LLPS-Orc-4087
CDC6
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cell division control protein |
| Gene Name: | CDC6 |
| Ensembl Gene: | ENSOCUG00000004898.3 |
| Ensembl Protein: | ENSOCUP00000004238.3 |
| Organism: | Oryctolagus cuniculus |
| Taxa ID: | 9986 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Spindle apparatus | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOCUT00000004898.3 | ENSOCUP00000004238.3 |
| UniProt | G1SMR6, G1SMR6_RABIT | |
| GeneBank | AAGW02039706 | |
| RefSeq | XM_008271437.2, XM_008271438.2, XM_008271439.2, XM_008271441.2, XM_017349193.1 | XP_008269659.1, XP_008269660.1, XP_008269661.1, XP_008269663.1, XP_017204682.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPQTRSQAQA KISFPKKKFS RTVDKSKNPG DVKVEPANAH TLPSSPCTKI LPLSPRKRLG 60 61 DDNLCNTPQL PPCSPPKQGK KENGPPRSHT PKGRRLIFEN SLTVKSPSKK EQARVPQNKI 120 121 LSSSQKGQES TTNSEQRCPS EKESVCMRLF KQEGTCYQQA KLVLNTAVPD RLPAREKEMD 180 181 VIRNFLREHI CGRKSGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRSAQ 240 241 AVFPAIAQEI CQEEVSRPAG KEMMRKLERH LTAEKGPMIL LVLDEMDQLD SKGQDVLYTL 300 301 FEWPWLSSSR LVLIGIANTL DLTDRILPRL QARENCKPQL LNFPPYTRNQ IATILQDRLN 360 361 QASRDQVVDS AAIQFCARKV SAVSGDVRKA LDVCRRAIEI VESDIKSQTI LKPLSECKSS 420 421 SESPVPKRVG LTHISQVISE VDGNRMTLSR EGAQDSFPLQ QKILVCSLLL LTRQLKIKEV 480 481 TLGKLYEAYS NVCRKQQVAA VDQSECLSLS GLLEARGILG LKKNKETRFT KVSLKIEEKE 540 541 IEHALKDKAL MGNILATGLP 560 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCTCAAA CCCGATCCCA GGCACAGGCT AAAATCAGTT TTCCAAAGAA GAAGTTTTCT 60 61 CGGACAGTAG ACAAAAGTAA AAACCCTGGT GACGTCAAAG TAGAACCAGC AAATGCGCAC 120 121 ACTCTGCCCT CTTCTCCTTG CACAAAAATT CTGCCTCTGA GCCCCAGAAA ACGTCTGGGT 180 181 GATGACAACC TATGCAACAC TCCGCAGTTA CCTCCCTGTT CACCACCAAA GCAAGGCAAG 240 241 AAAGAGAACG GCCCCCCTCG CTCACATACA CCTAAGGGAC GCAGATTAAT ATTTGAAAAT 300 301 TCGTTGACAG TTAAGTCTCC TAGCAAAAAA GAACAAGCCA GAGTTCCCCA AAACAAAATA 360 361 CTTTCCTCGT CTCAAAAAGG TCAAGAGAGT ACAACAAATT CTGAGCAGAG ATGTCCATCG 420 421 GAGAAAGAAT CTGTATGCAT GAGACTGTTC AAGCAAGAAG GTACTTGCTA CCAGCAAGCG 480 481 AAGCTTGTCC TGAATACAGC TGTCCCGGAT CGGCTGCCTG CCAGGGAGAA GGAGATGGAT 540 541 GTCATCAGGA ATTTCCTGAG GGAGCACATC TGTGGGAGAA AATCGGGAAG TCTTTACCTC 600 601 TCTGGTGCTC CTGGAACTGG AAAAACTGCC TGCTTAAGCC GAATCCTGCA AGACCTCAAG 660 661 AAGGAACTGA AAGGCTTTAA AACTATCATG CTGAATTGCA TGTCCTTGAG GAGTGCCCAG 720 721 GCTGTGTTCC CAGCTATTGC TCAGGAGATT TGTCAGGAAG AAGTGTCCAG GCCAGCTGGG 780 781 AAGGAGATGA TGAGGAAACT GGAAAGACAT CTGACTGCAG AGAAGGGCCC CATGATTTTG 840 841 TTAGTGCTGG ACGAGATGGA TCAGCTGGAC AGCAAAGGAC AGGATGTGTT GTACACACTG 900 901 TTTGAATGGC CATGGCTGAG CAGTTCTCGA TTGGTGCTGA TTGGTATTGC TAATACCCTG 960 961 GACCTCACAG ACAGAATTCT GCCTAGGCTT CAAGCTAGAG AAAATTGTAA GCCTCAGCTG 1020 1021 TTGAACTTCC CACCTTATAC CAGAAATCAA ATAGCCACTA TCTTGCAGGA TCGACTTAAT 1080 1081 CAGGCGTCTA GAGATCAGGT TGTGGACAGT GCTGCCATTC AGTTCTGTGC CCGCAAAGTC 1140 1141 TCTGCTGTTT CAGGAGATGT TCGCAAAGCG CTAGATGTGT GCAGAAGAGC TATTGAAATC 1200 1201 GTAGAGTCGG ATATTAAAAG CCAGACTATC CTGAAACCAC TATCTGAATG TAAATCATCC 1260 1261 TCTGAGTCTC CGGTTCCCAA GAGAGTTGGT CTTACTCACA TATCCCAAGT CATTTCAGAA 1320 1321 GTTGATGGTA ATAGGATGAC TTTGAGCCGA GAAGGAGCAC AAGACTCCTT CCCTCTTCAG 1380 1381 CAGAAGATTT TGGTGTGCTC TCTGCTGCTC CTGACCAGGC AGCTGAAAAT CAAAGAGGTC 1440 1441 ACTCTGGGAA AGTTGTATGA AGCTTACAGT AACGTCTGTC GCAAACAGCA GGTGGCAGCT 1500 1501 GTGGATCAGT CAGAGTGTCT GTCACTTTCA GGGCTCTTGG AGGCCAGAGG CATTTTAGGA 1560 1561 TTAAAGAAAA ATAAGGAAAC CCGTTTCACA AAGGTGTCTT TGAAGATTGA AGAGAAGGAA 1620 1621 ATAGAGCATG CTCTGAAAGA CAAAGCTTTA ATGGGAAATA TCTTAGCTAC TGGATTGCCT 1680 1681 TAA 1683 |
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Cellular Component | Spindle midzone | |
Cellular Component | Spindle pole | |
Molecular Function | Kinase binding | |
Biological Process | Cell division | |
Biological Process | DNA replication initiation | |
Biological Process | Mitotic cell cycle | |
Biological Process | Positive regulation of chromosome segregation | |
Biological Process | Positive regulation of cytokinesis | |
Biological Process | Regulation of mitotic metaphase/anaphase transition |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cas-3855 | Carlito syrichta | 90.18 | 0.0 | 1027 |
| LLPS-Eqc-1433 | Equus caballus | 89.82 | 0.0 | 1028 |
| LLPS-Fec-3668 | Felis catus | 88.57 | 0.0 | 1015 |
| LLPS-Pat-2667 | Pan troglodytes | 87.86 | 0.0 | 1015 |
| LLPS-Pap-2051 | Pan paniscus | 87.86 | 0.0 | 1015 |
| LLPS-Urm-3093 | Ursus maritimus | 87.68 | 0.0 | 1003 |
| LLPS-Gog-2728 | Gorilla gorilla | 87.68 | 0.0 | 1011 |
| LLPS-Hos-4426 | Homo sapiens | 87.5 | 0.0 | 1013 |
| LLPS-Nol-1384 | Nomascus leucogenys | 87.5 | 0.0 | 1008 |
| LLPS-Poa-2036 | Pongo abelii | 87.32 | 0.0 | 1008 |
| LLPS-Ova-2541 | Ovis aries | 87.14 | 0.0 | 999 |
| LLPS-Aim-0757 | Ailuropoda melanoleuca | 86.86 | 0.0 | 993 |
| LLPS-Rhb-4474 | Rhinopithecus bieti | 86.79 | 0.0 | 997 |
| LLPS-Aon-4411 | Aotus nancymaae | 86.79 | 0.0 | 998 |
| LLPS-Mup-0751 | Mustela putorius furo | 86.79 | 0.0 | 990 |
| LLPS-Mam-2310 | Macaca mulatta | 86.61 | 0.0 | 995 |
| LLPS-Ict-3804 | Ictidomys tridecemlineatus | 86.61 | 0.0 | 999 |
| LLPS-Chs-4355 | Chlorocebus sabaeus | 86.61 | 0.0 | 993 |
| LLPS-Caj-3512 | Callithrix jacchus | 86.61 | 0.0 | 994 |
| LLPS-Bot-3024 | Bos taurus | 86.61 | 0.0 | 988 |
| LLPS-Paa-2958 | Papio anubis | 86.61 | 0.0 | 991 |
| LLPS-Mal-1523 | Mandrillus leucophaeus | 86.61 | 0.0 | 997 |
| LLPS-Loa-2197 | Loxodonta africana | 86.43 | 0.0 | 989 |
| LLPS-Maf-2057 | Macaca fascicularis | 86.43 | 0.0 | 994 |
| LLPS-Sus-4789 | Sus scrofa | 86.25 | 0.0 | 991 |
| LLPS-Caf-0843 | Canis familiaris | 85.89 | 0.0 | 981 |
| LLPS-Myl-1809 | Myotis lucifugus | 85.71 | 0.0 | 982 |
| LLPS-Otg-2299 | Otolemur garnettii | 85.59 | 0.0 | 967 |
| LLPS-Man-3379 | Macaca nemestrina | 85.43 | 0.0 | 868 |
| LLPS-Ran-1909 | Rattus norvegicus | 81.49 | 0.0 | 936 |
| LLPS-Mea-3877 | Mesocricetus auratus | 81.1 | 0.0 | 699 |
| LLPS-Mum-2044 | Mus musculus | 80.99 | 0.0 | 924 |
| LLPS-Cea-4453 | Cercocebus atys | 80.83 | 0.0 | 977 |
| LLPS-Fud-3695 | Fukomys damarensis | 79.68 | 0.0 | 924 |
| LLPS-Dio-3991 | Dipodomys ordii | 78.07 | 0.0 | 869 |
| LLPS-Cap-3580 | Cavia porcellus | 77.09 | 0.0 | 881 |
| LLPS-Mod-2641 | Monodelphis domestica | 74.87 | 0.0 | 853 |
| LLPS-Sah-3084 | Sarcophilus harrisii | 74.51 | 0.0 | 822 |
| LLPS-Ora-3206 | Ornithorhynchus anatinus | 70.66 | 5e-178 | 514 |
| LLPS-Pes-2476 | Pelodiscus sinensis | 66.25 | 0.0 | 709 |
| LLPS-Xet-2228 | Xenopus tropicalis | 64.3 | 0.0 | 689 |
| LLPS-Anc-3928 | Anolis carolinensis | 62.76 | 0.0 | 684 |
| LLPS-Tag-3041 | Taeniopygia guttata | 62.55 | 5e-114 | 347 |
| LLPS-Gaa-0861 | Gasterosteus aculeatus | 59.77 | 1e-92 | 291 |
| LLPS-Fia-3804 | Ficedula albicollis | 58.54 | 0.0 | 570 |
| LLPS-Orn-1443 | Oreochromis niloticus | 52.57 | 3e-154 | 462 |
| LLPS-Gaga-3983 | Gallus gallus | 52.08 | 0.0 | 556 |
| LLPS-Lac-1698 | Latimeria chalumnae | 52.0 | 7e-66 | 229 |
| LLPS-Xim-2317 | Xiphophorus maculatus | 51.66 | 2e-154 | 462 |
| LLPS-Pof-0540 | Poecilia formosa | 51.17 | 1e-150 | 452 |
| LLPS-Ten-1059 | Tetraodon nigroviridis | 50.44 | 4e-161 | 477 |
| LLPS-Leo-0155 | Lepisosteus oculatus | 50.34 | 0.0 | 535 |
| LLPS-Scf-1097 | Scleropages formosus | 49.8 | 9e-156 | 463 |
| LLPS-Dar-1998 | Danio rerio | 49.4 | 2e-166 | 492 |
| LLPS-Scm-0103 | Scophthalmus maximus | 49.08 | 2e-159 | 474 |
| LLPS-Asm-2820 | Astyanax mexicanus | 48.78 | 5e-173 | 510 |
| LLPS-Orl-3216 | Oryzias latipes | 47.63 | 1e-157 | 470 |
| LLPS-Icp-1280 | Ictalurus punctatus | 46.91 | 3e-158 | 472 |
| LLPS-Cii-1520 | Ciona intestinalis | 46.42 | 1e-119 | 369 |
| LLPS-Cis-1237 | Ciona savignyi | 46.31 | 3e-115 | 354 |
| LLPS-Tar-0817 | Takifugu rubripes | 46.21 | 7e-121 | 376 |
| LLPS-Drm-2015 | Drosophila melanogaster | 43.38 | 2e-97 | 317 |
| LLPS-Dos-1141 | Dothistroma septosporum | 37.4 | 1e-43 | 170 |
| LLPS-Zyt-0392 | Zymoseptoria tritici | 37.21 | 2e-43 | 169 |
| LLPS-Nec-1085 | Neurospora crassa | 37.04 | 2e-42 | 166 |
| LLPS-Phn-0100 | Phaeosphaeria nodorum | 36.08 | 1e-40 | 160 |
| LLPS-Asn-0796 | Aspergillus nidulans | 35.57 | 2e-39 | 157 |
| LLPS-Cus-2404 | Cucumis sativus | 35.27 | 9e-56 | 201 |
| LLPS-Asfu-0279 | Aspergillus fumigatus | 35.18 | 1e-39 | 158 |
| LLPS-Sot-2207 | Solanum tuberosum | 34.98 | 7e-55 | 199 |
| LLPS-Asc-0669 | Aspergillus clavatus | 34.78 | 4e-39 | 157 |
| LLPS-Aso-0408 | Aspergillus oryzae | 34.78 | 3e-40 | 157 |
| LLPS-Asf-0846 | Aspergillus flavus | 34.78 | 6e-39 | 156 |
| LLPS-Chr-1502 | Chlamydomonas reinhardtii | 34.76 | 5e-41 | 163 |
| LLPS-Dac-2329 | Daucus carota | 34.59 | 1e-55 | 201 |
| LLPS-Gag-0304 | Gaeumannomyces graminis | 34.47 | 3e-40 | 160 |
| LLPS-Sol-2414 | Solanum lycopersicum | 34.41 | 3e-54 | 198 |
| LLPS-Mao-0251 | Magnaporthe oryzae | 34.35 | 2e-39 | 157 |
| LLPS-Via-2364 | Vigna angularis | 34.17 | 2e-35 | 145 |
| LLPS-Viv-2080 | Vitis vinifera | 34.16 | 3e-52 | 191 |
| LLPS-Pytr-0872 | Pyrenophora triticirepentis | 34.04 | 7e-39 | 155 |
| LLPS-Met-1907 | Medicago truncatula | 33.92 | 1e-53 | 195 |
| LLPS-Chc-0589 | Chondrus crispus | 33.91 | 1e-44 | 170 |
| LLPS-Meg-1628 | Meleagris gallopavo | 33.84 | 1e-41 | 164 |
| LLPS-Scs-0975 | Sclerotinia sclerotiorum | 33.72 | 2e-46 | 177 |
| LLPS-Tra-0285 | Triticum aestivum | 33.68 | 3e-34 | 142 |
| LLPS-Hov-1284 | Hordeum vulgare | 33.68 | 6e-34 | 141 |
| LLPS-Scp-0474 | Schizosaccharomyces pombe | 33.33 | 1e-62 | 222 |
| LLPS-Abg-0734 | Absidia glauca | 33.33 | 1e-60 | 215 |
| LLPS-Vir-0405 | Vigna radiata | 33.33 | 1e-34 | 143 |
| LLPS-Cogr-1317 | Colletotrichum graminicola | 33.18 | 8e-49 | 184 |
| LLPS-Nia-1534 | Nicotiana attenuata | 33.17 | 3e-51 | 189 |
| LLPS-Scc-0964 | Schizosaccharomyces cryophilus | 33.17 | 1e-60 | 216 |
| LLPS-Brr-2233 | Brassica rapa | 32.99 | 1e-51 | 190 |
| LLPS-Art-2425 | Arabidopsis thaliana | 32.99 | 2e-36 | 148 |
| LLPS-Mua-0427 | Musa acuminata | 32.85 | 2e-55 | 200 |
| LLPS-Put-0683 | Puccinia triticina | 32.83 | 3e-36 | 144 |
| LLPS-Brd-0573 | Brachypodium distachyon | 32.73 | 5e-50 | 187 |
| LLPS-Cog-0822 | Colletotrichum gloeosporioides | 32.71 | 2e-52 | 194 |
| LLPS-Amt-1811 | Amborella trichopoda | 32.71 | 6e-56 | 203 |
| LLPS-Bro-1542 | Brassica oleracea | 32.49 | 4e-52 | 192 |
| LLPS-Brn-3369 | Brassica napus | 32.47 | 2e-51 | 189 |
| LLPS-Asni-1464 | Aspergillus niger | 32.31 | 2e-54 | 199 |
| LLPS-Ast-0729 | Aspergillus terreus | 32.3 | 2e-49 | 186 |
| LLPS-Hea-0384 | Helianthus annuus | 32.25 | 2e-50 | 187 |
| LLPS-Gor-2312 | Gossypium raimondii | 32.19 | 6e-53 | 194 |
| LLPS-Coo-1587 | Colletotrichum orbiculare | 32.08 | 1e-47 | 180 |
| LLPS-Arl-2788 | Arabidopsis lyrata | 32.08 | 2e-48 | 181 |
| LLPS-Sem-1275 | Selaginella moellendorffii | 32.02 | 1e-50 | 185 |
| LLPS-Nef-1638 | Neosartorya fischeri | 31.99 | 1e-47 | 181 |
| LLPS-Orm-1579 | Oryza meridionalis | 31.97 | 1e-51 | 190 |
| LLPS-Thc-2182 | Theobroma cacao | 31.97 | 2e-51 | 189 |
| LLPS-Orgl-1904 | Oryza glumaepatula | 31.97 | 3e-51 | 192 |
| LLPS-Ori-0701 | Oryza indica | 31.9 | 1e-51 | 191 |
| LLPS-Orni-0379 | Oryza nivara | 31.88 | 6e-51 | 188 |
| LLPS-Sei-2470 | Setaria italica | 31.87 | 3e-49 | 183 |
| LLPS-Coc-1854 | Corchorus capsularis | 31.85 | 2e-45 | 172 |
| LLPS-Orr-0250 | Oryza rufipogon | 31.79 | 2e-50 | 188 |
| LLPS-Ors-1285 | Oryza sativa | 31.69 | 8e-50 | 185 |
| LLPS-Orbr-2208 | Oryza brachyantha | 31.62 | 2e-48 | 181 |
| LLPS-Orb-2025 | Oryza barthii | 31.62 | 6e-50 | 187 |
| LLPS-Lem-1200 | Leptosphaeria maculans | 31.62 | 9e-43 | 167 |
| LLPS-Scj-1413 | Schizosaccharomyces japonicus | 31.52 | 2e-59 | 212 |
| LLPS-Zem-2578 | Zea mays | 31.51 | 4e-46 | 174 |
| LLPS-Prp-1337 | Prunus persica | 31.5 | 7e-46 | 174 |
| LLPS-Org-2243 | Oryza glaberrima | 31.43 | 1e-49 | 184 |
| LLPS-Sob-0079 | Sorghum bicolor | 31.41 | 3e-50 | 186 |
| LLPS-Tut-2011 | Tursiops truncatus | 31.4 | 3e-36 | 148 |
| LLPS-Beb-0111 | Beauveria bassiana | 31.25 | 2e-51 | 191 |
| LLPS-Map-0435 | Magnaporthe poae | 31.22 | 8e-46 | 175 |
| LLPS-Php-0747 | Physcomitrella patens | 31.18 | 8e-53 | 195 |
| LLPS-Pot-2291 | Populus trichocarpa | 31.12 | 4e-54 | 197 |
| LLPS-Blg-0779 | Blumeria graminis | 31.09 | 2e-45 | 174 |
| LLPS-Pyt-0429 | Pyrenophora teres | 31.08 | 2e-41 | 164 |
| LLPS-Fuo-0193 | Fusarium oxysporum | 31.05 | 2e-48 | 183 |
| LLPS-Ved-0436 | Verticillium dahliae | 31.05 | 8e-48 | 181 |
| LLPS-Osl-1160 | Ostreococcus lucimarinus | 30.98 | 4e-52 | 190 |
| LLPS-Glm-0908 | Glycine max | 30.84 | 1e-49 | 184 |
| LLPS-Mae-2152 | Manihot esculenta | 30.77 | 3e-52 | 192 |
| LLPS-Fuv-0861 | Fusarium verticillioides | 30.0 | 5e-49 | 185 |
| LLPS-Kop-1493 | Komagataella pastoris | 29.86 | 4e-47 | 176 |
| LLPS-Fus-1148 | Fusarium solani | 29.84 | 2e-46 | 176 |
| LLPS-Orp-2401 | Oryza punctata | 29.79 | 9e-43 | 164 |
| LLPS-Tru-1614 | Triticum urartu | 29.77 | 3e-45 | 171 |
| LLPS-Trr-0200 | Trichoderma reesei | 29.75 | 2e-48 | 184 |
| LLPS-Cae-0632 | Caenorhabditis elegans | 29.61 | 1e-39 | 155 |
| LLPS-Yal-1327 | Yarrowia lipolytica | 29.54 | 1e-40 | 160 |
| LLPS-Trv-0956 | Trichoderma virens | 29.52 | 4e-49 | 185 |
| LLPS-Phv-0973 | Phaseolus vulgaris | 29.36 | 2e-45 | 173 |
| LLPS-Lep-2308 | Leersia perrieri | 29.22 | 4e-52 | 192 |
| LLPS-Sac-1236 | Saccharomyces cerevisiae | 28.75 | 6e-34 | 138 |
| LLPS-Asg-1001 | Ashbya gossypii | 28.64 | 2e-36 | 146 |
| LLPS-Miv-0385 | Microbotryum violaceum | 28.15 | 9e-38 | 153 |
| LLPS-Spr-1225 | Sporisorium reilianum | 27.38 | 3e-34 | 142 |