• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Myl-2241
POLL

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA polymerase
Gene Name: POLL
Ensembl Gene: ENSMLUG00000004944.2
Ensembl Protein: ENSMLUP00000004507.2
Organism: Myotis lucifugus
Taxa ID: 59463
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDPRGILKAF  PKRKKILANP  SSKVLAKIPK  REDEEEAREW  LSSLRAHVVP  AGIGRARAEL  60
61    FEKQIVQHGG  QIYSAQAPGV  THIVVDDGMD  CERALRLLRL  PRLPPGAQLV  KSAWLSLCLQ  120
121   ERRLVDTAGF  SIFIPNRYLD  QPQLSKADQD  PSPGACEALL  RTAPSPPPTP  PRPVSPPQRI  180
181   EEAPNTQAQP  VSDDDISDGE  ETPVSAADLE  ALISGRYPIP  PEGDGEPSPA  PEGLNKWVCA  240
241   QPSSQKATNH  NTHITEKLEV  LAKAYSVQGD  KWRALGYDKA  INALKSFHKP  VTSYQEACSI  300
301   PGIGKRMAEK  IVEILESGHL  RKLDHISDSV  PVLELFSNIW  GAGTKTAQMW  YQQGFRSLED  360
361   IRNQASLTTQ  QAIGLKHYDD  FLERMPREEA  AEIEQTVRES  AQAFSPGLLC  VACGSYRRGK  420
421   ATCGDVDVLL  THPDGRSHQG  IFIRLLDSLR  QRGFLTDDLV  SHEENGQQQK  YLGVCQLPGP  480
481   GRRHRRLDII  IVPYSEFACA  LLYFTGSAHF  NRSMRALAKT  KGMSLSEHAL  SAAVVRDTRG  540
541   LKVGSGRVLP  TPTEKDVFRL  LGLPYREPAE  RDW  573
Nucleotide CDS Sequence (FASTA)
1     ATGGACCCCA  GGGGCATCTT  GAAGGCATTT  CCCAAGCGGA  AGAAAATCCT  TGCCAACCCA  60
61    TCATCAAAAG  TACTTGCAAA  GATTCCCAAG  AGGGAAGACG  AAGAAGAAGC  AAGAGAGTGG  120
121   CTGAGTTCCC  TACGGGCCCA  TGTTGTGCCC  GCTGGCATTG  GGCGAGCCCG  GGCAGAACTC  180
181   TTTGAGAAGC  AGATTGTCCA  ACATGGTGGC  CAGATATACT  CTGCCCAGGC  CCCAGGGGTC  240
241   ACTCACATTG  TGGTGGATGA  TGGCATGGAC  TGTGAGCGAG  CCCTTCGCCT  CCTTAGACTG  300
301   CCCCGGCTGC  CCCCAGGTGC  TCAGCTGGTA  AAGTCAGCCT  GGCTGAGCTT  GTGCCTGCAG  360
361   GAGAGAAGGC  TGGTGGACAC  GGCAGGATTC  AGCATCTTCA  TCCCCAACAG  GTACCTGGAC  420
421   CAACCACAGC  TCAGTAAGGC  AGACCAAGAC  CCTTCTCCCG  GAGCTTGTGA  GGCTCTGCTC  480
481   AGGACAGCCC  CCTCTCCTCC  CCCTACTCCC  CCTAGACCTG  TATCTCCTCC  CCAGAGGATA  540
541   GAAGAAGCTC  CAAACACCCA  AGCCCAGCCT  GTCTCGGATG  ATGACATCAG  TGATGGGGAA  600
601   GAGACCCCAG  TGAGCGCAGC  TGATTTGGAA  GCCCTGATCA  GTGGCCGCTA  CCCCATCCCC  660
661   CCTGAGGGAG  ATGGTGAGCC  CAGCCCCGCC  CCTGAGGGTC  TGAATAAGTG  GGTCTGTGCA  720
721   CAGCCTTCGA  GTCAAAAGGC  GACCAACCAC  AACACCCACA  TCACAGAAAA  GCTGGAAGTG  780
781   CTGGCCAAAG  CCTACAGTGT  TCAGGGAGAC  AAGTGGAGGG  CCCTTGGCTA  TGACAAGGCC  840
841   ATCAATGCCC  TCAAGAGCTT  CCACAAGCCT  GTCACCTCCT  ACCAGGAAGC  CTGCAGTATC  900
901   CCTGGGATTG  GGAAACGGAT  GGCCGAGAAG  ATCGTAGAGA  TCCTAGAAAG  TGGACATCTG  960
961   CGGAAGCTGG  ACCACATCAG  CGACAGCGTG  CCTGTCTTGG  AACTCTTCTC  TAATATTTGG  1020
1021  GGAGCTGGAA  CCAAGACTGC  CCAGATGTGG  TACCAACAGG  GTTTCCGGAG  CTTAGAAGAC  1080
1081  ATCCGCAACC  AGGCCTCCCT  GACTACCCAG  CAGGCCATTG  GCCTGAAGCA  TTACGATGAC  1140
1141  TTTCTGGAAC  GCATGCCCAG  AGAGGAGGCT  GCCGAGATCG  AGCAGACAGT  CCGGGAATCA  1200
1201  GCTCAGGCCT  TCAGCCCTGG  GCTGTTGTGC  GTGGCATGCG  GTTCCTACCG  ACGGGGGAAA  1260
1261  GCAACCTGTG  GTGATGTGGA  CGTGCTGCTC  ACTCACCCGG  ATGGCCGATC  TCACCAGGGC  1320
1321  ATCTTCATTC  GCCTCCTTGA  CAGCCTTCGG  CAGCGAGGGT  TCCTGACTGA  TGACTTGGTG  1380
1381  AGCCATGAGG  AGAATGGTCA  GCAGCAGAAG  TACCTGGGTG  TGTGCCAGCT  CCCAGGACCA  1440
1441  GGGCGACGGC  ACCGACGACT  GGACATCATC  ATTGTGCCCT  ACAGCGAGTT  TGCGTGCGCC  1500
1501  CTGCTCTACT  TCACCGGCTC  TGCCCACTTC  AACCGCTCCA  TGCGGGCTCT  GGCCAAGACC  1560
1561  AAGGGTATGA  GCTTGTCGGA  GCACGCCCTC  AGCGCAGCTG  TGGTGCGGGA  CACGCGAGGT  1620
1621  CTCAAGGTGG  GGTCTGGCCG  AGTGCTTCCC  ACCCCGACTG  AGAAGGATGT  CTTCAGGCTG  1680
1681  CTAGGCCTGC  CCTACCGAGA  ACCCGCTGAG  CGGGACTGGT  GA  1722

▼ KEYWORD

ID
Family
Complete proteome
DNA damage
DNA repair
DNA-directed DNA polymerase
Nucleotidyltransferase
Nucleus
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
5'-deoxyribose-5-phosphate lyase activity
Molecular Function
DNA binding
Molecular Function
DNA-directed DNA polymerase activity
Biological Process
Base-excision repair, gap-filling
Biological Process
Double-strand break repair via homologous recombination
Biological Process
Double-strand break repair via nonhomologous end joining
Biological Process
Nucleotide-excision repair

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-1595Macaca mulatta91.040.0 536
LLPS-Fec-2526Felis catus89.390.0 982
LLPS-Ere-1001Erinaceus europaeus88.770.0 709
LLPS-Sus-2984Sus scrofa88.520.0 981
LLPS-Aim-2533Ailuropoda melanoleuca88.520.0 979
LLPS-Urm-3860Ursus maritimus88.150.0 969
LLPS-Gog-4164Gorilla gorilla88.00.0 955
LLPS-Loa-1193Loxodonta africana88.00.0 982
LLPS-Pap-0708Pan paniscus87.830.0 954
LLPS-Pat-4196Pan troglodytes87.830.0 955
LLPS-Hos-4327Homo sapiens87.830.0 954
LLPS-Eqc-1271Equus caballus87.830.0 962
LLPS-Nol-1796Nomascus leucogenys87.830.0 961
LLPS-Caj-4435Callithrix jacchus87.650.0 954
LLPS-Rhb-4213Rhinopithecus bieti87.480.0 951
LLPS-Chs-1031Chlorocebus sabaeus87.130.0 949
LLPS-Maf-1476Macaca fascicularis87.130.0 951
LLPS-Ict-3555Ictidomys tridecemlineatus87.130.0 971
LLPS-Mup-2538Mustela putorius furo86.980.0 953
LLPS-Paa-3073Papio anubis86.960.0 949
LLPS-Man-3273Macaca nemestrina86.960.0 949
LLPS-Cea-4127Cercocebus atys86.780.0 947
LLPS-Mal-1276Mandrillus leucophaeus86.780.0 947
LLPS-Bot-1113Bos taurus86.610.0 957
LLPS-Ova-3833Ovis aries86.260.0 953
LLPS-Poa-4178Pongo abelii86.260.0 943
LLPS-Aon-1121Aotus nancymaae86.090.0 935
LLPS-Caf-4579Canis familiaris85.590.0 949
LLPS-Orc-2783Oryctolagus cuniculus85.220.0 952
LLPS-Otg-1462Otolemur garnettii84.470.0 948
LLPS-Dio-2444Dipodomys ordii83.480.0 922
LLPS-Mea-2630Mesocricetus auratus83.070.0 910
LLPS-Ran-4395Rattus norvegicus81.180.0 895
LLPS-Mum-3850Mus musculus80.840.0 888
LLPS-Fud-3295Fukomys damarensis80.70.0 902
LLPS-Cap-4393Cavia porcellus80.450.0 902
LLPS-Sah-2291Sarcophilus harrisii74.00.0 838
LLPS-Mod-4162Monodelphis domestica70.430.0 677
LLPS-Ora-3404Ornithorhynchus anatinus67.680.0 587
LLPS-Meg-3030Meleagris gallopavo66.210.0 763
LLPS-Gaga-0030Gallus gallus66.210.0 753
LLPS-Pes-3111Pelodiscus sinensis66.040.0 719
LLPS-Fia-2928Ficedula albicollis65.080.0 739
LLPS-Anp-2999Anas platyrhynchos65.060.0 745
LLPS-Anc-3652Anolis carolinensis62.890.0 714
LLPS-Lac-1550Latimeria chalumnae62.610.0 709
LLPS-Leo-2334Lepisosteus oculatus61.710.0 704
LLPS-Tag-0201Taeniopygia guttata61.490.0 536
LLPS-Xet-3796Xenopus tropicalis60.480.0 716
LLPS-Orl-2284Oryzias latipes59.450.0 655
LLPS-Ten-2239Tetraodon nigroviridis58.520.0 642
LLPS-Tar-1603Takifugu rubripes58.280.0 653
LLPS-Orn-3048Oreochromis niloticus58.080.0 663
LLPS-Scm-2480Scophthalmus maximus58.050.0 647
LLPS-Dar-2755Danio rerio57.890.0 637
LLPS-Pof-2436Poecilia formosa57.440.0 634
LLPS-Scf-0578Scleropages formosus57.090.0 636
LLPS-Xim-3453Xiphophorus maculatus56.90.0 629
LLPS-Asm-1436Astyanax mexicanus56.70.0 601
LLPS-Icp-4089Ictalurus punctatus56.480.0 606
LLPS-Gaa-2769Gasterosteus aculeatus55.610.0 638
LLPS-Ast-1316Aspergillus terreus41.02e-72 249
LLPS-Yal-0989Yarrowia lipolytica40.247e-70 244
LLPS-Aso-0365Aspergillus oryzae39.772e-71 248
LLPS-Asf-0738Aspergillus flavus39.774e-72 249
LLPS-Asn-1181Aspergillus nidulans39.267e-76 259
LLPS-Asfu-0375Aspergillus fumigatus38.952e-66 235
LLPS-Fuv-1312Fusarium verticillioides38.821e-67 231
LLPS-Asc-1615Aspergillus clavatus38.784e-68 239
LLPS-Gor-2190Gossypium raimondii38.62e-68 236
LLPS-Pot-1817Populus trichocarpa38.373e-67 234
LLPS-Fus-1353Fusarium solani38.351e-66 238
LLPS-Asni-1388Aspergillus niger38.225e-71 248
LLPS-Fuo-1443Fusarium oxysporum38.122e-63 228
LLPS-Met-1779Medicago truncatula38.071e-66 232
LLPS-Mua-1392Musa acuminata37.992e-65 229
LLPS-Sem-1033Selaginella moellendorffii37.917e-64 219
LLPS-Pyt-1107Pyrenophora teres37.189e-63 226
LLPS-Pytr-0062Pyrenophora triticirepentis37.188e-63 224
LLPS-Coo-0120Colletotrichum orbiculare37.095e-62 224
LLPS-Phn-0154Phaeosphaeria nodorum37.072e-61 222
LLPS-Lem-1403Leptosphaeria maculans36.652e-60 219
LLPS-Cogr-1408Colletotrichum graminicola36.129e-60 218
LLPS-Tum-1576Tuber melanosporum36.055e-54 201
LLPS-Nef-0861Neosartorya fischeri36.053e-54 200
LLPS-Nec-0115Neurospora crassa36.033e-59 216
LLPS-Cog-0371Colletotrichum gloeosporioides35.968e-64 229
LLPS-Dos-1523Dothistroma septosporum35.912e-53 199
LLPS-Cii-0841Ciona intestinalis35.792e-57 201
LLPS-Crn-0471Cryptococcus neoformans35.789e-51 192
LLPS-Ved-1454Verticillium dahliae35.736e-56 206
LLPS-Gag-1131Gaeumannomyces graminis35.653e-57 211
LLPS-Abg-1778Absidia glauca35.574e-60 214
LLPS-Prp-0496Prunus persica35.54e-69 238
LLPS-Trv-1059Trichoderma virens35.362e-60 217
LLPS-Zyt-1019Zymoseptoria tritici35.282e-60 216
LLPS-Cas-1074Carlito syrichta34.133e-50 182
LLPS-Mao-1344Magnaporthe oryzae34.03e-53 199
LLPS-Trr-0509Trichoderma reesei33.687e-59 214
LLPS-Beb-1473Beauveria bassiana31.895e-49 186
LLPS-Map-1267Magnaporthe poae31.363e-42 166
LLPS-Sac-0332Saccharomyces cerevisiae31.251e-1481.3
LLPS-Nia-0389Nicotiana attenuata30.04e-67 233
LLPS-Spr-1429Sporisorium reilianum29.962e-22 105
LLPS-Kop-0147Komagataella pastoris29.634e-37 149
LLPS-Dac-0347Daucus carota28.883e-65 228
LLPS-Scc-1285Schizosaccharomyces cryophilus28.772e-33 137
LLPS-Miv-1469Microbotryum violaceum28.273e-23 108
LLPS-Usm-1274Ustilago maydis27.343e-2099.0
LLPS-Scp-1632Schizosaccharomyces pombe27.186e-34 139
LLPS-Asg-1415Ashbya gossypii26.962e-25 114
LLPS-Cis-1804Ciona savignyi26.756e-33 135
LLPS-Chc-0704Chondrus crispus25.833e-1479.7