LLPS-Orn-3380
eif3l
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 3 subunit L |
| Gene Name: | eif3l, EIF3EIP, EIF3L, EIF3S6IP |
| Ensembl Gene: | ENSONIG00000010235.1 |
| Ensembl Protein: | ENSONIP00000012867.1 |
| Organism: | Oreochromis niloticus |
| Taxa ID: | 8128 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSONIT00000012877.1 | ENSONIP00000012867.1 |
| UniProt | I3JVH2, I3JVH2_ORENI | |
| GeneBank | AERX01006538 | |
| RefSeq | XM_003441051.4 | XP_003441099.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSYHDEEDYD PYSYTNDYDL HTGDPKADLA YERQYEQQTY HVIPEVIKNF LQYFHKTISD 60 61 LIDQKVYELQ SNRVSSESIE QKIYEIQDVY ENSWNKLTDR FFKTSPWPEA EAIASLVGND 120 121 AVFLILYKEL YYRHIYAKVS GGPTLDQRFE SYYNYCNLFN YILNADGPAP LELPNQWLWD 180 181 IIDEFIYQFQ SFSQYRCKTA KKSEEEIEFL RSNPKIWNVH SVLNVLHSLV DKSNINRQLE 240 241 VYTSGGDPES VAGEYGRHSL YKMLGYFSLV GLLRLHSLLG DYYQAIKVLE NIELNKKSMY 300 301 SRVPECQITT YYYVGFAYLM MRRYQDAIRV FANILLYIQR TRNMFQRSTY KYEMINKQNE 360 361 QMHGLLAIAL TMYPMRIDES IHTQLREKYG DKMLRMQKGD LQVFEELFSF ACPKFLSPVV 420 421 PNYDNVHPNY HKEPFQQQLK VFAEEVQQQA QLSTIRSFLK LYTTMPVAKL AGFLDMTEQE 480 481 FRIQLLVFKH KMKNLVWTSG ISALDGEFQS ASEVDFYIDK DMIHIADTKV ARRYGDFFIR 540 541 QIHKFEELNR TLKKMSTTAT TVTSGTATSR 570 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCATACC ACGACGAAGA GGATTACGAT CCTTACTCCT ACACAAACGA CTACGATCTG 60 61 CACACTGGTG ACCCTAAAGC AGACCTTGCC TACGAGAGGC AGTATGAGCA GCAGACCTAC 120 121 CATGTCATCC CAGAGGTGAT CAAGAACTTT CTGCAGTATT TCCACAAAAC CATCTCTGAC 180 181 TTGATTGACC AGAAGGTTTA TGAGCTGCAG TCCAACCGGG TGTCTAGTGA GAGCATTGAG 240 241 CAGAAGATCT ACGAGATCCA GGACGTCTAT GAAAACAGCT GGAACAAGTT GACTGACCGT 300 301 TTCTTCAAGA CCTCTCCCTG GCCAGAGGCT GAGGCCATTG CATCACTTGT TGGCAATGAT 360 361 GCCGTGTTTC TCATTCTCTA CAAGGAACTC TATTACAGAC ACATCTACGC TAAAGTCAGC 420 421 GGTGGACCAA CTTTGGACCA GAGATTTGAG TCCTACTACA ATTACTGCAA CCTCTTCAAC 480 481 TACATTCTCA ATGCTGATGG GCCGGCCCCC TTGGAGCTGC CAAACCAGTG GCTCTGGGAC 540 541 ATCATTGATG AGTTTATCTA CCAGTTTCAG TCATTCAGTC AGTACCGCTG TAAGACAGCC 600 601 AAAAAGTCTG AAGAGGAAAT TGAATTCCTG AGGAGCAATC CGAAGATCTG GAACGTCCAC 660 661 AGTGTCCTCA ATGTTCTCCA CTCCCTGGTG GACAAGAGCA ACATCAACCG TCAGCTTGAG 720 721 GTCTACACGA GTGGAGGAGA CCCAGAAAGC GTGGCTGGAG AATATGGACG TCACTCCCTG 780 781 TACAAGATGT TGGGTTACTT CAGCTTGGTC GGGCTTTTGA GGCTTCACTC TCTGCTTGGT 840 841 GACTATTACC AGGCCATCAA AGTCCTGGAG AACATTGAGC TCAATAAGAA GAGTATGTAC 900 901 TCGCGTGTTC CAGAGTGCCA AATCACCACA TATTACTATG TGGGTTTTGC CTACCTTATG 960 961 ATGAGGCGCT ACCAGGATGC CATTCGAGTC TTTGCTAACA TCCTGCTCTA TATCCAGAGA 1020 1021 ACAAGAAACA TGTTCCAGAG GTCAACGTAT AAATATGAGA TGATTAACAA ACAAAATGAG 1080 1081 CAGATGCACG GCCTGCTGGC TATCGCTCTG ACCATGTACC CGATGCGCAT CGACGAGAGC 1140 1141 ATCCACACCC AGCTGAGGGA GAAGTACGGA GATAAGATGC TCCGCATGCA AAAGGGAGAT 1200 1201 CTGCAGGTGT TCGAGGAGCT GTTCAGCTTT GCCTGTCCCA AGTTCTTGTC ACCTGTAGTG 1260 1261 CCAAACTACG ACAACGTCCA CCCGAACTAC CACAAAGAAC CTTTTCAACA GCAGTTGAAG 1320 1321 GTCTTTGCTG AGGAGGTGCA GCAGCAGGCC CAGCTCTCCA CCATTCGAAG CTTCTTGAAG 1380 1381 CTGTACACAA CCATGCCAGT AGCCAAGCTG GCCGGCTTTC TGGACATGAC AGAGCAGGAG 1440 1441 TTCCGCATTC AGCTGCTCGT CTTCAAACAC AAGATGAAGA ATCTGGTGTG GACCAGCGGC 1500 1501 ATCTCAGCGC TGGACGGAGA GTTCCAGTCT GCCTCTGAGG TCGACTTTTA CATTGACAAG 1560 1561 GACATGATCC ACATTGCCGA CACCAAAGTC GCTCGTCGGT ATGGAGACTT TTTCATCAGA 1620 1621 CAGATCCACA AGTTTGAGGA GTTGAACAGG ACTCTGAAGA AGATGTCAAC CACTGCTACC 1680 1681 ACTGTGACAT CAGGAACCGC TACAAGCCGA TGA 1713 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Formation of cytoplasmic translation initiation complex |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-0208 | Pongo abelii | 100.0 | 6e-14 | 77.0 |
| LLPS-Scf-1426 | Scleropages formosus | 98.93 | 0.0 | 902 |
| LLPS-Ten-0150 | Tetraodon nigroviridis | 98.72 | 0.0 | 1068 |
| LLPS-Xim-3681 | Xiphophorus maculatus | 98.56 | 0.0 | 1084 |
| LLPS-Asm-0052 | Astyanax mexicanus | 98.37 | 0.0 | 1074 |
| LLPS-Pof-1836 | Poecilia formosa | 98.2 | 0.0 | 1073 |
| LLPS-Icp-3196 | Ictalurus punctatus | 97.85 | 0.0 | 1066 |
| LLPS-Dar-3243 | Danio rerio | 97.5 | 0.0 | 1065 |
| LLPS-Scm-0137 | Scophthalmus maximus | 97.31 | 0.0 | 1060 |
| LLPS-Gaa-3230 | Gasterosteus aculeatus | 97.07 | 0.0 | 1055 |
| LLPS-Orl-0559 | Oryzias latipes | 96.29 | 0.0 | 1064 |
| LLPS-Otg-3993 | Otolemur garnettii | 96.13 | 0.0 | 828 |
| LLPS-Dio-3366 | Dipodomys ordii | 95.91 | 0.0 | 677 |
| LLPS-Pes-1346 | Pelodiscus sinensis | 95.9 | 0.0 | 556 |
| LLPS-Leo-2888 | Lepisosteus oculatus | 95.77 | 0.0 | 1065 |
| LLPS-Ran-0110 | Rattus norvegicus | 95.42 | 0.0 | 679 |
| LLPS-Ict-1151 | Ictidomys tridecemlineatus | 95.11 | 3e-123 | 368 |
| LLPS-Tar-0706 | Takifugu rubripes | 94.77 | 0.0 | 1027 |
| LLPS-Chs-1190 | Chlorocebus sabaeus | 94.76 | 0.0 | 539 |
| LLPS-Anp-1270 | Anas platyrhynchos | 94.01 | 0.0 | 998 |
| LLPS-Anc-1971 | Anolis carolinensis | 93.26 | 0.0 | 989 |
| LLPS-Tag-0208 | Taeniopygia guttata | 93.13 | 0.0 | 1027 |
| LLPS-Gaga-0991 | Gallus gallus | 92.95 | 0.0 | 1027 |
| LLPS-Meg-0710 | Meleagris gallopavo | 92.95 | 0.0 | 1026 |
| LLPS-Fia-0167 | Ficedula albicollis | 92.95 | 0.0 | 1026 |
| LLPS-Mea-1652 | Mesocricetus auratus | 92.59 | 0.0 | 1020 |
| LLPS-Ora-0849 | Ornithorhynchus anatinus | 92.59 | 0.0 | 1019 |
| LLPS-Sah-3086 | Sarcophilus harrisii | 92.59 | 0.0 | 1021 |
| LLPS-Caj-4298 | Callithrix jacchus | 92.59 | 0.0 | 1020 |
| LLPS-Ere-0699 | Erinaceus europaeus | 92.5 | 0.0 | 1013 |
| LLPS-Fec-1566 | Felis catus | 92.42 | 0.0 | 1021 |
| LLPS-Mal-0144 | Mandrillus leucophaeus | 92.41 | 0.0 | 1019 |
| LLPS-Paa-0753 | Papio anubis | 92.41 | 0.0 | 1019 |
| LLPS-Aim-3108 | Ailuropoda melanoleuca | 92.41 | 0.0 | 1019 |
| LLPS-Mup-1721 | Mustela putorius furo | 92.41 | 0.0 | 1019 |
| LLPS-Maf-0878 | Macaca fascicularis | 92.41 | 0.0 | 1020 |
| LLPS-Gog-1120 | Gorilla gorilla | 92.41 | 0.0 | 1021 |
| LLPS-Caf-3353 | Canis familiaris | 92.41 | 0.0 | 1019 |
| LLPS-Nol-0985 | Nomascus leucogenys | 92.41 | 0.0 | 1020 |
| LLPS-Pap-0996 | Pan paniscus | 92.41 | 0.0 | 1021 |
| LLPS-Urm-0681 | Ursus maritimus | 92.41 | 0.0 | 1019 |
| LLPS-Pat-1719 | Pan troglodytes | 92.41 | 0.0 | 1021 |
| LLPS-Hos-1055 | Homo sapiens | 92.41 | 0.0 | 1021 |
| LLPS-Man-2687 | Macaca nemestrina | 92.41 | 0.0 | 1020 |
| LLPS-Loa-2966 | Loxodonta africana | 92.41 | 0.0 | 1019 |
| LLPS-Bot-3146 | Bos taurus | 92.22 | 0.0 | 1017 |
| LLPS-Ova-2246 | Ovis aries | 92.22 | 0.0 | 1018 |
| LLPS-Cea-1502 | Cercocebus atys | 92.22 | 0.0 | 1016 |
| LLPS-Mam-1255 | Macaca mulatta | 92.12 | 0.0 | 1005 |
| LLPS-Tut-0859 | Tursiops truncatus | 92.11 | 0.0 | 1001 |
| LLPS-Cap-0807 | Cavia porcellus | 92.11 | 0.0 | 999 |
| LLPS-Xet-1914 | Xenopus tropicalis | 92.11 | 0.0 | 1021 |
| LLPS-Mum-3388 | Mus musculus | 92.04 | 0.0 | 1016 |
| LLPS-Orc-1032 | Oryctolagus cuniculus | 91.86 | 0.0 | 1015 |
| LLPS-Eqc-0090 | Equus caballus | 91.71 | 0.0 | 948 |
| LLPS-Fud-1828 | Fukomys damarensis | 91.68 | 0.0 | 1011 |
| LLPS-Mod-0799 | Monodelphis domestica | 91.68 | 0.0 | 1011 |
| LLPS-Lac-0357 | Latimeria chalumnae | 90.5 | 0.0 | 986 |
| LLPS-Myl-0596 | Myotis lucifugus | 89.51 | 0.0 | 972 |
| LLPS-Sus-1761 | Sus scrofa | 89.09 | 0.0 | 952 |
| LLPS-Aon-0541 | Aotus nancymaae | 88.61 | 0.0 | 993 |
| LLPS-Cas-1938 | Carlito syrichta | 77.23 | 2e-160 | 467 |
| LLPS-Rhb-0895 | Rhinopithecus bieti | 75.09 | 0.0 | 748 |
| LLPS-Cii-1896 | Ciona intestinalis | 61.92 | 0.0 | 597 |
| LLPS-Cis-0899 | Ciona savignyi | 60.44 | 0.0 | 609 |
| LLPS-Drm-0741 | Drosophila melanogaster | 54.64 | 0.0 | 561 |
| LLPS-Phn-0619 | Phaeosphaeria nodorum | 52.89 | 8e-111 | 347 |
| LLPS-Nec-1432 | Neurospora crassa | 50.99 | 8e-125 | 382 |
| LLPS-Pyt-0714 | Pyrenophora teres | 50.86 | 7e-125 | 383 |
| LLPS-Pytr-0625 | Pyrenophora triticirepentis | 50.86 | 7e-125 | 383 |
| LLPS-Asn-0890 | Aspergillus nidulans | 50.61 | 2e-126 | 387 |
| LLPS-Usm-0248 | Ustilago maydis | 50.52 | 8e-148 | 448 |
| LLPS-Map-0941 | Magnaporthe poae | 50.49 | 8e-124 | 380 |
| LLPS-Trv-1261 | Trichoderma virens | 50.49 | 2e-124 | 381 |
| LLPS-Trr-1073 | Trichoderma reesei | 50.49 | 2e-124 | 382 |
| LLPS-Asfu-0481 | Aspergillus fumigatus | 50.37 | 2e-125 | 384 |
| LLPS-Nef-0949 | Neosartorya fischeri | 50.37 | 2e-125 | 384 |
| LLPS-Gag-1178 | Gaeumannomyces graminis | 50.25 | 4e-123 | 378 |
| LLPS-Lem-1497 | Leptosphaeria maculans | 50.12 | 7e-124 | 379 |
| LLPS-Ast-1441 | Aspergillus terreus | 50.12 | 5e-125 | 383 |
| LLPS-Abg-0640 | Absidia glauca | 50.09 | 3e-178 | 522 |
| LLPS-Fuv-0339 | Fusarium verticillioides | 50.0 | 4e-120 | 370 |
| LLPS-Fuo-0925 | Fusarium oxysporum | 50.0 | 6e-120 | 370 |
| LLPS-Fus-0176 | Fusarium solani | 50.0 | 2e-120 | 372 |
| LLPS-Aso-1245 | Aspergillus oryzae | 49.88 | 1e-124 | 382 |
| LLPS-Asf-0286 | Aspergillus flavus | 49.88 | 1e-124 | 382 |
| LLPS-Asc-0385 | Aspergillus clavatus | 49.88 | 4e-125 | 383 |
| LLPS-Blg-0273 | Blumeria graminis | 49.75 | 2e-121 | 374 |
| LLPS-Mao-0627 | Magnaporthe oryzae | 49.75 | 2e-121 | 374 |
| LLPS-Spr-0171 | Sporisorium reilianum | 49.69 | 1e-145 | 442 |
| LLPS-Coo-1114 | Colletotrichum orbiculare | 49.51 | 1e-122 | 377 |
| LLPS-Cogr-0471 | Colletotrichum graminicola | 49.51 | 5e-122 | 375 |
| LLPS-Asni-0831 | Aspergillus niger | 49.39 | 4e-123 | 378 |
| LLPS-Scs-0538 | Sclerotinia sclerotiorum | 49.26 | 4e-122 | 375 |
| LLPS-Beb-0768 | Beauveria bassiana | 49.26 | 8e-123 | 377 |
| LLPS-Tum-0584 | Tuber melanosporum | 48.28 | 4e-118 | 365 |
| LLPS-Vir-1390 | Vigna radiata | 48.18 | 2e-57 | 199 |
| LLPS-Php-1230 | Physcomitrella patens | 47.6 | 3e-147 | 442 |
| LLPS-Yal-0926 | Yarrowia lipolytica | 47.02 | 1e-140 | 424 |
| LLPS-Zyt-1327 | Zymoseptoria tritici | 47.0 | 1e-116 | 361 |
| LLPS-Dos-0733 | Dothistroma septosporum | 46.99 | 4e-116 | 360 |
| LLPS-Brn-0765 | Brassica napus | 46.95 | 2e-133 | 406 |
| LLPS-Gor-2759 | Gossypium raimondii | 46.95 | 3e-129 | 395 |
| LLPS-Brr-1074 | Brassica rapa | 46.95 | 4e-133 | 405 |
| LLPS-Phv-1352 | Phaseolus vulgaris | 46.95 | 4e-131 | 400 |
| LLPS-Met-0969 | Medicago truncatula | 46.75 | 2e-129 | 396 |
| LLPS-Glm-1359 | Glycine max | 46.53 | 2e-129 | 396 |
| LLPS-Bro-0915 | Brassica oleracea | 46.53 | 5e-132 | 403 |
| LLPS-Viv-2286 | Vitis vinifera | 46.49 | 4e-130 | 398 |
| LLPS-Orbr-1036 | Oryza brachyantha | 46.3 | 2e-125 | 386 |
| LLPS-Hea-2084 | Helianthus annuus | 46.12 | 2e-130 | 399 |
| LLPS-Dac-0052 | Daucus carota | 46.12 | 3e-127 | 390 |
| LLPS-Arl-2685 | Arabidopsis lyrata | 46.11 | 6e-122 | 377 |
| LLPS-Tru-0560 | Triticum urartu | 46.08 | 1e-92 | 299 |
| LLPS-Mel-0079 | Melampsora laricipopulina | 45.91 | 4e-139 | 424 |
| LLPS-Cog-0185 | Colletotrichum gloeosporioides | 45.61 | 2e-64 | 216 |
| LLPS-Cus-1933 | Cucumis sativus | 45.36 | 2e-120 | 373 |
| LLPS-Pot-1392 | Populus trichocarpa | 45.3 | 5e-136 | 413 |
| LLPS-Art-0924 | Arabidopsis thaliana | 44.16 | 2e-124 | 383 |
| LLPS-Pug-1190 | Puccinia graminis | 44.05 | 2e-136 | 419 |
| LLPS-Cae-1235 | Caenorhabditis elegans | 43.88 | 3e-125 | 386 |
| LLPS-Amt-0046 | Amborella trichopoda | 43.81 | 5e-133 | 405 |
| LLPS-Thc-1809 | Theobroma cacao | 43.67 | 1e-130 | 399 |
| LLPS-Miv-0359 | Microbotryum violaceum | 43.57 | 1e-125 | 389 |
| LLPS-Mae-1491 | Manihot esculenta | 43.51 | 7e-134 | 407 |
| LLPS-Hov-0401 | Hordeum vulgare | 43.3 | 4e-125 | 385 |
| LLPS-Tra-1050 | Triticum aestivum | 43.3 | 4e-125 | 385 |
| LLPS-Brd-1805 | Brachypodium distachyon | 43.28 | 8e-125 | 384 |
| LLPS-Prp-0953 | Prunus persica | 43.19 | 4e-133 | 406 |
| LLPS-Sob-0924 | Sorghum bicolor | 43.04 | 2e-125 | 385 |
| LLPS-Sei-0370 | Setaria italica | 42.99 | 2e-123 | 380 |
| LLPS-Coc-0666 | Corchorus capsularis | 42.91 | 1e-128 | 394 |
| LLPS-Org-1170 | Oryza glaberrima | 42.91 | 1e-122 | 378 |
| LLPS-Orm-0286 | Oryza meridionalis | 42.88 | 2e-125 | 386 |
| LLPS-Orb-0429 | Oryza barthii | 42.8 | 1e-125 | 387 |
| LLPS-Orni-1002 | Oryza nivara | 42.8 | 1e-125 | 387 |
| LLPS-Orr-1654 | Oryza rufipogon | 42.8 | 1e-125 | 387 |
| LLPS-Ors-0084 | Oryza sativa | 42.8 | 1e-125 | 387 |
| LLPS-Sol-0886 | Solanum lycopersicum | 42.75 | 2e-122 | 391 |
| LLPS-Orgl-0790 | Oryza glumaepatula | 42.61 | 6e-125 | 385 |
| LLPS-Lep-0412 | Leersia perrieri | 42.61 | 3e-125 | 385 |
| LLPS-Ori-1129 | Oryza indica | 42.61 | 6e-125 | 385 |
| LLPS-Sem-0376 | Selaginella moellendorffii | 42.56 | 8e-128 | 392 |
| LLPS-Zem-0071 | Zea mays | 42.44 | 6e-123 | 379 |
| LLPS-Sot-0383 | Solanum tuberosum | 42.19 | 1e-127 | 391 |
| LLPS-Gas-0480 | Galdieria sulphuraria | 42.02 | 3e-127 | 391 |
| LLPS-Nia-1144 | Nicotiana attenuata | 42.01 | 2e-128 | 393 |
| LLPS-Orp-0655 | Oryza punctata | 41.96 | 4e-127 | 390 |
| LLPS-Crn-0389 | Cryptococcus neoformans | 41.4 | 4e-121 | 378 |
| LLPS-Chc-0279 | Chondrus crispus | 41.04 | 5e-126 | 388 |
| LLPS-Via-0536 | Vigna angularis | 40.19 | 2e-110 | 348 |
| LLPS-Chr-1384 | Chlamydomonas reinhardtii | 39.77 | 5e-114 | 356 |
| LLPS-Ved-0780 | Verticillium dahliae | 39.75 | 6e-52 | 184 |
| LLPS-Mua-2479 | Musa acuminata | 38.68 | 8e-110 | 345 |
| LLPS-Put-1013 | Puccinia triticina | 37.67 | 5e-100 | 322 |
| LLPS-Osl-1297 | Ostreococcus lucimarinus | 34.91 | 2e-88 | 289 |
| LLPS-Cym-0713 | Cyanidioschyzon merolae | 34.72 | 2e-39 | 157 |