• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ora-1277
RBFOX1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RNA binding protein fox-1 homolog
Gene Name: RBFOX1
Ensembl Gene: ENSOANG00000002379.2
Ensembl Protein: ENSOANP00000003771.2
Organism: Ornithorhynchus anatinus
Taxa ID: 9258
LLPS Type: Scaffold


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, Stress granulePredicted from orthologs(View)

▼ FUNCTION

RNA-binding protein that regulates alternative splicing events.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEAKGSRMVQ  QGNQEATAAP  DTMAQPYASA  QFAPPQNGIP  AEYTAPHPHP  APEYTGQTTV  60
61    PEHTLNMYPP  AQTHSEQSAT  DTSAQTVSGT  ATQTDDAAQT  DGQHQTQSSE  NTENKSQPKR  120
121   LHVSNIPFRF  RDPDLRQMFG  QFGKILDVEI  IFNERGSKGF  GFVTFENSAD  ADRAREKLHG  180
181   TVVEGRKIEV  NNATARVMTN  KKTVNPYTNG  WKLNPVVGAV  YSPEFYAGTV  LLCQANQEGS  240
241   SVYSAPSSLV  YTSTMPGFPY  PAATAAAAYR  GAHLRGRGRA  VYNTFRAAAP  PPPIPAYGGV  300
301   VYQDGFYGAD  IYGGYAAYRY  AQPATATAAA  YSDRNQFVFV  AADEISCNTS  AVTDEFMLPT  360
361   PTTTHLLQPP  PTALVP  376
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCTA  AAGGGAGCAG  GATGGTACAG  CAGGGTAATC  AGGAAGCAAC  AGCAGCTCCT  60
61    GACACAATGG  CGCAGCCTTA  CGCCTCTGCC  CAGTTTGCCC  CCCCTCAGAA  TGGTATCCCA  120
121   GCAGAGTACA  CGGCTCCTCA  TCCCCACCCC  GCTCCAGAGT  ACACAGGCCA  GACGACAGTC  180
181   CCAGAGCACA  CGTTAAACAT  GTACCCTCCT  GCGCAGACAC  ACTCTGAACA  AAGTGCCACG  240
241   GACACAAGCG  CTCAGACCGT  CTCTGGCACA  GCCACACAGA  CAGACGATGC  AGCACAGACC  300
301   GACGGTCAGC  ACCAGACACA  ATCTTCTGAA  AACACAGAAA  ATAAATCACA  GCCAAAGCGG  360
361   CTTCACGTCT  CTAATATTCC  CTTCAGATTC  CGGGATCCAG  ACCTCAGACA  AATGTTTGGT  420
421   CAATTTGGTA  AAATCTTAGA  TGTTGAAATT  ATTTTTAATG  AGCGGGGCTC  AAAGGGATTT  480
481   GGTTTCGTAA  CTTTCGAAAA  TAGTGCCGAT  GCGGACAGGG  CGAGGGAGAA  ATTACACGGC  540
541   ACCGTGGTAG  AGGGCCGTAA  AATCGAGGTG  AATAATGCTA  CAGCACGTGT  AATGACAAAC  600
601   AAAAAGACAG  TCAACCCTTA  TACAAATGGC  TGGAAATTGA  ATCCAGTTGT  GGGTGCCGTT  660
661   TATAGTCCAG  AGTTCTATGC  AGGCACGGTG  CTGTTGTGCC  AGGCAAACCA  GGAAGGATCT  720
721   TCCGTGTACA  GTGCCCCCAG  TTCACTAGTA  TACACTTCCA  CAATGCCCGG  CTTCCCTTAT  780
781   CCGGCTGCAA  CTGCTGCTGC  TGCCTACAGA  GGAGCCCACC  TCAGAGGCCG  TGGTCGCGCA  840
841   GTCTACAATA  CATTTCGGGC  AGCCGCTCCC  CCTCCCCCGA  TCCCAGCCTA  TGGCGGTGTT  900
901   GTGTACCAGG  ATGGATTTTA  TGGTGCAGAC  ATTTATGGTG  GTTATGCTGC  CTACAGGTAT  960
961   GCCCAACCTG  CCACTGCCAC  TGCAGCTGCC  TACAGTGACA  GAAATCAATT  CGTCTTCGTT  1020
1021  GCAGCAGATG  AAATTTCTTG  TAACACCTCT  GCAGTTACGG  ACGAGTTTAT  GCTGCCGACC  1080
1081  CCTACCACCA  CACACTTGCT  CCAGCCCCCA  CCTACGGCGT  TGGTGCCATG  A  1131

▼ KEYWORD

ID
Family
Complete proteome
mRNA processing
mRNA splicing
Nucleus
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
MRNA binding
Biological Process
MRNA processing
Biological Process
Nervous system development
Biological Process
Neuromuscular process controlling balance
Biological Process
Regulation of alternative mRNA splicing, via spliceosome
Biological Process
Regulation of skeletal muscle cell differentiation
Biological Process
RNA splicing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mod-0355Monodelphis domestica99.15e-179 509
LLPS-Myl-3001Myotis lucifugus98.472e-112 338
LLPS-Loa-2123Loxodonta africana98.473e-112 337
LLPS-Urm-2927Ursus maritimus97.125e-155 448
LLPS-Fia-2567Ficedula albicollis96.942e-168 481
LLPS-Tag-3364Taeniopygia guttata96.943e-168 483
LLPS-Pes-2762Pelodiscus sinensis96.713e-175 501
LLPS-Caf-4600Canis familiaris96.64e-167 481
LLPS-Poa-3525Pongo abelii96.540.0 521
LLPS-Rhb-0494Rhinopithecus bieti96.530.0 520
LLPS-Chs-4273Chlorocebus sabaeus96.360.0 540
LLPS-Anp-0972Anas platyrhynchos96.287e-169 485
LLPS-Fud-1323Fukomys damarensis96.262e-166 479
LLPS-Mal-1269Mandrillus leucophaeus96.250.0 521
LLPS-Mup-1397Mustela putorius furo96.250.0 522
LLPS-Mam-2759Macaca mulatta95.970.0 520
LLPS-Cas-2920Carlito syrichta95.950.0 517
LLPS-Eqc-4000Equus caballus95.613e-167 482
LLPS-Tut-0015Tursiops truncatus95.581e-164 475
LLPS-Cap-4455Cavia porcellus95.586e-165 476
LLPS-Gaga-0477Gallus gallus95.583e-165 476
LLPS-Cea-3459Cercocebus atys95.440.0 523
LLPS-Gog-3482Gorilla gorilla95.440.0 524
LLPS-Paa-0841Papio anubis95.440.0 523
LLPS-Pat-1058Pan troglodytes95.440.0 523
LLPS-Pap-2117Pan paniscus95.440.0 523
LLPS-Hos-0644Homo sapiens95.440.0 524
LLPS-Fec-0511Felis catus95.440.0 526
LLPS-Bot-1548Bos taurus95.397e-174 498
LLPS-Maf-3015Macaca fascicularis95.160.0 522
LLPS-Aon-1049Aotus nancymaae95.160.0 523
LLPS-Man-3685Macaca nemestrina95.160.0 522
LLPS-Nol-3855Nomascus leucogenys95.160.0 523
LLPS-Otg-4680Otolemur garnettii94.971e-166 479
LLPS-Caj-0033Callithrix jacchus94.875e-180 519
LLPS-Ran-3727Rattus norvegicus94.593e-163 471
LLPS-Ict-4554Ictidomys tridecemlineatus94.563e-163 471
LLPS-Orc-1820Oryctolagus cuniculus94.473e-134 390
LLPS-Mum-4742Mus musculus94.261e-162 470
LLPS-Aim-0985Ailuropoda melanoleuca94.146e-137 398
LLPS-Sah-4060Sarcophilus harrisii93.522e-158 458
LLPS-Sus-3601Sus scrofa93.12e-179 514
LLPS-Dio-2026Dipodomys ordii92.832e-144 423
LLPS-Meg-0224Meleagris gallopavo90.212e-155 447
LLPS-Leo-2342Lepisosteus oculatus86.871e-143 421
LLPS-Scf-1703Scleropages formosus86.176e-138 404
LLPS-Anc-1625Anolis carolinensis85.715e-141 414
LLPS-Ova-2375Ovis aries80.662e-124 365
LLPS-Dar-0980Danio rerio79.021e-126 376
LLPS-Icp-3902Ictalurus punctatus74.661e-102 315
LLPS-Scm-2815Scophthalmus maximus71.572e-103 318
LLPS-Tar-1018Takifugu rubripes70.291e-101 312
LLPS-Gaa-1024Gasterosteus aculeatus69.936e-63 213
LLPS-Orn-2894Oreochromis niloticus68.334e-114 344
LLPS-Ten-0840Tetraodon nigroviridis67.222e-112 341
LLPS-Pof-1427Poecilia formosa66.884e-62 212
LLPS-Orl-2845Oryzias latipes66.831e-63 216
LLPS-Xim-0110Xiphophorus maculatus65.889e-64 217
LLPS-Cae-2013Caenorhabditis elegans65.489e-31 125
LLPS-Xet-2608Xenopus tropicalis65.021e-81 261
LLPS-Asm-3896Astyanax mexicanus63.825e-90 283
LLPS-Mea-0106Mesocricetus auratus62.031e-96 300
LLPS-Lac-0757Latimeria chalumnae60.263e-83 265
LLPS-Ere-0206Erinaceus europaeus45.03e-0960.8
LLPS-Tra-3046Triticum aestivum41.673e-0960.1
LLPS-Tru-1540Triticum urartu41.674e-0958.9
LLPS-Dac-1385Daucus carota40.245e-1063.5
LLPS-Sot-2028Solanum tuberosum39.245e-0960.8
LLPS-Brd-0209Brachypodium distachyon39.244e-0961.2
LLPS-Sob-1001Sorghum bicolor39.242e-0962.0
LLPS-Usm-1349Ustilago maydis39.248e-0958.2
LLPS-Prp-2015Prunus persica39.249e-1063.5
LLPS-Mae-2025Manihot esculenta39.028e-0960.8
LLPS-Drm-0962Drosophila melanogaster38.894e-1065.5
LLPS-Nia-2415Nicotiana attenuata38.377e-0960.8
LLPS-Vir-1348Vigna radiata36.269e-0960.5
LLPS-Cus-1787Cucumis sativus35.719e-0960.1
LLPS-Amt-1984Amborella trichopoda32.324e-1063.9