• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-3682
ATP6V1H

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: V-type proton ATPase subunit H
Gene Name: ATP6V1H
Ensembl Gene: ENSMODG00000009431.3
Ensembl Protein: ENSMODP00000011785.3
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMODT00000012008.3ENSMODP00000011785.3
UniProtF7BKR7, F7BKR7_MONDO

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTKMDIRGAV  DAAVPTNIIA  AKAAEVRANK  VNWQSYLQGQ  MISGEDCEFI  QRFEMKRSPE  60
61    EMQEMLQTEG  SQCAKTFINL  MTHISKEQTV  QYILTLVDDM  LQENHQRVSI  FFDYAKRSKT  120
121   TAWSYFLPML  NRQDLFTVHM  AARIIAKLAV  WGKELMEGSD  LNYYFNWIKT  QLSSQKLLGS  180
181   SIALDAGTTG  GANESSQYVQ  CVAGCLQLML  RVNEYRFAWV  EADGVNCIMG  VLSNKCGFQL  240
241   QYQMIFSIWL  LAFSPQMCEH  LRCYNIIPVL  SDILQESVKE  KVTRIILAAF  RNLLEKSTEK  300
301   ETRQEYALAM  IQCKVLKQLE  NLDQQKYDDE  DISEDIKFLL  NKLGESVQDL  SSFDEYSSEL  360
361   KSGRLEWSPV  HKSEKFWREN  AIRLNEKNYE  LLKILTKLLE  VSDDPQVLAV  AAHDVGEYVR  420
421   HYPRGKRVIE  QLGGKQLVMN  HMHHEDQQVR  YNALLAVQKL  MVHNCISLCQ  YVGSNKGTTS  480
481   DTSFGISW  488
Nucleotide CDS Sequence (FASTA)
1     ATGACCAAAA  TGGATATTCG  AGGTGCTGTG  GATGCTGCTG  TCCCAACAAA  CATCATTGCT  60
61    GCAAAGGCTG  CAGAAGTTCG  GGCCAACAAA  GTAAACTGGC  AGTCTTATCT  TCAGGGACAG  120
121   ATGATTTCAG  GTGAAGATTG  TGAATTTATC  CAAAGGTTTG  AGATGAAAAG  AAGTCCAGAA  180
181   GAGATGCAAG  AAATGCTTCA  AACTGAAGGC  AGCCAGTGTG  CCAAAACATT  TATAAACTTA  240
241   ATGACTCACA  TCTCCAAAGA  ACAGACAGTT  CAATACATAC  TAACCCTGGT  TGATGATATG  300
301   CTTCAGGAAA  ATCACCAACG  TGTTAGCATT  TTCTTTGATT  ATGCTAAACG  TAGTAAGACT  360
361   ACAGCATGGT  CCTACTTTCT  GCCAATGTTG  AATCGCCAGG  ATCTTTTCAC  TGTCCACATG  420
421   GCAGCAAGAA  TTATTGCCAA  ATTGGCAGTA  TGGGGAAAAG  AATTGATGGA  AGGCAGTGAC  480
481   TTAAATTATT  ATTTCAACTG  GATAAAAACT  CAGCTGAGTT  CACAGAAACT  GTTGGGTAGC  540
541   AGTATTGCTC  TTGACGCAGG  AACAACAGGC  GGTGCAAATG  AGAGTTCCCA  GTACGTGCAG  600
601   TGTGTTGCTG  GATGTCTTCA  GTTGATGCTG  CGTGTTAATG  AATATCGCTT  TGCTTGGGTA  660
661   GAAGCTGATG  GAGTCAACTG  TATAATGGGA  GTTTTGAGTA  ACAAATGTGG  CTTCCAACTC  720
721   CAATATCAAA  TGATTTTCTC  AATATGGCTA  CTGGCATTTA  GCCCTCAAAT  GTGTGAACAT  780
781   CTTCGTTGCT  ATAACATCAT  TCCTGTTCTG  TCTGATATCC  TTCAAGAATC  TGTTAAAGAG  840
841   AAAGTAACTA  GAATCATTCT  TGCAGCATTC  CGGAACCTTT  TAGAAAAATC  AACTGAAAAG  900
901   GAAACTCGCC  AAGAATATGC  CCTGGCTATG  ATTCAGTGCA  AAGTTCTGAA  GCAGTTGGAG  960
961   AACTTGGATC  AGCAAAAGTA  TGATGACGAA  GATATCAGTG  AAGATATAAA  ATTTCTTTTA  1020
1021  AACAAACTTG  GTGAAAGTGT  TCAGGATCTT  AGCTCATTTG  ATGAATACAG  TTCAGAACTC  1080
1081  AAGTCAGGAA  GGCTGGAATG  GAGCCCTGTT  CACAAATCAG  AGAAGTTTTG  GAGGGAGAAT  1140
1141  GCTATAAGAT  TAAATGAAAA  GAACTATGAG  CTATTGAAAA  TCTTGACAAA  GCTTCTGGAG  1200
1201  GTATCAGATG  ATCCACAGGT  CTTAGCTGTT  GCTGCACATG  ATGTAGGAGA  ATATGTAAGA  1260
1261  CATTACCCAC  GAGGCAAAAG  GGTTATTGAG  CAACTTGGTG  GGAAGCAGCT  GGTAATGAAC  1320
1321  CATATGCATC  ATGAAGACCA  GCAGGTTCGC  TATAATGCTC  TTCTGGCTGT  GCAGAAGTTA  1380
1381  ATGGTTCACA  ACTGCATCTC  ACTATGCCAA  TATGTTGGCT  CTAATAAGGG  GACGACTTCT  1440
1441  GATACTTCGT  TTGGAATATC  TTGGTAA  1467

▼ KEYWORD

ID
Family
Complete proteome
Hydrogen ion transport
Ion transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function
Proton-transporting ATPase activity, rotational mechanism
Biological Process
ATP hydrolysis coupled proton transport
Biological Process
Endocytosis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Myl-4238Myotis lucifugus94.410.0 917
LLPS-Aim-2148Ailuropoda melanoleuca94.150.0 771
LLPS-Paa-3566Papio anubis93.970.0 910
LLPS-Sah-2263Sarcophilus harrisii93.120.0 919
LLPS-Anp-1899Anas platyrhynchos92.660.0 894
LLPS-Aon-0914Aotus nancymaae92.540.0 902
LLPS-Urm-3652Ursus maritimus92.50.0 922
LLPS-Mup-2080Mustela putorius furo92.50.0 922
LLPS-Man-4133Macaca nemestrina92.390.0 909
LLPS-Eqc-2045Equus caballus92.290.0 921
LLPS-Ova-0301Ovis aries92.290.0 917
LLPS-Tag-2875Taeniopygia guttata92.250.0 825
LLPS-Otg-3201Otolemur garnettii92.240.0 912
LLPS-Orc-2100Oryctolagus cuniculus92.080.0 917
LLPS-Caf-2219Canis familiaris92.080.0 917
LLPS-Sus-4499Sus scrofa92.080.0 917
LLPS-Dio-1512Dipodomys ordii92.080.0 920
LLPS-Loa-0263Loxodonta africana91.880.0 915
LLPS-Fec-2023Felis catus91.880.0 914
LLPS-Ict-4507Ictidomys tridecemlineatus91.880.0 917
LLPS-Caj-3322Callithrix jacchus91.880.0 915
LLPS-Bot-3827Bos taurus91.880.0 914
LLPS-Ran-0138Rattus norvegicus91.880.0 912
LLPS-Mum-4988Mus musculus91.670.0 914
LLPS-Fud-3168Fukomys damarensis91.670.0 915
LLPS-Ere-0955Erinaceus europaeus91.670.0 777
LLPS-Tut-1265Tursiops truncatus91.650.0 908
LLPS-Hos-3632Homo sapiens91.460.0 909
LLPS-Pap-1010Pan paniscus91.460.0 909
LLPS-Pat-0663Pan troglodytes91.460.0 909
LLPS-Rhb-0596Rhinopithecus bieti91.460.0 911
LLPS-Nol-2313Nomascus leucogenys91.460.0 909
LLPS-Maf-4197Macaca fascicularis91.460.0 911
LLPS-Mea-3482Mesocricetus auratus91.460.0 907
LLPS-Chs-3811Chlorocebus sabaeus91.460.0 911
LLPS-Gog-3815Gorilla gorilla91.460.0 909
LLPS-Mal-3440Mandrillus leucophaeus91.460.0 911
LLPS-Pes-1791Pelodiscus sinensis91.40.0 905
LLPS-Cap-0958Cavia porcellus91.250.0 912
LLPS-Ora-1382Ornithorhynchus anatinus90.620.0 905
LLPS-Gaga-3726Gallus gallus90.570.0 899
LLPS-Fia-0131Ficedula albicollis90.360.0 896
LLPS-Anc-3035Anolis carolinensis90.360.0 894
LLPS-Xet-1466Xenopus tropicalis90.280.0 868
LLPS-Poa-3771Pongo abelii90.00.0 885
LLPS-Mam-4272Macaca mulatta88.620.0 894
LLPS-Leo-2710Lepisosteus oculatus88.530.0 853
LLPS-Pof-0017Poecilia formosa86.80.0 835
LLPS-Meg-0724Meleagris gallopavo86.780.0 866
LLPS-Cea-3953Cercocebus atys86.670.0 851
LLPS-Xim-1173Xiphophorus maculatus86.580.0 834
LLPS-Orl-1142Oryzias latipes86.550.0 838
LLPS-Scm-3560Scophthalmus maximus86.360.0 835
LLPS-Gaa-2615Gasterosteus aculeatus86.150.0 829
LLPS-Cas-2782Carlito syrichta86.040.0 838
LLPS-Orn-3418Oreochromis niloticus85.960.0 834
LLPS-Ten-2895Tetraodon nigroviridis85.680.0 830
LLPS-Tar-0202Takifugu rubripes85.060.0 823
LLPS-Lac-2690Latimeria chalumnae84.620.0 845
LLPS-Scf-3159Scleropages formosus84.480.0 817
LLPS-Dar-1046Danio rerio84.30.0 850
LLPS-Asm-2673Astyanax mexicanus84.30.0 842
LLPS-Icp-3618Ictalurus punctatus84.090.0 839
LLPS-Cii-1438Ciona intestinalis58.720.0 555
LLPS-Cis-0372Ciona savignyi56.960.0 540
LLPS-Cae-0603Caenorhabditis elegans49.584e-155 457
LLPS-Osl-0823Ostreococcus lucimarinus49.021e-25 105
LLPS-Drm-1610Drosophila melanogaster48.829e-170 497
LLPS-Scc-0660Schizosaccharomyces cryophilus40.612e-50 184
LLPS-Asc-0404Aspergillus clavatus39.395e-35 140
LLPS-Scp-0419Schizosaccharomyces pombe39.113e-51 186
LLPS-Ast-1095Aspergillus terreus35.57e-29 122
LLPS-Blg-0663Blumeria graminis34.755e-31 129
LLPS-Usm-0741Ustilago maydis34.741e-43 167
LLPS-Ors-0394Oryza sativa34.446e-1370.5
LLPS-Org-2018Oryza glaberrima34.442e-1269.3
LLPS-Ved-1398Verticillium dahliae34.392e-26 115
LLPS-Lem-1311Leptosphaeria maculans34.332e-23 106
LLPS-Gag-1273Gaeumannomyces graminis34.315e-33 134
LLPS-Abg-0825Absidia glauca34.217e-83 270
LLPS-Spr-0039Sporisorium reilianum34.131e-44 170
LLPS-Orm-0851Oryza meridionalis34.11e-47 173
LLPS-Fuv-0867Fusarium verticillioides33.922e-28 121
LLPS-Asni-1252Aspergillus niger33.98e-29 122
LLPS-Phv-0977Phaseolus vulgaris33.719e-49 180
LLPS-Fuo-1424Fusarium oxysporum33.632e-27 118
LLPS-Aso-1295Aspergillus oryzae33.619e-27 116
LLPS-Asf-1599Aspergillus flavus33.619e-27 116
LLPS-Cog-1162Colletotrichum gloeosporioides33.482e-27 118
LLPS-Map-0715Magnaporthe poae33.472e-28 121
LLPS-Miv-1201Microbotryum violaceum33.411e-79 261
LLPS-Asn-0707Aspergillus nidulans33.335e-27 117
LLPS-Tum-0593Tuber melanosporum33.333e-31 129
LLPS-Brd-1017Brachypodium distachyon32.961e-45 172
LLPS-Pytr-1553Pyrenophora triticirepentis32.919e-26 113
LLPS-Pyt-1650Pyrenophora teres32.916e-25 111
LLPS-Trr-1631Trichoderma reesei32.794e-30 126
LLPS-Trv-1425Trichoderma virens32.794e-31 129
LLPS-Mao-1519Magnaporthe oryzae32.773e-32 132
LLPS-Crn-0860Cryptococcus neoformans32.581e-63 219
LLPS-Nec-1614Neurospora crassa32.164e-28 120
LLPS-Chc-0943Chondrus crispus31.512e-37 148
LLPS-Gas-0473Galdieria sulphuraria31.42e-24 109
LLPS-Asg-0601Ashbya gossypii31.382e-26 115
LLPS-Php-1662Physcomitrella patens31.314e-68 231
LLPS-Put-1201Puccinia triticina30.791e-43 167
LLPS-Sac-1199Saccharomyces cerevisiae30.524e-27 117
LLPS-Orb-0755Oryza barthii30.471e-68 233
LLPS-Ori-1329Oryza indica30.473e-68 233
LLPS-Orni-1626Oryza nivara30.471e-68 233
LLPS-Orgl-1169Oryza glumaepatula30.471e-68 233
LLPS-Pug-0279Puccinia graminis30.314e-64 221
LLPS-Orr-0453Oryza rufipogon30.251e-65 229
LLPS-Zem-0323Zea mays30.257e-67 228
LLPS-Mua-0236Musa acuminata30.043e-65 229
LLPS-Orp-1326Oryza punctata30.028e-64 226
LLPS-Orbr-0721Oryza brachyantha30.029e-67 228
LLPS-Hov-2003Hordeum vulgare30.027e-68 232
LLPS-Tra-1524Triticum aestivum30.021e-69 236
LLPS-Cus-1979Cucumis sativus29.82e-68 232
LLPS-Cym-0033Cyanidioschyzon merolae29.723e-26 115
LLPS-Tru-1465Triticum urartu29.522e-65 224
LLPS-Chr-1383Chlamydomonas reinhardtii29.486e-63 218
LLPS-Vir-0672Vigna radiata29.331e-61 214
LLPS-Sei-0982Setaria italica29.248e-67 228
LLPS-Mel-0908Melampsora laricipopulina29.222e-55 197
LLPS-Bro-0619Brassica oleracea29.134e-64 221
LLPS-Mae-2404Manihot esculenta28.968e-66 225
LLPS-Gor-0443Gossypium raimondii28.922e-66 227
LLPS-Prp-1880Prunus persica28.914e-64 223
LLPS-Lep-1790Leersia perrieri28.891e-52 194
LLPS-Sem-2370Selaginella moellendorffii28.445e-63 218
LLPS-Sob-0279Sorghum bicolor28.332e-63 219
LLPS-Thc-1117Theobroma cacao28.298e-65 223
LLPS-Glm-0787Glycine max28.282e-60 211
LLPS-Hea-2509Helianthus annuus28.268e-67 228
LLPS-Sot-2212Solanum tuberosum28.056e-66 226
LLPS-Dos-1381Dothistroma septosporum27.962e-36 145
LLPS-Dac-0982Daucus carota27.956e-59 207
LLPS-Pot-1875Populus trichocarpa27.874e-59 207
LLPS-Art-0388Arabidopsis thaliana27.818e-60 209
LLPS-Arl-1192Arabidopsis lyrata27.656e-54 192
LLPS-Brr-1494Brassica rapa27.61e-62 217
LLPS-Nia-2196Nicotiana attenuata27.67e-67 228
LLPS-Brn-2205Brassica napus27.61e-62 217
LLPS-Kop-1492Komagataella pastoris27.457e-41 157
LLPS-Met-0628Medicago truncatula27.412e-60 212
LLPS-Asfu-1578Aspergillus fumigatus27.041e-30 127
LLPS-Yal-0642Yarrowia lipolytica27.033e-49 181
LLPS-Amt-1066Amborella trichopoda26.988e-63 218
LLPS-Sol-0068Solanum lycopersicum26.926e-61 213
LLPS-Scj-0603Schizosaccharomyces japonicus26.885e-46 171
LLPS-Viv-2070Vitis vinifera26.783e-60 211
LLPS-Nef-0697Neosartorya fischeri26.628e-31 128
LLPS-Zyt-1261Zymoseptoria tritici26.573e-31 129
LLPS-Coc-0591Corchorus capsularis25.972e-50 183
LLPS-Coo-1273Colletotrichum orbiculare25.882e-33 135
LLPS-Cogr-0702Colletotrichum graminicola25.637e-29 122
LLPS-Fus-1397Fusarium solani25.416e-31 128
LLPS-Phn-0075Phaeosphaeria nodorum24.741e-28 122
LLPS-Beb-1074Beauveria bassiana24.583e-28 120
LLPS-Via-1152Vigna angularis23.231e-1787.4