LLPS-Mum-4184
Lats1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase
Gene Name: Lats1, Warts
Ensembl Gene: ENSMUSG00000040021.13
Ensembl Protein: ENSMUSP00000041915.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client
PDB: 5B6B (A, J) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKRGEKPEGY  RQMRPKTFPA  SNYPGSSRQM  LQEIRESLRN  LSKPSDASKA  EHNLNKMSTE  60
61    DPRQVRNPPK  FGTHHKALQE  IRNSLLPFAN  ETSSSRSPSE  VNPQMFQDLQ  AAGFDEDMVI  120
121   QALQKTNNRS  IEAAVEFISK  MSYQDPRREQ  MSAAAARPIN  ATMKPGNVQH  SINRKQSWKG  180
181   SKESLVPQRH  GPSLGENVVY  RSESPNSQAD  VGRPLSGSGI  AAFAQAHPSN  GQRVNPPPPP  240
241   QVRSVTPPPP  PRGQTPPPRG  TTPPPPSWEP  SSQTKRYSGN  MEYVISRISP  VPPGAWQEGY  300
301   PPPPLTTSPM  NPPSQAQRAI  SSVPVGRQPI  IMQSTSKFNF  TPGRPGVQNG  GGQSDFIVHQ  360
361   NVPTGSVTRQ  PPPPYPLTPA  NGQSPSALQT  GASAAPPSFA  NGNVPQSMMV  PNRNSHNMEL  420
421   YNINVPGLQT  AWPQSSSAPA  QSSPSGGHEI  PTWQPNIPVR  SNSFNNPLGS  RASHSANSQP  480
481   SATTVTAITP  APIQQPVKSM  RVLKPELQTA  LAPTHPSWMP  QPVQTVQPTP  FSEGTASSVP  540
541   VIPPVAEAPS  YQGPPPPYPK  HLLHQNPSVP  PYESVSKPCK  DEQPSLPKED  DSEKSADSGD  600
601   SGDKEKKQIT  TSPITVRKNK  KDEERRESRI  QSYSPQAFKF  FMEQHVENVL  KSHQQRLHRK  660
661   KQLENEMMRV  GLSQDAQDQM  RKMLCQKESN  YIRLKRAKMD  KSMFVKIKTL  GIGAFGEVCL  720
721   ARKVDTKALY  ATKTLRKKDV  LLRNQVAHVK  AERDILAEAD  NEWVVRLYYS  FQDKDNLYFV  780
781   MDYIPGGDMM  SLLIRMGIFP  ENLARFYIAE  LTCAVESVHK  MGFIHRDIKP  DNILIDRDGH  840
841   IKLTDFGLCT  GFRWTHDSKY  YQSGDHPRQD  SMDFSNEWGD  PSNCRCGDRL  KPLERRAARQ  900
901   HQRCLAHSLV  GTPNYIAPEV  LLRTGYTQLC  DWWSVGVILF  EMLVGQPPFL  AQTPLETQMK  960
961   VINWQTSLHI  PPQAKLSPEA  SDLIIKLCRG  PEDRLGKNGA  DEIKAHPFFK  TIDFSSDLRQ  1020
1021  QSASYIPKIT  HPTDTSNFDP  VDPDKLWSDG  SEEENISDTL  NGWYKNGKHP  EHAFYEFTFR  1080
1081  RFFDDNGYPY  NYPKPIEYEY  IHSQGSEQQS  DEDDQHTSSD  GNNRDLVYV  1129
Nucleotide CDS Sequence (FASTA)
1     ATGAAGAGGG  GTGAAAAGCC  AGAAGGGTAC  AGACAGATGA  GGCCTAAGAC  CTTTCCTGCC  60
61    AGCAACTACC  CTGGCAGCAG  CCGACAGATG  CTGCAGGAGA  TCCGAGAATC  CCTGAGGAAT  120
121   TTATCAAAAC  CATCTGATGC  TTCGAAGGCC  GAGCATAACC  TGAATAAGAT  GTCGACTGAA  180
181   GATCCCAGGC  AGGTGAGAAA  TCCACCCAAA  TTTGGCACAC  ATCATAAAGC  CTTGCAAGAA  240
241   ATTCGAAACT  CTCTACTACC  ATTTGCAAAT  GAAACAAGTT  CTTCCCGGAG  CCCTTCAGAA  300
301   GTTAATCCAC  AGATGTTTCA  GGATTTGCAG  GCTGCTGGCT  TTGATGAGGA  CATGGTTATT  360
361   CAAGCTCTTC  AGAAAACCAA  TAACAGAAGC  ATAGAAGCCG  CTGTTGAATT  CATTAGTAAA  420
421   ATGAGTTACC  AAGACCCTCG  TCGAGAGCAG  ATGTCTGCAG  CAGCTGCCAG  GCCTATTAAT  480
481   GCCACCATGA  AACCAGGAAA  TGTGCAACAT  TCAATTAACC  GAAAACAAAG  CTGGAAAGGT  540
541   TCTAAAGAGT  CTCTAGTTCC  TCAGAGACAC  GGCCCATCTC  TAGGAGAAAA  TGTGGTTTAT  600
601   CGTTCTGAAA  GCCCCAACTC  ACAGGCGGAT  GTAGGAAGAC  CTCTGTCTGG  ATCCGGCATT  660
661   GCAGCATTTG  CTCAAGCTCA  CCCAAGCAAT  GGACAGAGAG  TGAACCCCCC  ACCACCACCT  720
721   CAAGTTAGGA  GTGTTACTCC  TCCACCACCT  CCGAGAGGCC  AGACCCCACC  TCCCCGAGGC  780
781   ACCACTCCCC  CTCCCCCCTC  ATGGGAACCA  AGCTCTCAGA  CAAAGCGCTA  CTCTGGGAAC  840
841   ATGGAGTACG  TAATCTCCCG  AATCTCCCCT  GTTCCACCTG  GGGCGTGGCA  GGAGGGCTAC  900
901   CCTCCACCAC  CTCTTACCAC  TTCTCCCATG  AATCCCCCTA  GCCAGGCTCA  GAGGGCCATT  960
961   AGTTCTGTTC  CAGTTGGTAG  ACAACCCATC  ATCATGCAGA  GTACTAGCAA  ATTTAACTTT  1020
1021  ACACCAGGGC  GACCTGGAGT  TCAGAATGGT  GGTGGTCAGT  CTGATTTTAT  CGTGCACCAA  1080
1081  AATGTCCCCA  CTGGTTCTGT  GACTCGGCAG  CCACCACCTC  CATATCCTCT  GACCCCAGCT  1140
1141  AATGGACAAA  GCCCCTCTGC  TTTACAAACA  GGGGCTTCTG  CTGCTCCACC  ATCATTCGCC  1200
1201  AATGGAAACG  TTCCTCAGTC  GATGATGGTG  CCCAACAGGA  ACAGTCATAA  CATGGAGCTT  1260
1261  TATAATATTA  ATGTCCCTGG  ACTGCAAACA  GCCTGGCCCC  AGTCGTCTTC  TGCTCCTGCG  1320
1321  CAGTCATCCC  CAAGCGGTGG  GCATGAAATT  CCTACATGGC  AACCTAACAT  ACCAGTGAGG  1380
1381  TCAAATTCTT  TTAATAACCC  ATTAGGAAGT  AGAGCAAGTC  ACTCTGCTAA  TTCTCAGCCT  1440
1441  TCTGCCACTA  CAGTCACTGC  CATCACACCC  GCTCCTATTC  AACAGCCCGT  GAAAAGCATG  1500
1501  CGCGTCCTGA  AACCAGAGCT  GCAGACTGCT  TTAGCCCCAA  CCCATCCTTC  TTGGATGCCA  1560
1561  CAGCCAGTTC  AGACTGTTCA  GCCTACCCCT  TTTTCTGAGG  GTACAGCTTC  AAGTGTGCCT  1620
1621  GTCATCCCAC  CTGTTGCTGA  AGCTCCAAGC  TATCAAGGTC  CACCACCGCC  TTATCCAAAA  1680
1681  CATCTGCTAC  ACCAAAACCC  ATCTGTCCCT  CCATATGAGT  CAGTAAGTAA  GCCCTGCAAA  1740
1741  GATGAACAGC  CTAGCTTACC  CAAGGAAGAT  GATAGTGAGA  AGAGTGCGGA  CAGTGGTGAC  1800
1801  TCTGGGGATA  AAGAAAAGAA  ACAGATTACA  ACTTCACCTA  TCACTGTTCG  GAAAAACAAG  1860
1861  AAAGATGAAG  AACGAAGAGA  GTCTCGGATT  CAGAGTTACT  CCCCACAGGC  CTTTAAGTTC  1920
1921  TTCATGGAGC  AGCACGTAGA  GAACGTCCTG  AAGTCTCATC  AGCAGCGTCT  GCATCGGAAG  1980
1981  AAGCAGCTAG  AAAATGAAAT  GATGCGGGTT  GGATTATCTC  AAGATGCCCA  GGATCAAATG  2040
2041  AGAAAGATGC  TTTGCCAGAA  AGAGTCTAAC  TATATTCGTC  TTAAAAGGGC  TAAAATGGAC  2100
2101  AAGTCTATGT  TTGTAAAGAT  AAAGACATTA  GGAATAGGAG  CGTTTGGTGA  AGTCTGTCTA  2160
2161  GCAAGAAAAG  TCGATACTAA  AGCTTTGTAT  GCAACAAAGA  CTCTTCGAAA  GAAAGACGTT  2220
2221  CTGCTCCGAA  ATCAGGTGGC  TCATGTGAAA  GCGGAGAGGG  ATATCCTAGC  AGAAGCCGAC  2280
2281  AATGAGTGGG  TGGTCCGCCT  GTACTACTCT  TTCCAGGACA  AGGACAACTT  GTACTTTGTG  2340
2341  ATGGACTACA  TTCCTGGGGG  GGATATGATG  AGCCTATTAA  TTAGAATGGG  CATCTTTCCT  2400
2401  GAAAATCTGG  CACGATTCTA  CATAGCAGAA  CTTACCTGTG  CAGTTGAAAG  TGTTCATAAA  2460
2461  ATGGGTTTTA  TTCATAGAGA  TATTAAACCT  GATAACATTT  TGATTGACCG  TGATGGCCAT  2520
2521  ATTAAATTGA  CTGACTTTGG  CTTGTGCACT  GGCTTCAGAT  GGACACATGA  CTCCAAGTAC  2580
2581  TACCAGAGTG  GGGATCACCC  ACGGCAAGAT  AGCATGGATT  TCAGTAACGA  ATGGGGAGAT  2640
2641  CCTTCCAATT  GTCGGTGTGG  GGACAGACTG  AAGCCACTGG  AGCGGAGAGC  TGCTCGCCAG  2700
2701  CACCAGCGAT  GTCTAGCCCA  TTCTCTGGTT  GGGACTCCCA  ATTATATTGC  ACCTGAAGTG  2760
2761  CTACTGCGAA  CAGGATATAC  ACAGCTGTGT  GACTGGTGGA  GTGTTGGTGT  TATTCTTTTT  2820
2821  GAAATGTTGG  TGGGACAACC  TCCTTTCTTG  GCACAAACCC  CATTAGAAAC  ACAAATGAAG  2880
2881  GTTATCAACT  GGCAAACTTC  TCTTCACATC  CCTCCTCAAG  CTAAGCTGAG  TCCTGAAGCC  2940
2941  TCTGACCTCA  TTATCAAACT  TTGTCGAGGA  CCAGAAGACC  GCCTCGGCAA  GAACGGTGCT  3000
3001  GATGAGATAA  AGGCTCATCC  ATTTTTTAAG  ACCATCGATT  TCTCTAGTGA  TCTGAGACAG  3060
3061  CAGTCTGCTT  CATACATCCC  TAAAATCACG  CATCCAACAG  ATACATCCAA  TTTCGACCCT  3120
3121  GTTGATCCTG  ATAAATTGTG  GAGCGATGGC  AGCGAGGAGG  AAAATATCAG  TGACACTCTG  3180
3181  AACGGATGGT  ATAAAAATGG  GAAGCACCCC  GAGCACGCTT  TCTATGAGTT  CACCTTTCGG  3240
3241  AGGTTTTTTG  ATGACAATGG  CTACCCATAT  AATTATCCAA  AGCCTATTGA  GTATGAATAC  3300
3301  ATTCATTCAC  AGGGCTCAGA  ACAACAGTCT  GATGAAGATG  ATCAACACAC  AAGCTCCGAT  3360
3361  GGAAACAACC  GAGATCTAGT  GTATGTTTAA  3390

▼ KEYWORD

ID
Family
3D-structure
ATP-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Magnesium
Metal-binding
Mitosis
Nucleotide-binding
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase
Tumor suppressor

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule organizing center
Cellular Component
Spindle pole
Molecular Function
ATP binding
Molecular Function
Estrogen receptor binding
Molecular Function
Magnesium ion binding
Molecular Function
Protein kinase binding
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Cell division
Biological Process
Cellular protein localization
Biological Process
Cytoplasmic sequestering of protein
Biological Process
G1/S transition of mitotic cell cycle
Biological Process
G2/M transition of mitotic cell cycle
Biological Process
Hippo signaling
Biological Process
Hormone-mediated signaling pathway
Biological Process
Inner cell mass cell fate commitment
Biological Process
Inner cell mass cellular morphogenesis
Biological Process
Intracellular signal transduction
Biological Process
Keratinocyte differentiation
Biological Process
Mammary gland epithelial cell differentiation
Biological Process
Negative regulation of canonical Wnt signaling pathway
Biological Process
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of peptidyl-serine phosphorylation
Biological Process
Protein phosphorylation
Biological Process
Regulation of actin filament polymerization
Biological Process
Regulation of intracellular estrogen receptor signaling pathway
Biological Process
Regulation of organ growth
Biological Process
Regulation of protein complex assembly
Biological Process
Regulation of ubiquitin-dependent protein catabolic process
Biological Process
Sister chromatid segregation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0920Rattus norvegicus96.190.01976
LLPS-Mal-2628Mandrillus leucophaeus95.851e-166 526
LLPS-Paa-2765Papio anubis93.360.01922
LLPS-Chs-4574Chlorocebus sabaeus93.360.01921
LLPS-Gog-2075Gorilla gorilla93.360.01921
LLPS-Nol-3095Nomascus leucogenys93.360.01931
LLPS-Maf-4833Macaca fascicularis93.270.01920
LLPS-Poa-1002Pongo abelii93.270.01919
LLPS-Pap-4303Pan paniscus93.270.01919
LLPS-Pat-2525Pan troglodytes93.270.01919
LLPS-Man-2144Macaca nemestrina93.190.01915
LLPS-Cea-4194Cercocebus atys93.10.01698
LLPS-Mam-2541Macaca mulatta93.10.01915
LLPS-Hos-1421Homo sapiens93.10.01914
LLPS-Rhb-3719Rhinopithecus bieti93.10.01697
LLPS-Caj-4791Callithrix jacchus93.090.01917
LLPS-Aon-4063Aotus nancymaae92.920.01907
LLPS-Urm-2805Ursus maritimus92.660.01609
LLPS-Fec-0195Felis catus92.650.01903
LLPS-Aim-2285Ailuropoda melanoleuca92.570.01909
LLPS-Cas-3613Carlito syrichta92.570.01898
LLPS-Mup-2698Mustela putorius furo92.560.01898
LLPS-Orc-4328Oryctolagus cuniculus92.470.01394
LLPS-Ict-0070Ictidomys tridecemlineatus92.220.01889
LLPS-Caf-4008Canis familiaris92.030.01894
LLPS-Ova-1763Ovis aries91.870.01881
LLPS-Bot-3127Bos taurus91.860.01874
LLPS-Eqc-0360Equus caballus91.860.01873
LLPS-Dio-4184Dipodomys ordii91.780.01874
LLPS-Tut-2112Tursiops truncatus91.780.01581
LLPS-Sus-2974Sus scrofa91.410.01893
LLPS-Cap-1113Cavia porcellus91.380.01585
LLPS-Fud-4074Fukomys damarensis91.340.01875
LLPS-Myl-3215Myotis lucifugus91.140.01885
LLPS-Loa-4115Loxodonta africana90.810.01867
LLPS-Otg-4295Otolemur garnettii90.640.01840
LLPS-Mea-4017Mesocricetus auratus90.00.01822
LLPS-Ere-0204Erinaceus europaeus89.470.01829
LLPS-Sah-1623Sarcophilus harrisii86.70.01798
LLPS-Mod-4359Monodelphis domestica85.760.01768
LLPS-Ora-3225Ornithorhynchus anatinus84.910.01561
LLPS-Fia-2623Ficedula albicollis83.830.01731
LLPS-Pes-0410Pelodiscus sinensis83.730.01453
LLPS-Anp-2276Anas platyrhynchos83.130.01706
LLPS-Tag-0627Taeniopygia guttata83.110.01713
LLPS-Gaga-3981Gallus gallus83.030.01731
LLPS-Meg-0797Meleagris gallopavo82.70.01725
LLPS-Anc-1601Anolis carolinensis80.460.01676
LLPS-Asm-1942Astyanax mexicanus77.290.0 827
LLPS-Lac-1182Latimeria chalumnae77.20.01613
LLPS-Drm-1241Drosophila melanogaster74.590.0 662
LLPS-Scf-2945Scleropages formosus73.040.0 644
LLPS-Xet-3885Xenopus tropicalis71.470.01211
LLPS-Leo-1076Lepisosteus oculatus67.530.01325
LLPS-Gaa-2256Gasterosteus aculeatus64.910.01254
LLPS-Cii-2222Ciona intestinalis64.492e-161 492
LLPS-Tar-0094Takifugu rubripes64.210.01248
LLPS-Icp-3189Ictalurus punctatus64.00.01251
LLPS-Dar-3120Danio rerio62.420.01207
LLPS-Pof-2522Poecilia formosa62.360.0 853
LLPS-Ten-1424Tetraodon nigroviridis62.20.01193
LLPS-Xim-0344Xiphophorus maculatus61.710.0 850
LLPS-Orl-0452Oryzias latipes61.560.0 858
LLPS-Orn-1963Oreochromis niloticus61.090.01200
LLPS-Scm-0065Scophthalmus maximus61.080.0 847
LLPS-Cae-1695Caenorhabditis elegans50.116e-140 452
LLPS-Tum-0580Tuber melanosporum47.776e-121 391
LLPS-Glm-2155Glycine max45.578e-115 374
LLPS-Yal-0600Yarrowia lipolytica44.715e-115 376
LLPS-Sei-1720Setaria italica44.586e-114 372
LLPS-Sob-1641Sorghum bicolor44.251e-114 374
LLPS-Cus-0345Cucumis sativus43.792e-116 379
LLPS-Amt-0383Amborella trichopoda43.512e-113 371
LLPS-Nia-2390Nicotiana attenuata43.284e-118 381
LLPS-Org-1517Oryza glaberrima42.952e-113 370
LLPS-Viv-0664Vitis vinifera42.953e-113 370
LLPS-Sot-0511Solanum tuberosum42.761e-115 375
LLPS-Prp-0533Prunus persica42.766e-114 372
LLPS-Coc-0256Corchorus capsularis42.761e-114 373
LLPS-Mae-1038Manihot esculenta42.75e-114 372
LLPS-Gor-1558Gossypium raimondii42.681e-115 376
LLPS-Pot-0319Populus trichocarpa42.323e-113 370
LLPS-Sol-2048Solanum lycopersicum42.113e-114 371
LLPS-Dac-0125Daucus carota41.282e-115 375