• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fia-1806

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin alpha chain
Ensembl Gene: ENSFALG00000000219.1
Ensembl Protein: ENSFALP00000000225.1
Organism: Ficedula albicollis
Taxa ID: 59894
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSFALT00000000228.1ENSFALP00000000225.1
UniProtU3JBS1, U3JBS1_FICAL
GeneBankAGTO01011822

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAVSGQDLPP  ASLGEGLFPA  RWVLGGDKRG  DPVRRVPPQR  ECISIHVGQA  GVQIGNACWE  60
61    LYCLEHGIQP  DGQMPSDKTI  GGGDDSFNTF  FSETGAGKHV  PRAVFVDLEP  TVIDEVRTGT  120
121   YRQLFHPEQL  ITGKEDAANN  YARGHYTIGK  EIIDLVLDRI  RKLADQCTGL  QGFLVFHSFG  180
181   GGTGSGFTSL  LMERLSVDYG  KKSKLEFSIY  PAPQVSTAVV  EPYNSILTTH  TTLEHSDCAF  240
241   MVDNEAIYDI  CRRNLDIERP  TYTNLNRLIG  QIVSSITASL  RFDGALNVDL  TEFQTNLVPY  300
301   PRIHFPLATY  APVISAEKAY  HEQLSVAEIT  NACFEPANQM  VKCDPRHGKY  MACCLLYRGD  360
361   VVPKDVNAAI  ATIKTKRSIQ  FVDWCPTGFK  VGINYQPPTV  VPGGDLAKVQ  RAVCMLSNTT  420
421   AIAEAWARLD  HKFDLMYAKR  AFVHWYVGEG  MEEGEFSEAR  EDMAALEKDY  EEVGVDSVEG  480
481   EGEEEGEEY  489
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGTGT  CCGGGCAGGA  TCTGCCCCCA  GCCAGCCTTG  GGGAGGGGCT  CTTCCCAGCC  60
61    CGGTGGGTGC  TGGGGGGGGA  CAAGAGGGGT  GACCCGGTGC  GGCGTGTGCC  CCCACAGCGC  120
121   GAGTGCATCT  CCATCCACGT  GGGCCAAGCG  GGCGTGCAGA  TCGGCAATGC  GTGCTGGGAG  180
181   CTGTACTGCC  TGGAGCACGG  CATCCAGCCC  GACGGGCAGA  TGCCCAGCGA  CAAGACCATC  240
241   GGCGGGGGGG  ACGACTCCTT  CAACACCTTC  TTCAGCGAGA  CGGGCGCCGG  CAAGCACGTG  300
301   CCCCGGGCCG  TGTTCGTGGA  CCTGGAGCCC  ACGGTGATCG  ACGAGGTGCG  CACCGGGACG  360
361   TACCGGCAGC  TCTTCCACCC  CGAGCAGCTG  ATCACGGGCA  AGGAGGATGC  GGCCAACAAC  420
421   TACGCCCGCG  GGCACTACAC  CATCGGCAAG  GAGATCATCG  ACCTGGTCCT  TGACCGCATC  480
481   CGCAAGCTGG  CTGACCAGTG  CACAGGGCTG  CAGGGCTTCC  TGGTGTTCCA  CAGCTTTGGC  540
541   GGTGGCACCG  GCTCTGGCTT  CACCTCCCTG  CTCATGGAGC  GGCTCTCTGT  CGACTACGGC  600
601   AAGAAGTCCA  AGCTGGAGTT  CTCCATCTAC  CCGGCCCCGC  AGGTGTCCAC  GGCCGTGGTG  660
661   GAGCCCTACA  ACTCCATCCT  CACCACCCAC  ACCACCCTGG  AGCACTCCGA  CTGTGCCTTC  720
721   ATGGTGGACA  ACGAGGCCAT  CTACGACATC  TGCCGCCGCA  ACCTGGACAT  CGAGCGCCCC  780
781   ACCTACACCA  ACCTCAACAG  GCTGATCGGG  CAGATCGTGT  CCTCCATCAC  GGCCTCGCTG  840
841   CGCTTTGACG  GAGCCCTGAA  CGTCGACCTG  ACAGAATTCC  AGACCAACCT  GGTGCCGTAC  900
901   CCGCGCATCC  ACTTCCCGCT  GGCCACCTAC  GCCCCGGTCA  TCTCTGCTGA  GAAGGCTTAT  960
961   CACGAGCAGC  TCTCGGTGGC  CGAGATCACC  AACGCCTGCT  TCGAGCCGGC  CAACCAGATG  1020
1021  GTGAAGTGCG  ACCCGCGGCA  CGGCAAGTAC  ATGGCGTGCT  GCCTGCTGTA  CCGCGGGGAC  1080
1081  GTGGTGCCCA  AGGATGTCAA  CGCCGCCATC  GCCACCATCA  AGACCAAGCG  CAGCATCCAG  1140
1141  TTTGTGGACT  GGTGCCCCAC  CGGTTTCAAG  GTGGGCATCA  ACTACCAGCC  GCCCACGGTG  1200
1201  GTGCCCGGGG  GCGACCTGGC  CAAGGTGCAG  CGCGCCGTGT  GCATGCTGAG  CAACACCACG  1260
1261  GCCATCGCCG  AGGCCTGGGC  CCGCCTGGAC  CACAAGTTTG  ACCTGATGTA  CGCCAAGCGG  1320
1321  GCGTTCGTGC  ACTGGTACGT  GGGGGAGGGC  ATGGAGGAGG  GAGAGTTCTC  AGAGGCCCGT  1380
1381  GAGGATATGG  CTGCCCTGGA  GAAGGATTAT  GAGGAGGTGG  GGGTGGATTC  TGTGGAAGGA  1440
1441  GAGGGAGAGG  AGGAAGGGGA  GGAATACTAA  1470

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-2143Ictidomys tridecemlineatus100.00.0 874
LLPS-Pes-2445Pelodiscus sinensis100.03e-79 264
LLPS-Asm-1295Astyanax mexicanus100.00.0 874
LLPS-Mam-0274Macaca mulatta99.770.0 872
LLPS-Cap-3401Cavia porcellus99.770.0 872
LLPS-Caf-1216Canis familiaris99.770.0 874
LLPS-Ten-2970Tetraodon nigroviridis99.770.0 874
LLPS-Poa-2507Pongo abelii99.770.0 872
LLPS-Anc-2036Anolis carolinensis99.770.0 872
LLPS-Cas-1839Carlito syrichta99.770.0 871
LLPS-Gaga-2212Gallus gallus99.770.0 872
LLPS-Man-2936Macaca nemestrina99.770.0 872
LLPS-Mod-1950Monodelphis domestica99.770.0 872
LLPS-Fec-0466Felis catus99.770.0 872
LLPS-Pap-4472Pan paniscus99.770.0 872
LLPS-Urm-3000Ursus maritimus99.770.0 872
LLPS-Pat-2764Pan troglodytes99.770.0 873
LLPS-Hos-0454Homo sapiens99.770.0 872
LLPS-Meg-1613Meleagris gallopavo99.770.0 876
LLPS-Dar-1690Danio rerio99.770.0 872
LLPS-Orc-2690Oryctolagus cuniculus99.770.0 872
LLPS-Bot-1689Bos taurus99.770.0 872
LLPS-Dio-2079Dipodomys ordii99.770.0 872
LLPS-Tut-0018Tursiops truncatus99.770.0 872
LLPS-Myl-1343Myotis lucifugus99.770.0 872
LLPS-Paa-3203Papio anubis99.770.0 877
LLPS-Ran-1474Rattus norvegicus99.770.0 872
LLPS-Aon-0811Aotus nancymaae99.770.0 874
LLPS-Sus-3651Sus scrofa99.770.0 872
LLPS-Ora-0959Ornithorhynchus anatinus99.770.0 874
LLPS-Chs-1766Chlorocebus sabaeus99.770.0 872
LLPS-Mum-2981Mus musculus99.770.0 872
LLPS-Maf-0074Macaca fascicularis99.770.0 872
LLPS-Caj-2133Callithrix jacchus99.770.0 873
LLPS-Gog-4173Gorilla gorilla99.770.0 872
LLPS-Loa-3422Loxodonta africana99.540.0 870
LLPS-Lac-1000Latimeria chalumnae99.540.0 874
LLPS-Pof-3465Poecilia formosa99.540.0 870
LLPS-Otg-3152Otolemur garnettii99.540.0 874
LLPS-Scf-2328Scleropages formosus99.540.0 870
LLPS-Mal-4330Mandrillus leucophaeus99.540.0 870
LLPS-Icp-1141Ictalurus punctatus99.540.0 870
LLPS-Fud-4403Fukomys damarensis99.540.0 871
LLPS-Nol-3118Nomascus leucogenys99.310.0 869
LLPS-Aim-3885Ailuropoda melanoleuca99.310.0 868
LLPS-Xim-1672Xiphophorus maculatus99.070.0 869
LLPS-Ova-0174Ovis aries99.070.0 871
LLPS-Orl-0238Oryzias latipes99.070.0 870
LLPS-Scm-0904Scophthalmus maximus98.840.0 868
LLPS-Tar-3942Takifugu rubripes98.840.0 866
LLPS-Leo-3078Lepisosteus oculatus98.840.0 872
LLPS-Xet-0144Xenopus tropicalis98.610.0 866
LLPS-Ere-0754Erinaceus europaeus98.610.0 862
LLPS-Sah-0275Sarcophilus harrisii98.610.0 870
LLPS-Eqc-0975Equus caballus98.380.0 866
LLPS-Orn-1753Oreochromis niloticus98.380.0 859
LLPS-Mup-4254Mustela putorius furo98.140.0 855
LLPS-Cii-2287Ciona intestinalis98.140.0 867
LLPS-Gaa-2776Gasterosteus aculeatus97.910.0 863
LLPS-Drm-0758Drosophila melanogaster97.910.0 866
LLPS-Cea-1318Cercocebus atys97.910.0 866
LLPS-Anp-1080Anas platyrhynchos97.690.0 866
LLPS-Mea-1952Mesocricetus auratus97.680.0 864
LLPS-Cis-1254Ciona savignyi97.220.0 868
LLPS-Tag-0253Taeniopygia guttata95.610.0 855
LLPS-Cae-0112Caenorhabditis elegans94.20.0 833