• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Otg-4149
HMBS

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Hydroxymethylbilane synthase
Gene Name: HMBS
Ensembl Gene: ENSOGAG00000007289.2
Ensembl Protein: ENSOGAP00000006526.2
Organism: Otolemur garnettii
Taxa ID: 30611
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOGAT00000007294.2ENSOGAP00000006526.2
UniProtH0WW05, H0WW05_OTOGA
GeneBankAAQR03130823

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSGNSSAAAT  AEENNPKMRV  IRVGTRKSQL  ARIQTDSVVA  TLKALYPGLQ  FEIIAMSTTG  60
61    DKILDTALSK  IGEKSLFTKE  LEHALERNEV  DLVVHSLKDL  PTVLPPAFTI  GAICKRENPC  120
121   DAVVFHPKFV  GKTLETLPER  SVVGTSSLRR  AAQLQRKFPH  LEFRSIRGNL  NTRLRKLDEL  180
181   QEFSAIILAV  AGLQRMGWQN  RLGQILHPEE  CMYAVGQGAL  GVEVRAKDQD  ILDLVGVLHD  240
241   PETLLRCIAE  RAFLRHLEGG  CSVPVAVHTD  IKDGQLYLTG  GVWSLDGSDS  MQETMQATIH  300
301   VPAQHVDGPE  DDPQLVGITA  RNIPRGAQLA  AENLGISLAS  LLLSKGAKNI  LDVARQLNDA  360
361   HSHC  364
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGGTA  ACAGCAGCGC  GGCTGCAACG  GCGGAAGAAA  ACAACCCAAA  GATGAGGGTG  60
61    ATTCGTGTGG  GTACCCGCAA  AAGCCAGCTG  GCTCGCATAC  AGACGGACAG  TGTGGTAGCA  120
121   ACGCTGAAAG  CCTTATACCC  TGGCCTGCAG  TTTGAAATCA  TTGCTATGTC  CACCACAGGG  180
181   GACAAGATTC  TTGATACTGC  ACTCTCTAAG  ATTGGAGAGA  AGAGCCTGTT  TACCAAGGAG  240
241   CTGGAACATG  CCCTGGAGAG  GAATGAAGTA  GACCTTGTTG  TCCACTCCCT  GAAGGACCTG  300
301   CCCACTGTGC  TTCCTCCTGC  CTTCACCATT  GGCGCCATCT  GCAAGCGGGA  AAACCCTTGT  360
361   GATGCTGTTG  TCTTTCACCC  AAAATTTGTT  GGGAAGACCC  TAGAAACCTT  GCCAGAGAGG  420
421   AGTGTGGTGG  GAACCAGCTC  CCTAAGGAGA  GCGGCTCAGC  TGCAGAGAAA  GTTCCCACAT  480
481   CTGGAATTCA  GAAGTATTCG  GGGAAACCTG  AACACCAGGC  TTCGGAAGCT  GGATGAGCTG  540
541   CAGGAGTTCA  GCGCCATCAT  CCTGGCAGTA  GCTGGCCTGC  AGCGCATGGG  CTGGCAGAAC  600
601   CGTCTGGGGC  AGATCTTGCA  TCCTGAGGAA  TGCATGTATG  CTGTGGGCCA  GGGGGCCCTG  660
661   GGTGTGGAAG  TCCGAGCCAA  AGACCAGGAC  ATCTTGGATC  TAGTGGGTGT  ATTGCATGAT  720
721   CCTGAGACTC  TACTTCGCTG  CATTGCTGAA  AGGGCCTTCC  TGAGGCACCT  GGAAGGAGGC  780
781   TGCAGTGTGC  CAGTAGCTGT  GCATACAGAT  ATAAAGGATG  GGCAGCTATA  CCTGACTGGA  840
841   GGAGTCTGGA  GTCTAGATGG  CTCAGATAGC  ATGCAAGAAA  CTATGCAGGC  TACCATCCAT  900
901   GTCCCTGCCC  AGCATGTAGA  TGGCCCTGAG  GATGATCCGC  AGCTGGTAGG  CATCACTGCC  960
961   CGGAACATTC  CACGAGGAGC  CCAGTTGGCT  GCTGAGAACC  TGGGCATCAG  CCTGGCTAGC  1020
1021  TTGTTGCTGA  GCAAAGGAGC  CAAGAACATC  CTGGATGTTG  CACGGCAACT  TAATGATGCC  1080
1081  CATTCTCACT  GCTAA  1095

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-3827Pan paniscus95.350.0 639
LLPS-Gog-1911Gorilla gorilla95.350.0 638
LLPS-Eqc-4682Equus caballus95.090.0 643
LLPS-Rhb-3903Rhinopithecus bieti95.060.0 637
LLPS-Fec-3905Felis catus94.80.0 641
LLPS-Ict-4361Ictidomys tridecemlineatus94.780.0 637
LLPS-Hos-3423Homo sapiens94.740.0 647
LLPS-Pat-2518Pan troglodytes94.740.0 647
LLPS-Man-4665Macaca nemestrina94.460.0 645
LLPS-Mam-4427Macaca mulatta94.460.0 645
LLPS-Chs-2768Chlorocebus sabaeus94.460.0 645
LLPS-Maf-3146Macaca fascicularis94.460.0 645
LLPS-Sus-1943Sus scrofa94.460.0 649
LLPS-Nol-2800Nomascus leucogenys94.280.0 622
LLPS-Poa-2209Pongo abelii94.180.0 643
LLPS-Paa-2197Papio anubis94.180.0 641
LLPS-Mal-0713Mandrillus leucophaeus94.180.0 644
LLPS-Caj-4615Callithrix jacchus93.910.0 648
LLPS-Caf-0790Canis familiaris93.650.0 643
LLPS-Orc-0385Oryctolagus cuniculus93.640.0 642
LLPS-Cas-2960Carlito syrichta93.610.0 641
LLPS-Mup-4458Mustela putorius furo93.350.0 639
LLPS-Aim-4193Ailuropoda melanoleuca93.070.0 638
LLPS-Urm-3200Ursus maritimus92.80.0 638
LLPS-Ova-3912Ovis aries92.520.0 640
LLPS-Dio-4183Dipodomys ordii92.50.0 632
LLPS-Fud-2397Fukomys damarensis92.460.0 628
LLPS-Ere-0807Erinaceus europaeus92.240.0 631
LLPS-Bot-4595Bos taurus92.240.0 640
LLPS-Mum-4735Mus musculus91.920.0 633
LLPS-Ran-2739Rattus norvegicus91.920.0 632
LLPS-Myl-0067Myotis lucifugus91.640.0 625
LLPS-Cap-2768Cavia porcellus91.410.0 621
LLPS-Loa-0152Loxodonta africana90.930.0 624
LLPS-Cea-2468Cercocebus atys90.460.0 601
LLPS-Mea-2719Mesocricetus auratus90.30.0 623
LLPS-Tut-1336Tursiops truncatus89.390.0 559
LLPS-Mod-2323Monodelphis domestica86.960.0 592
LLPS-Sah-3941Sarcophilus harrisii86.090.0 580
LLPS-Ora-1477Ornithorhynchus anatinus86.022e-49 168
LLPS-Aon-4500Aotus nancymaae80.231e-178 508
LLPS-Tag-2934Taeniopygia guttata78.070.0 523
LLPS-Anp-3036Anas platyrhynchos77.711e-177 504
LLPS-Gaga-2331Gallus gallus77.490.0 516
LLPS-Leo-1875Lepisosteus oculatus76.743e-172 492
LLPS-Fia-0401Ficedula albicollis76.680.0 516
LLPS-Meg-1847Meleagris gallopavo76.611e-176 503
LLPS-Pes-3247Pelodiscus sinensis75.372e-174 496
LLPS-Ten-1146Tetraodon nigroviridis74.573e-163 469
LLPS-Orn-1656Oreochromis niloticus74.279e-167 478
LLPS-Anc-1661Anolis carolinensis73.553e-174 496
LLPS-Asm-3343Astyanax mexicanus73.475e-169 485
LLPS-Orl-3526Oryzias latipes72.594e-161 463
LLPS-Dar-3986Danio rerio72.172e-168 482
LLPS-Gaa-0202Gasterosteus aculeatus71.975e-168 481
LLPS-Pof-2438Poecilia formosa71.595e-156 450
LLPS-Scm-3685Scophthalmus maximus71.312e-160 462
LLPS-Tar-2159Takifugu rubripes71.31e-155 449
LLPS-Icp-3299Ictalurus punctatus70.098e-155 447
LLPS-Scf-2800Scleropages formosus69.598e-161 462
LLPS-Xim-3236Xiphophorus maculatus68.014e-143 417
LLPS-Xet-3532Xenopus tropicalis67.737e-152 440
LLPS-Cis-1865Ciona savignyi62.023e-120 359
LLPS-Lac-2016Latimeria chalumnae60.174e-120 359
LLPS-Cii-1856Ciona intestinalis59.62e-120 359
LLPS-Abg-1901Absidia glauca56.682e-97 299
LLPS-Drm-1210Drosophila melanogaster55.361e-91 294
LLPS-Dos-0113Dothistroma septosporum50.192e-76 248
LLPS-Beb-0976Beauveria bassiana49.827e-79 252
LLPS-Blg-1215Blumeria graminis49.292e-81 259
LLPS-Scj-1597Schizosaccharomyces japonicus49.14e-74 239
LLPS-Zyt-0054Zymoseptoria tritici48.782e-82 262
LLPS-Cogr-1083Colletotrichum graminicola48.484e-77 248
LLPS-Fus-0544Fusarium solani48.283e-77 248
LLPS-Fuo-1075Fusarium oxysporum48.187e-76 244
LLPS-Fuv-0769Fusarium verticillioides48.186e-76 244
LLPS-Scs-1124Sclerotinia sclerotiorum47.955e-76 246
LLPS-Ved-1525Verticillium dahliae47.774e-73 238
LLPS-Tum-0922Tuber melanosporum47.729e-80 254
LLPS-Trv-1087Trichoderma virens47.672e-75 243
LLPS-Lem-1487Leptosphaeria maculans47.397e-67 223
LLPS-Trr-0743Trichoderma reesei47.312e-73 238
LLPS-Gag-0789Gaeumannomyces graminis47.17e-73 237
LLPS-Coo-1517Colletotrichum orbiculare46.914e-75 243
LLPS-Pytr-1547Pyrenophora triticirepentis46.391e-66 222
LLPS-Mao-0807Magnaporthe oryzae46.394e-70 229
LLPS-Scp-1659Schizosaccharomyces pombe46.267e-72 234
LLPS-Spr-1437Sporisorium reilianum46.191e-53 193
LLPS-Cog-0444Colletotrichum gloeosporioides46.092e-58 198
LLPS-Scc-1378Schizosaccharomyces cryophilus46.042e-70 230
LLPS-Pyt-0583Pyrenophora teres45.92e-66 222
LLPS-Ast-1248Aspergillus terreus45.689e-69 226
LLPS-Miv-0778Microbotryum violaceum45.458e-64 218
LLPS-Asfu-0779Aspergillus fumigatus45.394e-73 237
LLPS-Nec-0888Neurospora crassa45.363e-70 229
LLPS-Phn-0880Phaeosphaeria nodorum45.352e-67 224
LLPS-Kop-1106Komagataella pastoris45.33e-76 245
LLPS-Usm-1207Ustilago maydis44.922e-52 190
LLPS-Asc-0393Aspergillus clavatus44.642e-71 233
LLPS-Asn-1263Aspergillus nidulans44.526e-73 237
LLPS-Asf-0920Aspergillus flavus44.258e-75 241
LLPS-Asni-1126Aspergillus niger44.151e-73 238
LLPS-Chc-1069Chondrus crispus44.04e-1061.6
LLPS-Yal-1191Yarrowia lipolytica43.933e-70 230
LLPS-Asg-0816Ashbya gossypii43.555e-71 231
LLPS-Pug-1063Puccinia graminis43.399e-64 216
LLPS-Aso-1024Aspergillus oryzae43.164e-74 239
LLPS-Crn-0983Cryptococcus neoformans42.916e-55 193
LLPS-Mel-0790Melampsora laricipopulina42.863e-70 233
LLPS-Nef-0209Neosartorya fischeri42.813e-73 238
LLPS-Put-1278Puccinia triticina42.525e-65 219
LLPS-Gas-1135Galdieria sulphuraria42.51e-56 195
LLPS-Sac-1443Saccharomyces cerevisiae41.966e-72 234
LLPS-Brd-1331Brachypodium distachyon41.377e-54 187
LLPS-Hov-2166Hordeum vulgare41.013e-53 186
LLPS-Cym-0322Cyanidioschyzon merolae40.741e-48 175
LLPS-Tra-0164Triticum aestivum40.653e-54 188
LLPS-Sot-1287Solanum tuberosum40.651e-53 187
LLPS-Nia-1836Nicotiana attenuata40.292e-52 184
LLPS-Lep-1792Leersia perrieri40.152e-51 181
LLPS-Zem-1498Zea mays40.072e-45 166
LLPS-Sem-1618Selaginella moellendorffii40.072e-52 184
LLPS-Thc-1772Theobroma cacao40.06e-43 159
LLPS-Tru-0338Triticum urartu39.932e-49 174
LLPS-Sol-1058Solanum lycopersicum39.934e-52 183
LLPS-Chr-1599Chlamydomonas reinhardtii39.85e-55 190
LLPS-Ors-1853Oryza sativa39.711e-51 181
LLPS-Org-0884Oryza glaberrima39.711e-51 181
LLPS-Ori-2365Oryza indica39.711e-51 182
LLPS-Orbr-0856Oryza brachyantha39.655e-43 156
LLPS-Sob-1545Sorghum bicolor39.587e-47 168
LLPS-Osl-0716Ostreococcus lucimarinus39.582e-54 188
LLPS-Brn-0622Brassica napus39.582e-49 176
LLPS-Amt-0563Amborella trichopoda39.521e-53 189
LLPS-Brr-2178Brassica rapa39.221e-48 174
LLPS-Bro-3039Brassica oleracea39.224e-49 176
LLPS-Phv-0417Phaseolus vulgaris39.212e-49 175
LLPS-Vir-2118Vigna radiata39.074e-49 176
LLPS-Art-0727Arabidopsis thaliana38.879e-47 169
LLPS-Met-2608Medicago truncatula38.855e-49 175
LLPS-Cus-0970Cucumis sativus38.855e-44 161
LLPS-Mae-1627Manihot esculenta38.816e-50 178
LLPS-Orp-0476Oryza punctata38.818e-50 177
LLPS-Orm-1722Oryza meridionalis38.818e-50 177
LLPS-Glm-2907Glycine max38.732e-49 176
LLPS-Php-1614Physcomitrella patens38.683e-52 184
LLPS-Prp-0287Prunus persica38.543e-52 184
LLPS-Arl-2441Arabidopsis lyrata38.522e-46 168
LLPS-Dac-0744Daucus carota38.495e-49 176
LLPS-Orr-0772Oryza rufipogon38.462e-49 176
LLPS-Orni-1645Oryza nivara38.462e-49 176
LLPS-Orb-1353Oryza barthii38.462e-49 176
LLPS-Orgl-0854Oryza glumaepatula38.462e-49 176
LLPS-Gor-1063Gossypium raimondii38.432e-43 160
LLPS-Coc-1991Corchorus capsularis38.413e-42 157
LLPS-Hea-1303Helianthus annuus38.196e-50 177
LLPS-Mua-1403Musa acuminata38.161e-50 180
LLPS-Via-2292Vigna angularis37.892e-47 171
LLPS-Pot-1975Populus trichocarpa37.772e-47 171
LLPS-Viv-0790Vitis vinifera37.681e-48 173
LLPS-Sei-2443Setaria italica36.45e-46 167