• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Maf-0626
POLR3B

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA-directed RNA polymerase subunit beta
Gene Name: POLR3B, EGM_03706
Ensembl Gene: ENSMFAG00000038425.1
Ensembl Protein: ENSMFAP00000038193.1
Organism: Macaca fascicularis
Taxa ID: 9541
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDVLAEEFGN  LTPEQLAAPI  PTVEEKWRLL  PAFLKVKGLV  KQHIDSFNYF  INVEIKKIMK  60
61    ANEKVTSDAD  PMWYLKYLNI  YVGLPDVEES  FNVTRPVSPH  ECRLRDMTYS  APITVDIEYT  120
121   RGSQRIIRNA  LPIGRMPIML  RSSNCVLTGK  TPAEFAKLNE  CPLDPGGYFI  VKGVEKVILI  180
181   QEQLSKNRII  VEADRKGAVG  ASVTSSTHEK  KSRTNMAVKQ  GRFYLRHNTL  SEDIPIVIIF  240
241   KAMGVESDQE  IVQMIGTEEH  VMAAFGPSLE  ECQKAQIFTQ  MQALKYIGNK  VRRQRMWGGG  300
301   PKKTKIEEAR  ELLASTILTH  VPVKEFNFRA  KCIYTAVMVR  RVILAQGDNK  VDDRDYYGNK  360
361   RLELAGQLLS  LLFEDLFKKF  NSEMKKIADQ  VIPKQRAAQF  DVVKHMRQDQ  ITNGMVNAIS  420
421   TGNWSLKRFK  MDRQGVTQVL  SRLSYISALG  MMTRISSQFE  KTRKVSGPRS  LQPSQWGMLC  480
481   PSDTPEGEAC  GLVKNLALMT  HITTDMEDGP  IVKLASNLGV  EDVNLLCGEE  LSYPNVFLVF  540
541   LNGNILGVIR  DHKKLVNTFR  LMRRAGYINE  FVSISTNLTD  RCVYISSDGG  RLCRPYIIVK  600
601   KQKPAVTNKH  MEELAQGYRN  FEDFLHESLV  EYLDVNEEND  CNIALYEHTI  NKDTTHLEIE  660
661   PFTLLGVCAG  LIPYPHHNQS  PRNTYQCAMG  KQAMGTIGYN  QRNRIDTLMY  LLAYPQKPMV  720
721   KTKTIELIEF  EKLPAGQNAT  VAVMSYSGYD  IEDALVLNKA  SLDRGFGRCL  VYKNAKCTLK  780
781   RYTNQTFDKV  MGPMLDAATR  KPIWRHEILD  ADGICSPGEK  VENKQVLVNK  SMPTVTQIPL  840
841   EGSNVPQQPQ  YKDVPITYKG  ATDSYIEKVM  ISSNAEDAFL  IKMLLRQTRR  PEIGDKFSSR  900
901   HGQKGVCGLI  VPQEDMPFCD  SGICPDIIMN  PHGFPSRMTV  GKLIELLAGK  AGVLDGRFHY  960
961   GTAFGGSKVK  DVCEDLVRHG  YNYLGKDYVT  SGITGEPLEA  YIYFGPVYYQ  KLKHMVLDKM  1020
1021  HARARGPRAV  LTRQPTEGRS  RDGGLRLGEM  ERDCLIGYGA  SMLLLERLMI  SSDAFEVDVC  1080
1081  GQCGLLGYSG  WCHYCKSSCH  VSSLRIPYAC  KLLFQELQSM  NIIPRLKLSK  YNE  1133
Nucleotide CDS Sequence (FASTA)
1     ATGGACGTGC  TAGCGGAGGA  GTTTGGGAAC  CTGACTCCGG  AGCAGCTGGC  TGCGCCTATC  60
61    CCGACTGTAG  AGGAAAAATG  GAGGCTGCTT  CCAGCATTTT  TAAAGGTGAA  AGGCCTTGTG  120
121   AAACAGCATA  TAGATTCATT  TAACTATTTC  ATTAATGTAG  AGATAAAGAA  GATAATGAAA  180
181   GCCAATGAAA  AGGTTACAAG  TGATGCTGAC  CCTATGTGGT  ACTTAAAATA  TCTTAATATC  240
241   TACGTTGGGC  TTCCTGATGT  TGAAGAAAGC  TTCAATGTAA  CTAGACCAGT  GTCCCCTCAT  300
301   GAGTGCCGTT  TGAGAGACAT  GACATACTCT  GCCCCTATTA  CAGTGGATAT  TGAATATACC  360
361   CGAGGCAGCC  AGAGGATCAT  CCGCAATGCC  TTACCCATCG  GCAGAATGCC  CATAATGCTA  420
421   CGTAGTTCAA  ACTGTGTTCT  TACTGGAAAA  ACGCCAGCAG  AATTTGCCAA  ACTGAACGAA  480
481   TGTCCTTTAG  ATCCAGGTGG  CTACTTCATT  GTTAAAGGAG  TAGAAAAAGT  TATTCTTATC  540
541   CAAGAGCAGC  TGTCTAAGAA  CAGGATCATC  GTGGAGGCTG  ATAGAAAAGG  AGCCGTTGGA  600
601   GCTTCAGTTA  CCAGCTCTAC  CCATGAGAAA  AAAAGCAGAA  CCAATATGGC  TGTGAAACAA  660
661   GGACGATTTT  ATTTGAGGCA  TAATACTTTG  TCAGAAGATA  TACCCATTGT  CATCATATTT  720
721   AAGGCCATGG  GTGTTGAGAG  TGACCAGGAA  ATTGTGCAGA  TGATTGGAAC  AGAGGAGCAC  780
781   GTGATGGCTG  CATTTGGGCC  CAGTCTGGAA  GAGTGCCAGA  AAGCTCAGAT  TTTCACACAG  840
841   ATGCAGGCAT  TAAAATATAT  AGGGAACAAA  GTAAGAAGGC  AAAGGATGTG  GGGAGGTGGA  900
901   CCAAAGAAAA  CCAAAATAGA  AGAAGCAAGA  GAGCTCCTGG  CTTCCACCAT  TCTGACCCAT  960
961   GTCCCAGTTA  AGGAATTCAA  TTTCCGAGCC  AAATGTATCT  ATACTGCAGT  GATGGTGCGA  1020
1021  AGAGTAATTC  TGGCCCAAGG  AGATAATAAA  GTTGATGACA  GAGATTATTA  TGGGAACAAG  1080
1081  CGACTGGAAT  TGGCAGGACA  GCTTTTATCT  CTTCTTTTTG  AAGACTTGTT  CAAAAAATTT  1140
1141  AATTCTGAAA  TGAAAAAGAT  TGCCGACCAG  GTGATTCCTA  AGCAAAGAGC  AGCCCAGTTT  1200
1201  GATGTTGTCA  AACACATGCG  CCAAGACCAG  ATCACCAATG  GCATGGTGAA  CGCTATTTCT  1260
1261  ACCGGAAATT  GGTCTCTAAA  GAGATTTAAA  ATGGACCGCC  AGGGTGTAAC  ACAAGTGCTG  1320
1321  TCTCGCTTGT  CATATATATC  CGCACTGGGC  ATGATGACAA  GAATCTCTTC  CCAGTTTGAA  1380
1381  AAAACAAGAA  AAGTGAGTGG  TCCTCGCTCC  CTCCAGCCAT  CTCAGTGGGG  AATGCTTTGT  1440
1441  CCTTCGGACA  CTCCTGAAGG  AGAGGCATGT  GGTTTGGTTA  AAAACTTGGC  CCTTATGACA  1500
1501  CACATCACAA  CTGATATGGA  AGATGGACCC  ATTGTTAAAT  TAGCCAGTAA  CTTGGGAGTA  1560
1561  GAAGATGTGA  ATTTATTATG  TGGGGAAGAG  CTCTCTTACC  CAAATGTGTT  TCTTGTGTTT  1620
1621  CTTAATGGTA  ACATCTTGGG  TGTCATTCGC  GACCACAAAA  AGCTGGTGAA  TACATTTCGA  1680
1681  CTCATGAGAA  GAGCAGGATA  TATCAATGAA  TTTGTTTCCA  TCTCAACAAA  TCTTACAGAT  1740
1741  CGATGTGTCT  ATATTTCTTC  TGATGGAGGA  AGGCTATGCA  GACCCTACAT  AATTGTCAAG  1800
1801  AAACAGAAGC  CAGCAGTCAC  AAATAAACAT  ATGGAAGAGC  TGGCTCAAGG  GTACAGGAAT  1860
1861  TTTGAAGATT  TCTTACATGA  GAGTCTGGTT  GAATATTTAG  ATGTGAATGA  AGAAAATGAT  1920
1921  TGTAACATTG  CACTGTACGA  ACACACAATT  AATAAAGACA  CCACCCACTT  GGAGATTGAG  1980
1981  CCCTTCACTC  TTCTCGGCGT  GTGTGCTGGA  CTGATCCCAT  ACCCTCACCA  TAACCAGTCA  2040
2041  CCGAGAAACA  CTTACCAGTG  TGCCATGGGG  AAACAAGCCA  TGGGTACTAT  AGGATACAAC  2100
2101  CAGCGAAACA  GAATTGATAC  TCTCATGTAT  CTACTAGCAT  ATCCACAAAA  ACCCATGGTT  2160
2161  AAGACAAAAA  CCATTGAATT  GATAGAATTT  GAGAAACTGC  CAGCTGGACA  GAATGCAACA  2220
2221  GTTGCTGTGA  TGAGCTATAG  TGGCTATGAT  ATTGAAGATG  CCCTTGTTTT  AAACAAGGCC  2280
2281  TCTTTAGACA  GAGGCTTTGG  GCGTTGCCTT  GTATATAAAA  ATGCTAAATG  TACATTGAAA  2340
2341  CGATATACCA  ATCAGACTTT  TGATAAAGTA  ATGGGGCCCA  TGTTGGATGC  TGCTACAAGG  2400
2401  AAACCTATCT  GGCGACATGA  AATCTTAGAT  GCAGATGGTA  TTTGTTCTCC  AGGTGAGAAA  2460
2461  GTAGAAAACA  AACAAGTGCT  TGTAAATAAG  TCCATGCCCA  CGGTGACTCA  GATTCCTTTG  2520
2521  GAAGGAAGTA  ATGTACCACA  GCAACCACAG  TACAAAGATG  TACCCATAAC  CTATAAAGGA  2580
2581  GCCACAGATT  CATACATTGA  AAAAGTGATG  ATATCTTCAA  ATGCTGAAGA  TGCTTTTCTG  2640
2641  ATCAAAATGC  TGCTGAGACA  GACAAGGCGC  CCAGAAATTG  GAGACAAATT  CAGCAGTCGT  2700
2701  CATGGGCAAA  AAGGTGTTTG  TGGCTTGATT  GTCCCCCAGG  AAGACATGCC  ATTTTGTGAT  2760
2761  TCTGGCATCT  GTCCGGATAT  CATCATGAAC  CCACACGGCT  TCCCATCACG  AATGACGGTG  2820
2821  GGGAAGCTCA  TTGAGCTGCT  GGCTGGCAAG  GCCGGTGTGC  TGGACGGCAG  ATTCCACTAC  2880
2881  GGCACTGCGT  TTGGAGGCAG  TAAAGTGAAG  GATGTGTGTG  AGGACCTCGT  TCGCCACGGT  2940
2941  TATAACTACT  TGGGGAAAGA  CTATGTTACA  TCGGGCATCA  CAGGTGAGCC  CTTAGAAGCA  3000
3001  TACATATATT  TTGGCCCCGT  GTACTATCAG  AAGCTGAAAC  ACATGGTGCT  GGATAAAATG  3060
3061  CATGCCCGGG  CCCGGGGCCC  ACGAGCTGTC  CTTACCAGGC  AACCCACTGA  AGGACGGTCT  3120
3121  CGTGATGGTG  GCTTGCGTCT  TGGGGAAATG  GAACGTGACT  GTTTAATCGG  TTATGGAGCC  3180
3181  AGTATGCTTT  TGCTAGAGAG  ACTAATGATT  TCAAGTGATG  CCTTTGAGGT  TGATGTCTGT  3240
3241  GGGCAGTGTG  GACTTCTGGG  GTATTCTGGC  TGGTGCCATT  ACTGCAAGTC  ATCCTGCCAC  3300
3301  GTGTCTTCCC  TCCGTATTCC  ATATGCCTGC  AAGCTGCTCT  TCCAGGAGCT  ACAGTCTATG  3360
3361  AACATTATCC  CCAGGTTAAA  ACTGTCCAAG  TACAATGAAT  GA  3402

▼ KEYWORD

ID
Family
Complete proteome
DNA-directed RNA polymerase
Nucleotidyltransferase
Reference proteome
Transcription
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
RNA polymerase III complex
Molecular Function
DNA binding
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Molecular Function
Ribonucleoside binding
Biological Process
Positive regulation of innate immune response
Biological Process
Positive regulation of interferon-beta production
Biological Process
Transcription, DNA-templated

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-3630Pan troglodytes100.00.02364
LLPS-Urm-2340Ursus maritimus100.00.02364
LLPS-Pap-2015Pan paniscus100.00.02364
LLPS-Hos-0249Homo sapiens100.00.02364
LLPS-Mam-3334Macaca mulatta100.00.02364
LLPS-Poa-1582Pongo abelii100.00.02364
LLPS-Gog-1091Gorilla gorilla100.00.02364
LLPS-Chs-4177Chlorocebus sabaeus100.00.02004
LLPS-Aim-3692Ailuropoda melanoleuca100.00.02364
LLPS-Mal-0308Mandrillus leucophaeus100.00.02364
LLPS-Otg-4418Otolemur garnettii99.910.02362
LLPS-Ict-1920Ictidomys tridecemlineatus99.910.02363
LLPS-Nol-2852Nomascus leucogenys99.910.02361
LLPS-Paa-2512Papio anubis99.910.02362
LLPS-Fec-1925Felis catus99.820.02361
LLPS-Cas-0116Carlito syrichta99.820.02357
LLPS-Eqc-3698Equus caballus99.820.02360
LLPS-Caf-0747Canis familiaris99.820.02361
LLPS-Sus-4181Sus scrofa99.820.02360
LLPS-Mup-0936Mustela putorius furo99.820.02360
LLPS-Dio-0309Dipodomys ordii99.820.02359
LLPS-Bot-0962Bos taurus99.740.02360
LLPS-Ova-2218Ovis aries99.650.02354
LLPS-Caj-3886Callithrix jacchus99.560.02353
LLPS-Orc-2515Oryctolagus cuniculus99.470.02355
LLPS-Mum-3936Mus musculus99.380.02354
LLPS-Ran-3571Rattus norvegicus99.380.02354
LLPS-Ora-1553Ornithorhynchus anatinus99.370.02307
LLPS-Mod-2313Monodelphis domestica99.290.02352
LLPS-Mea-1795Mesocricetus auratus99.290.02353
LLPS-Sah-0969Sarcophilus harrisii99.20.02348
LLPS-Fud-0805Fukomys damarensis99.030.02345
LLPS-Aon-1092Aotus nancymaae99.020.02302
LLPS-Myl-0637Myotis lucifugus98.850.02328
LLPS-Man-3572Macaca nemestrina98.690.02353
LLPS-Cea-3260Cercocebus atys98.690.02353
LLPS-Pes-0211Pelodiscus sinensis98.050.02210
LLPS-Loa-2616Loxodonta africana97.450.02303
LLPS-Tag-0905Taeniopygia guttata97.420.02298
LLPS-Fia-0179Ficedula albicollis97.340.02297
LLPS-Gaga-0792Gallus gallus97.00.02306
LLPS-Anc-2111Anolis carolinensis96.470.02292
LLPS-Lac-1984Latimeria chalumnae94.970.02269
LLPS-Cap-3404Cavia porcellus94.620.02212
LLPS-Leo-2449Lepisosteus oculatus94.350.02254
LLPS-Dar-0765Danio rerio94.250.02247
LLPS-Scf-1818Scleropages formosus94.170.02243
LLPS-Orn-2781Oreochromis niloticus94.090.02045
LLPS-Icp-1146Ictalurus punctatus93.730.02239
LLPS-Scm-3600Scophthalmus maximus93.380.02228
LLPS-Asm-3288Astyanax mexicanus93.330.02227
LLPS-Pof-0752Poecilia formosa93.20.02232
LLPS-Tar-0153Takifugu rubripes93.030.02224
LLPS-Gaa-3718Gasterosteus aculeatus92.940.02220
LLPS-Anp-0507Anas platyrhynchos92.790.02130
LLPS-Orl-2631Oryzias latipes92.190.02202
LLPS-Ten-0716Tetraodon nigroviridis92.040.02144
LLPS-Xet-3380Xenopus tropicalis91.890.02185
LLPS-Xim-2898Xiphophorus maculatus91.030.02217
LLPS-Cis-0785Ciona savignyi70.420.01695
LLPS-Drm-0564Drosophila melanogaster69.110.01644
LLPS-Vir-0899Vigna radiata67.164e-81 292
LLPS-Abg-1201Absidia glauca65.270.01515
LLPS-Scj-0109Schizosaccharomyces japonicus64.650.01498
LLPS-Scc-0115Schizosaccharomyces cryophilus64.120.01501
LLPS-Scp-0623Schizosaccharomyces pombe64.120.01494
LLPS-Asg-0661Ashbya gossypii63.730.01447
LLPS-Cae-0102Caenorhabditis elegans63.720.01516
LLPS-Usm-0121Ustilago maydis63.110.01481
LLPS-Sac-1204Saccharomyces cerevisiae63.070.01433
LLPS-Spr-1537Sporisorium reilianum62.50.01467
LLPS-Mel-1176Melampsora laricipopulina62.340.01456
LLPS-Pug-0855Puccinia graminis62.330.01454
LLPS-Osl-0010Ostreococcus lucimarinus62.310.01492
LLPS-Php-1074Physcomitrella patens62.270.01502
LLPS-Kop-1077Komagataella pastoris62.240.01415
LLPS-Blg-0170Blumeria graminis62.060.01432
LLPS-Yal-0912Yarrowia lipolytica61.950.01434
LLPS-Miv-0555Microbotryum violaceum61.570.01452
LLPS-Put-0759Puccinia triticina61.360.01362
LLPS-Gas-0685Galdieria sulphuraria61.010.01407
LLPS-Crn-0738Cryptococcus neoformans60.830.01390
LLPS-Asfu-0035Aspergillus fumigatus60.350.01382
LLPS-Nef-1131Neosartorya fischeri60.260.01382
LLPS-Lem-0862Leptosphaeria maculans60.140.01351
LLPS-Pyt-0739Pyrenophora teres60.140.01355
LLPS-Phn-0836Phaeosphaeria nodorum60.120.01339
LLPS-Scs-0796Sclerotinia sclerotiorum60.050.01385
LLPS-Asc-1129Aspergillus clavatus59.980.01376
LLPS-Asf-0581Aspergillus flavus59.540.01373
LLPS-Aso-1376Aspergillus oryzae59.540.01373
LLPS-Chc-1010Chondrus crispus59.390.01375
LLPS-Asni-0605Aspergillus niger59.370.01382
LLPS-Asn-0417Aspergillus nidulans59.270.01367
LLPS-Ast-0573Aspergillus terreus58.90.01355
LLPS-Sem-1658Selaginella moellendorffii58.890.01423
LLPS-Zyt-0610Zymoseptoria tritici58.330.01283
LLPS-Mua-0980Musa acuminata58.140.01335
LLPS-Nia-1480Nicotiana attenuata58.050.01350
LLPS-Thc-0720Theobroma cacao57.960.01345
LLPS-Gag-0379Gaeumannomyces graminis57.850.01323
LLPS-Trv-1326Trichoderma virens57.830.01325
LLPS-Sei-0390Setaria italica57.820.01336
LLPS-Map-0804Magnaporthe poae57.770.01323
LLPS-Brd-0656Brachypodium distachyon57.770.01323
LLPS-Dos-0899Dothistroma septosporum57.690.01301
LLPS-Prp-0183Prunus persica57.660.01323
LLPS-Gor-1982Gossypium raimondii57.540.01334
LLPS-Pytr-0450Pyrenophora triticirepentis57.460.01268
LLPS-Pot-1647Populus trichocarpa57.420.01353
LLPS-Chr-0057Chlamydomonas reinhardtii57.390.01362
LLPS-Cogr-0012Colletotrichum graminicola57.380.01303
LLPS-Sot-0751Solanum tuberosum57.380.01338
LLPS-Mao-0645Magnaporthe oryzae57.290.01318
LLPS-Nec-0600Neurospora crassa57.260.01304
LLPS-Hov-0846Hordeum vulgare57.240.01325
LLPS-Coo-0556Colletotrichum orbiculare57.210.01299
LLPS-Via-0115Vigna angularis57.190.01090
LLPS-Trr-0876Trichoderma reesei57.170.01311
LLPS-Beb-0611Beauveria bassiana57.170.01301
LLPS-Cog-1000Colletotrichum gloeosporioides57.160.01298
LLPS-Tra-0966Triticum aestivum57.160.01320
LLPS-Sob-0486Sorghum bicolor57.130.01316
LLPS-Fuo-0932Fusarium oxysporum57.090.01308
LLPS-Mae-1658Manihot esculenta57.080.01330
LLPS-Sol-0079Solanum lycopersicum57.030.01333
LLPS-Hea-0624Helianthus annuus56.940.01321
LLPS-Ved-1430Verticillium dahliae56.910.01303
LLPS-Phv-0636Phaseolus vulgaris56.740.01314
LLPS-Glm-0004Glycine max56.740.01316
LLPS-Arl-0357Arabidopsis lyrata56.660.01316
LLPS-Ors-1045Oryza sativa56.580.01319
LLPS-Org-1376Oryza glaberrima56.580.01319
LLPS-Fus-1211Fusarium solani56.40.01301
LLPS-Met-0804Medicago truncatula56.40.01301
LLPS-Orbr-1627Oryza brachyantha56.230.01315
LLPS-Bro-1950Brassica oleracea56.220.01299
LLPS-Art-2750Arabidopsis thaliana56.080.01303
LLPS-Dac-1904Daucus carota55.850.01288
LLPS-Fuv-1081Fusarium verticillioides55.80.01244
LLPS-Brn-1449Brassica napus55.150.01282
LLPS-Viv-0312Vitis vinifera54.370.0 796
LLPS-Brr-1362Brassica rapa53.870.01243
LLPS-Lep-1850Leersia perrieri53.20.01195
LLPS-Orr-0301Oryza rufipogon52.110.01164
LLPS-Orni-2111Oryza nivara52.110.01164
LLPS-Orb-1815Oryza barthii52.110.01167
LLPS-Tru-0348Triticum urartu52.060.01191
LLPS-Orp-0749Oryza punctata51.560.01155
LLPS-Ori-1597Oryza indica49.60.01078
LLPS-Cym-0063Cyanidioschyzon merolae46.670.01131
LLPS-Cus-0573Cucumis sativus38.920.0 776
LLPS-Cii-1947Ciona intestinalis38.90.0 804
LLPS-Tut-0112Tursiops truncatus38.630.0 783
LLPS-Rhb-0164Rhinopithecus bieti38.250.0 775
LLPS-Amt-0160Amborella trichopoda37.640.0 775
LLPS-Zem-1134Zea mays37.20.0 766