• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mup-4254
TUBA1A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin alpha chain
Gene Name: TUBA1A
Ensembl Gene: ENSMPUG00000019643.1
Ensembl Protein: ENSMPUP00000019515.1
Organism: Mustela putorius furo
Taxa ID: 9669
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRECISIHVG  QAGVQIGNAC  WELYCLEHGI  QPDGQMPSDK  TIGGGDDSFN  TFFSETGAGK  60
61    HVPRAMFVDL  GPTVIDEVCT  GTYRQLFHPE  QLITGKEDAA  NNYVQGHYTI  GKEIIDLVLD  120
121   RIRKLADQCT  GLQGFLVFHS  FGGGTGSGFT  SLLMERLSVD  YGKKSKLEFS  IYPAPQVSTA  180
181   VVEPYNSILT  THTTLEHSDC  AFMVDNEAIY  DICCRNLDIE  RPTYTNLNRL  IGQIVSSITA  240
241   SLRFDGALNV  DLTEFQTNLV  PYPRIHFPLA  TYAPVISAEK  AYHEQLSVAE  ITNACFEPAN  300
301   QMVKCDPRHG  KYMACCLLYR  GDVVPKDVNA  AIATIKTKRT  IQFVDWCPTG  FKVGINYQPP  360
361   TVVPGGDLAK  VQRAVCMLSN  TTAIAEAWAR  LDHKFDLMYA  KRAFVHWYVG  EDMEEGEFSE  420
421   AREDMAALEK  DYEEVGVDSV  EGEGEEEGEE  Y  451
Nucleotide CDS Sequence (FASTA)
1     ATGCGTGAGT  GTATCTCCAT  CCACGTTGGC  CAGGCTGGTG  TCCAGATTGG  CAATGCCTGC  60
61    TGGGAGCTCT  ATTGCCTGGA  GCATGGCATT  CAGCCCGATG  GCCAGATGCC  AAGTGACAAG  120
121   ACCATCGGGG  GAGGAGACGA  CTCCTTCAAC  ACCTTCTTCA  GTGAGACTGG  TGCTGGCAAG  180
181   CATGTGCCCC  GGGCCATGTT  TGTAGACCTG  GGACCCACAG  TCATTGATGA  AGTTTGCACT  240
241   GGCACCTACC  GCCAGCTCTT  CCACCCTGAG  CAGCTCATCA  CAGGCAAGGA  AGATGCTGCC  300
301   AACAACTACG  TCCAAGGGCA  CTACACCATT  GGCAAAGAGA  TCATTGACCT  TGTCTTGGAC  360
361   CGAATTCGGA  AGCTGGCTGA  CCAGTGCACA  GGTCTTCAGG  GCTTCTTGGT  TTTCCACAGC  420
421   TTTGGAGGGG  GAACTGGTTC  CGGGTTCACC  TCCCTGCTGA  TGGAACGTCT  CTCTGTCGAT  480
481   TATGGCAAGA  AGTCCAAGCT  GGAGTTCTCC  ATCTACCCAG  CCCCTCAGGT  TTCCACAGCT  540
541   GTAGTTGAGC  CCTACAACTC  CATCCTCACT  ACCCACACCA  CCCTGGAGCA  CTCTGATTGT  600
601   GCCTTCATGG  TAGACAATGA  GGCCATCTAT  GACATCTGTT  GTAGAAACCT  TGATATTGAA  660
661   CGCCCAACCT  ACACTAATCT  AAATAGGTTG  ATAGGCCAGA  TTGTGTCCTC  CATCACCGCT  720
721   TCCCTCAGAT  TTGATGGAGC  CCTGAACGTT  GATCTGACAG  AATTCCAGAC  CAACCTGGTG  780
781   CCCTATCCCC  GTATCCACTT  CCCTCTGGCC  ACCTATGCCC  CTGTCATCTC  TGCTGAGAAA  840
841   GCCTACCATG  AACAGCTTTC  TGTAGCAGAG  ATCACCAACG  CGTGCTTTGA  GCCAGCCAAC  900
901   CAGATGGTGA  AATGTGACCC  TCGCCATGGT  AAATACATGG  CTTGCTGCCT  GTTGTACCGT  960
961   GGCGATGTGG  TTCCCAAAGA  TGTCAATGCT  GCCATTGCCA  CCATCAAGAC  CAAGCGTACC  1020
1021  ATCCAGTTTG  TGGACTGGTG  CCCCACTGGC  TTCAAAGTGG  GCATTAATTA  CCAGCCTCCC  1080
1081  ACTGTGGTGC  CCGGTGGAGA  CCTGGCCAAA  GTCCAGCGAG  CTGTGTGCAT  GCTGAGCAAC  1140
1141  ACCACAGCCA  TCGCTGAGGC  CTGGGCTCGC  CTGGACCACA  AGTTTGACCT  GATGTATGCC  1200
1201  AAGCGTGCCT  TTGTTCACTG  GTATGTGGGG  GAAGACATGG  AGGAAGGAGA  GTTTTCTGAG  1260
1261  GCCCGTGAGG  ACATGGCTGC  CCTTGAGAAG  GATTATGAGG  AGGTTGGTGT  GGATTCTGTT  1320
1321  GAAGGAGAGG  GTGAAGAAGA  AGGAGAGGAA  TACTAA  1356

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic microtubule
Cellular Component
Cytoplasmic ribonucleoprotein granule
Cellular Component
Neuromuscular junction
Cellular Component
Recycling endosome
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process
Biological Process
Regulation of synapse organization

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-2079Dipodomys ordii98.380.0 860
LLPS-Bot-1689Bos taurus98.380.0 860
LLPS-Ran-1850Rattus norvegicus98.380.0 860
LLPS-Paa-3203Papio anubis98.380.0 857
LLPS-Mum-2981Mus musculus98.380.0 860
LLPS-Chs-1766Chlorocebus sabaeus98.380.0 860
LLPS-Aon-0811Aotus nancymaae98.380.0 858
LLPS-Sus-3651Sus scrofa98.380.0 860
LLPS-Gog-1557Gorilla gorilla98.380.0 860
LLPS-Icp-1801Ictalurus punctatus98.380.0 861
LLPS-Poa-2507Pongo abelii98.380.0 860
LLPS-Ten-2970Tetraodon nigroviridis98.380.0 860
LLPS-Mam-0274Macaca mulatta98.380.0 860
LLPS-Gaga-2212Gallus gallus98.380.0 860
LLPS-Anc-2036Anolis carolinensis98.380.0 860
LLPS-Pat-0032Pan troglodytes98.380.0 860
LLPS-Hos-0454Homo sapiens98.380.0 860
LLPS-Dar-1690Danio rerio98.380.0 860
LLPS-Orc-2690Oryctolagus cuniculus98.380.0 860
LLPS-Scf-2328Scleropages formosus98.150.0 858
LLPS-Myl-1786Myotis lucifugus98.150.0 853
LLPS-Fud-2337Fukomys damarensis98.150.0 858
LLPS-Asm-1295Astyanax mexicanus98.150.0 859
LLPS-Ict-2143Ictidomys tridecemlineatus98.150.0 859
LLPS-Lac-1000Latimeria chalumnae98.140.0 857
LLPS-Fia-1806Ficedula albicollis98.140.0 855
LLPS-Maf-0074Macaca fascicularis97.920.0 857
LLPS-Cap-3401Cavia porcellus97.920.0 857
LLPS-Pap-4472Pan paniscus97.920.0 857
LLPS-Urm-3000Ursus maritimus97.920.0 857
LLPS-Mod-1950Monodelphis domestica97.920.0 857
LLPS-Fec-0466Felis catus97.920.0 857
LLPS-Man-2936Macaca nemestrina97.920.0 857
LLPS-Tut-0018Tursiops truncatus97.910.0 855
LLPS-Ora-0959Ornithorhynchus anatinus97.910.0 854
LLPS-Caj-2133Callithrix jacchus97.910.0 855
LLPS-Caf-1216Canis familiaris97.910.0 854
LLPS-Cas-1839Carlito syrichta97.910.0 854
LLPS-Meg-1613Meleagris gallopavo97.910.0 855
LLPS-Xim-1672Xiphophorus maculatus97.690.0 856
LLPS-Mal-4330Mandrillus leucophaeus97.690.0 854
LLPS-Ova-0174Ovis aries97.690.0 858
LLPS-Pof-3465Poecilia formosa97.690.0 855
LLPS-Loa-3422Loxodonta africana97.690.0 850
LLPS-Pes-2445Pelodiscus sinensis97.690.0 854
LLPS-Aim-3885Ailuropoda melanoleuca97.680.0 850
LLPS-Nol-3118Nomascus leucogenys97.680.0 851
LLPS-Otg-3152Otolemur garnettii97.680.0 855
LLPS-Tar-3942Takifugu rubripes97.450.0 850
LLPS-Sah-0275Sarcophilus harrisii97.450.0 856
LLPS-Leo-3078Lepisosteus oculatus97.450.0 853
LLPS-Scm-0904Scophthalmus maximus97.450.0 855
LLPS-Orl-0238Oryzias latipes97.220.0 854
LLPS-Xet-0144Xenopus tropicalis97.220.0 853
LLPS-Ere-0754Erinaceus europaeus96.980.0 847
LLPS-Cii-2287Ciona intestinalis96.760.0 854
LLPS-Drm-0758Drosophila melanogaster96.530.0 853
LLPS-Cea-1318Cercocebus atys96.530.0 853
LLPS-Eqc-0069Equus caballus96.530.0 853
LLPS-Orn-1753Oreochromis niloticus96.530.0 845
LLPS-Gaa-2011Gasterosteus aculeatus96.30.0 850
LLPS-Anp-1080Anas platyrhynchos96.290.0 850
LLPS-Mea-1952Mesocricetus auratus96.060.0 849
LLPS-Cis-1254Ciona savignyi95.820.0 851
LLPS-Tag-0253Taeniopygia guttata93.740.0 833
LLPS-Cae-0112Caenorhabditis elegans92.360.0 819