• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asf-0286
AFLA_044230

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit L
Gene Name: AFLA_044230
Ensembl Gene: AFLA_044230
Ensembl Protein: EED52721
Organism: Aspergillus flavus
Taxa ID: 332952
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEED52721EED52721
UniProtB8NB48, B8NB48_ASPFN
GeneBankEQ963476EED52721.1
RefSeqXM_002377844.1XP_002377885.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSYEERANAH  PNLGDESDVE  EEALVNDYRE  QVNFDDSMSE  LDRTTSLGAG  SQTQDLQAQL  60
61    AAAATPLEYQ  ATLETKFASY  DNYCSLFHYI  LNSDGPVELE  VPSYYWAWDV  IDEFIYQFES  120
121   FCRYRNRVAR  SGSNEEEAQL  LRENPNTWGC  YSVLNVLYSL  IQRSQINEQL  AAIKRGEDPM  180
181   AFAGEYGSRP  LYKMLGYFSI  IGLLRVHCLL  GDFSLALKTL  DDIEMNKKAM  FARVMAAHFT  240
241   TYYYVGFSYM  MMRRYGDAIR  MFSHILVYVS  RTKNFQKGGN  SYDAIAKKND  QMYALIAICV  300
301   ALHPTRLDDT  IHSALREKYG  EQLHRLQHGG  PEALPLFEEL  FRSACPKFIS  PTPPDFDNPS  360
361   VNVDPVDHHT  AIFMDEVKNT  LYNPTIRSYL  KLYTTMDLQK  LAGFLEVEPE  KLRSWLLVNK  420
421   QRSRQVRWVE  GGLLEGEPVA  ANDLDYALEN  DLIHVSETKA  GRRLVDWYLR  NLARVY  476
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTACG  AAGAGCGCGC  CAATGCGCAC  CCTAACCTGG  GCGACGAGTC  CGATGTTGAG  60
61    GAGGAAGCGC  TCGTCAACGA  TTACCGCGAG  CAAGTCAACT  TCGACGATAG  CATGAGCGAA  120
121   CTGGACCGGA  CTACTTCCCT  TGGAGCTGGC  TCTCAGACGC  AAGATCTCCA  GGCACAGCTC  180
181   GCCGCTGCCG  CGACCCCGCT  TGAATACCAG  GCCACACTGG  AGACCAAGTT  TGCAAGCTAT  240
241   GACAACTACT  GCAGCCTTTT  CCACTACATC  CTCAACTCGG  ATGGCCCTGT  TGAATTGGAG  300
301   GTTCCTTCTT  ACTACTGGGC  TTGGGATGTG  ATCGATGAAT  TCATCTACCA  GTTCGAATCG  360
361   TTCTGCCGTT  ACCGCAACCG  CGTCGCTCGC  AGCGGCTCCA  ACGAGGAGGA  GGCCCAGCTT  420
421   CTGCGTGAGA  ACCCGAACAC  CTGGGGTTGC  TACTCCGTGC  TCAACGTTCT  TTACTCCCTT  480
481   ATCCAGAGGT  CCCAAATCAA  TGAGCAATTG  GCTGCTATCA  AGCGTGGAGA  GGACCCCATG  540
541   GCGTTCGCTG  GAGAGTATGG  CTCTCGGCCT  CTGTACAAGA  TGCTCGGATA  CTTCTCGATC  600
601   ATCGGACTTC  TGCGTGTCCA  CTGCTTGCTC  GGTGACTTCA  GCCTTGCCCT  CAAGACCCTT  660
661   GACGACATCG  AAATGAACAA  GAAGGCTATG  TTCGCTCGTG  TCATGGCAGC  TCACTTCACC  720
721   ACCTACTACT  ATGTGGGTTT  CTCCTACATG  ATGATGCGCC  GTTACGGTGA  CGCCATCCGC  780
781   ATGTTCAGCC  ACATCCTGGT  CTACGTCTCC  CGGACCAAGA  ACTTCCAGAA  GGGTGGCAAC  840
841   AGCTATGATG  CTATCGCCAA  GAAGAACGAC  CAGATGTATG  CTCTCATTGC  CATCTGCGTT  900
901   GCCCTCCACC  CCACCCGTCT  CGACGACACT  ATTCACTCCG  CTCTCCGCGA  GAAGTACGGC  960
961   GAGCAGCTCC  ACCGTCTCCA  GCACGGTGGC  CCCGAGGCCC  TCCCTCTGTT  TGAGGAGCTC  1020
1021  TTCCGTTCCG  CTTGCCCCAA  GTTCATCAGC  CCCACTCCTC  CCGACTTCGA  CAACCCCTCC  1080
1081  GTCAACGTCG  ACCCCGTCGA  TCACCACACA  GCTATCTTCA  TGGATGAGGT  CAAGAACACG  1140
1141  CTGTACAACC  CTACTATCCG  TTCTTACCTG  AAGCTGTACA  CTACGATGGA  TCTGCAGAAG  1200
1201  CTGGCCGGCT  TCCTGGAAGT  CGAGCCCGAG  AAGCTCCGCT  CCTGGCTGTT  GGTGAACAAG  1260
1261  CAGCGCAGCC  GTCAGGTCCG  CTGGGTTGAG  GGCGGTCTGC  TGGAGGGTGA  GCCCGTCGCC  1320
1321  GCTAACGACC  TGGACTACGC  TCTGGAGAAC  GATCTGATCC  ACGTCAGCGA  GACCAAGGCC  1380
1381  GGCCGTCGCC  TGGTGGACTG  GTACCTTCGG  AACCTCGCCC  GCGTCTACTA  A  1431

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Membrane
Protein biosynthesis
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Cellular Component
Integral component of membrane
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aso-1245Aspergillus oryzae100.00.0 961
LLPS-Ast-1441Aspergillus terreus97.90.0 942
LLPS-Asni-0831Aspergillus niger97.690.0 943
LLPS-Asc-0385Aspergillus clavatus97.480.0 938
LLPS-Asn-0890Aspergillus nidulans96.640.0 934
LLPS-Asfu-0481Aspergillus fumigatus96.640.0 933
LLPS-Nef-0949Neosartorya fischeri96.430.0 932
LLPS-Lem-1497Leptosphaeria maculans80.180.0 744
LLPS-Pyt-0714Pyrenophora teres79.270.0 777
LLPS-Pytr-0625Pyrenophora triticirepentis79.270.0 777
LLPS-Phn-0619Phaeosphaeria nodorum77.40.0 697
LLPS-Scs-0538Sclerotinia sclerotiorum77.260.0 772
LLPS-Fus-0176Fusarium solani76.720.0 739
LLPS-Fuv-0339Fusarium verticillioides76.510.0 741
LLPS-Fuo-0925Fusarium oxysporum76.290.0 738
LLPS-Trr-1073Trichoderma reesei76.080.0 744
LLPS-Trv-1261Trichoderma virens75.860.0 742
LLPS-Coo-1114Colletotrichum orbiculare75.70.0 741
LLPS-Blg-0273Blumeria graminis75.680.0 759
LLPS-Cog-0185Colletotrichum gloeosporioides75.221e-127 377
LLPS-Dos-0733Dothistroma septosporum75.160.0 719
LLPS-Cogr-0471Colletotrichum graminicola75.110.0 733
LLPS-Beb-0768Beauveria bassiana75.050.0 723
LLPS-Mao-0627Magnaporthe oryzae74.890.0 736
LLPS-Nec-1432Neurospora crassa74.630.0 740
LLPS-Gag-1178Gaeumannomyces graminis73.350.0 738
LLPS-Map-0941Magnaporthe poae73.350.0 737
LLPS-Zyt-1327Zymoseptoria tritici72.990.0 730
LLPS-Tum-0584Tuber melanosporum69.940.0 674
LLPS-Ved-0780Verticillium dahliae65.45e-112 338
LLPS-Abg-0640Absidia glauca58.527e-172 502
LLPS-Yal-0926Yarrowia lipolytica56.611e-151 449
LLPS-Scf-1426Scleropages formosus53.854e-126 382
LLPS-Mel-0079Melampsora laricipopulina51.697e-149 446
LLPS-Pug-1190Puccinia graminis51.218e-149 448
LLPS-Usm-0248Ustilago maydis50.613e-147 443
LLPS-Eqc-0090Equus caballus50.521e-131 401
LLPS-Mea-1652Mesocricetus auratus50.122e-142 427
LLPS-Orl-0559Oryzias latipes50.129e-143 429
LLPS-Asm-0052Astyanax mexicanus50.122e-143 430
LLPS-Xim-3681Xiphophorus maculatus50.128e-144 431
LLPS-Pof-1836Poecilia formosa50.129e-144 431
LLPS-Meg-0710Meleagris gallopavo50.121e-141 426
LLPS-Anp-1270Anas platyrhynchos50.122e-142 426
LLPS-Fia-0167Ficedula albicollis50.126e-142 426
LLPS-Spr-0171Sporisorium reilianum50.122e-145 438
LLPS-Xet-1914Xenopus tropicalis50.122e-143 430
LLPS-Gaga-0991Gallus gallus50.126e-142 426
LLPS-Tag-0208Taeniopygia guttata50.121e-141 426
LLPS-Put-1013Puccinia triticina50.01e-135 410
LLPS-Maf-0878Macaca fascicularis49.884e-141 426
LLPS-Mum-3388Mus musculus49.882e-141 425
LLPS-Ora-0849Ornithorhynchus anatinus49.884e-142 427
LLPS-Sah-3086Sarcophilus harrisii49.885e-142 426
LLPS-Sus-1761Sus scrofa49.881e-139 422
LLPS-Gog-1120Gorilla gorilla49.883e-141 426
LLPS-Fud-1828Fukomys damarensis49.884e-142 426
LLPS-Icp-3196Ictalurus punctatus49.889e-143 429
LLPS-Caj-4298Callithrix jacchus49.881e-141 426
LLPS-Tut-0859Tursiops truncatus49.883e-141 425
LLPS-Tar-0706Takifugu rubripes49.884e-143 429
LLPS-Bot-3146Bos taurus49.885e-142 426
LLPS-Mal-0144Mandrillus leucophaeus49.884e-141 426
LLPS-Paa-0753Papio anubis49.884e-141 426
LLPS-Aim-3108Ailuropoda melanoleuca49.882e-141 426
LLPS-Mup-1721Mustela putorius furo49.883e-141 426
LLPS-Myl-0596Myotis lucifugus49.883e-141 426
LLPS-Ova-2246Ovis aries49.881e-141 426
LLPS-Pat-1719Pan troglodytes49.883e-141 426
LLPS-Pap-0996Pan paniscus49.883e-141 426
LLPS-Urm-0681Ursus maritimus49.885e-142 426
LLPS-Hos-1055Homo sapiens49.883e-141 426
LLPS-Lac-0357Latimeria chalumnae49.886e-143 429
LLPS-Fec-1566Felis catus49.882e-141 426
LLPS-Man-2687Macaca nemestrina49.884e-141 426
LLPS-Loa-2966Loxodonta africana49.885e-142 426
LLPS-Otg-3993Otolemur garnettii49.882e-143 426
LLPS-Orn-3380Oreochromis niloticus49.886e-143 429
LLPS-Caf-3353Canis familiaris49.885e-142 426
LLPS-Ten-0150Tetraodon nigroviridis49.884e-143 429
LLPS-Mam-1255Macaca mulatta49.889e-141 425
LLPS-Anc-1971Anolis carolinensis49.889e-142 425
LLPS-Nol-0985Nomascus leucogenys49.883e-141 426
LLPS-Miv-0359Microbotryum violaceum49.642e-132 403
LLPS-Cea-1502Cercocebus atys49.639e-140 422
LLPS-Leo-2888Lepisosteus oculatus49.632e-142 428
LLPS-Ere-0699Erinaceus europaeus49.637e-142 426
LLPS-Dar-3243Danio rerio49.635e-142 427
LLPS-Mod-0799Monodelphis domestica49.632e-141 425
LLPS-Scm-0137Scophthalmus maximus49.639e-142 426
LLPS-Cap-0807Cavia porcellus49.634e-139 421
LLPS-Orc-1032Oryctolagus cuniculus49.391e-139 422
LLPS-Gaa-3230Gasterosteus aculeatus49.142e-141 425
LLPS-Ran-0110Rattus norvegicus48.342e-120 364
LLPS-Dio-3366Dipodomys ordii47.922e-119 362
LLPS-Pes-1346Pelodiscus sinensis47.722e-92 290
LLPS-Chs-1190Chlorocebus sabaeus47.376e-92 288
LLPS-Aon-0541Aotus nancymaae45.952e-123 380
LLPS-Cis-0899Ciona savignyi44.471e-113 352
LLPS-Drm-0741Drosophila melanogaster43.933e-113 351
LLPS-Cii-1896Ciona intestinalis43.512e-112 348
LLPS-Crn-0389Cryptococcus neoformans43.24e-111 348
LLPS-Poa-0208Pongo abelii41.787e-44 163
LLPS-Vir-1390Vigna radiata41.42e-42 157
LLPS-Cas-1938Carlito syrichta41.312e-75 246
LLPS-Rhb-0895Rhinopithecus bieti40.914e-82 270
LLPS-Ict-1151Ictidomys tridecemlineatus40.912e-41 152
LLPS-Art-0924Arabidopsis thaliana40.821e-95 305
LLPS-Cus-1933Cucumis sativus40.786e-97 309
LLPS-Prp-0953Prunus persica40.633e-105 330
LLPS-Pot-1515Populus trichocarpa40.496e-104 327
LLPS-Glm-1359Glycine max40.393e-102 322
LLPS-Gor-2759Gossypium raimondii40.392e-103 325
LLPS-Phv-1352Phaseolus vulgaris40.392e-104 328
LLPS-Mae-1491Manihot esculenta40.391e-105 331
LLPS-Bro-0915Brassica oleracea40.399e-105 329
LLPS-Php-1230Physcomitrella patens40.292e-104 328
LLPS-Brn-0765Brassica napus40.156e-105 329
LLPS-Thc-1809Theobroma cacao40.151e-103 326
LLPS-Brr-1074Brassica rapa40.152e-104 328
LLPS-Met-0969Medicago truncatula39.92e-100 318
LLPS-Arl-2685Arabidopsis lyrata39.666e-96 306
LLPS-Coc-0666Corchorus capsularis39.562e-101 320
LLPS-Sei-0370Setaria italica39.451e-95 305
LLPS-Brd-1805Brachypodium distachyon39.453e-96 307
LLPS-Orbr-1036Oryza brachyantha39.455e-96 306
LLPS-Hea-2084Helianthus annuus39.421e-104 328
LLPS-Viv-2286Vitis vinifera39.424e-102 322
LLPS-Nia-1144Nicotiana attenuata39.422e-100 318
LLPS-Tru-0560Triticum urartu39.18e-91 291
LLPS-Hov-0401Hordeum vulgare38.962e-95 305
LLPS-Tra-1050Triticum aestivum38.969e-96 305
LLPS-Orp-0655Oryza punctata38.969e-96 306
LLPS-Sob-0924Sorghum bicolor38.969e-95 303
LLPS-Chc-0279Chondrus crispus38.946e-95 304
LLPS-Sol-0886Solanum lycopersicum38.934e-94 312
LLPS-Dac-0052Daucus carota38.931e-99 315
LLPS-Amt-0046Amborella trichopoda38.784e-98 312
LLPS-Orb-0429Oryza barthii38.712e-95 305
LLPS-Orni-1002Oryza nivara38.712e-95 305
LLPS-Mua-2479Musa acuminata38.719e-93 297
LLPS-Ors-0084Oryza sativa38.712e-95 305
LLPS-Orm-0286Oryza meridionalis38.712e-95 305
LLPS-Orr-1654Oryza rufipogon38.712e-95 305
LLPS-Org-1170Oryza glaberrima38.711e-94 303
LLPS-Zem-0071Zea mays38.719e-94 300
LLPS-Ori-1129Oryza indica38.469e-95 303
LLPS-Orgl-0790Oryza glumaepatula38.469e-95 303
LLPS-Lep-0412Leersia perrieri38.462e-95 305
LLPS-Sot-0383Solanum tuberosum38.441e-97 310
LLPS-Gas-0480Galdieria sulphuraria38.072e-93 300
LLPS-Sem-0376Selaginella moellendorffii37.182e-87 284
LLPS-Cae-1235Caenorhabditis elegans37.144e-92 296
LLPS-Chr-1384Chlamydomonas reinhardtii36.216e-79 262
LLPS-Cym-0713Cyanidioschyzon merolae35.429e-0858.9
LLPS-Via-0536Vigna angularis35.121e-85 280
LLPS-Osl-1297Ostreococcus lucimarinus34.077e-65 224