• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Otg-2483
ORC4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Origin recognition complex subunit 4
Gene Name: ORC4
Ensembl Gene: ENSOGAG00000004022.2
Ensembl Protein: ENSOGAP00000003583.2
Organism: Otolemur garnettii
Taxa ID: 30611
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Component of the origin recognition complex (ORC) that binds origins of replication.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSRKSKSNN  LIHVDCLSQV  QRILRERFCH  QSPHNNLYGV  QVQYKHLIEL  LKRTAINGES  60
61    NSVLIIGPRG  SGKTMLINHA  LKELMEIEDV  SENILHVHLN  GLLQINDKIA  LKEITRQLNL  120
121   ENVVGDKVFG  SFAENLSFLL  EALKKGDRTS  SCPVIFILDE  FDLFAHHKNQ  TLLYNLFDIS  180
181   QSAQTPVAIV  GLTCRLDILE  LLEKRVKSRF  SHRQIHLMNS  FGFPQYVKIF  KEQLSLPAEF  240
241   PEKLFAEKWN  ENVQCLSEDR  SVREVLQKHF  SVSKSLRSLH  MLLMFALNLV  TASHPFISAT  300
301   DLMEANQLCS  MDSKANIVHG  LSVLEICLVI  AMKHLNDIYE  EEPFNFQMVY  NEFQKFVQRK  360
361   AHSVYNFEKP  VVMKAFEHLQ  QLELIKPMER  TSGNSQREYQ  LMKLLLDNTQ  IMNALQKYPN  420
421   CPTDVRQWAA  SSLSWF  436
Nucleotide CDS Sequence (FASTA)
1     ATGAGCAGTC  GTAAATCAAA  AAGTAACAAC  TTAATTCATG  TGGACTGCCT  TTCACAGGTA  60
61    CAGAGAATTT  TACGTGAAAG  ATTCTGTCAT  CAGAGTCCAC  ATAATAACCT  ATATGGAGTA  120
121   CAAGTACAAT  ACAAACACTT  AATTGAACTG  CTAAAAAGAA  CTGCTATCAA  TGGAGAAAGT  180
181   AACTCTGTAC  TCATTATTGG  ACCCCGAGGA  TCAGGAAAGA  CTATGTTAAT  AAATCATGCT  240
241   TTGAAAGAAC  TCATGGAAAT  AGAAGACGTG  AGTGAAAACA  TACTACATGT  TCACCTAAAT  300
301   GGCCTGCTGC  AGATCAATGA  TAAAATTGCC  CTAAAGGAAA  TTACAAGGCA  GTTAAATCTG  360
361   GAAAATGTAG  TTGGAGATAA  AGTTTTTGGA  AGCTTTGCTG  AAAATCTTTC  ATTTCTTCTG  420
421   GAAGCCTTAA  AAAAAGGTGA  TCGGACAAGC  AGTTGCCCAG  TGATCTTCAT  ACTAGATGAG  480
481   TTTGATCTTT  TTGCTCATCA  TAAAAACCAA  ACACTTCTCT  ATAATCTTTT  TGACATTTCT  540
541   CAGTCTGCAC  AAACCCCAGT  AGCAATTGTT  GGACTTACAT  GTAGATTGGA  TATTTTGGAA  600
601   CTCTTAGAAA  AAAGAGTGAA  GTCACGATTT  TCTCACCGGC  AGATCCACTT  AATGAATTCA  660
661   TTTGGTTTTC  CACAGTATGT  TAAAATATTT  AAAGAACAAT  TATCTCTACC  TGCAGAATTT  720
721   CCAGAAAAGC  TTTTTGCTGA  GAAATGGAAT  GAAAATGTTC  AGTGTCTTTC  AGAAGATAGA  780
781   AGCGTGCGAG  AAGTCCTACA  GAAGCATTTT  AGTGTCAGCA  AAAGCCTGCG  GTCACTGCAC  840
841   ATGCTATTGA  TGTTTGCTTT  AAATCTAGTG  ACAGCATCGC  ACCCGTTTAT  TAGTGCTACA  900
901   GACCTCATGG  AGGCAAACCA  GCTCTGTAGC  ATGGACTCTA  AAGCAAATAT  TGTACATGGT  960
961   CTCTCAGTCT  TGGAAATCTG  TCTTGTAATA  GCAATGAAAC  ATTTAAATGA  CATCTATGAA  1020
1021  GAGGAGCCAT  TTAATTTTCA  AATGGTCTAT  AATGAGTTTC  AGAAGTTTGT  TCAAAGGAAG  1080
1081  GCCCATTCTG  TTTACAATTT  TGAGAAACCT  GTTGTCATGA  AGGCTTTTGA  ACATTTACAA  1140
1141  CAATTAGAGT  TAATAAAGCC  CATGGAAAGA  ACTTCAGGAA  ATTCACAGAG  AGAATACCAG  1200
1201  CTGATGAAAC  TACTTTTGGA  TAATACCCAA  ATTATGAATG  CTCTGCAGAA  ATACCCCAAC  1260
1261  TGTCCTACAG  ATGTTAGGCA  GTGGGCAGCA  TCCTCACTAA  GCTGGTTCTG  A  1311

▼ KEYWORD

ID
Family
Complete proteome
DNA replication
DNA-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nuclear origin of replication recognition complex
Cellular Component
Nucleolus
Molecular Function
DNA replication origin binding
Molecular Function
Nucleotide binding
Biological Process
DNA replication initiation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-0902Mandrillus leucophaeus93.350.0 850
LLPS-Chs-4728Chlorocebus sabaeus93.120.0 848
LLPS-Eqc-2657Equus caballus93.120.0 844
LLPS-Paa-2941Papio anubis92.890.0 848
LLPS-Aon-2259Aotus nancymaae92.890.0 830
LLPS-Maf-1136Macaca fascicularis92.890.0 848
LLPS-Mam-2816Macaca mulatta92.890.0 848
LLPS-Cas-2142Carlito syrichta92.890.0 842
LLPS-Man-0838Macaca nemestrina92.890.0 848
LLPS-Hos-4182Homo sapiens92.890.0 847
LLPS-Pap-1707Pan paniscus92.890.0 847
LLPS-Gog-0563Gorilla gorilla92.660.0 845
LLPS-Poa-3891Pongo abelii92.660.0 847
LLPS-Nol-1167Nomascus leucogenys92.660.0 845
LLPS-Cea-0028Cercocebus atys92.610.0 546
LLPS-Bot-3067Bos taurus92.570.0 804
LLPS-Caj-4451Callithrix jacchus92.430.0 827
LLPS-Pat-3153Pan troglodytes92.430.0 843
LLPS-Rhb-4249Rhinopithecus bieti92.430.0 839
LLPS-Tut-2064Tursiops truncatus92.20.0 835
LLPS-Caf-3287Canis familiaris92.20.0 842
LLPS-Urm-3198Ursus maritimus92.20.0 846
LLPS-Ova-4311Ovis aries91.970.0 830
LLPS-Myl-2207Myotis lucifugus91.740.0 840
LLPS-Orc-3149Oryctolagus cuniculus91.740.0 839
LLPS-Aim-3147Ailuropoda melanoleuca91.510.0 842
LLPS-Sus-1848Sus scrofa91.280.0 835
LLPS-Fec-0510Felis catus91.060.0 837
LLPS-Dio-3883Dipodomys ordii90.830.0 805
LLPS-Mup-3691Mustela putorius furo90.830.0 831
LLPS-Ict-1881Ictidomys tridecemlineatus90.60.0 823
LLPS-Loa-3065Loxodonta africana89.930.0 815
LLPS-Fud-2489Fukomys damarensis88.530.0 812
LLPS-Mea-2812Mesocricetus auratus87.160.0 799
LLPS-Mum-0895Mus musculus86.930.0 789
LLPS-Ran-4743Rattus norvegicus86.240.0 791
LLPS-Cap-4545Cavia porcellus85.780.0 778
LLPS-Sah-1207Sarcophilus harrisii84.170.0 769
LLPS-Mod-4101Monodelphis domestica83.490.0 761
LLPS-Ora-3016Ornithorhynchus anatinus80.730.0 745
LLPS-Pes-1405Pelodiscus sinensis78.670.0 726
LLPS-Meg-3214Meleagris gallopavo74.770.0 687
LLPS-Tag-0684Taeniopygia guttata74.580.0 638
LLPS-Lac-3445Latimeria chalumnae74.170.0 560
LLPS-Anp-0728Anas platyrhynchos74.080.0 682
LLPS-Anc-0548Anolis carolinensis73.960.0 679
LLPS-Gaga-1908Gallus gallus73.850.0 686
LLPS-Fia-0673Ficedula albicollis72.680.0 550
LLPS-Leo-3351Lepisosteus oculatus68.890.0 638
LLPS-Xet-0988Xenopus tropicalis68.880.0 595
LLPS-Scf-2197Scleropages formosus68.660.0 634
LLPS-Asm-4055Astyanax mexicanus68.660.0 627
LLPS-Scm-3348Scophthalmus maximus68.521e-158 463
LLPS-Orn-3268Oreochromis niloticus67.430.0 631
LLPS-Icp-2131Ictalurus punctatus66.670.0 606
LLPS-Tar-2482Takifugu rubripes66.580.0 527
LLPS-Xim-3036Xiphophorus maculatus65.90.0 615
LLPS-Pof-1529Poecilia formosa65.90.0 621
LLPS-Dar-3607Danio rerio65.210.0 599
LLPS-Orl-1768Oryzias latipes64.750.0 601
LLPS-Gaa-3488Gasterosteus aculeatus63.30.0 603
LLPS-Ten-2830Tetraodon nigroviridis62.390.0 596
LLPS-Cis-1935Ciona savignyi50.913e-151 444
LLPS-Cii-2211Ciona intestinalis50.122e-134 400
LLPS-Dos-1339Dothistroma septosporum48.174e-35 138
LLPS-Abg-1770Absidia glauca43.733e-68 228
LLPS-Drm-2291Drosophila melanogaster42.421e-104 325
LLPS-Ast-0576Aspergillus terreus40.763e-37 148
LLPS-Pytr-1194Pyrenophora triticirepentis39.223e-42 162
LLPS-Aso-1100Aspergillus oryzae38.573e-36 145
LLPS-Asni-1602Aspergillus niger38.571e-38 152
LLPS-Spr-1172Sporisorium reilianum38.142e-0963.5
LLPS-Coc-0688Corchorus capsularis38.031e-32 129
LLPS-Asc-1560Aspergillus clavatus37.141e-35 144
LLPS-Tum-1616Tuber melanosporum36.895e-55 194
LLPS-Asf-1018Aspergillus flavus36.752e-37 148
LLPS-Trr-0297Trichoderma reesei35.894e-62 220
LLPS-Map-1177Magnaporthe poae35.744e-48 180
LLPS-Usm-0663Ustilago maydis35.642e-0757.4
LLPS-Php-1886Physcomitrella patens35.282e-59 206
LLPS-Scc-1116Schizosaccharomyces cryophilus34.835e-51 189
LLPS-Pyt-1415Pyrenophora teres34.772e-47 178
LLPS-Nef-1026Neosartorya fischeri34.32e-38 151
LLPS-Ved-1543Verticillium dahliae34.175e-47 177
LLPS-Cogr-1657Colletotrichum graminicola34.153e-52 193
LLPS-Lem-1441Leptosphaeria maculans34.142e-45 172
LLPS-Trv-1590Trichoderma virens34.148e-61 214
LLPS-Nec-1288Neurospora crassa33.957e-48 181
LLPS-Cog-0931Colletotrichum gloeosporioides33.881e-53 196
LLPS-Asfu-1407Aspergillus fumigatus33.334e-39 153
LLPS-Via-1169Vigna angularis33.174e-53 189
LLPS-Zyt-1527Zymoseptoria tritici33.082e-45 173
LLPS-Phn-1104Phaeosphaeria nodorum33.032e-48 181
LLPS-Scp-1546Schizosaccharomyces pombe32.958e-51 189
LLPS-Mao-1501Magnaporthe oryzae32.952e-55 202
LLPS-Met-1079Medicago truncatula32.812e-46 171
LLPS-Scj-1129Schizosaccharomyces japonicus32.377e-53 194
LLPS-Dac-0695Daucus carota32.292e-44 169
LLPS-Gor-0994Gossypium raimondii32.236e-51 183
LLPS-Beb-1255Beauveria bassiana32.185e-52 192
LLPS-Amt-1290Amborella trichopoda32.083e-46 171
LLPS-Coo-0802Colletotrichum orbiculare32.013e-52 192
LLPS-Asg-1501Ashbya gossypii31.952e-29 124
LLPS-Fus-1556Fusarium solani31.953e-56 203
LLPS-Vir-1994Vigna radiata31.947e-40 154
LLPS-Fuv-0439Fusarium verticillioides31.923e-55 199
LLPS-Fuo-1009Fusarium oxysporum31.929e-55 199
LLPS-Gag-0117Gaeumannomyces graminis31.82e-50 187
LLPS-Phv-1462Phaseolus vulgaris31.683e-50 181
LLPS-Blg-1531Blumeria graminis31.41e-50 188
LLPS-Glm-0146Glycine max31.38e-49 177
LLPS-Sac-0983Saccharomyces cerevisiae31.211e-30 127
LLPS-Thc-0030Theobroma cacao31.173e-49 179
LLPS-Bro-2044Brassica oleracea31.155e-50 181
LLPS-Prp-0795Prunus persica31.092e-47 174
LLPS-Orbr-1711Oryza brachyantha30.986e-49 178
LLPS-Asn-1277Aspergillus nidulans30.973e-37 149
LLPS-Pot-1534Populus trichocarpa30.791e-50 183
LLPS-Brn-1010Brassica napus30.738e-48 175
LLPS-Mua-2394Musa acuminata30.546e-46 169
LLPS-Ori-1934Oryza indica30.353e-42 159
LLPS-Sot-0450Solanum tuberosum30.053e-47 173
LLPS-Nia-2139Nicotiana attenuata30.055e-47 172
LLPS-Tra-1053Triticum aestivum30.022e-47 174
LLPS-Arl-1682Arabidopsis lyrata29.853e-49 179
LLPS-Sob-2517Sorghum bicolor29.761e-46 172
LLPS-Chr-1128Chlamydomonas reinhardtii29.722e-1582.4
LLPS-Yal-0609Yarrowia lipolytica29.692e-46 173
LLPS-Viv-0381Vitis vinifera29.55e-49 179
LLPS-Mae-0549Manihot esculenta29.121e-46 171
LLPS-Sol-0622Solanum lycopersicum29.067e-36 145
LLPS-Sei-0444Setaria italica28.991e-45 169
LLPS-Hea-1679Helianthus annuus28.925e-43 162
LLPS-Kop-0640Komagataella pastoris28.891e-31 130
LLPS-Mel-0065Melampsora laricipopulina28.836e-29 124
LLPS-Cus-0275Cucumis sativus28.758e-42 158
LLPS-Crn-1250Cryptococcus neoformans28.753e-28 122
LLPS-Brd-0755Brachypodium distachyon28.439e-43 161
LLPS-Brr-2296Brassica rapa28.396e-41 156
LLPS-Miv-1381Microbotryum violaceum27.882e-31 132
LLPS-Hov-1227Hordeum vulgare27.824e-33 135
LLPS-Org-2096Oryza glaberrima27.583e-41 158
LLPS-Ors-2334Oryza sativa27.583e-41 158
LLPS-Orm-0364Oryza meridionalis27.295e-33 134
LLPS-Osl-0747Ostreococcus lucimarinus27.173e-0653.9
LLPS-Orgl-1862Oryza glumaepatula27.141e-36 144
LLPS-Orp-1564Oryza punctata27.061e-34 138
LLPS-Zem-2305Zea mays26.615e-35 139
LLPS-Orb-0835Oryza barthii26.045e-28 118
LLPS-Orr-2114Oryza rufipogon26.045e-28 118
LLPS-Tru-1259Triticum urartu25.981e-1993.2
LLPS-Orni-0496Oryza nivara25.01e-25 111
LLPS-Gas-0364Galdieria sulphuraria24.681e-1994.7
LLPS-Pug-0318Puccinia graminis24.35e-1994.0
LLPS-Cym-0356Cyanidioschyzon merolae23.52e-1273.2