LLPS-Maf-1476
POLL
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA polymerase |
| Gene Name: | POLL, EGM_18298 |
| Ensembl Gene: | ENSMFAG00000043080.1 |
| Ensembl Protein: | ENSMFAP00000022783.1 |
| Organism: | Macaca fascicularis |
| Taxa ID: | 9541 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMFAT00000030915.1 | ENSMFAP00000022783.1 |
| Ensembl | ENSMFAT00000030934.1 | ENSMFAP00000022802.1 |
| Ensembl | ENSMFAT00000030925.1 | ENSMFAP00000022793.1 |
| UniProt | E5FGI8, E5FGI8_MACFA | |
| GeneBank | HM486795, AQIA01072333, CM001284 | , EHH64963.1, ADQ01132.1 |
| RefSeq | XM_015455868.1, XM_015455869.1, XM_015455870.1, XM_015455871.1 | XP_015311354.1, XP_015311355.1, XP_015311356.1, XP_015311357.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDPRGILKAF PKRKKIHADA SSKVLAKIPR KEEGEEAEEW LSSLRAHVVR TGIGRARAEL 60 61 FEKQIVQHGG QLCPVQGPGV THIVVDEGMD YERALRLLRL PRLPPGAQLV KSAWLSLCLQ 120 121 ERRLVDVAGF SIFIPSRYLD QSQPSKAEQD ASLPPGTHEA LLQTALPPPP SPTRPVSPPQ 180 181 KTKEAPNTQA QPISDDEASD GEETQVSAAD LEALISGHYP ASLEGDCDPS PAPVVLDKWV 240 241 CAQPSSQKAT NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC 300 301 SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ MWYQQGFRSL 360 361 EDIRSQASLT TQQAIGLKHY NDFLERMPRE EATEIEQTVQ KAAQAFNSGL LCVACGSYRR 420 421 GKATCGDVDV LITHPDGRSH RGIFSRLLDS LRQQGFLTDD LVSQEENGQQ QKYLGVCRLP 480 481 GPGWRHRRLD IIVVPYSEFA CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT 540 541 HGCKMGPGRV LPTPTEKDVF RLLGLPYREP AERDW 575 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATCCCA GGGGTATCTT GAAGGCGTTT CCCAAACGGA AGAAAATTCA TGCTGATGCA 60 61 TCATCAAAAG TACTTGCAAA GATTCCCAGG AAGGAAGAGG GAGAAGAAGC AGAAGAGTGG 120 121 CTGAGCTCCC TTCGGGCCCA TGTTGTGCGC ACTGGCATTG GACGAGCCCG GGCAGAACTC 180 181 TTTGAGAAGC AGATTGTTCA GCATGGTGGC CAGTTATGCC CTGTCCAGGG CCCAGGTGTC 240 241 ACTCACATTG TGGTGGATGA AGGCATGGAC TATGAGCGAG CCCTCCGCCT TCTCAGACTA 300 301 CCCCGGCTGC CCCCGGGTGC TCAGCTGGTG AAGTCAGCCT GGCTGAGCTT GTGCCTTCAG 360 361 GAGAGGAGGC TGGTGGATGT AGCTGGATTC AGCATCTTCA TCCCCAGTAG GTACTTGGAC 420 421 CAGTCACAGC CCAGCAAGGC AGAGCAGGAT GCTTCTCTTC CTCCTGGCAC CCATGAGGCC 480 481 CTGCTTCAGA CAGCGCTTCC TCCTCCTCCT TCTCCCACCA GGCCTGTGTC TCCTCCCCAA 540 541 AAGACAAAAG AGGCACCAAA CACCCAAGCC CAGCCCATCT CTGATGATGA AGCCAGCGAT 600 601 GGGGAAGAAA CCCAGGTTAG CGCAGCTGAT CTGGAAGCCC TCATCAGTGG CCACTACCCC 660 661 GCCTCCCTTG AGGGAGATTG TGATCCTAGC CCAGCCCCTG TGGTCCTGGA TAAGTGGGTC 720 721 TGTGCACAGC CCTCAAGCCA GAAGGCGACC AACCACAACC TCCATATCAC AGAGAAACTG 780 781 GAAGTTCTGG CCAAAGCCTA CAGTGTTCAG GGAGACAAGT GGAGGGCCCT GGGCTATGCC 840 841 AAGGCCATCA ATGCTCTCAA GAGCTTCCAT AAGCCTGTCA CCTCGTACCA GGAGGCCTGC 900 901 AGTATCCCTG GGATTGGGAA GCGGATGGCT GAGAAAATCA TAGAGATCCT GGAGAGCGGG 960 961 CATCTGCGAA AGCTGGACCA TATCAGTGAG AGTGTGCCTG TCTTGGAGCT CTTCTCCAAC 1020 1021 ATCTGGGGAG CTGGGACCAA GACTGCCCAG ATGTGGTACC AACAGGGCTT CCGAAGTCTG 1080 1081 GAAGACATCC GCAGCCAGGC CTCCCTGACA ACCCAGCAGG CCATTGGCCT GAAGCATTAC 1140 1141 AATGACTTCC TGGAACGCAT GCCCAGGGAG GAGGCTACAG AGATTGAGCA GACAGTCCAG 1200 1201 AAAGCAGCCC AGGCCTTTAA CTCCGGGCTG CTATGTGTGG CATGTGGTTC ATACCGACGG 1260 1261 GGAAAGGCAA CCTGTGGTGA TGTCGACGTG CTCATCACTC ACCCAGATGG CCGGTCCCAC 1320 1321 CGGGGTATCT TCAGCCGCCT CCTTGACAGC CTTCGGCAGC AAGGGTTCCT CACAGATGAC 1380 1381 TTGGTGAGCC AAGAGGAGAA TGGTCAGCAA CAGAAGTACT TGGGGGTGTG CCGGCTCCCA 1440 1441 GGGCCAGGGT GGCGACACCG GCGCCTGGAC ATCATCGTGG TGCCCTACAG CGAGTTTGCC 1500 1501 TGTGCCCTGC TCTACTTTAC CGGCTCTGCA CACTTCAACC GCTCCATGCG AGCCCTGGCC 1560 1561 AAGACCAAGG GCATGAGTCT GTCAGAACAT GCCCTCAGCA CTGCTGTGGT CCGGAACACC 1620 1621 CATGGCTGCA AGATGGGGCC TGGCCGAGTG CTGCCCACTC CCACTGAGAA GGATGTCTTC 1680 1681 AGGCTCTTAG GCCTCCCCTA CCGAGAACCT GCTGAGCGGG ACTGGTGA 1728 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | 5'-deoxyribose-5-phosphate lyase activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Biological Process | Base-excision repair, gap-filling | |
Biological Process | Double-strand break repair via homologous recombination | |
Biological Process | Double-strand break repair via nonhomologous end joining | |
Biological Process | Nucleotide-excision repair |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-3273 | Macaca nemestrina | 99.83 | 0.0 | 1112 |
| LLPS-Paa-3073 | Papio anubis | 99.83 | 0.0 | 1111 |
| LLPS-Mal-1276 | Mandrillus leucophaeus | 99.65 | 0.0 | 1109 |
| LLPS-Mam-1595 | Macaca mulatta | 99.64 | 0.0 | 585 |
| LLPS-Cea-4127 | Cercocebus atys | 99.48 | 0.0 | 1107 |
| LLPS-Rhb-4213 | Rhinopithecus bieti | 98.78 | 0.0 | 1103 |
| LLPS-Chs-1031 | Chlorocebus sabaeus | 98.78 | 0.0 | 1102 |
| LLPS-Gog-4164 | Gorilla gorilla | 97.39 | 0.0 | 1086 |
| LLPS-Hos-4327 | Homo sapiens | 97.04 | 0.0 | 1082 |
| LLPS-Pap-0708 | Pan paniscus | 96.87 | 0.0 | 1081 |
| LLPS-Nol-1796 | Nomascus leucogenys | 96.52 | 0.0 | 1078 |
| LLPS-Pat-4196 | Pan troglodytes | 96.52 | 0.0 | 1077 |
| LLPS-Poa-4178 | Pongo abelii | 95.48 | 0.0 | 1076 |
| LLPS-Caj-4435 | Callithrix jacchus | 93.57 | 0.0 | 1048 |
| LLPS-Aon-1121 | Aotus nancymaae | 93.04 | 0.0 | 1032 |
| LLPS-Eqc-1271 | Equus caballus | 87.65 | 0.0 | 979 |
| LLPS-Loa-1193 | Loxodonta africana | 87.48 | 0.0 | 983 |
| LLPS-Aim-2533 | Ailuropoda melanoleuca | 87.3 | 0.0 | 971 |
| LLPS-Ere-1001 | Erinaceus europaeus | 87.21 | 0.0 | 700 |
| LLPS-Fec-2526 | Felis catus | 87.13 | 0.0 | 970 |
| LLPS-Myl-2241 | Myotis lucifugus | 87.13 | 0.0 | 957 |
| LLPS-Sus-2984 | Sus scrofa | 86.61 | 0.0 | 963 |
| LLPS-Urm-3860 | Ursus maritimus | 86.59 | 0.0 | 960 |
| LLPS-Ict-3555 | Ictidomys tridecemlineatus | 86.26 | 0.0 | 962 |
| LLPS-Mup-2538 | Mustela putorius furo | 85.59 | 0.0 | 953 |
| LLPS-Orc-2783 | Oryctolagus cuniculus | 85.57 | 0.0 | 971 |
| LLPS-Dio-2444 | Dipodomys ordii | 85.57 | 0.0 | 948 |
| LLPS-Otg-1462 | Otolemur garnettii | 85.39 | 0.0 | 965 |
| LLPS-Caf-4579 | Canis familiaris | 85.24 | 0.0 | 952 |
| LLPS-Bot-1113 | Bos taurus | 83.83 | 0.0 | 931 |
| LLPS-Ova-3833 | Ovis aries | 83.13 | 0.0 | 921 |
| LLPS-Cap-4393 | Cavia porcellus | 81.83 | 0.0 | 915 |
| LLPS-Mea-2630 | Mesocricetus auratus | 81.22 | 0.0 | 899 |
| LLPS-Ran-4395 | Rattus norvegicus | 81.04 | 0.0 | 899 |
| LLPS-Mum-3850 | Mus musculus | 81.04 | 0.0 | 899 |
| LLPS-Fud-3295 | Fukomys damarensis | 80.7 | 0.0 | 909 |
| LLPS-Sah-2291 | Sarcophilus harrisii | 73.57 | 0.0 | 831 |
| LLPS-Mod-4162 | Monodelphis domestica | 68.02 | 0.0 | 657 |
| LLPS-Pes-3111 | Pelodiscus sinensis | 66.67 | 0.0 | 721 |
| LLPS-Gaga-0030 | Gallus gallus | 66.61 | 0.0 | 749 |
| LLPS-Ora-3404 | Ornithorhynchus anatinus | 66.17 | 0.0 | 566 |
| LLPS-Meg-3030 | Meleagris gallopavo | 65.98 | 0.0 | 759 |
| LLPS-Anp-2999 | Anas platyrhynchos | 65.75 | 0.0 | 754 |
| LLPS-Fia-2928 | Ficedula albicollis | 65.58 | 0.0 | 732 |
| LLPS-Anc-3652 | Anolis carolinensis | 63.56 | 0.0 | 722 |
| LLPS-Tag-0201 | Taeniopygia guttata | 63.24 | 0.0 | 551 |
| LLPS-Leo-2334 | Lepisosteus oculatus | 61.6 | 0.0 | 696 |
| LLPS-Lac-1550 | Latimeria chalumnae | 61.03 | 0.0 | 695 |
| LLPS-Xet-3796 | Xenopus tropicalis | 60.31 | 0.0 | 701 |
| LLPS-Orn-3048 | Oreochromis niloticus | 59.15 | 0.0 | 658 |
| LLPS-Tar-1603 | Takifugu rubripes | 58.25 | 0.0 | 648 |
| LLPS-Ten-2239 | Tetraodon nigroviridis | 58.22 | 0.0 | 639 |
| LLPS-Scm-2480 | Scophthalmus maximus | 58.05 | 0.0 | 646 |
| LLPS-Orl-2284 | Oryzias latipes | 58.03 | 0.0 | 639 |
| LLPS-Pof-2436 | Poecilia formosa | 57.34 | 0.0 | 622 |
| LLPS-Scf-0578 | Scleropages formosus | 57.17 | 0.0 | 636 |
| LLPS-Dar-2755 | Danio rerio | 57.14 | 0.0 | 629 |
| LLPS-Asm-1436 | Astyanax mexicanus | 56.95 | 0.0 | 617 |
| LLPS-Xim-3453 | Xiphophorus maculatus | 56.51 | 0.0 | 625 |
| LLPS-Gaa-2769 | Gasterosteus aculeatus | 56.33 | 0.0 | 627 |
| LLPS-Icp-4089 | Ictalurus punctatus | 55.46 | 0.0 | 603 |
| LLPS-Asn-1181 | Aspergillus nidulans | 41.62 | 1e-73 | 253 |
| LLPS-Yal-0989 | Yarrowia lipolytica | 40.73 | 2e-71 | 249 |
| LLPS-Ast-1316 | Aspergillus terreus | 40.71 | 3e-72 | 249 |
| LLPS-Asf-0738 | Aspergillus flavus | 39.53 | 1e-71 | 247 |
| LLPS-Aso-0365 | Aspergillus oryzae | 39.53 | 8e-71 | 247 |
| LLPS-Asni-1388 | Aspergillus niger | 39.14 | 1e-70 | 246 |
| LLPS-Pot-1817 | Populus trichocarpa | 38.97 | 8e-67 | 232 |
| LLPS-Fus-1353 | Fusarium solani | 38.89 | 2e-67 | 239 |
| LLPS-Asfu-0375 | Aspergillus fumigatus | 38.84 | 5e-66 | 234 |
| LLPS-Prp-0496 | Prunus persica | 38.67 | 9e-68 | 234 |
| LLPS-Gor-2190 | Gossypium raimondii | 38.36 | 1e-68 | 237 |
| LLPS-Sem-1033 | Selaginella moellendorffii | 37.91 | 3e-63 | 217 |
| LLPS-Lem-1403 | Leptosphaeria maculans | 37.68 | 7e-61 | 221 |
| LLPS-Met-1779 | Medicago truncatula | 37.58 | 3e-66 | 231 |
| LLPS-Nia-0389 | Nicotiana attenuata | 37.43 | 1e-66 | 232 |
| LLPS-Mua-1392 | Musa acuminata | 37.39 | 6e-64 | 224 |
| LLPS-Phn-0154 | Phaeosphaeria nodorum | 37.36 | 4e-61 | 221 |
| LLPS-Trv-1059 | Trichoderma virens | 37.11 | 5e-66 | 232 |
| LLPS-Cog-0371 | Colletotrichum gloeosporioides | 36.83 | 9e-64 | 229 |
| LLPS-Dac-0347 | Daucus carota | 36.78 | 2e-64 | 226 |
| LLPS-Fuv-1312 | Fusarium verticillioides | 36.72 | 9e-67 | 229 |
| LLPS-Pyt-1107 | Pyrenophora teres | 36.68 | 2e-62 | 225 |
| LLPS-Zyt-1019 | Zymoseptoria tritici | 36.63 | 1e-61 | 219 |
| LLPS-Tum-1576 | Tuber melanosporum | 36.44 | 7e-58 | 212 |
| LLPS-Dos-1523 | Dothistroma septosporum | 36.42 | 1e-54 | 203 |
| LLPS-Fuo-1443 | Fusarium oxysporum | 36.06 | 9e-63 | 226 |
| LLPS-Cii-0841 | Ciona intestinalis | 35.45 | 1e-56 | 199 |
| LLPS-Coo-0120 | Colletotrichum orbiculare | 35.41 | 2e-61 | 222 |
| LLPS-Abg-1778 | Absidia glauca | 35.28 | 4e-60 | 214 |
| LLPS-Ved-1454 | Verticillium dahliae | 35.16 | 2e-55 | 205 |
| LLPS-Cogr-1408 | Colletotrichum graminicola | 35.13 | 2e-59 | 217 |
| LLPS-Nec-0115 | Neurospora crassa | 35.11 | 7e-60 | 218 |
| LLPS-Pytr-0062 | Pyrenophora triticirepentis | 34.83 | 3e-62 | 223 |
| LLPS-Gag-1131 | Gaeumannomyces graminis | 34.51 | 1e-56 | 209 |
| LLPS-Mao-1344 | Magnaporthe oryzae | 34.0 | 3e-54 | 202 |
| LLPS-Trr-0509 | Trichoderma reesei | 33.94 | 7e-62 | 223 |
| LLPS-Nef-0861 | Neosartorya fischeri | 33.92 | 6e-54 | 199 |
| LLPS-Cas-1074 | Carlito syrichta | 33.72 | 5e-50 | 181 |
| LLPS-Asc-0095 | Aspergillus clavatus | 33.67 | 5e-21 | 101 |
| LLPS-Crn-0471 | Cryptococcus neoformans | 33.5 | 2e-51 | 194 |
| LLPS-Map-1267 | Magnaporthe poae | 31.95 | 6e-41 | 162 |
| LLPS-Kop-0147 | Komagataella pastoris | 30.46 | 5e-38 | 151 |
| LLPS-Beb-1473 | Beauveria bassiana | 29.64 | 1e-47 | 182 |
| LLPS-Asg-1415 | Ashbya gossypii | 29.35 | 3e-16 | 85.9 |
| LLPS-Scc-1285 | Schizosaccharomyces cryophilus | 28.57 | 2e-34 | 140 |
| LLPS-Cis-1804 | Ciona savignyi | 28.43 | 2e-36 | 146 |
| LLPS-Miv-1469 | Microbotryum violaceum | 28.37 | 2e-24 | 112 |
| LLPS-Usm-1274 | Ustilago maydis | 28.12 | 2e-22 | 105 |
| LLPS-Scp-1632 | Schizosaccharomyces pombe | 27.72 | 6e-35 | 141 |
| LLPS-Sac-0332 | Saccharomyces cerevisiae | 27.56 | 4e-15 | 82.4 |
| LLPS-Spr-1429 | Sporisorium reilianum | 26.03 | 1e-22 | 106 |
| LLPS-Chc-0704 | Chondrus crispus | 25.98 | 7e-16 | 84.7 |