LLPS-Mum-2551
Tubgcp4

▼ OVERVIEW

Status: Reviewed
Protein Name: Gamma-tubulin complex component 4
Gene Name: Tubgcp4, D2Ertd435e, Gcp4
Ensembl Gene: ENSMUSG00000027263.12
Ensembl Protein: ENSMUSP00000106286.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A15784680

▼ FUNCTION

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MIHELLLALS  GYPGSIFTWN  KRSGLQVSQD  FPFLHPSETS  VLNRLCRLGT  DYIRFTEFIE  60
61    QYTGHVQQQD  HHPPQQGQGG  LHGIYLRAFC  TGLDSVLQPY  RQALLDLEQE  FLADPHLSIS  120
121   HVNYSLDQFQ  LLFPSVMVVV  EQIKSQKIHG  CQILETVYKH  SCGGLPPVRS  ALEKILAVCH  180
181   GVMYKQLSAW  MLHGLLLDQH  EEFFIKQGPS  SGTLSAQLEE  DEEDLGIGGL  TGKQLRELQD  240
241   LRLIEEENML  APSLKQFSLR  VEILPSYIPV  RVAEKILFVG  ESVQMFENQN  VNLTRKGSIL  300
301   KNQEDTFAAE  LHRLKQQPLF  SLVDFEQVVD  RIRSTVAEHL  WKLMVEESDL  LGQLKIIKDF  360
361   YLLGRGELFQ  AFIDTAQHML  KTPPTAVTEH  DVNVAFQQSA  HKVLLDDDNL  LPLLHLTIEY  420
421   HGKDHKADAT  QPREVPSRET  SPREAPSSGW  AALGLSYKVQ  WPLHILFTPA  VLEKYNVVFK  480
481   YLLSVRRVQA  ELQHCWALQM  QRKHLKSNQT  DAVKWRLRNH  MAFLVDNLQY  YLQVDVLESQ  540
541   FSQLLHQINS  TRDFESIRLA  HDHFLSNLLA  QSFILLKPVF  HCLNEILDLC  HSFCSLVSQN  600
601   LGPLDERGAA  QLSILVKGFS  RQSSLLFKIL  SSVRNHQINS  DLAQLLLRLD  YNKYYTQAGG  660
661   TLGSFGM  667
Nucleotide CDS Sequence (FASTA)
1     ATGATTCACG  AACTGCTCTT  GGCCCTGAGT  GGGTACCCAG  GGTCCATTTT  CACCTGGAAC  60
61    AAGCGGAGTG  GCCTGCAGGT  TTCCCAGGAT  TTTCCATTTC  TTCACCCCAG  TGAGACTAGT  120
121   GTCCTGAATC  GACTCTGCCG  GCTTGGCACA  GACTACATTC  GATTCACTGA  GTTCATTGAA  180
181   CAGTATACAG  GCCATGTGCA  GCAACAGGAC  CACCATCCTC  CCCAGCAGGG  CCAAGGGGGA  240
241   CTGCATGGGA  TCTACCTGAG  AGCCTTCTGC  ACAGGGCTGG  ATTCAGTTTT  GCAGCCGTAT  300
301   CGCCAAGCAC  TGCTTGATTT  GGAACAAGAG  TTCCTGGCTG  ACCCGCATCT  CTCCATATCA  360
361   CATGTCAATT  ACTCCTTAGA  TCAGTTCCAG  CTCCTTTTCC  CCTCTGTGAT  GGTTGTAGTG  420
421   GAGCAAATTA  AAAGCCAAAA  GATTCATGGC  TGTCAAATCC  TGGAAACAGT  TTACAAACAT  480
481   AGCTGTGGGG  GCTTGCCTCC  AGTCCGAAGC  GCATTAGAAA  AAATCCTGGC  TGTGTGCCAT  540
541   GGAGTCATGT  ATAAACAGCT  CTCAGCCTGG  ATGCTGCATG  GACTCCTTTT  GGATCAGCAT  600
601   GAAGAGTTCT  TCATCAAACA  GGGCCCATCT  TCTGGTACTC  TCAGTGCGCA  GCTGGAAGAG  660
661   GATGAGGAGG  ACCTGGGCAT  TGGAGGCCTG  ACAGGAAAAC  AGCTGAGAGA  ACTGCAGGAC  720
721   CTGCGCCTAA  TTGAGGAAGA  GAATATGCTG  GCCCCATCTC  TGAAGCAGTT  TTCGCTGAGG  780
781   GTAGAGATTT  TACCATCATA  CATTCCAGTG  AGAGTTGCTG  AAAAAATCCT  CTTTGTTGGA  840
841   GAATCTGTCC  AAATGTTTGA  GAATCAAAAT  GTGAACCTGA  CAAGGAAAGG  GTCCATCTTG  900
901   AAAAACCAGG  AGGACACATT  CGCTGCCGAG  CTGCACCGGC  TCAAGCAGCA  GCCACTCTTC  960
961   AGCCTGGTGG  ATTTTGAGCA  GGTGGTAGAT  CGGATTCGTA  GCACTGTGGC  TGAGCACCTC  1020
1021  TGGAAGCTAA  TGGTGGAAGA  GTCAGATTTA  CTGGGTCAGC  TGAAGATCAT  TAAAGACTTT  1080
1081  TACCTGCTGG  GACGAGGAGA  ACTGTTCCAG  GCCTTCATTG  ACACAGCTCA  GCACATGTTG  1140
1141  AAAACACCAC  CCACTGCAGT  AACAGAGCAT  GATGTGAATG  TGGCCTTTCA  ACAGTCAGCA  1200
1201  CACAAGGTGT  TGCTAGATGA  CGACAACCTT  CTCCCTCTGT  TGCACCTGAC  GATTGAGTAT  1260
1261  CATGGGAAGG  ACCACAAAGC  AGATGCCACC  CAGCCAAGAG  AAGTGCCTTC  TCGGGAGACA  1320
1321  TCCCCCCGGG  AAGCTCCTTC  TTCCGGCTGG  GCTGCTCTAG  GGCTTTCCTA  CAAAGTACAG  1380
1381  TGGCCACTGC  ACATTCTCTT  CACCCCAGCT  GTCTTGGAAA  AGTACAATGT  TGTTTTTAAG  1440
1441  TACTTACTGA  GTGTGCGCCG  TGTCCAAGCT  GAACTGCAGC  ACTGCTGGGC  ACTCCAGATG  1500
1501  CAGCGCAAAC  ACCTCAAATC  TAACCAGACG  GACGCAGTCA  AGTGGCGCCT  AAGAAACCAC  1560
1561  ATGGCCTTCT  TGGTAGATAA  TCTTCAGTAC  TATCTCCAGG  TAGATGTGCT  GGAGTCTCAG  1620
1621  TTCTCACAGC  TGCTTCATCA  GATCAATTCT  ACGAGGGACT  TTGAAAGCAT  CCGATTGGCA  1680
1681  CACGACCACT  TCCTAAGCAA  TCTGCTGGCC  CAATCCTTTA  TTTTGCTGAA  GCCTGTGTTT  1740
1741  CACTGCCTGA  ATGAAATCCT  AGATCTCTGT  CACAGTTTTT  GTTCACTGGT  CAGTCAGAAC  1800
1801  CTAGGTCCAC  TGGATGAGCG  CGGAGCGGCC  CAGCTGAGCA  TTCTCGTGAA  GGGCTTTAGT  1860
1861  CGCCAGTCTT  CACTCCTGTT  CAAGATTCTT  TCCAGTGTTC  GGAATCACCA  GATCAACTCA  1920
1921  GATTTGGCTC  AGTTACTGCT  CCGGCTAGAC  TATAATAAAT  ACTATACCCA  GGCTGGTGGG  1980
1981  ACTCTGGGCA  GTTTTGGGAT  GTAA  2004

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoskeleton
Microtubule
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Equatorial microtubule organizing center
Cellular Component
Gamma-tubulin complex
Cellular Component
Microtubule
Cellular Component
Recycling endosome
Cellular Component
Spindle pole
Molecular Function
Gamma-tubulin binding
Biological Process
Cytoplasmic microtubule organization
Biological Process
Meiotic cell cycle
Biological Process
Microtubule nucleation by interphase microtubule organizing center
Biological Process
Mitotic cell cycle
Biological Process
Spindle assembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1235Rattus norvegicus99.10.01242
LLPS-Mea-3102Mesocricetus auratus98.950.01244
LLPS-Mam-3674Macaca mulatta98.50.01237
LLPS-Fec-0948Felis catus98.50.01233
LLPS-Man-2354Macaca nemestrina98.50.01237
LLPS-Mal-1936Mandrillus leucophaeus98.50.01237
LLPS-Maf-0543Macaca fascicularis98.50.01237
LLPS-Cea-3254Cercocebus atys98.50.01237
LLPS-Caf-0709Canis familiaris98.350.01232
LLPS-Cas-0021Carlito syrichta98.350.01233
LLPS-Pap-2134Pan paniscus98.350.01234
LLPS-Hos-0470Homo sapiens98.350.01234
LLPS-Aim-3361Ailuropoda melanoleuca98.350.01229
LLPS-Paa-3256Papio anubis98.350.01234
LLPS-Aon-3297Aotus nancymaae98.350.01233
LLPS-Caj-0684Callithrix jacchus98.350.01236
LLPS-Rhb-0833Rhinopithecus bieti98.340.01228
LLPS-Chs-0699Chlorocebus sabaeus98.340.01221
LLPS-Eqc-1307Equus caballus98.20.01230
LLPS-Nol-2176Nomascus leucogenys98.20.01234
LLPS-Pat-1056Pan troglodytes98.20.01229
LLPS-Sus-1487Sus scrofa98.20.01228
LLPS-Gog-0849Gorilla gorilla98.20.01233
LLPS-Poa-1679Pongo abelii98.180.01214
LLPS-Ict-0457Ictidomys tridecemlineatus98.050.01231
LLPS-Bot-1242Bos taurus98.050.01224
LLPS-Mup-1865Mustela putorius furo97.750.01222
LLPS-Orc-1716Oryctolagus cuniculus97.60.01220
LLPS-Ova-2292Ovis aries97.60.01226
LLPS-Myl-1949Myotis lucifugus97.60.01220
LLPS-Dio-0561Dipodomys ordii97.350.01170
LLPS-Cap-1185Cavia porcellus97.150.01218
LLPS-Fud-0287Fukomys damarensis96.850.01214
LLPS-Mod-1575Monodelphis domestica96.710.01212
LLPS-Sah-2607Sarcophilus harrisii96.560.01219
LLPS-Loa-1847Loxodonta africana96.250.01209
LLPS-Otg-0156Otolemur garnettii96.10.01192
LLPS-Tut-0069Tursiops truncatus95.950.01189
LLPS-Anp-0626Anas platyrhynchos95.210.01077
LLPS-Fia-0934Ficedula albicollis94.00.01186
LLPS-Pes-0359Pelodiscus sinensis93.950.01106
LLPS-Meg-0738Meleagris gallopavo93.890.01163
LLPS-Gaga-0793Gallus gallus93.550.01183
LLPS-Tag-0450Taeniopygia guttata93.270.01170
LLPS-Xet-1395Xenopus tropicalis91.750.01157
LLPS-Scf-3663Scleropages formosus88.170.01114
LLPS-Icp-0646Ictalurus punctatus88.020.01115
LLPS-Leo-2388Lepisosteus oculatus86.830.01110
LLPS-Orn-0012Oreochromis niloticus86.680.01108
LLPS-Tar-2584Takifugu rubripes86.060.01099
LLPS-Ten-1157Tetraodon nigroviridis85.650.01097
LLPS-Gaa-3005Gasterosteus aculeatus85.590.01096
LLPS-Scm-1978Scophthalmus maximus85.440.01086
LLPS-Xim-0494Xiphophorus maculatus85.310.01087
LLPS-Pof-2013Poecilia formosa85.160.01085
LLPS-Orl-0742Oryzias latipes84.430.01059
LLPS-Dar-0541Danio rerio84.220.01102
LLPS-Asm-0648Astyanax mexicanus84.110.01053
LLPS-Lac-2295Latimeria chalumnae82.320.01019
LLPS-Ora-0944Ornithorhynchus anatinus80.710.0 948
LLPS-Anc-2077Anolis carolinensis74.720.0 952
LLPS-Cis-1008Ciona savignyi42.184e-159 480
LLPS-Cii-0374Ciona intestinalis42.153e-159 481
LLPS-Sot-0612Solanum tuberosum34.731e-36 144
LLPS-Via-1384Vigna angularis33.83e-52 192
LLPS-Sem-2401Selaginella moellendorffii32.971e-110 357
LLPS-Cus-1486Cucumis sativus32.418e-60 215
LLPS-Php-1286Physcomitrella patens31.662e-105 343
LLPS-Brr-0619Brassica rapa31.281e-87 301
LLPS-Hea-1240Helianthus annuus31.121e-87 295
LLPS-Dac-1055Daucus carota30.874e-56 208
LLPS-Hov-1220Hordeum vulgare30.736e-92 308
LLPS-Tra-1435Triticum aestivum30.632e-91 306
LLPS-Nia-0972Nicotiana attenuata30.622e-55 209
LLPS-Orbr-0755Oryza brachyantha30.491e-92 310
LLPS-Brd-0133Brachypodium distachyon30.452e-92 309
LLPS-Viv-2162Vitis vinifera30.412e-89 301
LLPS-Sei-1038Setaria italica30.322e-96 320
LLPS-Art-1056Arabidopsis thaliana30.244e-94 313
LLPS-Phv-0676Phaseolus vulgaris30.231e-87 295
LLPS-Sob-0065Sorghum bicolor30.185e-95 316
LLPS-Org-0632Oryza glaberrima30.172e-94 315
LLPS-Ori-0020Oryza indica30.173e-94 314
LLPS-Arl-1202Arabidopsis lyrata30.11e-93 312
LLPS-Abg-0473Absidia glauca30.042e-1997.1
LLPS-Ors-0104Oryza sativa30.032e-93 312
LLPS-Mua-0902Musa acuminata30.037e-94 313
LLPS-Gor-2487Gossypium raimondii29.894e-90 304
LLPS-Amt-1264Amborella trichopoda29.843e-87 295
LLPS-Glm-0439Glycine max29.616e-85 288
LLPS-Brn-0492Brassica napus29.561e-91 306
LLPS-Bro-1151Brassica oleracea29.322e-90 303
LLPS-Pot-1980Populus trichocarpa28.975e-87 294
LLPS-Orm-1440Oryza meridionalis28.921e-75 264
LLPS-Prp-1929Prunus persica28.917e-88 296
LLPS-Mae-1591Manihot esculenta28.877e-84 286
LLPS-Thc-0963Theobroma cacao28.723e-88 298
LLPS-Lep-1252Leersia perrieri28.72e-78 271
LLPS-Vir-1083Vigna radiata28.683e-77 268
LLPS-Coc-0992Corchorus capsularis28.635e-88 297
LLPS-Met-1250Medicago truncatula28.594e-80 276
LLPS-Sol-0606Solanum lycopersicum28.554e-82 281
LLPS-Orr-0157Oryza rufipogon28.491e-80 276
LLPS-Orgl-1364Oryza glumaepatula28.491e-80 276
LLPS-Orb-0608Oryza barthii28.491e-80 276
LLPS-Orni-0262Oryza nivara28.491e-80 276
LLPS-Orp-0582Oryza punctata28.111e-77 268
LLPS-Chr-0197Chlamydomonas reinhardtii27.852e-56 209
LLPS-Zem-0633Zea mays27.637e-78 271
LLPS-Drm-0393Drosophila melanogaster27.269e-60 218
LLPS-Osl-0644Ostreococcus lucimarinus25.332e-54 202
LLPS-Mel-0513Melampsora laricipopulina22.987e-2098.2
LLPS-Pug-0208Puccinia graminis22.782e-22 107
LLPS-Yal-0390Yarrowia lipolytica22.51e-21 103
LLPS-Gas-0384Galdieria sulphuraria22.373e-40 159
LLPS-Scp-0038Schizosaccharomyces pombe22.182e-1894.4
LLPS-Urm-0061Ursus maritimus19.334e-1686.7