• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Myl-0637
POLR3B

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA-directed RNA polymerase subunit beta
Gene Name: POLR3B
Ensembl Gene: ENSMLUG00000016235.2
Ensembl Protein: ENSMLUP00000014810.2
Organism: Myotis lucifugus
Taxa ID: 59463
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDVLAEEFGN  LTPEQLAAPI  PTVEEKWRLL  PAFLKVKGLV  KQHIDSFNYF  INVEIKKIMK  60
61    ANEKVTSDAD  PMWYLKYLNI  YVGLPDVEES  FNVTRPVSPH  ECRLRDMTYS  APITVDIEYT  120
121   RGSQRIIRNA  LPIGRMPIML  RSSNCVLTGK  TPAEFAKLNE  CPLDPGGYFI  VKGVEKVILI  180
181   QEQLSKNRII  VEADRKGTVG  ASVTSSTHEK  KSRTNMAVKQ  GRFYLRHNTL  SEDIPIVIIF  240
241   KAMGVECDQE  IVQMIGTEEH  VMAAFGPSLE  ECQKAQIFTQ  MQALKYIGNK  VRRQRMWGGG  300
301   PKKTKIEEAR  ELLASTILTH  VPVKEFNFRA  KCIYTAVMVR  RVILAQGDNK  VDDRDYYGNK  360
361   RLELAGQLLS  LLFEDLFKKF  NSEMKKIADQ  VIPKQRAAQF  DVVKHMRQDQ  ITNGMVNAIS  420
421   TGNWSLKRFK  MDRQGVTQVL  SRLSYISALG  MMTRISSQFE  KTRKVSGPRS  LQPSQWGMLC  480
481   PSDTPEGEAC  GLVKNLALMT  HITTDMEDGP  IVRLASNLGV  EDVNLLCGEE  LSYPNVFLVF  540
541   LNGNILGVIR  DHKKLVNTFR  LMRRAGYINE  FVSISTNLTD  RCVYISSDGG  RLCRPYIIVK  600
601   KQKPAVTNKH  MEELAQGYRN  FEDFLHESLV  EYLDVNEEND  CNIALYEHTI  NKDTTHLEIE  660
661   PFTLLGVCAG  LIPYPHHNQS  PRNTYQCAMG  KQAMGTIGYN  QRNRIDTLMY  LLAYPQKPMV  720
721   KTKTIELIEF  EKLPAGQNAT  VAVMSYSGYD  IEDALVLNKA  SLDRGFGRCL  VYKNAKCTLK  780
781   RYTNQTFDKV  MGPILDAATR  KPIWRHEILD  ADGICSPGEK  VENKQVLVNK  SMPTVTQIPL  840
841   EGSNVPQQPQ  YKDVPITYKG  ATDSYIEKVM  ISSNAEDAFL  IKMLLRQTRR  PEIGDKFSSR  900
901   HGQKGVCGLI  VPQEDMPFCD  SGICPDIIMP  HGFPSRMTVG  KLIELLAGKA  GVLDGRFHYG  960
961   TAFGGSKVKD  VCEDLVRHGY  NYLGKDYVTS  GITGEPLEAY  IYFGPVYYQK  LKHMVLDKMH  1020
1021  ARARDHGCPY  QRQPTEGRSR  DGGLRLGEME  RDCLIGYGAS  MLLLERLMIS  SDAFEVDVCG  1080
1081  QCGLLGYSGW  CHYCKSSCHV  SSLRIPYACK  LLFQELQSMN  IIPRLKLAKY  NE  1132
Nucleotide CDS Sequence (FASTA)
1     ATGGACGTGC  TTGCGGAAGA  ATTTGGAAAC  CTGACCCCGG  AGCAGCTAGC  TGCGCCAATA  60
61    CCGACTGTAG  AGGAAAAATG  GAGGCTGCTT  CCAGCATTTT  TAAAGGTGAA  AGGCCTTGTA  120
121   AAACAGCATA  TAGATTCATT  CAACTATTTT  ATTAATGTAG  AGATAAAGAA  GATCATGAAA  180
181   GCCAATGAAA  AGGTTACAAG  TGATGCTGAC  CCCATGTGGT  ACCTAAAATA  TCTTAATATC  240
241   TATGTTGGGC  TTCCTGATGT  TGAAGAAAGC  TTCAATGTAA  CCAGACCAGT  GTCCCCTCAT  300
301   GAGTGCCGCC  TGCGGGACAT  GACATACTCT  GCCCCCATTA  CAGTGGATAT  TGAATATACC  360
361   CGGGGCAGCC  AGAGGATCAT  CCGCAATGCT  TTACCCATTG  GCAGAATGCC  CATAATGCTT  420
421   CGTAGTTCAA  ACTGTGTTCT  TACAGGGAAA  ACGCCAGCAG  AATTTGCCAA  ACTGAATGAA  480
481   TGCCCTTTAG  ATCCAGGTGG  CTACTTCATT  GTTAAAGGAG  TGGAGAAAGT  TATTCTTATC  540
541   CAAGAGCAGC  TGTCTAAGAA  CAGGATTATT  GTGGAGGCTG  ACAGAAAAGG  GACAGTTGGT  600
601   GCGTCAGTTA  CCAGCTCTAC  CCATGAGAAA  AAAAGCAGAA  CCAATATGGC  TGTGAAACAA  660
661   GGACGATTTT  ATTTGAGGCA  TAATACTTTA  TCAGAAGATA  TACCGATTGT  AATTATATTT  720
721   AAGGCCATGG  GTGTTGAGTG  TGACCAAGAA  ATTGTGCAGA  TGATTGGAAC  AGAGGAGCAC  780
781   GTGATGGCAG  CCTTTGGGCC  CAGTTTGGAA  GAATGCCAGA  AAGCTCAGAT  TTTCACACAG  840
841   ATGCAGGCAT  TAAAATATAT  AGGGAACAAA  GTAAGAAGGC  AAAGGATGTG  GGGAGGTGGA  900
901   CCAAAGAAAA  CCAAAATAGA  AGAAGCAAGA  GAGCTCCTCG  CTTCTACCAT  CTTGACCCAT  960
961   GTACCAGTTA  AAGAATTCAA  TTTCCGAGCC  AAATGTATCT  ATACTGCAGT  GATGGTAAGA  1020
1021  AGGGTAATTC  TGGCCCAAGG  AGATAATAAA  GTTGATGACA  GAGACTATTA  TGGTAACAAG  1080
1081  CGATTGGAGT  TGGCAGGACA  GCTTTTATCT  CTTCTTTTTG  AAGATTTGTT  CAAAAAATTT  1140
1141  AATTCTGAAA  TGAAGAAGAT  TGCAGACCAG  GTGATTCCTA  AGCAAAGAGC  AGCCCAGTTT  1200
1201  GATGTAGTCA  AACACATGCG  TCAAGACCAG  ATTACCAATG  GCATGGTGAA  TGCCATTTCT  1260
1261  ACTGGAAATT  GGTCTCTAAA  GAGATTTAAA  ATGGACCGTC  AAGGTGTGAC  TCAAGTGTTG  1320
1321  TCTCGCTTGT  CATATATATC  CGCACTGGGC  ATGATGACAA  GAATCTCTTC  CCAGTTTGAA  1380
1381  AAAACAAGAA  AAGTGAGTGG  TCCTCGATCG  CTCCAACCAT  CTCAGTGGGG  AATGCTCTGT  1440
1441  CCTTCAGACA  CTCCTGAAGG  AGAGGCATGT  GGTTTGGTAA  AAAACTTGGC  CCTTATGACG  1500
1501  CACATCACGA  CTGACATGGA  AGATGGACCC  ATTGTTAGAT  TAGCCAGTAA  CCTGGGAGTA  1560
1561  GAAGATGTGA  ATTTATTATG  TGGAGAAGAG  CTCTCTTACC  CAAATGTGTT  TCTCGTCTTC  1620
1621  CTCAATGGTA  ACATCCTGGG  TGTCATTCGA  GACCATAAGA  AGCTAGTGAA  TACGTTTCGA  1680
1681  CTGATGCGAA  GAGCAGGATA  CATCAATGAA  TTTGTCTCCA  TCTCAACAAA  TCTTACAGAT  1740
1741  CGATGTGTCT  ATATTTCTTC  TGATGGAGGA  AGGTTGTGCA  GACCCTACAT  AATAGTTAAG  1800
1801  AAACAAAAGC  CTGCAGTCAC  GAATAAGCAT  ATGGAAGAGC  TGGCTCAGGG  GTACAGAAAT  1860
1861  TTTGAAGATT  TCTTACATGA  GAGTCTGGTG  GAATATCTAG  ATGTGAATGA  AGAAAATGAT  1920
1921  TGTAACATCG  CACTCTATGA  GCATACAATT  AATAAAGATA  CCACCCACTT  GGAGATTGAA  1980
1981  CCCTTTACTC  TTCTTGGAGT  TTGTGCGGGC  CTGATTCCAT  ACCCTCATCA  TAACCAGTCC  2040
2041  CCAAGAAACA  CATATCAGTG  TGCCATGGGA  AAACAAGCTA  TGGGTACCAT  TGGATATAAC  2100
2101  CAGCGGAACA  GAATTGATAC  TCTCATGTAT  CTACTAGCAT  ACCCACAAAA  ACCTATGGTT  2160
2161  AAAACGAAAA  CCATTGAGTT  GATAGAATTT  GAGAAACTGC  CGGCTGGACA  GAATGCGACA  2220
2221  GTTGCTGTGA  TGAGTTATAG  TGGCTATGAT  ATTGAAGATG  CTCTTGTTTT  AAACAAGGCC  2280
2281  TCCCTGGACA  GAGGTTTTGG  GCGTTGCCTT  GTATATAAAA  ATGCTAAGTG  TACATTGAAA  2340
2341  CGATATACCA  ATCAGACTTT  TGATAAAGTG  ATGGGGCCGA  TATTGGATGC  TGCCACAAGG  2400
2401  AAACCCATCT  GGCGACATGA  AATTTTAGAT  GCAGATGGTA  TTTGTTCTCC  AGGTGAGAAA  2460
2461  GTAGAAAACA  AACAAGTGCT  CGTAAATAAA  TCCATGCCCA  CGGTAACTCA  GATCCCCTTG  2520
2521  GAAGGAAGCA  ATGTGCCACA  GCAACCACAG  TACAAAGATG  TGCCCATCAC  CTACAAAGGG  2580
2581  GCAACAGATT  CATACATTGA  AAAAGTGATG  ATATCTTCAA  ATGCTGAAGA  TGCTTTCCTA  2640
2641  ATCAAAATGC  TGCTGAGACA  GACAAGGCGT  CCAGAAATTG  GAGACAAATT  CAGCAGTCGT  2700
2701  CATGGGCAAA  AAGGTGTCTG  CGGTTTGATC  GTCCCTCAGG  AAGACATGCC  GTTTTGTGAC  2760
2761  TCTGGCATCT  GTCCGGACAT  CATCATGCCT  CACGGCTTCC  CATCACGAAT  GACGGTGGGA  2820
2821  AAGTTAATTG  AGCTGTTGGC  GGGCAAGGCA  GGCGTGTTAG  ATGGCAGATT  CCACTACGGC  2880
2881  ACCGCCTTTG  GAGGCAGTAA  AGTGAAGGAT  GTGTGTGAAG  ACCTCGTTCG  CCATGGTTAT  2940
2941  AACTACTTGG  GGAAAGACTA  TGTTACATCT  GGCATCACAG  GGGAGCCTTT  GGAAGCATAC  3000
3001  ATTTACTTCG  GCCCCGTGTA  CTACCAGAAG  CTGAAACACA  TGGTGCTGGA  TAAGATGCAT  3060
3061  GCCCGTGCCC  GGGACCACGG  CTGTCCTTAC  CAGAGGCAGC  CCACTGAAGG  TCGATCTCGT  3120
3121  GATGGTGGTT  TGCGTCTTGG  AGAAATGGAA  CGTGACTGTT  TAATTGGTTA  TGGAGCCAGT  3180
3181  ATGCTTTTAC  TAGAGCGACT  AATGATTTCA  AGTGATGCCT  TTGAGGTTGA  TGTCTGTGGG  3240
3241  CAGTGTGGAC  TTCTGGGGTA  TTCCGGCTGG  TGCCATTACT  GCAAGTCGTC  CTGTCACGTG  3300
3301  TCTTCCCTTC  GTATTCCGTA  TGCCTGCAAG  CTGCTCTTCC  AGGAACTGCA  GTCTATGAAC  3360
3361  ATTATCCCCA  GGTTAAAACT  GGCCAAATAC  AATGAGTGA  3399

▼ KEYWORD

ID
Family
Complete proteome
DNA-directed RNA polymerase
Nucleotidyltransferase
Reference proteome
Transcription
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
RNA polymerase III complex
Molecular Function
DNA binding
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Molecular Function
Ribonucleoside binding
Biological Process
Positive regulation of innate immune response
Biological Process
Positive regulation of interferon-beta production
Biological Process
Transcription, DNA-templated

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Chs-4177Chlorocebus sabaeus99.480.01989
LLPS-Sus-4181Sus scrofa98.940.02333
LLPS-Mal-0308Mandrillus leucophaeus98.850.02328
LLPS-Aim-3692Ailuropoda melanoleuca98.850.02328
LLPS-Gog-1091Gorilla gorilla98.850.02328
LLPS-Maf-0626Macaca fascicularis98.850.02328
LLPS-Mam-3334Macaca mulatta98.850.02328
LLPS-Poa-1582Pongo abelii98.850.02328
LLPS-Caf-0747Canis familiaris98.850.02330
LLPS-Eqc-3698Equus caballus98.850.02330
LLPS-Pat-3630Pan troglodytes98.850.02328
LLPS-Urm-2340Ursus maritimus98.850.02328
LLPS-Pap-2015Pan paniscus98.850.02328
LLPS-Hos-0249Homo sapiens98.850.02328
LLPS-Paa-2512Papio anubis98.760.02329
LLPS-Bot-0962Bos taurus98.760.02329
LLPS-Ict-1920Ictidomys tridecemlineatus98.760.02327
LLPS-Nol-2852Nomascus leucogenys98.760.02327
LLPS-Otg-4418Otolemur garnettii98.760.02328
LLPS-Mup-0936Mustela putorius furo98.680.02326
LLPS-Dio-0309Dipodomys ordii98.680.02327
LLPS-Cas-0116Carlito syrichta98.680.02325
LLPS-Fec-1925Felis catus98.680.02327
LLPS-Ova-2218Ovis aries98.50.02320
LLPS-Orc-2515Oryctolagus cuniculus98.50.02326
LLPS-Ran-3571Rattus norvegicus98.410.02321
LLPS-Caj-3886Callithrix jacchus98.410.02319
LLPS-Mum-3936Mus musculus98.410.02320
LLPS-Mod-2313Monodelphis domestica98.320.02320
LLPS-Sah-0969Sarcophilus harrisii98.230.02316
LLPS-Ora-1553Ornithorhynchus anatinus98.20.02273
LLPS-Mea-1795Mesocricetus auratus98.150.02318
LLPS-Fud-0805Fukomys damarensis98.060.02314
LLPS-Aon-1092Aotus nancymaae97.860.02268
LLPS-Cea-3260Cercocebus atys97.560.02318
LLPS-Man-3572Macaca nemestrina97.560.02318
LLPS-Pes-0211Pelodiscus sinensis97.210.02180
LLPS-Tag-0905Taeniopygia guttata96.630.02269
LLPS-Fia-0179Ficedula albicollis96.540.02267
LLPS-Loa-2616Loxodonta africana96.310.02267
LLPS-Gaga-0792Gallus gallus96.20.02277
LLPS-Anc-2111Anolis carolinensis95.50.02261
LLPS-Lac-1984Latimeria chalumnae94.00.02236
LLPS-Cap-3404Cavia porcellus93.470.02177
LLPS-Dar-0765Danio rerio93.460.02216
LLPS-Leo-2449Lepisosteus oculatus93.20.02218
LLPS-Scf-1818Scleropages formosus93.030.02206
LLPS-Orn-2781Oreochromis niloticus92.840.02010
LLPS-Icp-1146Ictalurus punctatus92.760.02207
LLPS-Scm-3600Scophthalmus maximus92.230.02192
LLPS-Asm-3288Astyanax mexicanus92.190.02191
LLPS-Pof-0752Poecilia formosa92.060.02196
LLPS-Anp-0507Anas platyrhynchos91.970.02098
LLPS-Tar-0153Takifugu rubripes91.880.02189
LLPS-Gaa-3718Gasterosteus aculeatus91.790.02186
LLPS-Orl-2631Oryzias latipes91.220.02171
LLPS-Xet-3380Xenopus tropicalis91.190.02160
LLPS-Ten-0716Tetraodon nigroviridis90.880.02108
LLPS-Xim-2898Xiphophorus maculatus89.910.02184
LLPS-Cis-0785Ciona savignyi69.720.01667
LLPS-Drm-0564Drosophila melanogaster68.310.01615
LLPS-Vir-0899Vigna radiata65.22e-76 277
LLPS-Abg-1201Absidia glauca64.590.01491
LLPS-Scj-0109Schizosaccharomyces japonicus63.940.01471
LLPS-Scc-0115Schizosaccharomyces cryophilus63.410.01473
LLPS-Scp-0623Schizosaccharomyces pombe63.240.01464
LLPS-Cae-0102Caenorhabditis elegans63.190.01493
LLPS-Asg-0661Ashbya gossypii62.840.01415
LLPS-Usm-0121Ustilago maydis62.590.01459
LLPS-Sac-1204Saccharomyces cerevisiae62.180.01403
LLPS-Spr-1537Sporisorium reilianum61.980.01444
LLPS-Osl-0010Ostreococcus lucimarinus61.70.01466
LLPS-Php-1074Physcomitrella patens61.660.01475
LLPS-Mel-1176Melampsora laricipopulina61.630.01429
LLPS-Pug-0855Puccinia graminis61.620.01427
LLPS-Yal-0912Yarrowia lipolytica61.350.01407
LLPS-Blg-0170Blumeria graminis61.260.01402
LLPS-Kop-1077Komagataella pastoris61.210.01384
LLPS-Miv-0555Microbotryum violaceum60.770.01422
LLPS-Put-0759Puccinia triticina60.630.01336
LLPS-Gas-0685Galdieria sulphuraria60.30.01379
LLPS-Crn-0738Cryptococcus neoformans60.120.01366
LLPS-Asfu-0035Aspergillus fumigatus59.740.01356
LLPS-Nef-1131Neosartorya fischeri59.650.01356
LLPS-Asc-1129Aspergillus clavatus59.370.01349
LLPS-Lem-0862Leptosphaeria maculans59.340.01324
LLPS-Pyt-0739Pyrenophora teres59.340.01326
LLPS-Scs-0796Sclerotinia sclerotiorum59.270.01358
LLPS-Phn-0836Phaeosphaeria nodorum59.130.01311
LLPS-Asf-0581Aspergillus flavus58.930.01347
LLPS-Aso-1376Aspergillus oryzae58.930.01346
LLPS-Chc-1010Chondrus crispus58.810.01350
LLPS-Asni-0605Aspergillus niger58.760.01355
LLPS-Asn-0417Aspergillus nidulans58.650.01343
LLPS-Sem-1658Selaginella moellendorffii58.280.01397
LLPS-Ast-0573Aspergillus terreus58.280.01328
LLPS-Nia-1480Nicotiana attenuata57.710.01325
LLPS-Zyt-0610Zymoseptoria tritici57.620.01256
LLPS-Mua-0980Musa acuminata57.440.01309
LLPS-Thc-0720Theobroma cacao57.340.01320
LLPS-Trv-1326Trichoderma virens57.30.01299
LLPS-Gag-0379Gaeumannomyces graminis57.240.01297
LLPS-Sei-0390Setaria italica57.210.01309
LLPS-Brd-0656Brachypodium distachyon57.160.01296
LLPS-Map-0804Magnaporthe poae57.160.01296
LLPS-Prp-0183Prunus persica57.130.01301
LLPS-Dos-0899Dothistroma septosporum57.080.01273
LLPS-Gor-1982Gossypium raimondii57.020.01309
LLPS-Sot-0751Solanum tuberosum56.940.01314
LLPS-Chr-0057Chlamydomonas reinhardtii56.890.01337
LLPS-Pot-1647Populus trichocarpa56.890.01330
LLPS-Cogr-0012Colletotrichum graminicola56.860.01278
LLPS-Mao-0645Magnaporthe oryzae56.770.01291
LLPS-Hov-0846Hordeum vulgare56.720.01298
LLPS-Cog-1000Colletotrichum gloeosporioides56.720.01274
LLPS-Pytr-0450Pyrenophora triticirepentis56.660.01239
LLPS-Trr-0876Trichoderma reesei56.650.01287
LLPS-Beb-0611Beauveria bassiana56.650.01277
LLPS-Tra-0966Triticum aestivum56.630.01295
LLPS-Hea-0624Helianthus annuus56.590.01297
LLPS-Coo-0556Colletotrichum orbiculare56.590.01274
LLPS-Sol-0079Solanum lycopersicum56.590.01308
LLPS-Mae-1658Manihot esculenta56.550.01306
LLPS-Via-0115Vigna angularis56.540.01065
LLPS-Sob-0486Sorghum bicolor56.520.01289
LLPS-Fuo-0932Fusarium oxysporum56.480.01281
LLPS-Nec-0600Neurospora crassa56.380.01274
LLPS-Ved-1430Verticillium dahliae56.30.01278
LLPS-Glm-0004Glycine max56.210.01292
LLPS-Phv-0636Phaseolus vulgaris56.210.01288
LLPS-Arl-0357Arabidopsis lyrata56.040.01292
LLPS-Met-0804Medicago truncatula55.960.01278
LLPS-Org-1376Oryza glaberrima55.960.01290
LLPS-Ors-1045Oryza sativa55.960.01290
LLPS-Fus-1211Fusarium solani55.870.01274
LLPS-Orbr-1627Oryza brachyantha55.610.01288
LLPS-Bro-1950Brassica oleracea55.590.01275
LLPS-Art-2750Arabidopsis thaliana55.560.01277
LLPS-Dac-1904Daucus carota55.410.01263
LLPS-Fuv-1081Fusarium verticillioides55.190.01218
LLPS-Brn-1449Brassica napus54.550.01258
LLPS-Viv-0312Vitis vinifera54.230.0 794
LLPS-Brr-1362Brassica rapa53.260.01219
LLPS-Lep-1850Leersia perrieri52.590.01167
LLPS-Orni-2111Oryza nivara51.490.01137
LLPS-Orb-1815Oryza barthii51.490.01139
LLPS-Orr-0301Oryza rufipogon51.490.01137
LLPS-Tru-0348Triticum urartu51.470.01165
LLPS-Orp-0749Oryza punctata50.950.01128
LLPS-Ori-1597Oryza indica48.990.01052
LLPS-Cym-0063Cyanidioschyzon merolae45.810.01104
LLPS-Cii-1947Ciona intestinalis38.350.0 780
LLPS-Cus-0573Cucumis sativus38.290.0 752
LLPS-Tut-0112Tursiops truncatus37.980.0 762
LLPS-Rhb-0164Rhinopithecus bieti37.60.0 753
LLPS-Amt-0160Amborella trichopoda37.130.0 750
LLPS-Zem-1908Zea mays36.860.0 744