LLPS-Cae-0112
mec-12

▼ OVERVIEW

Status: Reviewed
Protein Name: Tubulin alpha-3 chain; Mechanosensory abnormality protein 12; MEC-12
Gene Name: mec-12, tba-3, C44B11.3
Ensembl Gene: WBGene00003175
Ensembl Protein: C44B11.3
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: LLPS protein


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Droplet
"...SPD-5/ZYG-9/TPXL-1 Condensates Concentrate Tubulin In vitro."
In vitro28575670
Nucleolus, Stress granule, Postsynaptic densityPredicted from orthologsN/A(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments (PubMed:9885292). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:9885292, PubMed:19652181).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREVISIHIG  QAGVQIGNAC  WELYCLEHGI  QPDGQMPSDK  SLGGSDDSFS  TFFSETGSGR  60
61    HVPRAVMVDL  EPTVIDEIRT  GTYRSLFHPE  QLITGKEDAA  NNYARGHYTI  GKEIIDLTLD  120
121   RIRRLADNCT  GLQGFLVFHS  FGGGTGSGFT  SLLMERLSVD  YGKKAKLEFS  IYPAPQVSTA  180
181   VVEPYNSILT  THTTLEHSDC  SFMVDNEAIY  DICRRNLDIE  RPSYTNLNRL  IGQIVSSITA  240
241   SLRFDGALNV  DLTEFQTNLV  PYPRIHFPLA  TFSPVISAEK  AYHEQLSVAE  ITNMCFEPHN  300
301   QMVKCDPRHG  KYMAVCLLFR  GDVVPKDVNA  AIATIKTKRS  IQFVDWCPTG  FKVGINYQPP  360
361   TVVPGGDLAK  VPRAVCMLSN  TTAIAEAWAR  LDHKFDLMYA  KRAFVHWYVG  EGMEEGEFSE  420
421   AREDLAALEK  DYEEVGVDSM  EDNGEEGDEY  450
Nucleotide CDS Sequence (FASTA)
1     ATGAGAGAAG  TAATTTCGAT  TCACATCGGA  CAAGCCGGAG  TCCAAATCGG  AAATGCTTGC  60
61    TGGGAGCTCT  ACTGCCTGGA  GCACGGAATT  CAGCCCGATG  GTCAAATGCC  TTCTGACAAG  120
121   TCCCTCGGAG  GATCCGATGA  CTCTTTCAGC  ACTTTCTTCT  CGGAAACTGG  AAGTGGACGT  180
181   CATGTGCCAA  GAGCCGTCAT  GGTCGACTTG  GAGCCAACTG  TCATTGACGA  AATCCGCACT  240
241   GGAACCTATC  GCTCCCTCTT  CCACCCGGAA  CAACTCATCA  CTGGTAAGGA  AGATGCCGCA  300
301   AATAACTACG  CTCGTGGTCA  CTACACCATC  GGAAAAGAAA  TCATCGACCT  AACCCTTGAC  360
361   CGTATCCGCC  GTCTAGCTGA  CAACTGTACC  GGACTTCAAG  GATTCCTAGT  GTTCCACTCT  420
421   TTCGGAGGAG  GTACTGGATC  CGGTTTCACT  TCTCTTTTGA  TGGAAAGACT  ATCTGTGGAC  480
481   TATGGAAAAA  AGGCCAAGCT  CGAGTTCTCC  ATCTATCCGG  CTCCTCAAGT  CTCCACTGCT  540
541   GTCGTAGAGC  CATATAACTC  GATTTTGACC  ACCCATACCA  CTTTGGAGCA  CTCGGATTGC  600
601   TCATTTATGG  TTGATAATGA  GGCAATCTAC  GACATTTGCC  GTCGCAACCT  GGACATCGAA  660
661   CGTCCATCCT  ACACAAATTT  GAATCGTCTC  ATCGGTCAAA  TCGTCAGCTC  CATCACCGCT  720
721   TCCCTCCGAT  TCGACGGAGC  CCTCAACGTC  GACTTGACCG  AGTTCCAGAC  AAACTTGGTT  780
781   CCCTATCCAC  GTATTCACTT  CCCGCTAGCC  ACATTTTCTC  CGGTTATCTC  AGCGGAAAAA  840
841   GCCTATCACG  AGCAGCTATC  AGTGGCTGAA  ATCACTAATA  TGTGCTTCGA  GCCACATAAC  900
901   CAGATGGTCA  AGTGTGATCC  GAGACACGGA  AAGTATATGG  CAGTTTGTCT  GCTTTTCCGT  960
961   GGAGATGTAG  TGCCAAAGGA  TGTGAATGCT  GCAATTGCAA  CTATTAAGAC  TAAGAGAAGC  1020
1021  ATTCAATTTG  TAGATTGGTG  CCCAACTGGA  TTTAAGGTCG  GAATCAACTA  CCAACCACCA  1080
1081  ACGGTAGTCC  CAGGAGGTGA  CCTGGCAAAG  GTACCCCGTG  CCGTGTGCAT  GCTCTCCAAC  1140
1141  ACCACCGCAA  TCGCTGAAGC  CTGGGCTCGT  CTGGACCATA  AATTCGACCT  AATGTATGCG  1200
1201  AAGAGAGCAT  TCGTCCACTG  GTATGTTGGT  GAAGGAATGG  AGGAAGGAGA  ATTTAGTGAG  1260
1261  GCTCGTGAAG  ATTTGGCTGC  TCTTGAGAAG  GATTATGAGG  AAGTCGGTGT  GGACAGTATG  1320
1321  GAGGATAATG  GAGAAGAAGG  AGATGAGTAT  TAG  1353

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Cellular Component
Neuronal cell body
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Detection of mechanical stimulus involved in sensory perception of touch
Biological Process
Mechanosensory behavior
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule-based process
Biological Process
Mitotic cell cycle
Biological Process
Positive regulation of detection of mechanical stimulus involved in sensory perception of touch
Biological Process
Positive regulation of mechanosensory behavior
Biological Process
Response to mechanical stimulus
Biological Process
Thigmotaxis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-1672Xiphophorus maculatus94.090.0 809
LLPS-Asm-1295Astyanax mexicanus94.090.0 811
LLPS-Ict-2143Ictidomys tridecemlineatus94.090.0 811
LLPS-Fia-1806Ficedula albicollis94.080.0 807
LLPS-Caj-2133Callithrix jacchus94.00.0 797
LLPS-Bot-1689Bos taurus93.860.0 810
LLPS-Dio-2079Dipodomys ordii93.860.0 810
LLPS-Ran-1474Rattus norvegicus93.860.0 809
LLPS-Chs-1766Chlorocebus sabaeus93.860.0 810
LLPS-Mum-4242Mus musculus93.860.0 809
LLPS-Maf-0074Macaca fascicularis93.860.0 809
LLPS-Sus-3651Sus scrofa93.860.0 810
LLPS-Gog-4173Gorilla gorilla93.860.0 809
LLPS-Icp-1801Ictalurus punctatus93.860.0 811
LLPS-Cap-3401Cavia porcellus93.860.0 809
LLPS-Poa-2507Pongo abelii93.860.0 810
LLPS-Mam-2467Macaca mulatta93.860.0 809
LLPS-Gaga-2212Gallus gallus93.860.0 810
LLPS-Anc-2036Anolis carolinensis93.860.0 810
LLPS-Mod-1950Monodelphis domestica93.860.0 809
LLPS-Fec-0466Felis catus93.860.0 809
LLPS-Scm-0904Scophthalmus maximus93.860.0 808
LLPS-Hos-1518Homo sapiens93.860.0 809
LLPS-Dar-1690Danio rerio93.860.0 810
LLPS-Pap-4472Pan paniscus93.860.0 809
LLPS-Urm-3000Ursus maritimus93.860.0 809
LLPS-Pof-3465Poecilia formosa93.860.0 810
LLPS-Pat-0032Pan troglodytes93.860.0 810
LLPS-Man-2936Macaca nemestrina93.860.0 810
LLPS-Orc-2690Oryctolagus cuniculus93.860.0 810
LLPS-Tut-0018Tursiops truncatus93.850.0 807
LLPS-Myl-1343Myotis lucifugus93.850.0 807
LLPS-Paa-3203Papio anubis93.850.0 808
LLPS-Ora-0959Ornithorhynchus anatinus93.850.0 808
LLPS-Aon-0811Aotus nancymaae93.850.0 808
LLPS-Caf-1216Canis familiaris93.850.0 808
LLPS-Cas-1839Carlito syrichta93.850.0 806
LLPS-Meg-1613Meleagris gallopavo93.850.0 806
LLPS-Scf-2328Scleropages formosus93.640.0 808
LLPS-Mal-4330Mandrillus leucophaeus93.640.0 808
LLPS-Orl-0238Oryzias latipes93.640.0 809
LLPS-Fud-4403Fukomys damarensis93.640.0 808
LLPS-Loa-3422Loxodonta africana93.640.0 803
LLPS-Pes-2445Pelodiscus sinensis93.640.0 807
LLPS-Aim-3885Ailuropoda melanoleuca93.620.0 804
LLPS-Lac-1000Latimeria chalumnae93.620.0 806
LLPS-Otg-3152Otolemur garnettii93.620.0 807
LLPS-Orn-1753Oreochromis niloticus93.410.0 805
LLPS-Ten-2970Tetraodon nigroviridis93.240.0 811
LLPS-Ova-1774Ovis aries93.170.0 802
LLPS-Mup-0654Mustela putorius furo92.730.0 807
LLPS-Cii-2287Ciona intestinalis92.730.0 806
LLPS-Cea-1318Cercocebus atys92.730.0 807
LLPS-Eqc-0069Equus caballus92.730.0 807
LLPS-Nol-2673Nomascus leucogenys92.730.0 807
LLPS-Tar-3942Takifugu rubripes92.710.0 799
LLPS-Drm-0758Drosophila melanogaster92.710.0 804
LLPS-Ere-0754Erinaceus europaeus92.710.0 798
LLPS-Sah-0275Sarcophilus harrisii92.710.0 805
LLPS-Xet-0291Xenopus tropicalis92.330.0 810
LLPS-Mea-1952Mesocricetus auratus92.270.0 803
LLPS-Leo-1381Lepisosteus oculatus92.260.0 804
LLPS-Gaa-2776Gasterosteus aculeatus92.060.0 801
LLPS-Anp-1080Anas platyrhynchos91.980.0 817
LLPS-Cis-1254Ciona savignyi91.80.0 803
LLPS-Tag-0253Taeniopygia guttata90.650.0 800