LLPS-Mum-0072
Polr1c

▼ OVERVIEW

Status: Reviewed
Protein Name: DNA-directed RNA polymerases I and III subunit RPAC1
Gene Name: Polr1c, Rpo1-1
Ensembl Gene: ENSMUSG00000067148.15
Ensembl Protein: ENSMUSP00000133597.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body, Stress granule, OthersPredicted from orthologsN/A(View)

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAQAVEEM  RTRVVLGEFG  VRNVHTTDFP  GNYAGYDDAW  DQNRFEKNFR  VDVVQMDEDT  60
61    LEFDMVGIDA  AIANAFRRIL  LAEVPTMAVE  KVLVYNNTSI  VQDEILAHRL  GLIPILADPR  120
121   LFEYRNQGEE  EGTEIDTLQF  RLQVRCTRNP  NAAKDSSDPN  ELYVNHKVYT  RHMTWVPLGN  180
181   QADVFPEGTI  RPVHDDILIA  QLRPGQEIDL  MMHCVKGIGK  DHAKFSPVAT  ASYRLLPAIT  240
241   LLEPVEGEAA  EELSQCFSPG  VIEVEEVQGK  KVARVANARL  DTFSREIFRH  EKLKKAVRLA  300
301   RVRDHYIFSV  ESTGVLPPDV  LVSEAIKILM  GKCRRFLDEL  DAVEMD  346
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGG  CTCAGGCGGT  GGAGGAGATG  CGGACTCGCG  TGGTTCTCGG  AGAGTTTGGG  60
61    GTTCGCAATG  TCCACACCAC  GGACTTTCCC  GGTAACTACG  CCGGTTATGA  TGATGCCTGG  120
121   GACCAGAACC  GCTTCGAGAA  GAATTTCCGT  GTGGACGTGG  TGCAAATGGA  TGAAGACACG  180
181   CTGGAGTTCG  ACATGGTGGG  GATTGATGCT  GCCATCGCCA  ATGCTTTCCG  GAGAATCCTG  240
241   TTAGCTGAGG  TGCCGACAAT  GGCCGTGGAG  AAGGTCTTGG  TGTATAACAA  CACGTCCATA  300
301   GTCCAGGATG  AGATCCTTGC  TCACCGCCTG  GGGCTCATCC  CCATCCTCGC  TGATCCTCGT  360
361   CTCTTTGAAT  ATCGGAACCA  AGGAGAGGAG  GAAGGAACAG  AGATAGACAC  GCTGCAGTTC  420
421   CGGCTGCAGG  TCAGGTGTAC  CAGGAACCCC  AATGCTGCCA  AGGATTCCTC  AGACCCCAAT  480
481   GAACTCTATG  TCAACCATAA  AGTCTACACC  AGGCATATGA  CATGGGTCCC  CTTGGGAAAT  540
541   CAGGCTGATG  TCTTCCCAGA  GGGCACAATC  CGTCCAGTGC  ACGACGACAT  CCTCATCGCT  600
601   CAGCTTCGGC  CTGGCCAGGA  AATTGACTTG  ATGATGCATT  GCGTCAAGGG  CATTGGCAAA  660
661   GACCATGCCA  AGTTCTCACC  AGTGGCCACA  GCCAGCTACA  GACTGCTACC  GGCCATCACT  720
721   CTGCTTGAGC  CTGTGGAAGG  AGAAGCGGCT  GAGGAGCTGA  GCCAGTGTTT  CTCCCCTGGC  780
781   GTGATTGAGG  TGGAGGAAGT  ACAAGGTAAA  AAGGTGGCCA  GGGTGGCCAA  TGCTCGGCTG  840
841   GATACCTTCA  GCAGGGAAAT  CTTCCGGCAT  GAGAAACTCA  AGAAGGCTGT  GCGGCTTGCC  900
901   CGGGTTCGGG  ACCATTATAT  CTTTTCTGTG  GAGTCTACTG  GAGTTTTGCC  ACCAGATGTG  960
961   TTGGTGAGTG  AAGCCATCAA  GATCCTGATG  GGGAAGTGCC  GGCGGTTCTT  GGATGAACTG  1020
1021  GATGCAGTTG  AGATGGACTG  A  1041

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
DNA-directed RNA polymerase
Nucleus
Reference proteome
Transcription

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
RNA polymerase I complex
Cellular Component
RNA polymerase III complex
Molecular Function
DNA binding
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Molecular Function
Protein dimerization activity
Biological Process
Transcription by RNA polymerase I
Biological Process
Transcription by RNA polymerase III

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1242Rattus norvegicus97.110.0 695
LLPS-Mea-0280Mesocricetus auratus96.530.0 693
LLPS-Ict-1899Ictidomys tridecemlineatus95.660.0 689
LLPS-Myl-0961Myotis lucifugus94.510.0 681
LLPS-Cas-0060Carlito syrichta93.930.0 677
LLPS-Cap-0472Cavia porcellus93.930.0 679
LLPS-Orc-0384Oryctolagus cuniculus93.930.0 679
LLPS-Hos-2159Homo sapiens93.930.0 680
LLPS-Pat-0287Pan troglodytes93.930.0 680
LLPS-Pap-0728Pan paniscus93.930.0 680
LLPS-Urm-0152Ursus maritimus93.930.0 677
LLPS-Paa-2288Papio anubis93.930.0 680
LLPS-Mup-1468Mustela putorius furo93.930.0 677
LLPS-Gog-0513Gorilla gorilla93.930.0 680
LLPS-Cea-1040Cercocebus atys93.930.0 680
LLPS-Poa-2772Pongo abelii93.640.0 678
LLPS-Mam-3012Macaca mulatta93.640.0 677
LLPS-Rhb-1174Rhinopithecus bieti93.640.0 679
LLPS-Man-0396Macaca nemestrina93.640.0 678
LLPS-Mal-0572Mandrillus leucophaeus93.640.0 676
LLPS-Dio-0379Dipodomys ordii93.640.0 676
LLPS-Fud-1041Fukomys damarensis93.640.0 675
LLPS-Maf-0562Macaca fascicularis93.640.0 678
LLPS-Aon-0025Aotus nancymaae93.640.0 681
LLPS-Caf-1355Canis familiaris93.350.0 677
LLPS-Ere-0166Erinaceus europaeus93.350.0 674
LLPS-Caj-1804Callithrix jacchus93.350.0 678
LLPS-Chs-2325Chlorocebus sabaeus93.350.0 677
LLPS-Otg-1631Otolemur garnettii93.10.0 671
LLPS-Aim-2483Ailuropoda melanoleuca93.060.0 672
LLPS-Ova-0751Ovis aries93.060.0 672
LLPS-Loa-0181Loxodonta africana93.020.0 576
LLPS-Eqc-1243Equus caballus92.770.0 672
LLPS-Fec-1689Felis catus92.770.0 669
LLPS-Bot-0027Bos taurus92.770.0 672
LLPS-Sus-0094Sus scrofa92.490.0 670
LLPS-Nol-0421Nomascus leucogenys91.910.0 660
LLPS-Mod-1612Monodelphis domestica89.00.0 553
LLPS-Ora-0078Ornithorhynchus anatinus84.970.0 631
LLPS-Tag-0989Taeniopygia guttata82.830.0 590
LLPS-Pes-0148Pelodiscus sinensis82.660.0 618
LLPS-Fia-0926Ficedula albicollis82.350.0 571
LLPS-Gaga-0717Gallus gallus82.080.0 607
LLPS-Anc-0838Anolis carolinensis82.080.0 531
LLPS-Anp-0491Anas platyrhynchos82.00.0 515
LLPS-Sah-1950Sarcophilus harrisii80.640.0 577
LLPS-Meg-0890Meleagris gallopavo78.016e-171 484
LLPS-Xet-0786Xenopus tropicalis77.810.0 569
LLPS-Leo-0342Lepisosteus oculatus75.470.0 526
LLPS-Scf-0423Scleropages formosus74.490.0 566
LLPS-Icp-1707Ictalurus punctatus74.180.0 553
LLPS-Scm-0841Scophthalmus maximus73.040.0 550
LLPS-Asm-0135Astyanax mexicanus72.750.0 553
LLPS-Ten-0112Tetraodon nigroviridis72.441e-60 197
LLPS-Orn-1493Oreochromis niloticus72.210.0 536
LLPS-Pof-0330Poecilia formosa72.080.0 547
LLPS-Xim-2365Xiphophorus maculatus71.790.0 547
LLPS-Dar-1172Danio rerio71.760.0 548
LLPS-Orl-0725Oryzias latipes69.570.0 521
LLPS-Tar-0813Takifugu rubripes69.250.0 535
LLPS-Gaa-0094Gasterosteus aculeatus66.299e-174 495
LLPS-Lac-0286Latimeria chalumnae61.455e-141 410
LLPS-Drm-0991Drosophila melanogaster54.785e-124 367
LLPS-Cii-0396Ciona intestinalis54.495e-142 413
LLPS-Abg-0941Absidia glauca51.189e-127 375
LLPS-Scp-0341Schizosaccharomyces pombe51.166e-120 357
LLPS-Pug-0074Puccinia graminis50.792e-109 331
LLPS-Tum-0270Tuber melanosporum50.625e-105 320
LLPS-Mel-0232Melampsora laricipopulina49.853e-111 335
LLPS-Put-0184Puccinia triticina49.521e-104 319
LLPS-Gor-0314Gossypium raimondii49.57e-88 273
LLPS-Crn-0311Cryptococcus neoformans49.222e-109 330
LLPS-Scj-0024Schizosaccharomyces japonicus48.491e-108 328
LLPS-Thc-1546Theobroma cacao48.014e-96 297
LLPS-Spr-0186Sporisorium reilianum47.985e-111 336
LLPS-Mae-0069Manihot esculenta47.975e-95 294
LLPS-Cae-0103Caenorhabditis elegans47.882e-103 315
LLPS-Scc-0753Schizosaccharomyces cryophilus47.521e-112 338
LLPS-Usm-0914Ustilago maydis47.381e-109 332
LLPS-Cogr-1107Colletotrichum graminicola47.192e-106 323
LLPS-Sol-0491Solanum lycopersicum47.163e-96 298
LLPS-Coo-0821Colletotrichum orbiculare47.084e-110 333
LLPS-Sac-0408Saccharomyces cerevisiae46.984e-105 319
LLPS-Sot-0477Solanum tuberosum46.886e-97 300
LLPS-Sem-1665Selaginella moellendorffii46.881e-94 292
LLPS-Kop-0270Komagataella pastoris46.671e-99 305
LLPS-Asg-0057Ashbya gossypii46.673e-100 307
LLPS-Asn-0130Aspergillus nidulans46.636e-105 320
LLPS-Arl-0255Arabidopsis lyrata46.481e-84 267
LLPS-Coc-0546Corchorus capsularis46.443e-92 287
LLPS-Glm-0244Glycine max46.159e-91 284
LLPS-Nia-1512Nicotiana attenuata46.024e-94 293
LLPS-Nec-1035Neurospora crassa45.983e-101 310
LLPS-Asfu-0587Aspergillus fumigatus45.947e-103 314
LLPS-Art-2556Arabidopsis thaliana45.884e-91 285
LLPS-Php-0183Physcomitrella patens45.764e-96 296
LLPS-Asf-0377Aspergillus flavus45.719e-103 314
LLPS-Aso-0670Aspergillus oryzae45.719e-103 314
LLPS-Viv-1197Vitis vinifera45.684e-93 289
LLPS-Nef-0319Neosartorya fischeri45.661e-101 311
LLPS-Asni-0319Aspergillus niger45.573e-98 302
LLPS-Fus-0797Fusarium solani45.327e-91 284
LLPS-Ast-0099Aspergillus terreus45.32e-100 308
LLPS-Cus-0001Cucumis sativus45.222e-87 275
LLPS-Mua-1653Musa acuminata45.229e-87 273
LLPS-Cog-0270Colletotrichum gloeosporioides45.132e-101 310
LLPS-Ved-0373Verticillium dahliae44.924e-98 302
LLPS-Asc-0155Aspergillus clavatus44.823e-100 308
LLPS-Map-0655Magnaporthe poae44.794e-92 287
LLPS-Yal-0044Yarrowia lipolytica44.756e-90 280
LLPS-Bro-0336Brassica oleracea44.714e-85 269
LLPS-Brr-1977Brassica rapa44.711e-85 270
LLPS-Brn-1555Brassica napus44.711e-85 270
LLPS-Phn-0236Phaeosphaeria nodorum44.583e-91 283
LLPS-Gas-0006Galdieria sulphuraria44.567e-71 229
LLPS-Blg-0148Blumeria graminis44.515e-90 281
LLPS-Pot-0647Populus trichocarpa44.484e-95 295
LLPS-Fuo-0562Fusarium oxysporum44.448e-88 276
LLPS-Fuv-0112Fusarium verticillioides44.446e-88 276
LLPS-Lep-0216Leersia perrieri44.382e-79 254
LLPS-Lem-1225Leptosphaeria maculans44.145e-98 302
LLPS-Prp-1946Prunus persica44.12e-86 273
LLPS-Orp-0434Oryza punctata44.032e-78 251
LLPS-Chc-0227Chondrus crispus43.981e-80 257
LLPS-Phv-0517Phaseolus vulgaris43.872e-86 273
LLPS-Pytr-0600Pyrenophora triticirepentis43.821e-95 296
LLPS-Via-1077Vigna angularis43.752e-87 275
LLPS-Gag-0275Gaeumannomyces graminis43.667e-89 278
LLPS-Zyt-0168Zymoseptoria tritici43.657e-91 287
LLPS-Vir-0430Vigna radiata43.591e-85 271
LLPS-Miv-0052Microbotryum violaceum43.577e-95 293
LLPS-Amt-0638Amborella trichopoda43.492e-68 223
LLPS-Orbr-0191Oryza brachyantha43.473e-81 259
LLPS-Trr-0337Trichoderma reesei43.275e-87 273
LLPS-Org-0040Oryza glaberrima43.021e-78 252
LLPS-Orr-0273Oryza rufipogon43.023e-77 249
LLPS-Ors-0914Oryza sativa43.021e-78 252
LLPS-Orni-0930Oryza nivara43.023e-77 249
LLPS-Orb-0910Oryza barthii43.023e-77 249
LLPS-Orgl-1779Oryza glumaepatula42.94e-76 248
LLPS-Scs-0086Sclerotinia sclerotiorum42.861e-94 293
LLPS-Ori-0111Oryza indica42.822e-78 251
LLPS-Met-1180Medicago truncatula42.473e-86 272
LLPS-Pyt-0261Pyrenophora teres42.471e-93 291
LLPS-Trv-0347Trichoderma virens42.452e-85 269
LLPS-Beb-0575Beauveria bassiana42.383e-87 275
LLPS-Tru-0886Triticum urartu42.143e-71 244
LLPS-Hea-0043Helianthus annuus42.063e-87 274
LLPS-Tra-0326Triticum aestivum41.913e-79 253
LLPS-Hov-0047Hordeum vulgare41.761e-78 253
LLPS-Dos-0046Dothistroma septosporum41.691e-83 265
LLPS-Zem-0476Zea mays41.626e-81 258
LLPS-Mao-0872Magnaporthe oryzae41.552e-91 285
LLPS-Brd-0536Brachypodium distachyon41.455e-78 250
LLPS-Sob-0988Sorghum bicolor41.342e-81 259
LLPS-Sei-0057Setaria italica41.231e-81 259
LLPS-Dac-0023Daucus carota39.324e-57 192
LLPS-Osl-0622Ostreococcus lucimarinus39.122e-76 246
LLPS-Chr-0173Chlamydomonas reinhardtii37.472e-69 229
LLPS-Cym-0628Cyanidioschyzon merolae31.255e-42 156