LLPS-Mum-4573
Rbfox3
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | RNA binding protein fox-1 homolog 3; Fox-1 homolog C; Hexaribonucleotide-binding protein 3; Fox-3; Neuronal nuclei antigen; NeuN antigen |
| Gene Name: | Rbfox3, D11Bwg0517e, Hrnbp3 |
| Ensembl Gene: | ENSMUSG00000025576.17 |
| Ensembl Protein: | ENSMUSP00000017576.4 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP PEHGMTLYTP AQTHPEQPGT 60 61 EASTQPIAGT QTVPQADEAA QTDNQQLHPS DPTEKQQPKR LHVSNIPFRF RDPDLRQMFG 120 121 QFGKILDVEI IFNERGSKGF GFVTFETSSD ADRAREKLNG TIVEGRKIEV NNATARVMTN 180 181 KKPGNPYANG WKLNPVVGTV YGPEFYAVTS FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA 240 241 APPPPPIPTY GAALEQTLVK MPVPWAGLAP CPLPPQQTPE PAYPTSPAFP PLSCPFASRV 300 301 VYQDGFYGAE IYGGYAAYRY AQPAAATAAA YSDSYGRVYA AADPYHHTIG PTATYSIGTM 360 361 ASLCRGGYSR FTPY 374 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCCAGC CCTACCCCCC TGCCCAGTAC CCTCCTCCGC CTCAGAATGG AATCCCAGCT 60 61 GAATATGCCC CACCTCCGCC TCATCCCACC CAGGACTACT CCGGCCAGAC CCCTGTTCCC 120 121 CCCGAGCACG GCATGACCCT CTACACACCC GCACAGACTC ATCCTGAGCA GCCAGGCACT 180 181 GAGGCCAGCA CACAGCCCAT TGCTGGGACC CAGACGGTGC CGCAGGCAGA TGAAGCAGCA 240 241 CAGACAGACA ACCAGCAACT CCACCCTTCC GACCCCACGG AGAAGCAGCA GCCCAAACGA 300 301 CTACATGTCT CCAACATCCC CTTCCGGTTC AGGGACCCCG ACCTGCGGCA AATGTTCGGG 360 361 CAATTCGGGA AAATTTTAGA CGTGGAGATC ATTTTTAACG AGCGGGGCTC CAAGGGTTTT 420 421 GGGTTTGTAA CTTTTGAAAC TAGCTCAGAT GCTGACCGAG CCCGGGAGAA GCTGAATGGG 480 481 ACGATCGTAG AGGGACGGAA AATTGAGGTC AATAATGCCA CAGCCCGGGT CATGACCAAT 540 541 AAGAAGCCTG GGAACCCATA TGCCAATGGC TGGAAGCTAA ACCCTGTGGT AGGAACAGTC 600 601 TATGGGCCTG AATTCTATGC AGTGACCAGT TTCCCCTACC CCACCACGGG CACCGCCGTT 660 661 GCCTACCGGG GTGCACACCT GCGGGGCCGG GGCCGTGCTG TGTATAATAC ATTTCGAGCT 720 721 GCACCACCTC CACCCCCCAT TCCAACTTAT GGAGCGGCAC TGGAGCAAAC GCTTGTTAAA 780 781 ATGCCAGTCC CGTGGGCGGG GCTGGCACCG TGCCCCCTCC CTCCTCAGCA GACACCGGAG 840 841 CCGGCCTACC CCACCTCTCC AGCGTTCCCA CCACTCTCTT GTCCGTTTGC TTCCAGGGTC 900 901 GTGTATCAGG ATGGATTTTA TGGTGCTGAG ATTTATGGAG GCTATGCAGC TTACAGATAT 960 961 GCTCAGCCAG CAGCCGCCAC CGCAGCAGCC TACAGTGACA GTTATGGTAG AGTCTATGCC 1020 1021 GCTGCTGATC CTTACCATCA CACCATCGGC CCCACAGCAA CCTACAGCAT CGGAACCATG 1080 1081 GCTAGCCTCT GCCGAGGAGG GTACAGCCGC TTCACCCCCT ACTAG 1125 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Neuronal cell body | |
Cellular Component | Nucleus | |
Cellular Component | Perikaryon | |
Molecular Function | DNA binding | |
Molecular Function | MRNA binding | |
Biological Process | MRNA processing | |
Biological Process | Nervous system development | |
Biological Process | Regulation of alternative mRNA splicing, via spliceosome | |
Biological Process | RNA splicing |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | PIRSF | ENPD | CellMarker | |
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mup-1513 | Mustela putorius furo | 97.67 | 5e-19 | 91.3 |
| LLPS-Cas-1986 | Carlito syrichta | 97.1 | 0.0 | 539 |
| LLPS-Caf-1903 | Canis familiaris | 96.55 | 4e-09 | 61.6 |
| LLPS-Gaga-1586 | Gallus gallus | 96.55 | 6e-09 | 61.6 |
| LLPS-Anc-3146 | Anolis carolinensis | 96.55 | 5e-09 | 61.2 |
| LLPS-Chs-4406 | Chlorocebus sabaeus | 96.55 | 6e-09 | 60.8 |
| LLPS-Mam-0988 | Macaca mulatta | 96.54 | 8e-172 | 490 |
| LLPS-Pap-0649 | Pan paniscus | 96.54 | 1e-171 | 490 |
| LLPS-Nol-3417 | Nomascus leucogenys | 96.3 | 5e-08 | 57.8 |
| LLPS-Ict-3593 | Ictidomys tridecemlineatus | 96.05 | 1e-110 | 333 |
| LLPS-Sus-2617 | Sus scrofa | 94.85 | 0.0 | 519 |
| LLPS-Eqc-4591 | Equus caballus | 94.61 | 2e-149 | 433 |
| LLPS-Otg-3345 | Otolemur garnettii | 94.61 | 3e-149 | 434 |
| LLPS-Ran-3168 | Rattus norvegicus | 94.44 | 0.0 | 584 |
| LLPS-Pes-3330 | Pelodiscus sinensis | 94.12 | 8e-12 | 71.2 |
| LLPS-Myl-3759 | Myotis lucifugus | 93.5 | 1e-70 | 224 |
| LLPS-Fec-4656 | Felis catus | 93.36 | 1e-146 | 427 |
| LLPS-Mod-2844 | Monodelphis domestica | 93.1 | 2e-08 | 59.7 |
| LLPS-Bot-3728 | Bos taurus | 92.53 | 7e-147 | 428 |
| LLPS-Pat-4391 | Pan troglodytes | 91.92 | 0.0 | 567 |
| LLPS-Gog-1233 | Gorilla gorilla | 91.92 | 0.0 | 567 |
| LLPS-Hos-2469 | Homo sapiens | 91.3 | 0.0 | 531 |
| LLPS-Rhb-2450 | Rhinopithecus bieti | 91.01 | 0.0 | 528 |
| LLPS-Cap-3988 | Cavia porcellus | 90.86 | 0.0 | 561 |
| LLPS-Mal-3432 | Mandrillus leucophaeus | 90.72 | 0.0 | 526 |
| LLPS-Paa-0884 | Papio anubis | 90.72 | 0.0 | 526 |
| LLPS-Cea-1128 | Cercocebus atys | 90.72 | 0.0 | 525 |
| LLPS-Caj-4032 | Callithrix jacchus | 90.43 | 0.0 | 526 |
| LLPS-Anp-2346 | Anas platyrhynchos | 90.1 | 5e-54 | 186 |
| LLPS-Man-2921 | Macaca nemestrina | 90.0 | 0.0 | 527 |
| LLPS-Maf-4363 | Macaca fascicularis | 89.71 | 0.0 | 525 |
| LLPS-Meg-0177 | Meleagris gallopavo | 89.58 | 2e-113 | 338 |
| LLPS-Fia-1260 | Ficedula albicollis | 89.06 | 3e-111 | 338 |
| LLPS-Poa-3408 | Pongo abelii | 87.97 | 5e-132 | 388 |
| LLPS-Aim-0253 | Ailuropoda melanoleuca | 87.64 | 3e-143 | 419 |
| LLPS-Fud-1402 | Fukomys damarensis | 86.43 | 0.0 | 518 |
| LLPS-Urm-3899 | Ursus maritimus | 82.67 | 7e-26 | 108 |
| LLPS-Aon-2977 | Aotus nancymaae | 81.74 | 2e-157 | 454 |
| LLPS-Dar-3687 | Danio rerio | 81.4 | 2e-14 | 77.0 |
| LLPS-Sah-2677 | Sarcophilus harrisii | 79.49 | 1e-133 | 395 |
| LLPS-Xet-2681 | Xenopus tropicalis | 79.27 | 5e-96 | 298 |
| LLPS-Dio-3651 | Dipodomys ordii | 78.55 | 2e-163 | 469 |
| LLPS-Ten-1598 | Tetraodon nigroviridis | 77.27 | 1e-13 | 73.9 |
| LLPS-Orc-1820 | Oryctolagus cuniculus | 76.29 | 6e-91 | 280 |
| LLPS-Scf-1703 | Scleropages formosus | 75.77 | 1e-91 | 285 |
| LLPS-Icp-2691 | Ictalurus punctatus | 73.75 | 2e-106 | 323 |
| LLPS-Xim-0110 | Xiphophorus maculatus | 73.26 | 6e-70 | 233 |
| LLPS-Ova-0869 | Ovis aries | 72.07 | 1e-81 | 261 |
| LLPS-Loa-4183 | Loxodonta africana | 71.64 | 3e-160 | 462 |
| LLPS-Asm-3896 | Astyanax mexicanus | 71.47 | 3e-135 | 399 |
| LLPS-Ora-1277 | Ornithorhynchus anatinus | 68.15 | 2e-102 | 314 |
| LLPS-Scm-0870 | Scophthalmus maximus | 67.91 | 1e-124 | 371 |
| LLPS-Pof-1427 | Poecilia formosa | 67.44 | 1e-07 | 57.4 |
| LLPS-Gaa-1024 | Gasterosteus aculeatus | 67.44 | 1e-07 | 57.4 |
| LLPS-Tut-0015 | Tursiops truncatus | 66.3 | 3e-98 | 305 |
| LLPS-Orl-2845 | Oryzias latipes | 65.8 | 2e-70 | 234 |
| LLPS-Cae-2013 | Caenorhabditis elegans | 65.48 | 1e-30 | 125 |
| LLPS-Orn-2894 | Oreochromis niloticus | 65.34 | 4e-123 | 367 |
| LLPS-Tag-0892 | Taeniopygia guttata | 65.12 | 2e-07 | 56.2 |
| LLPS-Mea-0106 | Mesocricetus auratus | 65.12 | 2e-07 | 56.6 |
| LLPS-Tar-1114 | Takifugu rubripes | 62.79 | 2e-06 | 53.1 |
| LLPS-Leo-2342 | Lepisosteus oculatus | 58.99 | 6e-111 | 337 |
| LLPS-Lac-0757 | Latimeria chalumnae | 56.88 | 4e-76 | 247 |
| LLPS-Dac-1385 | Daucus carota | 44.0 | 1e-10 | 65.1 |
| LLPS-Lep-1092 | Leersia perrieri | 41.77 | 5e-10 | 65.5 |
| LLPS-Sob-1001 | Sorghum bicolor | 40.51 | 2e-10 | 65.1 |
| LLPS-Mae-2025 | Manihot esculenta | 39.76 | 7e-10 | 63.9 |
| LLPS-Brd-1913 | Brachypodium distachyon | 37.8 | 5e-10 | 64.3 |
| LLPS-Sot-0829 | Solanum tuberosum | 37.37 | 7e-10 | 63.2 |
| LLPS-Prp-2015 | Prunus persica | 36.96 | 3e-10 | 65.1 |
| LLPS-Hov-1352 | Hordeum vulgare | 36.59 | 6e-10 | 64.3 |
| LLPS-Drm-0962 | Drosophila melanogaster | 35.54 | 2e-10 | 66.6 |
| LLPS-Ere-0206 | Erinaceus europaeus | 34.74 | 6e-10 | 63.2 |
| LLPS-Arl-2176 | Arabidopsis lyrata | 30.37 | 7e-10 | 63.9 |