LLPS-Hos-1421
LATS1

▼ OVERVIEW

Status: Reviewed
Protein Name: Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts
Gene Name: LATS1, WARTS
Ensembl Gene: ENSG00000131023.12
Ensembl Protein: ENSP00000444678.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 5BRK (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A10518011, 12372621; 17379520

▼ FUNCTION

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKRSEKPEGY  RQMRPKTFPA  SNYTVSSRQM  LQEIRESLRN  LSKPSDAAKA  EHNMSKMSTE  60
61    DPRQVRNPPK  FGTHHKALQE  IRNSLLPFAN  ETNSSRSTSE  VNPQMLQDLQ  AAGFDEDMVI  120
121   QALQKTNNRS  IEAAIEFISK  MSYQDPRREQ  MAAAAARPIN  ASMKPGNVQQ  SVNRKQSWKG  180
181   SKESLVPQRH  GPPLGESVAY  HSESPNSQTD  VGRPLSGSGI  SAFVQAHPSN  GQRVNPPPPP  240
241   QVRSVTPPPP  PRGQTPPPRG  TTPPPPSWEP  NSQTKRYSGN  MEYVISRISP  VPPGAWQEGY  300
301   PPPPLNTSPM  NPPNQGQRGI  SSVPVGRQPI  IMQSSSKFNF  PSGRPGMQNG  TGQTDFMIHQ  360
361   NVVPAGTVNR  QPPPPYPLTA  ANGQSPSALQ  TGGSAAPSSY  TNGSIPQSMM  VPNRNSHNME  420
421   LYNISVPGLQ  TNWPQSSSAP  AQSSPSSGHE  IPTWQPNIPV  RSNSFNNPLG  NRASHSANSQ  480
481   PSATTVTAIT  PAPIQQPVKS  MRVLKPELQT  ALAPTHPSWI  PQPIQTVQPS  PFPEGTASNV  540
541   TVMPPVAEAP  NYQGPPPPYP  KHLLHQNPSV  PPYESISKPS  KEDQPSLPKE  DESEKSYENV  600
601   DSGDKEKKQI  TTSPITVRKN  KKDEERRESR  IQSYSPQAFK  FFMEQHVENV  LKSHQQRLHR  660
661   KKQLENEMMR  VGLSQDAQDQ  MRKMLCQKES  NYIRLKRAKM  DKSMFVKIKT  LGIGAFGEVC  720
721   LARKVDTKAL  YATKTLRKKD  VLLRNQVAHV  KAERDILAEA  DNEWVVRLYY  SFQDKDNLYF  780
781   VMDYIPGGDM  MSLLIRMGIF  PESLARFYIA  ELTCAVESVH  KMGFIHRDIK  PDNILIDRDG  840
841   HIKLTDFGLC  TGFRWTHDSK  YYQSGDHPRQ  DSMDFSNEWG  DPSSCRCGDR  LKPLERRAAR  900
901   QHQRCLAHSL  VGTPNYIAPE  VLLRTGYTQL  CDWWSVGVIL  FEMLVGQPPF  LAQTPLETQM  960
961   KVINWQTSLH  IPPQAKLSPE  ASDLIIKLCR  GPEDRLGKNG  ADEIKAHPFF  KTIDFSSDLR  1020
1021  QQSASYIPKI  THPTDTSNFD  PVDPDKLWSD  DNEEENVNDT  LNGWYKNGKH  PEHAFYEFTF  1080
1081  RRFFDDNGYP  YNYPKPIEYE  YINSQGSEQQ  SDEDDQNTGS  EIKNRDLVYV  1130
Nucleotide CDS Sequence (FASTA)
1     ATGAAGAGGA  GTGAAAAGCC  AGAAGGATAT  AGACAAATGA  GGCCTAAGAC  CTTTCCTGCC  60
61    AGTAACTATA  CTGTCAGTAG  CCGGCAAATG  TTACAAGAAA  TTCGGGAATC  CCTTAGGAAT  120
121   TTATCTAAAC  CATCTGATGC  TGCTAAGGCT  GAGCATAACA  TGAGTAAAAT  GTCAACCGAA  180
181   GATCCTCGAC  AAGTCAGAAA  TCCACCCAAA  TTTGGGACGC  ATCATAAAGC  CTTGCAGGAA  240
241   ATTCGAAACT  CTCTGCTTCC  ATTTGCAAAT  GAAACAAATT  CTTCTCGGAG  TACTTCAGAA  300
301   GTTAATCCAC  AAATGCTTCA  AGACTTGCAA  GCTGCTGGAT  TTGATGAGGA  TATGGTTATA  360
361   CAAGCTCTTC  AGAAAACTAA  CAACAGAAGT  ATAGAAGCAG  CAATTGAATT  CATTAGTAAA  420
421   ATGAGTTACC  AAGATCCTCG  ACGAGAGCAG  ATGGCTGCAG  CAGCTGCCAG  ACCTATTAAT  480
481   GCCAGCATGA  AACCAGGGAA  TGTGCAGCAA  TCAGTTAACC  GCAAACAGAG  CTGGAAAGGT  540
541   TCTAAAGAAT  CCTTAGTTCC  TCAGAGGCAT  GGCCCGCCAC  TAGGAGAAAG  TGTGGCCTAT  600
601   CATTCTGAGA  GTCCCAACTC  ACAGACAGAT  GTAGGAAGAC  CTTTGTCTGG  ATCTGGTATA  660
661   TCAGCATTTG  TTCAAGCTCA  CCCTAGCAAC  GGACAGAGAG  TGAACCCCCC  ACCACCACCT  720
721   CAAGTAAGGA  GTGTTACTCC  TCCACCACCT  CCAAGAGGCC  AGACTCCCCC  TCCAAGAGGT  780
781   ACAACTCCAC  CTCCCCCTTC  ATGGGAACCA  AACTCTCAAA  CAAAGCGCTA  TTCTGGAAAC  840
841   ATGGAATACG  TAATCTCCCG  AATCTCTCCT  GTCCCACCTG  GGGCATGGCA  AGAGGGCTAT  900
901   CCTCCACCAC  CTCTCAACAC  TTCCCCCATG  AATCCTCCTA  ATCAAGGACA  GAGAGGCATT  960
961   AGTTCTGTTC  CTGTTGGCAG  ACAACCAATC  ATCATGCAGA  GTTCTAGCAA  ATTTAACTTT  1020
1021  CCATCAGGGA  GACCTGGAAT  GCAGAATGGT  ACTGGACAAA  CTGATTTCAT  GATACACCAA  1080
1081  AATGTTGTCC  CTGCTGGCAC  TGTGAATCGG  CAGCCACCAC  CTCCATATCC  TCTGACAGCA  1140
1141  GCTAATGGAC  AAAGCCCTTC  TGCTTTACAA  ACAGGGGGAT  CTGCTGCTCC  TTCGTCATAT  1200
1201  ACAAATGGAA  GTATTCCTCA  GTCTATGATG  GTGCCAAACA  GAAATAGTCA  TAACATGGAA  1260
1261  CTATATAACA  TTAGTGTACC  TGGACTGCAA  ACAAATTGGC  CTCAGTCATC  TTCTGCTCCA  1320
1321  GCCCAGTCAT  CCCCGAGCAG  TGGGCATGAA  ATCCCTACAT  GGCAACCTAA  CATACCAGTG  1380
1381  AGGTCAAATT  CTTTTAATAA  CCCATTAGGA  AATAGAGCAA  GTCACTCTGC  TAATTCTCAG  1440
1441  CCTTCTGCTA  CAACAGTCAC  TGCAATTACA  CCAGCTCCTA  TTCAACAGCC  TGTGAAAAGT  1500
1501  ATGCGTGTAT  TAAAACCAGA  GCTACAGACT  GCTTTAGCAC  CTACACACCC  TTCTTGGATA  1560
1561  CCACAGCCAA  TTCAAACTGT  TCAACCCAGT  CCTTTTCCTG  AGGGAACCGC  TTCAAATGTG  1620
1621  ACTGTGATGC  CACCTGTTGC  TGAAGCTCCA  AACTATCAAG  GACCACCACC  ACCCTACCCA  1680
1681  AAACATCTGC  TGCACCAAAA  CCCATCTGTT  CCTCCATACG  AGTCAATCAG  TAAGCCTAGC  1740
1741  AAAGAGGATC  AGCCAAGCTT  GCCCAAGGAA  GATGAGAGTG  AAAAGAGTTA  TGAAAATGTT  1800
1801  GATAGTGGGG  ATAAAGAAAA  GAAACAGATT  ACAACTTCAC  CTATTACTGT  TAGGAAAAAC  1860
1861  AAGAAAGATG  AAGAGCGAAG  GGAATCTCGT  ATTCAAAGTT  ATTCTCCTCA  AGCATTTAAA  1920
1921  TTCTTTATGG  AGCAACATGT  AGAAAATGTA  CTCAAATCTC  ATCAGCAGCG  TCTACATCGT  1980
1981  AAAAAACAAT  TAGAGAATGA  AATGATGCGG  GTTGGATTAT  CTCAAGATGC  CCAGGATCAA  2040
2041  ATGAGAAAGA  TGCTTTGCCA  AAAAGAATCT  AATTACATCC  GTCTTAAAAG  GGCTAAAATG  2100
2101  GACAAGTCTA  TGTTTGTGAA  GATAAAGACA  CTAGGAATAG  GAGCATTTGG  TGAAGTCTGT  2160
2161  CTAGCAAGAA  AAGTAGATAC  TAAGGCTTTG  TATGCAACAA  AAACTCTTCG  AAAGAAAGAT  2220
2221  GTTCTTCTTC  GAAATCAAGT  CGCTCATGTT  AAGGCTGAGA  GAGATATCCT  GGCTGAAGCT  2280
2281  GACAATGAAT  GGGTAGTTCG  TCTATATTAT  TCATTCCAAG  ATAAGGACAA  TTTATACTTT  2340
2341  GTAATGGACT  ACATTCCTGG  GGGTGATATG  ATGAGCCTAT  TAATTAGAAT  GGGCATCTTT  2400
2401  CCAGAAAGTC  TGGCACGATT  CTACATAGCA  GAACTTACCT  GTGCAGTTGA  AAGTGTTCAT  2460
2461  AAAATGGGTT  TTATTCATAG  AGATATTAAA  CCTGATAATA  TTTTGATTGA  TCGTGATGGT  2520
2521  CATATTAAAT  TGACTGACTT  TGGCCTCTGC  ACTGGCTTCA  GATGGACACA  CGATTCTAAG  2580
2581  TACTATCAGA  GTGGTGACCA  TCCACGGCAA  GATAGCATGG  ATTTCAGTAA  TGAATGGGGG  2640
2641  GATCCCTCAA  GCTGTCGATG  TGGAGACAGA  CTGAAGCCAT  TAGAGCGGAG  AGCTGCACGC  2700
2701  CAGCACCAGC  GATGTCTAGC  ACATTCTTTG  GTTGGGACTC  CCAATTATAT  TGCACCTGAA  2760
2761  GTGTTGCTAC  GAACAGGATA  CACACAGTTG  TGTGATTGGT  GGAGTGTTGG  TGTTATTCTT  2820
2821  TTTGAAATGT  TGGTGGGACA  ACCTCCTTTC  TTGGCACAAA  CACCATTAGA  AACACAAATG  2880
2881  AAGGTTATCA  ACTGGCAAAC  ATCTCTTCAC  ATTCCACCAC  AAGCTAAACT  CAGTCCTGAA  2940
2941  GCTTCTGATC  TTATTATTAA  ACTTTGCCGA  GGACCCGAAG  ATCGCTTAGG  CAAGAATGGT  3000
3001  GCTGATGAAA  TAAAAGCTCA  TCCATTTTTT  AAAACAATTG  ACTTCTCCAG  TGACCTGAGA  3060
3061  CAGCAGTCTG  CTTCATACAT  TCCTAAAATC  ACACACCCAA  CAGATACATC  AAATTTTGAT  3120
3121  CCTGTTGATC  CTGATAAATT  ATGGAGTGAT  GATAACGAGG  AAGAAAATGT  AAATGACACT  3180
3181  CTCAATGGAT  GGTATAAAAA  TGGAAAGCAT  CCTGAACATG  CATTCTATGA  ATTTACCTTC  3240
3241  CGAAGGTTTT  TTGATGACAA  TGGCTACCCA  TATAATTATC  CGAAGCCTAT  TGAATATGAA  3300
3301  TACATTAATT  CACAAGGCTC  AGAGCAGCAG  TCGGATGAAG  ATGATCAAAA  CACAGGCTCA  3360
3361  GAGATTAAAA  ATCGCGATCT  AGTATATGTT  TAA  3393

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
ATP-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Magnesium
Metal-binding
Mitosis
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tumor suppressor

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Microtubule organizing center
Cellular Component
Spindle pole
Molecular Function
ATP binding
Molecular Function
Estrogen receptor binding
Molecular Function
Magnesium ion binding
Molecular Function
Protein kinase binding
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Cell division
Biological Process
Cellular protein localization
Biological Process
Cytoplasmic sequestering of protein
Biological Process
G1/S transition of mitotic cell cycle
Biological Process
G2/M transition of mitotic cell cycle
Biological Process
Hippo signaling
Biological Process
Hormone-mediated signaling pathway
Biological Process
Inner cell mass cell fate commitment
Biological Process
Inner cell mass cellular morphogenesis
Biological Process
Intracellular signal transduction
Biological Process
Keratinocyte differentiation
Biological Process
Mammary gland epithelial cell differentiation
Biological Process
Negative regulation of canonical Wnt signaling pathway
Biological Process
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of peptidyl-serine phosphorylation
Biological Process
Protein phosphorylation
Biological Process
Regulation of actin filament polymerization
Biological Process
Regulation of intracellular estrogen receptor signaling pathway
Biological Process
Regulation of organ growth
Biological Process
Regulation of protein complex assembly
Biological Process
Regulation of ubiquitin-dependent protein catabolic process
Biological Process
Sister chromatid segregation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-2628Mandrillus leucophaeus100.04e-177 554
LLPS-Gog-2075Gorilla gorilla99.730.02097
LLPS-Pap-4303Pan paniscus99.650.02095
LLPS-Pat-2525Pan troglodytes99.650.02095
LLPS-Poa-1002Pongo abelii99.560.02094
LLPS-Nol-3095Nomascus leucogenys99.20.02100
LLPS-Paa-2765Papio anubis99.120.02090
LLPS-Maf-4833Macaca fascicularis99.030.02088
LLPS-Cea-4194Cercocebus atys99.010.01858
LLPS-Man-2144Macaca nemestrina98.850.02083
LLPS-Mam-2541Macaca mulatta98.850.02080
LLPS-Rhb-3719Rhinopithecus bieti98.720.01853
LLPS-Chs-4574Chlorocebus sabaeus98.670.02083
LLPS-Aon-4063Aotus nancymaae98.580.02074
LLPS-Caj-4791Callithrix jacchus98.050.02058
LLPS-Urm-2805Ursus maritimus96.80.01697
LLPS-Fec-0195Felis catus96.730.02001
LLPS-Orc-4328Oryctolagus cuniculus96.30.01476
LLPS-Cas-3613Carlito syrichta96.290.01997
LLPS-Caf-4008Canis familiaris96.280.01996
LLPS-Aim-2285Ailuropoda melanoleuca96.20.02000
LLPS-Eqc-0360Equus caballus96.020.01984
LLPS-Mup-2698Mustela putorius furo95.750.01986
LLPS-Tut-2112Tursiops truncatus95.530.01663
LLPS-Sus-2974Sus scrofa95.40.01994
LLPS-Ict-0070Ictidomys tridecemlineatus95.310.01980
LLPS-Bot-3127Bos taurus94.960.01964
LLPS-Ova-1763Ovis aries94.870.01972
LLPS-Otg-4295Otolemur garnettii94.620.01952
LLPS-Fud-4074Fukomys damarensis94.430.01969
LLPS-Dio-4184Dipodomys ordii94.340.01952
LLPS-Cap-1113Cavia porcellus94.290.01649
LLPS-Myl-3215Myotis lucifugus94.160.01976
LLPS-Loa-4115Loxodonta africana93.90.01950
LLPS-Ran-0920Rattus norvegicus93.540.01956
LLPS-Mum-4184Mus musculus93.10.01941
LLPS-Ere-0204Erinaceus europaeus92.750.01939
LLPS-Mea-4017Mesocricetus auratus89.730.01850
LLPS-Sah-1623Sarcophilus harrisii89.250.01878
LLPS-Mod-4359Monodelphis domestica87.520.01830
LLPS-Ora-3225Ornithorhynchus anatinus86.420.01600
LLPS-Pes-0410Pelodiscus sinensis85.480.01499
LLPS-Gaga-3981Gallus gallus84.530.01806
LLPS-Anp-2276Anas platyrhynchos84.370.01785
LLPS-Meg-0797Meleagris gallopavo83.770.01801
LLPS-Fia-2623Ficedula albicollis83.760.01802
LLPS-Tag-0627Taeniopygia guttata83.580.01783
LLPS-Anc-1601Anolis carolinensis82.220.01745
LLPS-Lac-1182Latimeria chalumnae79.290.01695
LLPS-Drm-1241Drosophila melanogaster73.440.0 665
LLPS-Scf-2945Scleropages formosus73.040.0 645
LLPS-Xet-3885Xenopus tropicalis72.120.01234
LLPS-Leo-1076Lepisosteus oculatus67.470.01348
LLPS-Asm-2514Astyanax mexicanus65.630.01321
LLPS-Tar-0094Takifugu rubripes64.580.01265
LLPS-Icp-3189Ictalurus punctatus64.470.01255
LLPS-Gaa-2256Gasterosteus aculeatus64.250.01272
LLPS-Cii-2222Ciona intestinalis63.681e-161 493
LLPS-Ten-1424Tetraodon nigroviridis62.30.01199
LLPS-Scm-0065Scophthalmus maximus62.140.0 846
LLPS-Orl-1788Oryzias latipes62.120.01158
LLPS-Dar-3120Danio rerio61.880.01216
LLPS-Xim-0344Xiphophorus maculatus61.570.0 847
LLPS-Pof-2522Poecilia formosa60.760.0 848
LLPS-Orn-1174Oreochromis niloticus60.520.0 848
LLPS-Cae-1695Caenorhabditis elegans50.323e-140 453
LLPS-Tum-0580Tuber melanosporum47.776e-121 391
LLPS-Sei-0767Setaria italica46.849e-116 377
LLPS-Sob-1641Sorghum bicolor46.61e-114 374
LLPS-Viv-0664Vitis vinifera45.75e-113 369
LLPS-Coc-0256Corchorus capsularis45.71e-114 374
LLPS-Glm-2155Glycine max45.571e-114 374
LLPS-Org-1517Oryza glaberrima45.417e-113 369
LLPS-Met-2043Medicago truncatula44.712e-113 370
LLPS-Yal-0600Yarrowia lipolytica44.475e-114 373
LLPS-Cus-0345Cucumis sativus43.796e-117 380
LLPS-Prp-0533Prunus persica43.541e-114 374
LLPS-Nia-2390Nicotiana attenuata42.863e-117 379
LLPS-Gor-1558Gossypium raimondii42.462e-115 375
LLPS-Mae-1038Manihot esculenta42.377e-114 372
LLPS-Pot-0319Populus trichocarpa42.323e-113 370
LLPS-Sot-0511Solanum tuberosum42.323e-115 374
LLPS-Sol-2048Solanum lycopersicum41.675e-114 371
LLPS-Dac-0125Daucus carota41.352e-114 373