• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-2313
POLR3B

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA-directed RNA polymerase subunit beta
Gene Name: POLR3B
Ensembl Gene: ENSMODG00000001884.3
Ensembl Protein: ENSMODP00000002305.1
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDVLAEEFGN  LTPEQVAAPI  PTVEEKWRLL  PAFLKVKGLV  KQHIDSFNYF  INVEIKKIMK  60
61    ANEKVTSDAD  PMWYLKYLNI  YVGLPDVEES  FNVTRPVSPH  ECRLRDMTYS  APITVDIEYT  120
121   RGSQRIIRNA  LPIGRMPIML  RSSNCVLTGK  TPAEFAKLNE  CPLDPGGYFI  VKGVEKVILI  180
181   QEQLSKNRII  VEADRKGTVG  ASVTSSTHEK  KSRTNIAVKQ  GRFYLRHNTL  SEDIPIVIIF  240
241   KAMGVESDQE  IVQMIGTEEH  VMAAFGPSLE  ECQKAQIFTQ  MQALKYIGNK  VRRQRMWGGG  300
301   PKKTKMEEAR  ELLASTILTH  VPVKEFNFRA  KCIYTAVMVR  RVILAQGDNK  VDDRDYYGNK  360
361   RLELAGQLLS  LLFEDLFKKF  NSEMKKIADQ  VIPKQRAAQF  DVVKHMRQDQ  ITNGMVNAIS  420
421   TGNWSLKRFK  MDRQGVTQVL  SRLSYISALG  MMTRISSQFE  KTRKVSGPRS  LQPSQWGMLC  480
481   PSDTPEGEAC  GLVKNLALMT  HITTDMEDGP  IVKLASNLGV  EDVNLLCGEE  LSYPNVFLVF  540
541   LNGNILGVIR  DHKKLVNTFR  LMRRAGYINE  FVSISTNLTD  RCVYISSDGG  RLCRPYIIVK  600
601   KQKPAVTEKH  MDELAQGYRN  FEDFLHESLV  EYLDVNEEND  CNIALYEHTI  NKDTTHLEIE  660
661   PFTLLGVCAG  LIPYPHHNQS  PRNTYQCAMG  KQAMGTIGYN  QRNRIDTLMY  LLAYPQKPMV  720
721   KTKTIELIEF  EKLPAGQNAT  VAVMSYSGYD  IEDALVLNKA  SLDRGFGRCL  VYKNAKCTLK  780
781   RYTNQTFDKV  MGPMLDAATR  KPIWRHEILD  ADGICSPGEK  VENKQVLVNK  SMPTVTQIPL  840
841   EGSSVPQQPQ  YKDVPITYKG  ATDSYIEKVM  ISSNAEDAFL  IKMLLRQTRR  PEIGDKFSSR  900
901   HGQKGVCGLI  VPQEDMPFCD  SGICPDIIMN  PHGFPSRMTV  GKLIELLAGK  AGVLDGKFHY  960
961   GTAFGGSKVK  DVCEDLVRHG  YNYLGKDYVT  SGITGEPLEA  YIYFGPVYYQ  KLKHMVLDKM  1020
1021  HARARGPRAV  LTRQPTEGRS  RDGGLRLGEM  ERDCLIGYGA  SMLLLERLMI  SSDAFEVDVC  1080
1081  GQCGLLGYSG  WCHYCKSSCH  VSSLRIPYAC  KLLFQELQSM  NIIPRLKLSK  YNE  1133
Nucleotide CDS Sequence (FASTA)
1     ATGGACGTGC  TAGCTGAGGA  GTTCGGCAAC  TTGACTCCGG  AGCAAGTGGC  CGCTCCCATT  60
61    CCCACAGTAG  AGGAAAAATG  GAGGCTGCTT  CCAGCATTTC  TAAAGGTGAA  AGGACTTGTG  120
121   AAGCAGCACA  TTGATTCCTT  CAACTATTTC  ATCAACGTAG  AGATAAAGAA  GATTATGAAA  180
181   GCCAACGAGA  AAGTCACAAG  TGATGCTGAC  CCCATGTGGT  ACCTAAAATA  TCTTAATATC  240
241   TATGTGGGCC  TCCCTGATGT  TGAAGAAAGC  TTTAATGTGA  CAAGGCCCGT  GTCTCCCCAT  300
301   GAGTGCCGTT  TGCGAGACAT  GACATACTCA  GCTCCCATTA  CAGTGGATAT  CGAGTATACC  360
361   CGGGGCAGCC  AGAGGATTAT  TCGGAATGCT  TTGCCCATCG  GCAGAATGCC  CATTATGCTT  420
421   CGTAGCTCAA  ACTGTGTCCT  TACAGGGAAG  ACTCCGGCTG  AGTTTGCCAA  ACTCAATGAA  480
481   TGCCCCTTAG  ATCCTGGTGG  TTACTTCATT  GTCAAAGGAG  TAGAGAAGGT  TATTCTCATT  540
541   CAAGAGCAGT  TATCAAAAAA  CAGAATCATT  GTGGAAGCTG  ACAGAAAAGG  GACTGTTGGA  600
601   GCCTCGGTTA  CCAGTTCAAC  TCATGAGAAG  AAAAGTAGAA  CCAACATTGC  TGTGAAGCAG  660
661   GGGCGATTTT  ACCTGAGGCA  CAACACTTTG  TCAGAAGACA  TTCCCATCGT  GATCATCTTT  720
721   AAGGCCATGG  GTGTTGAGAG  TGACCAAGAA  ATCGTGCAGA  TGATTGGCAC  TGAGGAGCAC  780
781   GTGATGGCCG  CATTTGGGCC  CAGTTTGGAA  GAGTGCCAGA  AAGCTCAGAT  TTTCACACAG  840
841   ATGCAGGCCT  TGAAATATAT  AGGAAACAAA  GTAAGAAGAC  AAAGGATGTG  GGGAGGTGGA  900
901   CCAAAGAAAA  CAAAGATGGA  AGAGGCAAGA  GAACTGTTGG  CTTCAACCAT  TCTCACCCAT  960
961   GTTCCAGTAA  AGGAATTCAA  TTTCCGTGCA  AAGTGTATCT  ACACTGCAGT  GATGGTACGC  1020
1021  AGGGTGATTT  TGGCCCAAGG  AGATAATAAA  GTTGATGACC  GAGACTACTA  TGGAAACAAG  1080
1081  CGTTTGGAAT  TGGCAGGACA  ACTTCTGTCC  CTTCTCTTTG  AAGACTTGTT  CAAAAAATTT  1140
1141  AATTCTGAAA  TGAAGAAGAT  TGCTGACCAA  GTGATTCCAA  AGCAGAGGGC  TGCCCAGTTT  1200
1201  GATGTGGTAA  AGCATATGCG  CCAGGATCAG  ATCACCAATG  GCATGGTCAA  TGCCATCTCC  1260
1261  ACGGGAAATT  GGTCCCTAAA  GAGATTCAAG  ATGGACCGTC  AGGGAGTGAC  CCAGGTGCTC  1320
1321  TCTCGCCTCT  CCTATATATC  TGCTCTGGGC  ATGATGACAA  GAATCTCATC  ACAGTTTGAG  1380
1381  AAGACCAGGA  AAGTGAGCGG  TCCTCGGTCC  CTCCAGCCAT  CTCAGTGGGG  AATGCTCTGT  1440
1441  CCCTCTGACA  CTCCTGAAGG  GGAGGCTTGT  GGTCTGGTTA  AAAACCTGGC  TCTGATGACA  1500
1501  CATATTACAA  CTGACATGGA  AGATGGGCCC  ATTGTTAAAC  TGGCCAGTAA  CCTGGGAGTA  1560
1561  GAGGACGTTA  ACCTCCTCTG  TGGAGAAGAG  CTATCTTACC  CAAATGTGTT  CCTTGTCTTC  1620
1621  CTCAATGGCA  ACATTCTGGG  TGTCATTCGA  GATCATAAGA  AACTAGTGAA  TACATTTCGA  1680
1681  CTTATGCGCC  GAGCTGGTTA  CATCAATGAA  TTTGTCTCAA  TCTCAACAAA  CCTCACTGAT  1740
1741  AGATGCGTCT  ACATTTCATC  TGATGGGGGA  AGGTTGTGCA  GGCCATACAT  AATTGTGAAG  1800
1801  AAGCAAAAGC  CTGCTGTTAC  AGAAAAGCAC  ATGGATGAGC  TGGCCCAGGG  ATATAGAAAT  1860
1861  TTTGAAGATT  TTCTACATGA  GAGCCTGGTT  GAGTATTTGG  ATGTGAATGA  AGAAAATGAT  1920
1921  TGTAACATTG  CATTGTATGA  ACATACAATT  AACAAAGATA  CCACCCACTT  GGAGATTGAA  1980
1981  CCTTTCACAC  TTCTTGGTGT  ATGTGCTGGA  CTTATTCCAT  ACCCTCACCA  TAATCAATCC  2040
2041  CCCAGGAATA  CTTACCAGTG  TGCTATGGGG  AAACAAGCCA  TGGGTACCAT  TGGATACAAT  2100
2101  CAACGGAACA  GAATTGATAC  TCTCATGTAC  TTGCTGGCTT  ACCCACAGAA  ACCGATGGTT  2160
2161  AAAACAAAAA  CCATTGAGCT  GATAGAATTT  GAGAAACTCC  CAGCTGGGCA  GAATGCTACG  2220
2221  GTTGCTGTGA  TGAGCTACAG  TGGCTATGAT  ATTGAAGATG  CTTTAGTCCT  GAACAAAGCC  2280
2281  TCCTTGGACA  GAGGCTTTGG  GCGATGCCTT  GTGTATAAAA  ATGCTAAATG  TACTTTGAAG  2340
2341  CGGTATACCA  ACCAAACCTT  CGATAAAGTG  ATGGGGCCAA  TGTTGGATGC  AGCGACCAGG  2400
2401  AAGCCCATCT  GGCGTCATGA  GATCTTGGAT  GCTGATGGCA  TATGTTCTCC  AGGTGAGAAA  2460
2461  GTTGAGAACA  AACAAGTGCT  CGTGAACAAG  TCCATGCCCA  CAGTCACTCA  GATCCCCTTG  2520
2521  GAGGGGAGCA  GTGTGCCTCA  GCAGCCCCAG  TACAAAGATG  TCCCAATCAC  CTACAAAGGT  2580
2581  GCTACAGATT  CCTATATTGA  AAAAGTAATG  ATATCCTCAA  ATGCAGAGGA  TGCCTTTCTC  2640
2641  ATCAAAATGC  TCTTAAGACA  GACTAGACGT  CCAGAAATTG  GAGACAAATT  CAGTAGTCGC  2700
2701  CATGGGCAAA  AAGGTGTTTG  TGGGTTGATC  GTCCCTCAAG  AAGACATGCC  ATTTTGTGAT  2760
2761  TCTGGAATCT  GCCCTGACAT  CATCATGAAC  CCTCATGGTT  TCCCATCACG  TATGACGGTG  2820
2821  GGAAAACTGA  TTGAATTGTT  GGCCGGGAAG  GCTGGGGTGC  TTGATGGCAA  ATTTCACTAT  2880
2881  GGGACAGCTT  TCGGAGGCAG  CAAAGTTAAG  GATGTGTGTG  AAGATCTTGT  TCGTCATGGC  2940
2941  TATAACTACT  TAGGAAAAGA  TTACGTCACA  TCTGGCATCA  CTGGGGAACC  TCTGGAAGCC  3000
3001  TATATTTACT  TTGGACCTGT  CTACTATCAG  AAACTGAAGC  ATATGGTACT  AGATAAGATG  3060
3061  CATGCCAGAG  CACGGGGTCC  ACGCGCCGTA  CTTACCAGAC  AACCCACAGA  GGGGCGATCC  3120
3121  CGTGATGGTG  GTTTGCGTCT  TGGAGAAATG  GAACGTGACT  GCCTGATCGG  TTATGGAGCC  3180
3181  AGCATGCTTT  TGCTAGAGAG  ATTAATGATT  TCAAGTGATG  CCTTTGAGGT  AGATGTCTGT  3240
3241  GGGCAGTGTG  GACTTCTGGG  ATATTCTGGC  TGGTGCCATT  ACTGTAAATC  TTCATGTCAT  3300
3301  GTGTCTTCCT  TGCGAATTCC  GTATGCCTGC  AAACTGCTCT  TCCAAGAGCT  ACAGTCGATG  3360
3361  AACATCATCC  CCCGGCTAAA  ACTGTCCAAG  TACAATGAGT  GA  3402

▼ KEYWORD

ID
Family
Complete proteome
DNA-directed RNA polymerase
Nucleotidyltransferase
Reference proteome
Transcription
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
RNA polymerase III complex
Molecular Function
DNA binding
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Molecular Function
Ribonucleoside binding
Biological Process
Positive regulation of innate immune response
Biological Process
Positive regulation of interferon-beta production
Biological Process
Transcription by RNA polymerase III

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sah-0969Sarcophilus harrisii99.650.02355
LLPS-Maf-0626Macaca fascicularis99.290.02352
LLPS-Sus-4181Sus scrofa99.290.02353
LLPS-Gog-1091Gorilla gorilla99.290.02352
LLPS-Aim-3692Ailuropoda melanoleuca99.290.02352
LLPS-Mal-0308Mandrillus leucophaeus99.290.02352
LLPS-Hos-0249Homo sapiens99.290.02352
LLPS-Pat-3630Pan troglodytes99.290.02352
LLPS-Pap-2015Pan paniscus99.290.02352
LLPS-Urm-2340Ursus maritimus99.290.02352
LLPS-Eqc-3698Equus caballus99.290.02353
LLPS-Poa-1582Pongo abelii99.290.02352
LLPS-Caf-0747Canis familiaris99.290.02353
LLPS-Mam-3334Macaca mulatta99.290.02352
LLPS-Chs-4177Chlorocebus sabaeus99.270.01992
LLPS-Bot-0962Bos taurus99.210.02351
LLPS-Paa-2512Papio anubis99.210.02350
LLPS-Otg-4418Otolemur garnettii99.210.02350
LLPS-Nol-2852Nomascus leucogenys99.210.02349
LLPS-Ict-1920Ictidomys tridecemlineatus99.210.02350
LLPS-Ora-1553Ornithorhynchus anatinus99.190.02303
LLPS-Dio-0309Dipodomys ordii99.120.02348
LLPS-Mup-0936Mustela putorius furo99.120.02350
LLPS-Fec-1925Felis catus99.120.02348
LLPS-Cas-0116Carlito syrichta99.120.02345
LLPS-Ova-2218Ovis aries98.940.02341
LLPS-Orc-2515Oryctolagus cuniculus98.940.02348
LLPS-Caj-3886Callithrix jacchus98.850.02341
LLPS-Mum-3936Mus musculus98.680.02342
LLPS-Ran-3571Rattus norvegicus98.680.02342
LLPS-Mea-1795Mesocricetus auratus98.590.02341
LLPS-Fud-0805Fukomys damarensis98.50.02336
LLPS-Myl-0637Myotis lucifugus98.320.02320
LLPS-Aon-1092Aotus nancymaae98.30.02291
LLPS-Cea-3260Cercocebus atys98.00.02343
LLPS-Man-3572Macaca nemestrina98.00.02343
LLPS-Pes-0211Pelodiscus sinensis97.770.02203
LLPS-Fia-0179Ficedula albicollis97.420.02298
LLPS-Tag-0905Taeniopygia guttata97.340.02297
LLPS-Loa-2616Loxodonta africana97.190.02297
LLPS-Gaga-0792Gallus gallus96.910.02303
LLPS-Anc-2111Anolis carolinensis96.650.02297
LLPS-Lac-1984Latimeria chalumnae94.620.02263
LLPS-Cap-3404Cavia porcellus94.00.02201
LLPS-Dar-0765Danio rerio93.990.02244
LLPS-Leo-2449Lepisosteus oculatus93.910.02246
LLPS-Scf-1818Scleropages formosus93.910.02237
LLPS-Orn-2781Oreochromis niloticus93.90.02041
LLPS-Icp-1146Ictalurus punctatus93.290.02232
LLPS-Scm-3600Scophthalmus maximus92.940.02221
LLPS-Asm-3288Astyanax mexicanus92.890.02219
LLPS-Anp-0507Anas platyrhynchos92.790.02131
LLPS-Pof-0752Poecilia formosa92.760.02226
LLPS-Tar-0153Takifugu rubripes92.590.02216
LLPS-Gaa-3718Gasterosteus aculeatus92.50.02212
LLPS-Orl-2631Oryzias latipes92.190.02206
LLPS-Xet-3380Xenopus tropicalis91.720.02182
LLPS-Ten-0716Tetraodon nigroviridis91.680.02138
LLPS-Xim-2898Xiphophorus maculatus90.60.02212
LLPS-Cis-0785Ciona savignyi70.50.01697
LLPS-Drm-0564Drosophila melanogaster69.380.01649
LLPS-Vir-0899Vigna radiata66.671e-80 290
LLPS-Abg-1201Absidia glauca65.360.01519
LLPS-Scj-0109Schizosaccharomyces japonicus64.480.01496
LLPS-Scc-0115Schizosaccharomyces cryophilus64.150.01501
LLPS-Scp-0623Schizosaccharomyces pombe64.030.01493
LLPS-Cae-0102Caenorhabditis elegans63.810.01518
LLPS-Asg-0661Ashbya gossypii63.560.01445
LLPS-Usm-0121Ustilago maydis63.110.01483
LLPS-Sac-1204Saccharomyces cerevisiae62.890.01432
LLPS-Spr-1537Sporisorium reilianum62.50.01469
LLPS-Osl-0010Ostreococcus lucimarinus62.390.01494
LLPS-Mel-1176Melampsora laricipopulina62.340.01456
LLPS-Php-1074Physcomitrella patens62.270.01501
LLPS-Pug-0855Puccinia graminis62.240.01453
LLPS-Kop-1077Komagataella pastoris62.150.01414
LLPS-Blg-0170Blumeria graminis62.150.01429
LLPS-Yal-0912Yarrowia lipolytica62.040.01436
LLPS-Miv-0555Microbotryum violaceum61.740.01454
LLPS-Put-0759Puccinia triticina61.270.01362
LLPS-Crn-0738Cryptococcus neoformans60.920.01392
LLPS-Gas-0685Galdieria sulphuraria60.750.01404
LLPS-Pyt-0739Pyrenophora teres60.320.01355
LLPS-Phn-0836Phaeosphaeria nodorum60.30.01341
LLPS-Nef-1131Neosartorya fischeri60.260.01382
LLPS-Asfu-0035Aspergillus fumigatus60.180.01379
LLPS-Scs-0796Sclerotinia sclerotiorum60.050.01383
LLPS-Asc-1129Aspergillus clavatus59.810.01372
LLPS-Lem-0862Leptosphaeria maculans59.790.01350
LLPS-Aso-1376Aspergillus oryzae59.540.01370
LLPS-Asf-0581Aspergillus flavus59.540.01371
LLPS-Chc-1010Chondrus crispus59.390.01374
LLPS-Asni-0605Aspergillus niger59.370.01379
LLPS-Asn-0417Aspergillus nidulans59.270.01366
LLPS-Sem-1658Selaginella moellendorffii59.170.01425
LLPS-Ast-0573Aspergillus terreus58.810.01353
LLPS-Zyt-0610Zymoseptoria tritici58.50.01285
LLPS-Mua-0980Musa acuminata58.050.01335
LLPS-Thc-0720Theobroma cacao57.960.01347
LLPS-Nia-1480Nicotiana attenuata57.960.01350
LLPS-Trv-1326Trichoderma virens57.860.01322
LLPS-Brd-0656Brachypodium distachyon57.770.01325
LLPS-Prp-0183Prunus persica57.750.01325
LLPS-Sei-0390Setaria italica57.730.01337
LLPS-Pytr-0450Pyrenophora triticirepentis57.720.01269
LLPS-Dos-0899Dothistroma septosporum57.690.01301
LLPS-Gag-0379Gaeumannomyces graminis57.590.01320
LLPS-Gor-1982Gossypium raimondii57.540.01335
LLPS-Map-0804Magnaporthe poae57.50.01320
LLPS-Sot-0751Solanum tuberosum57.380.01340
LLPS-Pot-1647Populus trichocarpa57.360.01357
LLPS-Cogr-0012Colletotrichum graminicola57.290.01302
LLPS-Hov-0846Hordeum vulgare57.240.01325
LLPS-Chr-0057Chlamydomonas reinhardtii57.230.01360
LLPS-Mao-0645Magnaporthe oryzae57.210.01318
LLPS-Trr-0876Trichoderma reesei57.20.01310
LLPS-Nec-0600Neurospora crassa57.170.01305
LLPS-Tra-0966Triticum aestivum57.160.01322
LLPS-Hea-0624Helianthus annuus57.120.01322
LLPS-Beb-0611Beauveria bassiana57.080.01299
LLPS-Mae-1658Manihot esculenta57.080.01332
LLPS-Cog-1000Colletotrichum gloeosporioides57.070.01295
LLPS-Sob-0486Sorghum bicolor57.040.01316
LLPS-Sol-0079Solanum lycopersicum57.030.01335
LLPS-Coo-0556Colletotrichum orbiculare57.030.01295
LLPS-Via-0115Vigna angularis57.030.01088
LLPS-Fuo-0932Fusarium oxysporum56.920.01305
LLPS-Ved-1430Verticillium dahliae56.680.01300
LLPS-Ors-1045Oryza sativa56.670.01320
LLPS-Org-1376Oryza glaberrima56.670.01320
LLPS-Arl-0357Arabidopsis lyrata56.570.01315
LLPS-Phv-0636Phaseolus vulgaris56.560.01311
LLPS-Glm-0004Glycine max56.480.01315
LLPS-Fus-1211Fusarium solani56.430.01299
LLPS-Met-0804Medicago truncatula56.40.01301
LLPS-Orbr-1627Oryza brachyantha56.320.01316
LLPS-Bro-1950Brassica oleracea56.190.01299
LLPS-Art-2750Arabidopsis thaliana56.080.01303
LLPS-Dac-1904Daucus carota56.050.01287
LLPS-Fuv-1081Fusarium verticillioides55.620.01243
LLPS-Brn-1449Brassica napus55.120.01281
LLPS-Viv-0312Vitis vinifera54.650.0 799
LLPS-Brr-1362Brassica rapa53.840.01242
LLPS-Lep-1850Leersia perrieri53.160.01197
LLPS-Orb-1815Oryza barthii52.110.01166
LLPS-Orni-2111Oryza nivara52.110.01164
LLPS-Orr-0301Oryza rufipogon52.110.01164
LLPS-Tru-0348Triticum urartu51.90.01190
LLPS-Orp-0749Oryza punctata51.560.01155
LLPS-Ori-1597Oryza indica49.690.01079
LLPS-Cym-0063Cyanidioschyzon merolae46.590.01131
LLPS-Cus-0573Cucumis sativus38.730.0 774
LLPS-Cii-1947Ciona intestinalis38.690.0 801
LLPS-Rhb-0164Rhinopithecus bieti38.280.0 778
LLPS-Tut-0112Tursiops truncatus38.270.0 783
LLPS-Amt-0160Amborella trichopoda37.550.0 771
LLPS-Zem-1908Zea mays37.20.0 765