DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

LLPS-Hos-4426
CDC6

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
Gene Name:	CDC6, CDC18L
Ensembl Gene:	ENSG00000094804.10
Ensembl Protein:	ENSP00000497345.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	LLPS regulator

PDB: 4I5L (A, B, C, G) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Chromatin, Spindle apparatus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2044	O89033	Regulator	Chromatin, Spindle apparatus	79.93	0.0	865

▼ FUNCTION

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000649662.1	ENSP00000497345.1
Ensembl	ENST00000580824.5	ENSP00000463635.1
Ensembl	ENST00000577249.1	ENSP00000463004.1
Ensembl	ENST00000647931.1	ENSP00000497975.1
Ensembl	ENST00000209728.8	ENSP00000209728.4
Ensembl	ENST00000473555.1	ENSP00000464047.1
UniProt		Q99741, CDC6_HUMAN, Q8TB30
GeneBank	U77949, BC025232, AY150310, AF022109	AAN10296.1, AAB38317.1, AAH25232.1, AAC52071.1
RefSeq	NM_001254.3	NP_001245.1
Entrez	990

▼ SEQUENCE

Protein Sequence (FASTA)
1 MPQTRSQAQA TISFPKRKLS RALNKAKNSS DAKLEPTNVQ TVTCSPRVKA LPLSPRKRLG 60 61 DDNLCNTPHL PPCSPPKQGK KENGPPHSHT LKGRRLVFDN QLTIKSPSKR ELAKVHQNKI 120 121 LSSVRKSQEI TTNSEQRCPL KKESACVRLF KQEGTCYQQA KLVLNTAVPD RLPAREREMD 180 181 VIRNFLREHI CGKKAGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRTAQ 240 241 AVFPAIAQEI CQEEVSRPAG KDMMRKLEKH MTAEKGPMIV LVLDEMDQLD SKGQDVLYTL 300 301 FEWPWLSNSH LVLIGIANTL DLTDRILPRL QAREKCKPQL LNFPPYTRNQ IVTILQDRLN 360 361 QVSRDQVLDN AAVQFCARKV SAVSGDVRKA LDVCRRAIEI VESDVKSQTI LKPLSECKSP 420 421 SEPLIPKRVG LIHISQVISE VDGNRMTLSQ EGAQDSFPLQ QKILVCSLML LIRQLKIKEV 480 481 TLGKLYEAYS KVCRKQQVAA VDQSECLSLS GLLEARGILG LKRNKETRLT KVFFKIEEKE 540 541 IEHALKDKAL IGNILATGLP 560
Nucleotide CDS Sequence (FASTA)
1 ATGCCTCAAA CCCGATCCCA GGCACAGGCT ACAATCAGTT TTCCAAAAAG GAAGCTGTCT 60 61 CGGGCATTGA ACAAAGCTAA AAACTCCAGT GATGCCAAAC TAGAACCAAC AAATGTCCAA 120 121 ACCGTAACCT GTTCTCCTCG TGTAAAAGCC CTGCCTCTCA GCCCCAGGAA ACGTCTGGGC 180 181 GATGACAACC TATGCAACAC TCCCCATTTA CCTCCTTGTT CTCCACCAAA GCAAGGCAAG 240 241 AAAGAGAATG GTCCCCCTCA CTCACATACA CTTAAGGGAC GAAGATTGGT ATTTGACAAT 300 301 CAGCTGACAA TTAAGTCTCC TAGCAAAAGA GAACTAGCCA AAGTTCACCA AAACAAAATA 360 361 CTTTCTTCAG TTAGAAAAAG TCAAGAGATC ACAACAAATT CTGAGCAGAG ATGTCCACTG 420 421 AAGAAAGAAT CTGCATGTGT GAGACTATTC AAGCAAGAAG GCACTTGCTA CCAGCAAGCA 480 481 AAGCTGGTCC TGAACACAGC TGTCCCAGAT CGGCTGCCTG CCAGGGAAAG GGAGATGGAT 540 541 GTCATCAGGA ATTTCTTGAG GGAACACATC TGTGGGAAAA AAGCTGGAAG CCTTTACCTT 600 601 TCTGGTGCTC CTGGAACTGG AAAAACTGCC TGCTTAAGCC GGATTCTGCA AGACCTCAAG 660 661 AAGGAACTGA AAGGCTTTAA AACTATCATG CTGAATTGCA TGTCCTTGAG GACTGCCCAG 720 721 GCTGTATTCC CAGCTATTGC TCAGGAGATT TGTCAGGAAG AGGTATCCAG GCCAGCTGGG 780 781 AAGGACATGA TGAGGAAATT GGAAAAACAT ATGACTGCAG AGAAGGGCCC CATGATTGTG 840 841 TTGGTATTGG ACGAGATGGA TCAACTGGAC AGCAAAGGCC AGGATGTATT GTACACGCTA 900 901 TTTGAATGGC CATGGCTAAG CAATTCTCAC TTGGTGCTGA TTGGTATTGC TAATACCCTG 960 961 GATCTCACAG ATAGAATTCT ACCTAGGCTT CAAGCTAGAG AAAAATGTAA GCCACAGCTG 1020 1021 TTGAACTTCC CACCTTATAC CAGAAATCAG ATAGTCACTA TTTTGCAAGA TCGACTTAAT 1080 1081 CAGGTATCTA GAGATCAGGT TCTGGACAAT GCTGCAGTTC AATTCTGTGC CCGCAAAGTC 1140 1141 TCTGCTGTTT CAGGAGATGT TCGCAAAGCA CTGGATGTTT GCAGGAGAGC TATTGAAATT 1200 1201 GTAGAGTCAG ATGTCAAAAG CCAGACTATT CTCAAACCAC TGTCTGAATG TAAATCACCT 1260 1261 TCTGAGCCTC TGATTCCCAA GAGGGTTGGT CTTATTCACA TATCCCAAGT CATCTCAGAA 1320 1321 GTTGATGGTA ACAGGATGAC CTTGAGCCAA GAAGGAGCAC AAGATTCCTT CCCTCTTCAG 1380 1381 CAGAAGATCT TGGTTTGCTC TTTGATGCTC TTGATCAGGC AGTTGAAAAT CAAAGAGGTC 1440 1441 ACTCTGGGGA AGTTATATGA AGCCTACAGT AAAGTCTGTC GCAAACAGCA GGTGGCGGCT 1500 1501 GTGGACCAGT CAGAGTGTTT GTCACTTTCA GGGCTCTTGG AAGCCAGGGG CATTTTAGGA 1560 1561 TTAAAGAGAA ACAAGGAAAC CCGTTTGACA AAGGTGTTTT TCAAGATTGA AGAGAAAGAA 1620 1621 ATAGAACATG CTCTGAAAGA TAAAGCTTTA ATTGGAAATA TCTTAGCTAC TGGATTGCCT 1680 1681 TAA 1683

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0067	ATP-binding
KW-0131	Cell cycle
KW-0132	Cell division
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0225	Disease mutation
KW-0235	DNA replication
KW-0242	Dwarfism
KW-0498	Mitosis
KW-0547	Nucleotide-binding
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0005829	Cellular Component	Cytosol
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0051233	Cellular Component	Spindle midzone
GO:0000922	Cellular Component	Spindle pole
GO:0005524	Molecular Function	ATP binding
GO:0003688	Molecular Function	DNA replication origin binding
GO:0019900	Molecular Function	Kinase binding
GO:0000166	Molecular Function	Nucleotide binding
GO:0051301	Biological Process	Cell division
GO:1904385	Biological Process	Cellular response to angiotensin
GO:1904117	Biological Process	Cellular response to vasopressin
GO:0006260	Biological Process	DNA replication
GO:0000076	Biological Process	DNA replication checkpoint
GO:0006270	Biological Process	DNA replication initiation
GO:0000082	Biological Process	G1/S transition of mitotic cell cycle
GO:0000278	Biological Process	Mitotic cell cycle
GO:0033314	Biological Process	Mitotic DNA replication checkpoint
GO:0008285	Biological Process	Negative regulation of cell population proliferation
GO:0008156	Biological Process	Negative regulation of DNA replication
GO:0051984	Biological Process	Positive regulation of chromosome segregation
GO:0045737	Biological Process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0032467	Biological Process	Positive regulation of cytokinesis
GO:0048146	Biological Process	Positive regulation of fibroblast proliferation
GO:0000079	Biological Process	Regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0030071	Biological Process	Regulation of mitotic metaphase/anaphase transition
GO:0000083	Biological Process	Regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0007089	Biological Process	Traversing start control point of mitotic cell cycle

▼ KEGG

hsa:990

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	RAIN
Mentha	PINA	IID	MIST	DifferentialNET
RNAct

Disease
ClinVar	TumorFusions	OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CORUM	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pat-2667	Pan troglodytes	99.64	0.0	1118
LLPS-Pap-2051	Pan paniscus	99.64	0.0	1118
LLPS-Gog-2728	Gorilla gorilla	99.11	0.0	1112
LLPS-Nol-1384	Nomascus leucogenys	98.04	0.0	1099
LLPS-Poa-2036	Pongo abelii	97.68	0.0	1094
LLPS-Paa-2958	Papio anubis	96.61	0.0	1073
LLPS-Mal-1523	Mandrillus leucophaeus	96.61	0.0	1077
LLPS-Chs-4355	Chlorocebus sabaeus	96.43	0.0	1069
LLPS-Rhb-4474	Rhinopithecus bieti	96.43	0.0	1073
LLPS-Mam-2310	Macaca mulatta	96.07	0.0	1071
LLPS-Maf-2057	Macaca fascicularis	95.89	0.0	1070
LLPS-Aon-4411	Aotus nancymaae	95.36	0.0	1067
LLPS-Caj-3512	Callithrix jacchus	94.29	0.0	1051
LLPS-Man-3379	Macaca nemestrina	93.03	0.0	908
LLPS-Cas-3855	Carlito syrichta	90.71	0.0	1018
LLPS-Fec-3668	Felis catus	90.57	0.0	1015
LLPS-Eqc-1433	Equus caballus	90.54	0.0	1012
LLPS-Cea-4453	Cercocebus atys	90.17	0.0	1058
LLPS-Urm-3093	Ursus maritimus	90.0	0.0	1012
LLPS-Aim-0757	Ailuropoda melanoleuca	89.34	0.0	1003
LLPS-Loa-2197	Loxodonta africana	89.11	0.0	996
LLPS-Caf-0843	Canis familiaris	88.79	0.0	997
LLPS-Mup-0751	Mustela putorius furo	88.39	0.0	994
LLPS-Ict-3804	Ictidomys tridecemlineatus	88.39	0.0	1002
LLPS-Otg-2299	Otolemur garnettii	87.9	0.0	972
LLPS-Bot-3024	Bos taurus	87.68	0.0	990
LLPS-Orc-4087	Oryctolagus cuniculus	87.5	0.0	994
LLPS-Ova-2541	Ovis aries	87.14	0.0	979
LLPS-Sus-4789	Sus scrofa	86.96	0.0	981
LLPS-Myl-1809	Myotis lucifugus	85.89	0.0	967
LLPS-Mea-3877	Mesocricetus auratus	81.82	0.0	698
LLPS-Ran-1909	Rattus norvegicus	80.25	0.0	905
LLPS-Mum-2044	Mus musculus	79.93	0.0	890
LLPS-Fud-3695	Fukomys damarensis	79.11	0.0	896
LLPS-Dio-3991	Dipodomys ordii	78.61	0.0	863
LLPS-Cap-3580	Cavia porcellus	77.86	0.0	863
LLPS-Mod-2641	Monodelphis domestica	76.65	0.0	854
LLPS-Sah-3084	Sarcophilus harrisii	75.4	0.0	808
LLPS-Ora-3206	Ornithorhynchus anatinus	70.94	6e-176	509
LLPS-Pes-2476	Pelodiscus sinensis	64.83	0.0	687
LLPS-Xet-2228	Xenopus tropicalis	62.88	0.0	663
LLPS-Anc-3928	Anolis carolinensis	62.41	0.0	667
LLPS-Tag-3041	Taeniopygia guttata	61.03	1e-112	343
LLPS-Gaa-0861	Gasterosteus aculeatus	59.16	1e-84	270
LLPS-Lac-1698	Latimeria chalumnae	58.43	7e-62	218
LLPS-Fia-3804	Ficedula albicollis	54.37	0.0	560
LLPS-Gaga-3983	Gallus gallus	52.08	0.0	551
LLPS-Orn-1443	Oreochromis niloticus	51.53	5e-147	444
LLPS-Leo-0155	Lepisosteus oculatus	50.68	2e-175	515
LLPS-Asm-2820	Astyanax mexicanus	48.78	4e-166	492
LLPS-Dar-1998	Danio rerio	48.73	1e-159	474
LLPS-Scm-0103	Scophthalmus maximus	48.66	4e-151	452
LLPS-Ten-1059	Tetraodon nigroviridis	48.01	4e-150	449
LLPS-Orl-3216	Oryzias latipes	47.77	6e-149	447
LLPS-Cis-1237	Ciona savignyi	46.8	5e-110	341
LLPS-Cii-1520	Ciona intestinalis	46.73	5e-112	348
LLPS-Icp-1280	Ictalurus punctatus	46.28	7e-150	451
LLPS-Scf-1097	Scleropages formosus	45.99	2e-147	442
LLPS-Tar-0817	Takifugu rubripes	45.71	4e-124	384
LLPS-Xim-2317	Xiphophorus maculatus	45.0	4e-143	433
LLPS-Pof-0540	Poecilia formosa	44.11	8e-140	424
LLPS-Drm-2015	Drosophila melanogaster	42.2	2e-93	306
LLPS-Nec-0736	Neurospora crassa	37.11	1e-43	169
LLPS-Ved-0436	Verticillium dahliae	35.98	2e-43	167
LLPS-Zyt-0392	Zymoseptoria tritici	35.43	1e-42	166
LLPS-Scs-0975	Sclerotinia sclerotiorum	35.16	4e-44	170
LLPS-Gag-0304	Gaeumannomyces graminis	34.98	4e-41	162
LLPS-Sot-2207	Solanum tuberosum	34.89	8e-49	182
LLPS-Sol-2414	Solanum lycopersicum	34.48	6e-48	180
LLPS-Scj-1413	Schizosaccharomyces japonicus	34.15	5e-55	200
LLPS-Aso-0408	Aspergillus oryzae	34.13	1e-40	158
LLPS-Mao-0251	Magnaporthe oryzae	34.1	4e-40	159
LLPS-Chc-0866	Chondrus crispus	33.92	1e-37	149
LLPS-Via-2364	Vigna angularis	33.81	7e-35	144
LLPS-Tra-0285	Triticum aestivum	33.8	5e-35	144
LLPS-Tru-0765	Triticum urartu	33.8	5e-35	143
LLPS-Chr-1502	Chlamydomonas reinhardtii	33.74	2e-39	158
LLPS-Scp-0474	Schizosaccharomyces pombe	33.68	1e-59	214
LLPS-Dac-2329	Daucus carota	33.67	7e-49	182
LLPS-Hov-1284	Hordeum vulgare	33.33	6e-35	144
LLPS-Meg-1628	Meleagris gallopavo	33.23	2e-40	160
LLPS-Zem-0907	Zea mays	33.21	4e-39	157
LLPS-Scc-0964	Schizosaccharomyces cryophilus	33.16	3e-56	204
LLPS-Met-1907	Medicago truncatula	33.07	1e-49	184
LLPS-Asc-0669	Aspergillus clavatus	32.91	7e-41	162
LLPS-Viv-2080	Vitis vinifera	32.9	6e-46	174
LLPS-Orgl-0642	Oryza glumaepatula	32.8	6e-36	147
LLPS-Orb-0874	Oryza barthii	32.8	3e-35	145
LLPS-Org-0329	Oryza glaberrima	32.8	1e-35	146
LLPS-Orr-0689	Oryza rufipogon	32.8	8e-36	147
LLPS-Orm-0756	Oryza meridionalis	32.8	8e-36	147
LLPS-Orp-1340	Oryza punctata	32.8	2e-35	146
LLPS-Asn-0796	Aspergillus nidulans	32.76	1e-39	158
LLPS-Pytr-0872	Pyrenophora triticirepentis	32.75	1e-39	158
LLPS-Trv-0956	Trichoderma virens	32.74	1e-46	178
LLPS-Asfu-0279	Aspergillus fumigatus	32.72	7e-41	162
LLPS-Cus-2404	Cucumis sativus	32.68	1e-49	185
LLPS-Nia-1534	Nicotiana attenuata	32.68	3e-45	172
LLPS-Cogr-0765	Colletotrichum graminicola	32.67	4e-42	165
LLPS-Phn-0100	Phaeosphaeria nodorum	32.56	9e-42	164
LLPS-Art-2425	Arabidopsis thaliana	32.48	1e-35	146
LLPS-Coc-1854	Corchorus capsularis	32.4	2e-44	169
LLPS-Amt-1811	Amborella trichopoda	32.21	3e-50	187
LLPS-Put-0683	Puccinia triticina	32.2	2e-36	145
LLPS-Prp-1337	Prunus persica	32.2	2e-42	164
LLPS-Abg-0734	Absidia glauca	32.1	7e-56	202
LLPS-Fuo-0193	Fusarium oxysporum	32.09	9e-47	179
LLPS-Asf-0846	Aspergillus flavus	32.07	3e-39	157
LLPS-Fuv-0861	Fusarium verticillioides	32.01	6e-47	179
LLPS-Sem-1275	Selaginella moellendorffii	31.95	4e-47	175
LLPS-Trr-0200	Trichoderma reesei	31.9	2e-46	178
LLPS-Mua-0427	Musa acuminata	31.88	7e-50	185
LLPS-Dos-0649	Dothistroma septosporum	31.79	7e-51	191
LLPS-Pot-2291	Populus trichocarpa	31.78	2e-47	178
LLPS-Sei-2470	Setaria italica	31.72	1e-44	170
LLPS-Cae-0632	Caenorhabditis elegans	31.71	5e-38	151
LLPS-Hea-0384	Helianthus annuus	31.68	2e-44	171
LLPS-Arl-2788	Arabidopsis lyrata	31.66	7e-43	165
LLPS-Bro-1542	Brassica oleracea	31.65	9e-47	177
LLPS-Sob-0079	Sorghum bicolor	31.58	3e-46	174
LLPS-Mae-2152	Manihot esculenta	31.46	1e-44	171
LLPS-Php-0747	Physcomitrella patens	31.41	1e-49	186
LLPS-Cog-0822	Colletotrichum gloeosporioides	31.06	8e-47	178
LLPS-Asni-1464	Aspergillus niger	31.03	5e-51	190
LLPS-Gor-2312	Gossypium raimondii	30.98	1e-44	171
LLPS-Lem-1200	Leptosphaeria maculans	30.91	4e-42	166
LLPS-Kop-1493	Komagataella pastoris	30.9	7e-46	173
LLPS-Orbr-2208	Oryza brachyantha	30.88	2e-43	166
LLPS-Beb-0602	Beauveria bassiana	30.81	9e-45	172
LLPS-Brd-0573	Brachypodium distachyon	30.77	4e-44	169
LLPS-Thc-2182	Theobroma cacao	30.77	4e-45	172
LLPS-Glm-0908	Glycine max	30.77	2e-45	172
LLPS-Ast-0729	Aspergillus terreus	30.71	6e-47	179
LLPS-Coo-1587	Colletotrichum orbiculare	30.44	1e-43	168
LLPS-Lep-2308	Leersia perrieri	30.34	1e-45	174
LLPS-Orni-0379	Oryza nivara	30.33	1e-45	173
LLPS-Blg-0779	Blumeria graminis	30.27	2e-45	174
LLPS-Osl-1160	Ostreococcus lucimarinus	30.24	6e-48	178
LLPS-Map-0435	Magnaporthe poae	30.21	2e-41	162
LLPS-Ors-1285	Oryza sativa	30.15	2e-44	170
LLPS-Ori-0701	Oryza indica	30.13	3e-45	172
LLPS-Nef-1638	Neosartorya fischeri	30.12	6e-44	170
LLPS-Brn-3369	Brassica napus	29.96	2e-48	180
LLPS-Tut-2011	Tursiops truncatus	29.74	9e-36	147
LLPS-Brr-2233	Brassica rapa	29.72	5e-49	182
LLPS-Yal-1327	Yarrowia lipolytica	29.66	6e-39	155
LLPS-Phv-0973	Phaseolus vulgaris	29.65	3e-43	166
LLPS-Fus-0840	Fusarium solani	29.53	5e-47	179
LLPS-Spr-1225	Sporisorium reilianum	29.5	3e-34	142
LLPS-Pyt-0707	Pyrenophora teres	29.45	7e-46	175
LLPS-Asg-1001	Ashbya gossypii	28.29	2e-34	139
LLPS-Miv-0385	Microbotryum violaceum	28.22	1e-35	146
LLPS-Sac-1236	Saccharomyces cerevisiae	27.47	2e-34	139

LLPS-Hos-4426CDC6

Protein Sequence

Nucleotide Sequence

LLPS-Hos-4426
CDC6