0318Colletotrichum gloeosporioides57.285e-177 518
LLPS-Cogr-0059Colletotrichum graminicola57.099e-177 518
LLPS-Coo-1424Colletotrichum orbiculare57.091e-176 517
LLPS-Nec-0625Neurospora crassa56.852e-177 519
LLPS-Trv-1149Trichoderma virens56.845e-176 516
LLPS-Miv-0546Microbotryum violaceum56.830.0 541
LLPS-Fuo-0668Fusarium oxysporum56.814e-177 518
LLPS-Trr-0178Trichoderma reesei56.816e-177 518
LLPS-Fuv-1029Fusarium verticillioides56.814e-177 518
LLPS-Mao-1285Magnaporthe oryzae56.811e-174 512
LLPS-Pytr-0295Pyrenophora triticirepentis56.629e-173 507
LLPS-Crn-0453Cryptococcus neoformans56.595e-178 520
LLPS-Ast-0980Aspergillus terreus56.411e-176 517
LLPS-Lem-0538Leptosphaeria maculans56.25e-176 517
LLPS-Cus-0336Cucumis sativus56.076e-168 494
LLPS-Pyt-0403Pyrenophora teres56.028e-175 513
LLPS-Asn-0636Aspergillus nidulans56.021e-177 520
LLPS-Usm-0637Ustilago maydis56.011e-173 509
LLPS-Scp-1166Schizosaccharomyces pombe55.842e-172 506
LLPS-Aso-0120Aspergillus oryzae55.817e-176 515
LLPS-Asf-0705Aspergillus flavus55.817e-176 515
LLPS-Tum-0208Tuber melanosporum55.80.0 533
LLPS-Gas-0099Galdieria sulphuraria55.451e-169 498
LLPS-Mel-0289Melampsora laricipopulina55.452e-178 522
LLPS-Asfu-0373Aspergillus fumigatus55.395e-177 518
LLPS-Nef-0967Neosartorya fischeri55.391e-176 517
LLPS-Asc-0429Aspergillus clavatus55.393e-177 519
LLPS-Php-1721Physcomitrella patens55.296e-178 520
LLPS-Dos-0786Dothistroma septosporum55.285e-174 510
LLPS-Pug-0310Puccinia graminis55.174e-176 516
LLPS-Fus-1103Fusarium solani55.178e-177 518
LLPS-Gag-1206Gaeumannomyces graminis55.087e-178 520
LLPS-Met-0780Medicago truncatula54.836e-168 494
LLPS-Blg-0677Blumeria graminis54.813e-169 498
LLPS-Map-0249Magnaporthe poae54.714e-177 518
LLPS-Sei-0627Setaria italica54.443e-174 510
LLPS-Pot-1576Populus trichocarpa54.383e-173 508
LLPS-Sob-0362Sorghum bicolor54.342e-173 508
LLPS-Mae-1182Manihot esculenta54.233e-174 510
LLPS-Amt-1823Amborella trichopoda54.172e-175 513
LLPS-Spr-0381Sporisorium reilianum54.143e-170 501
LLPS-Nia-0168Nicotiana attenuata54.081e-173 508
LLPS-Scj-0572Schizosaccharomyces japonicus54.041e-175 514
LLPS-Scc-1227Schizosaccharomyces cryophilus54.015e-172 505
LLPS-Gor-0277Gossypium raimondii54.02e-174 511
LLPS-Zyt-0523Zymoseptoria tritici53.922e-169 499
LLPS-Coc-1938Corchorus capsularis53.852e-170 501
LLPS-Art-0129Arabidopsis thaliana53.837e-172 504
LLPS-Thc-0417Theobroma cacao53.833e-170 500
LLPS-Ori-0779Oryza indica53.82e-170 499
LLPS-Lep-1207Leersia perrieri53.792e-168 496
LLPS-Mua-0862Musa acuminata53.777e-170 499
LLPS-Orgl-1316Oryza glumaepatula53.734e-168 496
LLPS-Orb-0437Oryza barthii53.734e-168 496
LLPS-Zem-0534Zea mays53.74e-172 505
LLPS-Orbr-0801Oryza brachyantha53.72e-170 501
LLPS-Viv-0579Vitis vinifera53.666e-174 509
LLPS-Arl-1579Arabidopsis lyrata53.639e-170 499
LLPS-Orm-0572Oryza meridionalis53.592e-170 500
LLPS-Org-0778Oryza glaberrima53.592e-170 500
LLPS-Ors-1730Oryza sativa53.593e-170 500
LLPS-Chr-1314Chlamydomonas reinhardtii53.562e-179 525
LLPS-Brr-0552Brassica rapa53.391e-175 514
LLPS-Brd-2377Brachypodium distachyon53.329e-169 496
LLPS-Sol-0061Solanum lycopersicum53.282e-174 511
LLPS-Yal-0529Yarrowia lipolytica53.157e-169 496
LLPS-Sem-1193Selaginella moellendorffii53.143e-173 508
LLPS-Brn-0214Brassica napus53.032e-171 503
LLPS-Abg-1931Absidia glauca52.967e-176 514
LLPS-Sot-0788Solanum tuberosum52.924e-174 510
LLPS-Bro-0021Brassica oleracea52.362e-174 511
LLPS-Prp-2002Prunus persica52.16e-170 499
LLPS-Chc-0767Chondrus crispus52.047e-171 504