LLPS-Caj-4298
EIF3L
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 3 subunit L |
| Gene Name: | EIF3L, EIF3EIP, EIF3S6IP |
| Ensembl Gene: | ENSCJAG00000038841.1 |
| Ensembl Protein: | ENSCJAP00000056488.1 |
| Organism: | Callithrix jacchus |
| Taxa ID: | 9483 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCJAT00000071087.1 | ENSCJAP00000056488.1 |
| Ensembl | ENSCJAT00000086381.1 | ENSCJAP00000056128.1 |
| Ensembl | ENSCJAT00000015803.2 | ENSCJAP00000056484.1 |
| UniProt | A0A2R8M9Y1, A0A2R8M9Y1_CALJA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 YKRNRFIELT VPHGWEGLRI KSFPAVLVSP AAMSYAADDY ESEAAYDPYA YPGDYDMHTG 60 61 DPKQDLAYER QYEQQTYQVI PEVIKNFIQY FHKTVSDLID QKVYELQASR VSSDVIDQKV 120 121 YEIQDIYENS WTKLTERFFK NTPWPEAEAI APQVGNDAVF LILYKELYYR HIYAKVSGGP 180 181 SLEQRFESYY NYCNLFNYIL NADGPAPLEL PNQWLWDIID EFIYQFQSFS QYRCKTAKKS 240 241 EEEIDFLRSN PKIWNVHSVL NVLHSLVDKS NINRQLEVYT SGGDPESVAG EYGRHSLYKM 300 301 LGYFSLVGLL RLHSLLGDYY QAIKVLENIE LNKKSMYSRV PECQVTTYYY VGFAYLMMRR 360 361 YQDAIRVFAN ILLYIQRTKS MFQRTTYKYE MINKQNEQMH ALLAIALTMY PMRIDESIHL 420 421 QLREKYGDKM LRMQKGDPQV YEELFSYSCP KFLSPVVPNY DNVHPNYHKE PFLQQLKVFA 480 481 DEVQQQAQLS TIRSFLKLYT TMPVAKLAGF LDLTEQEFRI QLLVFKHKMK NLVWTSGISA 540 541 LDGEFQSASE VDFYIDKDMI HIADTKVARR YGDFFIRQIH KFEELNRTLK KMGQRP 596 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCCCTAA AACATAGCAT CTTAGAGCAA CAAATACTAT CTTATAGTTT TTGTTATCAG 60 61 TACCGCTGCA AGACTGCCAA GAAGTCAGAG GAGGAGATTG ACTTCCTTCG TTCCAATCCC 120 121 AAAATCTGGA ATGTTCACAG TGTCCTGAAT GTCCTTCATT CCCTAGTAGA CAAATCCAAC 180 181 ATCAACCGAC AGTTGGAGGT ATACACAAGC GGAGGTGACC CCGAGAGTGT GGCTGGGGAG 240 241 TATGGGCGGC ACTCCCTCTA CAAGATGCTT GGTTACTTCA GCCTGGTGGG GCTTCTCCGC 300 301 CTGCACTCCC TGTTGGGGGA TTACTACCAG GCCATCAAGG TGCTGGAGAA CATCGAACTG 360 361 AACAAAAAGA GTATGTATTC CCGTGTTCCA GAGTGCCAGG TCACCACGTA CTATTATGTT 420 421 GGATTTGCAT ATTTGATGAT GCGTCGCTAC CAGGATGCCA TCCGGGTCTT TGCCAACATC 480 481 CTCCTCTATA TCCAGAGGAC CAAGAGCATG TTCCAGAGGA CCACATATAA GTATGAGATG 540 541 ATTAACAAGC AGAATGAGCA GATGCATGCG CTGCTGGCCA TTGCCCTCAC CATGTACCCC 600 601 ATGCGTATCG ATGAGAGCAT TCACCTCCAA CTGCGGGAGA AATACGGGGA CAAGATGCTG 660 661 CGCATGCAGA AAGGTGACCC ACAAGTCTAT GAAGAACTTT TCAGTTACTC CTGCCCCAAG 720 721 TTTCTATCGC CAGTAGTGCC CAACTATGAT AATGTGCACC CCAACTACCA CAAAGAGCCC 780 781 TTCCTGCAGC AGCTGAAGGT GTTTGCTGAT GAGGTACAGC AGCAGGCCCA GCTTTCAACC 840 841 ATCCGCAGCT TCCTCAAGCT CTACACCACC ATGCCTGTGG CCAAGCTGGC TGGCTTCCTG 900 901 GATCTCACAG AGCAGGAGTT CCGGATCCAG CTGCTTGTAT TCAAACACAA GATGAAGAAC 960 961 CTGGTATGGA CCAGCGGTAT CTCAGCCCTG GATGGTGAAT TTCAGTCAGC CTCAGAGGTT 1020 1021 GACTTCTACA TTGATAAGGA TATGATCCAC ATCGCGGACA CCAAGGTCGC CAGGCGCTAT 1080 1081 GGGGATTTCT TCATCCGTCA GATCCACAAA TTCGAGGAGC TTAATCGAAC CCTGAAGAAG 1140 1141 ATGGGACAGA GACCCTGA 1158 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Formation of cytoplasmic translation initiation complex |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sah-3086 | Sarcophilus harrisii | 100.0 | 0.0 | 1062 |
| LLPS-Ora-0849 | Ornithorhynchus anatinus | 100.0 | 0.0 | 1061 |
| LLPS-Poa-0208 | Pongo abelii | 100.0 | 4e-17 | 87.0 |
| LLPS-Fec-1566 | Felis catus | 100.0 | 0.0 | 1062 |
| LLPS-Caf-3353 | Canis familiaris | 99.81 | 0.0 | 1060 |
| LLPS-Loa-2966 | Loxodonta africana | 99.81 | 0.0 | 1060 |
| LLPS-Urm-0681 | Ursus maritimus | 99.81 | 0.0 | 1060 |
| LLPS-Otg-3993 | Otolemur garnettii | 99.77 | 0.0 | 862 |
| LLPS-Dio-3366 | Dipodomys ordii | 99.73 | 0.0 | 711 |
| LLPS-Pes-1346 | Pelodiscus sinensis | 99.66 | 0.0 | 585 |
| LLPS-Ova-2246 | Ovis aries | 99.63 | 0.0 | 1058 |
| LLPS-Bot-3146 | Bos taurus | 99.63 | 0.0 | 1059 |
| LLPS-Mea-1652 | Mesocricetus auratus | 99.63 | 0.0 | 1059 |
| LLPS-Eqc-0090 | Equus caballus | 99.6 | 0.0 | 978 |
| LLPS-Ict-1151 | Ictidomys tridecemlineatus | 99.47 | 1e-132 | 392 |
| LLPS-Ran-0110 | Rattus norvegicus | 99.46 | 0.0 | 709 |
| LLPS-Tag-0208 | Taeniopygia guttata | 99.44 | 0.0 | 1056 |
| LLPS-Gaga-0991 | Gallus gallus | 99.44 | 0.0 | 1056 |
| LLPS-Meg-0710 | Meleagris gallopavo | 99.44 | 0.0 | 1057 |
| LLPS-Mup-1721 | Mustela putorius furo | 99.3 | 0.0 | 1061 |
| LLPS-Aim-3108 | Ailuropoda melanoleuca | 99.3 | 0.0 | 1061 |
| LLPS-Ere-0699 | Erinaceus europaeus | 99.26 | 0.0 | 1056 |
| LLPS-Fia-0167 | Ficedula albicollis | 99.26 | 0.0 | 1056 |
| LLPS-Anp-1270 | Anas platyrhynchos | 99.26 | 0.0 | 1051 |
| LLPS-Fud-1828 | Fukomys damarensis | 99.07 | 0.0 | 1052 |
| LLPS-Mum-3388 | Mus musculus | 99.07 | 0.0 | 1054 |
| LLPS-Mod-0799 | Monodelphis domestica | 99.07 | 0.0 | 1051 |
| LLPS-Cea-1502 | Cercocebus atys | 98.96 | 0.0 | 1067 |
| LLPS-Anc-1971 | Anolis carolinensis | 98.7 | 0.0 | 1047 |
| LLPS-Maf-0878 | Macaca fascicularis | 98.45 | 0.0 | 1072 |
| LLPS-Cap-0807 | Cavia porcellus | 98.33 | 0.0 | 1032 |
| LLPS-Paa-0753 | Papio anubis | 97.62 | 0.0 | 1071 |
| LLPS-Chs-1190 | Chlorocebus sabaeus | 97.62 | 0.0 | 561 |
| LLPS-Man-2687 | Macaca nemestrina | 97.45 | 0.0 | 1070 |
| LLPS-Mal-0144 | Mandrillus leucophaeus | 97.3 | 0.0 | 1072 |
| LLPS-Gog-1120 | Gorilla gorilla | 97.28 | 0.0 | 1071 |
| LLPS-Hos-1055 | Homo sapiens | 97.28 | 0.0 | 1070 |
| LLPS-Nol-0985 | Nomascus leucogenys | 97.11 | 0.0 | 1066 |
| LLPS-Pat-1719 | Pan troglodytes | 97.11 | 0.0 | 1068 |
| LLPS-Pap-0996 | Pan paniscus | 97.11 | 0.0 | 1068 |
| LLPS-Xet-1914 | Xenopus tropicalis | 97.04 | 0.0 | 1036 |
| LLPS-Tut-0859 | Tursiops truncatus | 96.88 | 0.0 | 1036 |
| LLPS-Sus-1761 | Sus scrofa | 96.46 | 0.0 | 1004 |
| LLPS-Orc-1032 | Oryctolagus cuniculus | 95.78 | 0.0 | 1061 |
| LLPS-Mam-1255 | Macaca mulatta | 95.61 | 0.0 | 1051 |
| LLPS-Myl-0596 | Myotis lucifugus | 94.59 | 0.0 | 998 |
| LLPS-Aon-0541 | Aotus nancymaae | 94.23 | 0.0 | 1050 |
| LLPS-Orn-3380 | Oreochromis niloticus | 93.66 | 0.0 | 999 |
| LLPS-Dar-3243 | Danio rerio | 93.47 | 0.0 | 992 |
| LLPS-Icp-3196 | Ictalurus punctatus | 93.3 | 0.0 | 994 |
| LLPS-Ten-0150 | Tetraodon nigroviridis | 93.28 | 0.0 | 999 |
| LLPS-Xim-3681 | Xiphophorus maculatus | 93.11 | 0.0 | 997 |
| LLPS-Asm-0052 | Astyanax mexicanus | 93.11 | 0.0 | 993 |
| LLPS-Pof-1836 | Poecilia formosa | 93.11 | 0.0 | 998 |
| LLPS-Orl-0559 | Oryzias latipes | 93.1 | 0.0 | 995 |
| LLPS-Scm-0137 | Scophthalmus maximus | 93.1 | 0.0 | 992 |
| LLPS-Scf-1426 | Scleropages formosus | 92.54 | 0.0 | 831 |
| LLPS-Gaa-3230 | Gasterosteus aculeatus | 92.54 | 0.0 | 993 |
| LLPS-Leo-2888 | Lepisosteus oculatus | 91.41 | 0.0 | 989 |
| LLPS-Lac-0357 | Latimeria chalumnae | 90.39 | 0.0 | 962 |
| LLPS-Tar-0706 | Takifugu rubripes | 88.99 | 0.0 | 937 |
| LLPS-Rhb-0895 | Rhinopithecus bieti | 80.59 | 0.0 | 776 |
| LLPS-Cas-1938 | Carlito syrichta | 79.33 | 1e-166 | 484 |
| LLPS-Cii-1896 | Ciona intestinalis | 60.77 | 0.0 | 586 |
| LLPS-Cis-0899 | Ciona savignyi | 60.37 | 0.0 | 597 |
| LLPS-Drm-0741 | Drosophila melanogaster | 53.78 | 0.0 | 548 |
| LLPS-Phn-0619 | Phaeosphaeria nodorum | 52.62 | 1e-109 | 344 |
| LLPS-Abg-0640 | Absidia glauca | 51.75 | 2e-174 | 513 |
| LLPS-Nec-1432 | Neurospora crassa | 51.35 | 9e-125 | 383 |
| LLPS-Trv-1261 | Trichoderma virens | 50.74 | 3e-123 | 379 |
| LLPS-Trr-1073 | Trichoderma reesei | 50.74 | 3e-123 | 379 |
| LLPS-Pyt-0714 | Pyrenophora teres | 50.61 | 7e-123 | 379 |
| LLPS-Asn-0890 | Aspergillus nidulans | 50.61 | 3e-125 | 384 |
| LLPS-Pytr-0625 | Pyrenophora triticirepentis | 50.61 | 7e-123 | 379 |
| LLPS-Map-0941 | Magnaporthe poae | 50.49 | 3e-122 | 376 |
| LLPS-Asfu-0481 | Aspergillus fumigatus | 50.37 | 1e-123 | 380 |
| LLPS-Nef-0949 | Neosartorya fischeri | 50.37 | 9e-124 | 381 |
| LLPS-Mao-0627 | Magnaporthe oryzae | 50.25 | 5e-121 | 374 |
| LLPS-Gag-1178 | Gaeumannomyces graminis | 50.25 | 1e-121 | 375 |
| LLPS-Ast-1441 | Aspergillus terreus | 50.12 | 1e-123 | 380 |
| LLPS-Fuv-0339 | Fusarium verticillioides | 50.0 | 1e-118 | 367 |
| LLPS-Fuo-0925 | Fusarium oxysporum | 50.0 | 1e-118 | 367 |
| LLPS-Fus-0176 | Fusarium solani | 50.0 | 6e-119 | 368 |
| LLPS-Asf-0286 | Aspergillus flavus | 49.88 | 2e-123 | 380 |
| LLPS-Aso-1245 | Aspergillus oryzae | 49.88 | 2e-123 | 380 |
| LLPS-Lem-1497 | Leptosphaeria maculans | 49.88 | 2e-122 | 376 |
| LLPS-Asc-0385 | Aspergillus clavatus | 49.88 | 1e-123 | 380 |
| LLPS-Coo-1114 | Colletotrichum orbiculare | 49.75 | 1e-121 | 375 |
| LLPS-Asni-0831 | Aspergillus niger | 49.39 | 8e-122 | 376 |
| LLPS-Blg-0273 | Blumeria graminis | 49.26 | 3e-119 | 369 |
| LLPS-Scs-0538 | Sclerotinia sclerotiorum | 49.26 | 7e-121 | 373 |
| LLPS-Cogr-0471 | Colletotrichum graminicola | 49.26 | 1e-119 | 370 |
| LLPS-Beb-0768 | Beauveria bassiana | 49.26 | 2e-121 | 374 |
| LLPS-Usm-0248 | Ustilago maydis | 48.96 | 3e-143 | 437 |
| LLPS-Tum-0584 | Tuber melanosporum | 48.28 | 9e-117 | 363 |
| LLPS-Spr-0171 | Sporisorium reilianum | 48.13 | 9e-142 | 434 |
| LLPS-Amt-0046 | Amborella trichopoda | 47.73 | 1e-132 | 405 |
| LLPS-Brn-0765 | Brassica napus | 47.58 | 2e-134 | 410 |
| LLPS-Brr-1074 | Brassica rapa | 47.58 | 4e-134 | 409 |
| LLPS-Bro-0915 | Brassica oleracea | 47.16 | 4e-133 | 406 |
| LLPS-Php-1230 | Physcomitrella patens | 47.02 | 6e-146 | 440 |
| LLPS-Zyt-1327 | Zymoseptoria tritici | 47.0 | 2e-115 | 359 |
| LLPS-Dos-0733 | Dothistroma septosporum | 46.99 | 4e-115 | 358 |
| LLPS-Arl-2685 | Arabidopsis lyrata | 46.74 | 2e-122 | 379 |
| LLPS-Brd-1805 | Brachypodium distachyon | 46.49 | 1e-125 | 387 |
| LLPS-Yal-0926 | Yarrowia lipolytica | 46.43 | 1e-136 | 416 |
| LLPS-Viv-2286 | Vitis vinifera | 46.28 | 1e-128 | 395 |
| LLPS-Hea-2084 | Helianthus annuus | 46.12 | 2e-128 | 394 |
| LLPS-Tru-0560 | Triticum urartu | 45.82 | 3e-91 | 296 |
| LLPS-Dac-0052 | Daucus carota | 45.66 | 6e-127 | 390 |
| LLPS-Cog-0185 | Colletotrichum gloeosporioides | 45.61 | 3e-63 | 214 |
| LLPS-Mel-0079 | Melampsora laricipopulina | 45.3 | 1e-138 | 424 |
| LLPS-Pot-1392 | Populus trichocarpa | 44.91 | 5e-135 | 411 |
| LLPS-Art-0924 | Arabidopsis thaliana | 44.83 | 9e-126 | 387 |
| LLPS-Cae-1235 | Caenorhabditis elegans | 44.27 | 6e-124 | 383 |
| LLPS-Mae-1491 | Manihot esculenta | 43.98 | 5e-132 | 404 |
| LLPS-Prp-0953 | Prunus persica | 43.96 | 2e-131 | 402 |
| LLPS-Orbr-1036 | Oryza brachyantha | 43.79 | 2e-125 | 387 |
| LLPS-Phv-1352 | Phaseolus vulgaris | 43.77 | 7e-131 | 400 |
| LLPS-Miv-0359 | Microbotryum violaceum | 43.68 | 4e-123 | 383 |
| LLPS-Thc-1809 | Theobroma cacao | 43.67 | 6e-130 | 398 |
| LLPS-Pug-1190 | Puccinia graminis | 43.66 | 5e-132 | 409 |
| LLPS-Met-0969 | Medicago truncatula | 43.58 | 5e-130 | 398 |
| LLPS-Glm-1359 | Glycine max | 43.37 | 4e-129 | 396 |
| LLPS-Sol-0886 | Solanum lycopersicum | 43.31 | 3e-124 | 397 |
| LLPS-Org-1170 | Oryza glaberrima | 43.29 | 4e-122 | 378 |
| LLPS-Gor-2759 | Gossypium raimondii | 43.29 | 1e-127 | 392 |
| LLPS-Sob-0924 | Sorghum bicolor | 43.19 | 4e-124 | 383 |
| LLPS-Orp-0655 | Oryza punctata | 43.1 | 3e-127 | 392 |
| LLPS-Sei-0370 | Setaria italica | 42.99 | 5e-123 | 380 |
| LLPS-Zem-0071 | Zea mays | 42.99 | 2e-122 | 379 |
| LLPS-Orm-0286 | Oryza meridionalis | 42.99 | 7e-126 | 388 |
| LLPS-Orni-1002 | Oryza nivara | 42.91 | 5e-126 | 388 |
| LLPS-Orb-0429 | Oryza barthii | 42.91 | 5e-126 | 388 |
| LLPS-Coc-0666 | Corchorus capsularis | 42.91 | 1e-127 | 392 |
| LLPS-Orr-1654 | Oryza rufipogon | 42.91 | 5e-126 | 388 |
| LLPS-Ors-0084 | Oryza sativa | 42.91 | 5e-126 | 388 |
| LLPS-Sot-0383 | Solanum tuberosum | 42.75 | 5e-129 | 396 |
| LLPS-Orgl-0790 | Oryza glumaepatula | 42.72 | 2e-125 | 387 |
| LLPS-Ori-1129 | Oryza indica | 42.72 | 2e-125 | 387 |
| LLPS-Lep-0412 | Leersia perrieri | 42.61 | 3e-126 | 389 |
| LLPS-Tra-1050 | Triticum aestivum | 42.54 | 1e-124 | 384 |
| LLPS-Hov-0401 | Hordeum vulgare | 42.54 | 1e-124 | 384 |
| LLPS-Gas-0480 | Galdieria sulphuraria | 42.31 | 1e-124 | 385 |
| LLPS-Sem-0376 | Selaginella moellendorffii | 42.11 | 1e-127 | 392 |
| LLPS-Mua-2479 | Musa acuminata | 42.06 | 1e-108 | 343 |
| LLPS-Cus-1933 | Cucumis sativus | 42.01 | 6e-119 | 370 |
| LLPS-Nia-1144 | Nicotiana attenuata | 41.93 | 4e-128 | 393 |
| LLPS-Vir-1390 | Vigna radiata | 41.67 | 2e-57 | 200 |
| LLPS-Chc-0279 | Chondrus crispus | 41.62 | 2e-127 | 392 |
| LLPS-Crn-0389 | Cryptococcus neoformans | 40.62 | 1e-116 | 367 |
| LLPS-Via-0536 | Vigna angularis | 40.57 | 3e-110 | 349 |
| LLPS-Ved-0780 | Verticillium dahliae | 38.91 | 2e-50 | 180 |
| LLPS-Chr-1384 | Chlamydomonas reinhardtii | 38.45 | 8e-110 | 346 |
| LLPS-Put-1013 | Puccinia triticina | 37.87 | 4e-97 | 315 |
| LLPS-Osl-1297 | Ostreococcus lucimarinus | 35.45 | 1e-89 | 293 |
| LLPS-Cym-0713 | Cyanidioschyzon merolae | 34.72 | 1e-38 | 155 |