• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-4101
ORC4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Origin recognition complex subunit 4
Gene Name: ORC4
Ensembl Gene: ENSMODG00000003327.3
Ensembl Protein: ENSMODP00000004068.2
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Component of the origin recognition complex (ORC) that binds origins of replication.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSRKSKNNN  LKYGECISQV  QRILRERFCH  QIPKGNLFGV  QTQYKLLIDL  LKRTAINGES  60
61    NSALIIGPRG  SGKTMILNQA  LEELMEIKQV  RENVLQVHLN  GLLQTSDKIA  LKEITKQLCL  120
121   ENVVGDKIFG  SFAENLSFLL  EALKKGDRTS  SCPVIFILDE  FDLFAHHKNQ  TLLYNLFDIS  180
181   QSAQTPVAVI  GLTCRLDILE  LLEKRVKSRF  SHRQIHLMNS  FSFSQYLKIF  KEQLTLPEEF  240
241   SDKHFTEKWN  ETIQCLSEDK  NVKEVLLKHF  HTSKDLRSLH  MLLMLALSHI  TPSRPFIIPT  300
301   DLVEANHLCS  MDSKGNIVHG  LSVLEICLLI  AMKHLNDIYQ  DEPFNFQMVY  NEFQKFIQRK  360
361   AHSVYNFEKP  VVMKAFEHLQ  QLELVKVMER  TSVNTQREFQ  LVKLLLDNNQ  IMDALQKYPN  420
421   CPTDVRQWAA  SSLSWL  436
Nucleotide CDS Sequence (FASTA)
1     ATGAGCAGTC  GGAAGTCAAA  AAACAACAAC  CTGAAATATG  GAGAGTGTAT  TTCACAGGTA  60
61    CAAAGAATTT  TACGTGAAAG  ATTTTGTCAC  CAGATTCCAA  AGGGCAACCT  GTTTGGAGTA  120
121   CAGACACAGT  ACAAACTCTT  AATTGATCTG  CTAAAACGAA  CAGCTATCAA  TGGAGAAAGT  180
181   AACTCTGCAT  TAATTATTGG  ACCTAGAGGA  TCAGGAAAAA  CCATGATATT  AAATCAAGCT  240
241   TTGGAAGAAC  TTATGGAAAT  AAAACAAGTG  AGAGAAAATG  TTTTGCAAGT  TCACCTAAAT  300
301   GGATTGCTGC  AGACCAGTGA  TAAAATTGCT  CTAAAGGAAA  TTACAAAGCA  ATTATGTCTG  360
361   GAAAATGTAG  TTGGAGATAA  AATTTTTGGA  TCCTTTGCTG  AAAATCTTTC  TTTTCTTCTG  420
421   GAAGCTTTAA  AAAAAGGTGA  CCGGACTAGC  TCTTGTCCTG  TGATCTTCAT  CTTGGATGAA  480
481   TTTGATCTCT  TTGCACATCA  TAAAAACCAA  ACACTTCTTT  ATAACCTTTT  TGACATATCT  540
541   CAGTCAGCAC  AGACTCCAGT  TGCTGTTATT  GGCCTTACAT  GTAGATTGGA  TATTTTGGAA  600
601   CTCCTAGAAA  AGAGAGTGAA  GTCACGATTT  TCTCACCGGC  AGATACATTT  AATGAATTCC  660
661   TTTAGTTTCT  CACAATATCT  TAAAATATTT  AAAGAACAAT  TAACACTACC  TGAAGAATTT  720
721   TCTGACAAGC  ACTTTACTGA  GAAATGGAAC  GAAACAATTC  AGTGTCTCTC  AGAAGACAAG  780
781   AATGTGAAAG  AAGTTCTGCT  AAAACATTTC  CACACAAGCA  AAGACCTTCG  ATCACTACAT  840
841   ATGTTACTGA  TGCTTGCCTT  AAGTCACATA  ACGCCATCTC  GCCCATTTAT  TATTCCAACA  900
901   GACCTGGTGG  AGGCAAACCA  TTTGTGTAGT  ATGGACTCTA  AAGGAAATAT  TGTACATGGT  960
961   CTTTCAGTGT  TAGAAATTTG  TCTTCTTATA  GCAATGAAAC  ATCTAAATGA  TATTTATCAG  1020
1021  GATGAGCCTT  TTAACTTTCA  GATGGTCTAT  AATGAATTTC  AGAAGTTTAT  CCAAAGGAAG  1080
1081  GCCCATTCAG  TTTATAATTT  TGAAAAACCT  GTTGTTATGA  AGGCATTTGA  ACATTTACAG  1140
1141  CAACTAGAAT  TAGTCAAAGT  AATGGAGAGA  ACATCAGTAA  ATACACAGAG  AGAATTCCAA  1200
1201  CTGGTGAAAT  TGCTTTTGGA  CAATAATCAA  ATTATGGATG  CTCTACAAAA  GTACCCAAAC  1260
1261  TGCCCTACAG  ATGTTAGGCA  GTGGGCAGCC  TCTTCACTGA  GCTGGTTGTG  A  1311

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
DNA replication
DNA-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nuclear origin of replication recognition complex
Cellular Component
Nucleolus
Molecular Function
DNA replication origin binding
Molecular Function
Nucleotide binding
Biological Process
DNA replication initiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sah-1207Sarcophilus harrisii95.640.0 830
LLPS-Bot-3067Bos taurus84.890.0 713
LLPS-Eqc-2657Equus caballus83.940.0 739
LLPS-Urm-3198Ursus maritimus83.940.0 741
LLPS-Caf-3287Canis familiaris83.720.0 738
LLPS-Fec-0510Felis catus83.720.0 738
LLPS-Aim-3147Ailuropoda melanoleuca83.720.0 739
LLPS-Ova-4311Ovis aries83.720.0 733
LLPS-Poa-3891Pongo abelii83.490.0 733
LLPS-Otg-2483Otolemur garnettii83.490.0 736
LLPS-Orc-3149Oryctolagus cuniculus83.490.0 739
LLPS-Ict-1881Ictidomys tridecemlineatus83.260.0 733
LLPS-Myl-2207Myotis lucifugus83.260.0 730
LLPS-Tut-2064Tursiops truncatus83.260.0 733
LLPS-Cas-2142Carlito syrichta83.030.0 725
LLPS-Hos-4182Homo sapiens83.030.0 727
LLPS-Pap-1707Pan paniscus83.030.0 727
LLPS-Mal-0902Mandrillus leucophaeus83.030.0 730
LLPS-Chs-4728Chlorocebus sabaeus83.030.0 731
LLPS-Cea-0028Cercocebus atys82.911e-162 469
LLPS-Nol-1167Nomascus leucogenys82.80.0 728
LLPS-Mam-2816Macaca mulatta82.80.0 729
LLPS-Pat-3153Pan troglodytes82.80.0 725
LLPS-Man-0838Macaca nemestrina82.80.0 729
LLPS-Mup-3691Mustela putorius furo82.80.0 726
LLPS-Paa-2941Papio anubis82.80.0 730
LLPS-Dio-3883Dipodomys ordii82.80.0 721
LLPS-Gog-0563Gorilla gorilla82.80.0 725
LLPS-Maf-1136Macaca fascicularis82.80.0 729
LLPS-Sus-1848Sus scrofa82.80.0 730
LLPS-Aon-2259Aotus nancymaae82.80.0 730
LLPS-Caj-4451Callithrix jacchus82.570.0 727
LLPS-Fud-2489Fukomys damarensis82.570.0 734
LLPS-Rhb-4249Rhinopithecus bieti82.340.0 722
LLPS-Ora-3016Ornithorhynchus anatinus81.880.0 731
LLPS-Ran-4743Rattus norvegicus81.650.0 710
LLPS-Loa-3065Loxodonta africana81.460.0 706
LLPS-Mum-0895Mus musculus81.190.0 707
LLPS-Mea-2812Mesocricetus auratus81.190.0 716
LLPS-Pes-1405Pelodiscus sinensis80.050.0 696
LLPS-Cap-4545Cavia porcellus79.360.0 691
LLPS-Meg-3214Meleagris gallopavo75.230.0 655
LLPS-Lac-3445Latimeria chalumnae74.720.0 535
LLPS-Gaga-1908Gallus gallus74.540.0 658
LLPS-Tag-0684Taeniopygia guttata74.340.0 624
LLPS-Anp-0728Anas platyrhynchos74.310.0 649
LLPS-Fia-0673Ficedula albicollis72.410.0 533
LLPS-Anc-0548Anolis carolinensis72.350.0 634
LLPS-Leo-3351Lepisosteus oculatus69.350.0 630
LLPS-Xet-0988Xenopus tropicalis68.190.0 563
LLPS-Asm-4055Astyanax mexicanus67.280.0 603
LLPS-Scm-3348Scophthalmus maximus66.891e-147 435
LLPS-Scf-2197Scleropages formosus66.820.0 600
LLPS-Icp-2131Ictalurus punctatus65.880.0 581
LLPS-Orn-3268Oreochromis niloticus65.830.0 598
LLPS-Tar-2482Takifugu rubripes65.512e-171 499
LLPS-Pof-1529Poecilia formosa65.210.0 592
LLPS-Xim-3036Xiphophorus maculatus64.980.0 590
LLPS-Orl-1768Oryzias latipes64.520.0 574
LLPS-Dar-3607Danio rerio63.950.0 567
LLPS-Gaa-3488Gasterosteus aculeatus63.30.0 582
LLPS-Ten-2830Tetraodon nigroviridis61.470.0 568
LLPS-Cis-1935Ciona savignyi48.973e-138 411
LLPS-Cii-2211Ciona intestinalis46.966e-123 371
LLPS-Dos-1339Dothistroma septosporum44.812e-34 136
LLPS-Abg-1770Absidia glauca43.321e-67 226
LLPS-Drm-2291Drosophila melanogaster41.297e-98 308
LLPS-Crn-1250Cryptococcus neoformans40.412e-26 116
LLPS-Asni-1602Aspergillus niger40.288e-39 153
LLPS-Pytr-1194Pyrenophora triticirepentis40.167e-44 167
LLPS-Ast-0576Aspergillus terreus39.811e-37 149
LLPS-Sol-0622Solanum lycopersicum39.73e-33 138
LLPS-Asc-1560Aspergillus clavatus38.352e-35 143
LLPS-Coc-0688Corchorus capsularis38.324e-35 135
LLPS-Trr-0297Trichoderma reesei38.125e-60 214
LLPS-Trv-1590Trichoderma virens37.852e-58 207
LLPS-Tum-1616Tuber melanosporum37.749e-53 188
LLPS-Ori-1934Oryza indica37.614e-33 133
LLPS-Php-1886Physcomitrella patens37.178e-60 207
LLPS-Aso-1100Aspergillus oryzae36.972e-36 146
LLPS-Pyt-1415Pyrenophora teres36.573e-47 178
LLPS-Coo-0802Colletotrichum orbiculare36.252e-49 184
LLPS-Asn-1277Aspergillus nidulans36.232e-36 146
LLPS-Nef-1026Neosartorya fischeri35.985e-38 150
LLPS-Asfu-1407Aspergillus fumigatus35.857e-39 153
LLPS-Asf-1018Aspergillus flavus35.54e-37 147
LLPS-Map-1177Magnaporthe poae35.477e-46 174
LLPS-Lem-1441Leptosphaeria maculans35.385e-46 174
LLPS-Miv-1381Microbotryum violaceum34.82e-28 122
LLPS-Cog-0931Colletotrichum gloeosporioides34.691e-53 196
LLPS-Ved-1543Verticillium dahliae34.545e-47 177
LLPS-Spr-1172Sporisorium reilianum34.537e-26 114
LLPS-Thc-0030Theobroma cacao34.522e-48 177
LLPS-Zyt-1527Zymoseptoria tritici34.363e-43 166
LLPS-Usm-0663Ustilago maydis33.935e-22 102
LLPS-Phn-1104Phaeosphaeria nodorum33.818e-50 185
LLPS-Cogr-1657Colletotrichum graminicola33.72e-50 187
LLPS-Nec-1288Neurospora crassa33.683e-46 177
LLPS-Scc-1116Schizosaccharomyces cryophilus33.492e-43 168
LLPS-Fus-1556Fusarium solani33.421e-51 190
LLPS-Met-1079Medicago truncatula33.421e-44 166
LLPS-Mao-1501Magnaporthe oryzae33.421e-48 182
LLPS-Gor-0994Gossypium raimondii33.161e-48 177
LLPS-Fuv-0439Fusarium verticillioides33.153e-52 191
LLPS-Via-1169Vigna angularis33.089e-49 177
LLPS-Scj-1129Schizosaccharomyces japonicus33.044e-49 184
LLPS-Scp-1546Schizosaccharomyces pombe33.041e-46 177
LLPS-Fuo-1009Fusarium oxysporum32.887e-51 188
LLPS-Gag-0117Gaeumannomyces graminis32.854e-50 187
LLPS-Beb-1255Beauveria bassiana32.673e-49 184
LLPS-Mua-2394Musa acuminata32.594e-46 170
LLPS-Blg-1531Blumeria graminis32.532e-47 179
LLPS-Dac-0695Daucus carota31.941e-41 161
LLPS-Phv-1462Phaseolus vulgaris31.849e-46 169
LLPS-Pot-1534Populus trichocarpa31.83e-50 182
LLPS-Tra-1053Triticum aestivum31.82e-47 174
LLPS-Bro-2044Brassica oleracea31.699e-45 166
LLPS-Amt-1290Amborella trichopoda31.681e-43 164
LLPS-Glm-0146Glycine max31.371e-43 163
LLPS-Asg-1501Ashbya gossypii31.345e-25 111
LLPS-Sot-0450Solanum tuberosum31.32e-46 171
LLPS-Sei-0444Setaria italica31.271e-43 163
LLPS-Brn-1010Brassica napus31.271e-42 161
LLPS-Orbr-1711Oryza brachyantha31.221e-47 174
LLPS-Prp-0795Prunus persica31.131e-44 166
LLPS-Chr-1128Chlamydomonas reinhardtii31.131e-1686.3
LLPS-Nia-2139Nicotiana attenuata30.816e-44 164
LLPS-Brd-0755Brachypodium distachyon30.751e-44 166
LLPS-Vir-1994Vigna radiata30.752e-35 141
LLPS-Sob-2517Sorghum bicolor30.734e-45 167
LLPS-Hov-1227Hordeum vulgare30.645e-35 140
LLPS-Hea-1679Helianthus annuus30.452e-41 157
LLPS-Kop-0640Komagataella pastoris30.383e-35 141
LLPS-Viv-0381Vitis vinifera30.173e-45 169
LLPS-Mae-0549Manihot esculenta29.836e-45 167
LLPS-Yal-0609Yarrowia lipolytica29.693e-43 164
LLPS-Sac-0983Saccharomyces cerevisiae29.574e-27 117
LLPS-Arl-1682Arabidopsis lyrata29.262e-43 164
LLPS-Cus-0275Cucumis sativus29.066e-39 150
LLPS-Mel-0065Melampsora laricipopulina28.725e-26 115
LLPS-Orgl-1862Oryza glumaepatula28.579e-34 135
LLPS-Brr-2296Brassica rapa28.321e-35 141
LLPS-Orr-2114Oryza rufipogon27.763e-27 115
LLPS-Orb-0835Oryza barthii27.763e-27 115
LLPS-Org-2096Oryza glaberrima27.587e-38 148
LLPS-Ors-2334Oryza sativa27.587e-38 148
LLPS-Zem-2305Zea mays27.469e-33 133
LLPS-Orp-1564Oryza punctata27.234e-31 128
LLPS-Orm-0364Oryza meridionalis26.762e-29 122
LLPS-Orni-0496Oryza nivara26.642e-24 107
LLPS-Tru-1259Triticum urartu25.726e-2094.7
LLPS-Gas-0364Galdieria sulphuraria25.06e-1477.8
LLPS-Cym-0356Cyanidioschyzon merolae24.843e-1375.5
LLPS-Pug-0318Puccinia graminis23.163e-1479.3