• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asm-2673

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: V-type proton ATPase subunit H
Ensembl Gene: ENSAMXG00000018200.2
Ensembl Protein: ENSAMXP00000018744.1
Organism: Astyanax mexicanus
Taxa ID: 7994
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDIRGAVDAA  VPTNIIAAKA  AEVRANKVNW  QSYLQGQMIS  GEDCEFIKKF  EVAHSEDKQA  60
61    ILTNEGHQCA  KTFLNLMAHI  SKEQTVQYIL  TLIDDTLQEN  HQRVNIFFDY  AKKTKNTAWS  120
121   YFLPMLNRQD  LFTVHMAARI  IAKLAAWGRD  LMEGSDLNYY  FNWIKTQLSS  QKLHGTGAET  180
181   GTGTISPNES  SQYVQCVAGC  LQLMLRVNEY  RFAWVEADGV  NCITAVLSNK  CGFQLQYQMI  240
241   FCVWLLAFSP  QLCEQLRRYN  VVPALSDILQ  ESVKEKVTRI  ILAAFRNLLE  KSAERETRQE  300
301   YALAMIQCKV  LKQLENLDQQ  KYDDEDITDD  IKFLLERLGE  SVQDLSSFDE  YSSELKSGRL  360
361   EWSPVHKSEK  FWRENAVRLN  EKNYELLKIL  TRLLEVSDDP  QVIAVAAHDV  GEYVRHYPRG  420
421   KRVIEQLGGK  QLVMNHMHHE  DQLVRYNALL  AVQKLMVHNW  EYLGKQLQST  EQSTPAVAAR  480
481   S  481
Nucleotide CDS Sequence (FASTA)
1     ATGGACATCC  GAGGAGCAGT  GGACGCTGCC  GTCCCGACCA  ATATCATCGC  AGCTAAGGCT  60
61    GCTGAGGTCC  GCGCCAACAA  GGTCAACTGG  CAGTCCTATT  TGCAGGGTCA  GATGATCTCT  120
121   GGAGAAGACT  GTGAGTTTAT  CAAGAAGTTT  GAAGTTGCCC  ACTCTGAGGA  TAAGCAGGCC  180
181   ATTCTGACCA  ATGAAGGACA  TCAGTGTGCA  AAGACCTTCC  TCAACCTCAT  GGCCCATATA  240
241   TCAAAGGAGC  AAACGGTTCA  ATACATCTTG  ACCCTGATTG  ATGACACTCT  ACAGGAAAAT  300
301   CATCAGAGGG  TCAACATTTT  CTTCGATTAT  GCCAAGAAGA  CCAAGAATAC  AGCCTGGTCC  360
361   TATTTTCTCC  CAATGCTGAA  CCGCCAGGAC  CTCTTCACCG  TCCATATGGC  TGCAAGGATC  420
421   ATTGCCAAGC  TCGCTGCCTG  GGGGCGGGAC  CTGATGGAGG  GGAGTGATCT  GAACTACTAC  480
481   TTTAACTGGA  TCAAGACTCA  GCTTAGCTCC  CAGAAGCTAC  ATGGTACAGG  TGCAGAGACA  540
541   GGAACAGGGA  CCATCTCTCC  CAATGAAAGC  TCTCAGTATG  TGCAGTGTGT  GGCTGGTTGC  600
601   CTGCAGCTGA  TGCTGAGGGT  GAACGAGTAC  AGGTTTGCCT  GGGTTGAGGC  GGATGGTGTG  660
661   AACTGCATCA  CGGCCGTGCT  GAGTAACAAG  TGCGGCTTCC  AGCTGCAGTA  CCAGATGATC  720
721   TTCTGCGTTT  GGCTCCTGGC  TTTCAGCCCT  CAGCTCTGTG  AACAGCTGCG  CCGCTACAAC  780
781   GTAGTGCCCG  CCCTCTCCGA  CATCCTCCAG  GAGTCTGTCA  AAGAGAAGGT  CACCCGCATC  840
841   ATCCTCGCTG  CATTCAGGAA  CCTGCTGGAG  AAGTCTGCGG  AGAGGGAGAC  TCGTCAGGAG  900
901   TACGCCTTGG  CCATGATTCA  GTGCAAAGTC  CTGAAGCAGC  TGGAGAATCT  GGACCAGCAG  960
961   AAGTACGATG  ATGAAGACAT  CACTGATGAC  ATCAAATTCC  TCCTGGAGAG  ACTGGGAGAA  1020
1021  AGCGTCCAGG  ACCTCAGCTC  TTTTGATGAG  TACAGCTCTG  AGCTGAAGTC  CGGCAGGCTG  1080
1081  GAGTGGAGTC  CCGTGCACAA  GTCGGAGAAG  TTCTGGAGGG  AGAACGCCGT  CCGCCTGAAC  1140
1141  GAGAAAAACT  ACGAACTGCT  GAAGATCCTG  ACCAGGCTGC  TGGAGGTGTC  TGATGATCCT  1200
1201  CAGGTTATTG  CCGTGGCCGC  TCATGATGTG  GGAGAGTATG  TGAGACATTA  CCCTCGTGGT  1260
1261  AAGAGGGTGA  TTGAACAGCT  GGGTGGAAAG  CAGCTGGTGA  TGAACCACAT  GCATCATGAG  1320
1321  GACCAATTGG  TGCGCTACAA  TGCGCTGCTG  GCGGTGCAGA  AGCTCATGGT  GCACAACTGG  1380
1381  ATTCCTCAGA  AAACAAAAGA  CCCTAACACA  GCAATCGTAG  AGATCTGA  1428

▼ KEYWORD

ID
Family
Complete proteome
Hydrogen ion transport
Ion transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function
Proton-transporting ATPase activity, rotational mechanism
Biological Process
ATP hydrolysis coupled proton transport
Biological Process
Bone development
Biological Process
Bone mineralization
Biological Process
Eye pigmentation
Biological Process
Positive regulation of neural retina development
Biological Process
Retina development in camera-type eye

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dar-1046Danio rerio99.170.0 995
LLPS-Icp-3618Ictalurus punctatus99.170.0 997
LLPS-Orn-3418Oreochromis niloticus95.450.0 961
LLPS-Xim-1173Xiphophorus maculatus95.040.0 957
LLPS-Scm-3560Scophthalmus maximus94.830.0 955
LLPS-Ten-2895Tetraodon nigroviridis94.820.0 951
LLPS-Pof-0017Poecilia formosa94.630.0 954
LLPS-Orl-1142Oryzias latipes94.40.0 953
LLPS-Tar-0202Takifugu rubripes94.210.0 948
LLPS-Gaa-2615Gasterosteus aculeatus93.390.0 942
LLPS-Leo-2710Lepisosteus oculatus93.350.0 936
LLPS-Scf-3159Scleropages formosus91.270.0 915
LLPS-Xet-1466Xenopus tropicalis89.40.0 909
LLPS-Lac-2690Latimeria chalumnae89.40.0 903
LLPS-Anp-1899Anas platyrhynchos89.350.0 862
LLPS-Ere-0955Erinaceus europaeus89.10.0 782
LLPS-Fia-0131Ficedula albicollis88.80.0 896
LLPS-Gaga-3726Gallus gallus88.590.0 895
LLPS-Pes-1791Pelodiscus sinensis88.380.0 892
LLPS-Bot-3827Bos taurus88.380.0 897
LLPS-Ova-0301Ovis aries88.380.0 897
LLPS-Otg-3201Otolemur garnettii88.290.0 864
LLPS-Myl-4238Myotis lucifugus88.250.0 876
LLPS-Loa-0263Loxodonta africana88.170.0 897
LLPS-Tut-1265Tursiops truncatus88.170.0 892
LLPS-Sah-2263Sarcophilus harrisii88.170.0 894
LLPS-Eqc-2045Equus caballus87.970.0 895
LLPS-Urm-3652Ursus maritimus87.970.0 895
LLPS-Mup-2080Mustela putorius furo87.970.0 895
LLPS-Sus-4499Sus scrofa87.970.0 896
LLPS-Ora-1382Ornithorhynchus anatinus87.970.0 895
LLPS-Man-4133Macaca nemestrina87.850.0 862
LLPS-Paa-3566Papio anubis87.850.0 863
LLPS-Caf-2219Canis familiaris87.760.0 892
LLPS-Fec-2023Felis catus87.760.0 894
LLPS-Mum-4988Mus musculus87.760.0 892
LLPS-Aim-2148Ailuropoda melanoleuca87.660.0 728
LLPS-Orc-2100Oryctolagus cuniculus87.550.0 891
LLPS-Ran-0138Rattus norvegicus87.550.0 889
LLPS-Mea-3482Mesocricetus auratus87.550.0 885
LLPS-Cap-0958Cavia porcellus87.340.0 889
LLPS-Anc-3035Anolis carolinensis87.340.0 878
LLPS-Caj-3322Callithrix jacchus87.340.0 889
LLPS-Fud-3168Fukomys damarensis87.340.0 889
LLPS-Ict-4507Ictidomys tridecemlineatus87.140.0 887
LLPS-Nol-2313Nomascus leucogenys87.140.0 884
LLPS-Pat-0663Pan troglodytes87.140.0 884
LLPS-Pap-1010Pan paniscus87.140.0 884
LLPS-Hos-3632Homo sapiens87.140.0 884
LLPS-Dio-1512Dipodomys ordii87.140.0 887
LLPS-Gog-3815Gorilla gorilla87.140.0 884
LLPS-Rhb-0596Rhinopithecus bieti86.930.0 885
LLPS-Mal-3440Mandrillus leucophaeus86.930.0 885
LLPS-Chs-3811Chlorocebus sabaeus86.930.0 885
LLPS-Maf-4197Macaca fascicularis86.930.0 885
LLPS-Aon-0914Aotus nancymaae86.670.0 853
LLPS-Poa-3771Pongo abelii85.480.0 853
LLPS-Meg-0724Meleagris gallopavo85.220.0 862
LLPS-Mod-3682Monodelphis domestica84.30.0 852
LLPS-Cea-3953Cercocebus atys83.510.0 831
LLPS-Mam-4272Macaca mulatta82.820.0 847
LLPS-Tag-2875Taeniopygia guttata81.780.0 808
LLPS-Cas-2782Carlito syrichta81.740.0 812
LLPS-Cii-1438Ciona intestinalis57.390.0 561
LLPS-Cis-0372Ciona savignyi56.650.0 544
LLPS-Cae-0603Caenorhabditis elegans51.059e-161 471
LLPS-Drm-1610Drosophila melanogaster48.963e-180 524
LLPS-Osl-0823Ostreococcus lucimarinus47.061e-24 102
LLPS-Scp-0419Schizosaccharomyces pombe40.452e-52 189
LLPS-Put-1201Puccinia triticina40.092e-45 172
LLPS-Scc-0660Schizosaccharomyces cryophilus39.773e-51 186
LLPS-Spr-0039Sporisorium reilianum39.152e-46 175
LLPS-Usm-0741Ustilago maydis38.087e-44 167
LLPS-Chc-0943Chondrus crispus35.61e-39 154
LLPS-Asc-0404Aspergillus clavatus35.11e-33 136
LLPS-Asni-1252Aspergillus niger35.16e-29 122
LLPS-Zyt-1261Zymoseptoria tritici34.712e-27 118
LLPS-Abg-0825Absidia glauca33.842e-84 274
LLPS-Cog-1162Colletotrichum gloeosporioides33.482e-27 118
LLPS-Orm-0851Oryza meridionalis33.333e-49 177
LLPS-Aso-1295Aspergillus oryzae32.819e-26 113
LLPS-Asf-1599Aspergillus flavus32.819e-26 113
LLPS-Ved-1398Verticillium dahliae32.746e-26 114
LLPS-Phv-0977Phaseolus vulgaris32.487e-49 180
LLPS-Gas-0473Galdieria sulphuraria31.886e-27 116
LLPS-Org-2018Oryza glaberrima31.822e-1165.9
LLPS-Ors-0394Oryza sativa31.825e-1267.8
LLPS-Miv-1201Microbotryum violaceum31.86e-78 256
LLPS-Pytr-1553Pyrenophora triticirepentis31.672e-25 112
LLPS-Pyt-1650Pyrenophora teres31.678e-25 110
LLPS-Trv-1425Trichoderma virens31.622e-30 127
LLPS-Crn-0860Cryptococcus neoformans31.534e-64 220
LLPS-Blg-0663Blumeria graminis31.336e-30 125
LLPS-Nec-1614Neurospora crassa31.337e-28 119
LLPS-Fuo-1424Fusarium oxysporum31.32e-27 118
LLPS-Sac-1199Saccharomyces cerevisiae31.251e-28 121
LLPS-Mao-1519Magnaporthe oryzae31.159e-31 127
LLPS-Brd-1017Brachypodium distachyon31.079e-48 177
LLPS-Cogr-0702Colletotrichum graminicola31.034e-26 114
LLPS-Zem-0323Zea mays30.392e-68 232
LLPS-Orgl-1169Oryza glumaepatula30.391e-69 235
LLPS-Tra-1524Triticum aestivum30.392e-71 240
LLPS-Ori-1329Oryza indica30.392e-69 236
LLPS-Orb-0755Oryza barthii30.391e-69 235
LLPS-Orni-1626Oryza nivara30.391e-69 235
LLPS-Orr-0453Oryza rufipogon30.163e-67 233
LLPS-Orp-1326Oryza punctata30.165e-65 230
LLPS-Orbr-0721Oryza brachyantha30.165e-68 231
LLPS-Hov-2003Hordeum vulgare30.164e-69 235
LLPS-Tru-1465Triticum urartu30.093e-67 229
LLPS-Cym-0033Cyanidioschyzon merolae30.01e-24 110
LLPS-Trr-1631Trichoderma reesei29.691e-28 121
LLPS-Sei-0982Setaria italica29.69e-69 233
LLPS-Mel-0908Melampsora laricipopulina29.355e-61 213
LLPS-Asg-0601Ashbya gossypii29.347e-25 110
LLPS-Mua-0236Musa acuminata29.282e-66 232
LLPS-Lep-1790Leersia perrieri29.194e-55 201
LLPS-Pug-0279Puccinia graminis29.165e-68 231
LLPS-Cus-1979Cucumis sativus29.085e-68 231
LLPS-Mae-2404Manihot esculenta29.022e-65 224
LLPS-Gor-0443Gossypium raimondii28.982e-66 227
LLPS-Php-1662Physcomitrella patens28.862e-67 229
LLPS-Hea-2509Helianthus annuus28.767e-70 236
LLPS-Kop-1492Komagataella pastoris28.73e-41 158
LLPS-Nia-2196Nicotiana attenuata28.574e-69 234
LLPS-Sot-2212Solanum tuberosum28.572e-66 227
LLPS-Chr-1383Chlamydomonas reinhardtii28.512e-64 222
LLPS-Sob-0279Sorghum bicolor28.154e-64 221
LLPS-Prp-1880Prunus persica28.121e-62 219
LLPS-Thc-1117Theobroma cacao28.122e-64 222
LLPS-Sol-0068Solanum lycopersicum27.891e-63 219
LLPS-Sem-2370Selaginella moellendorffii27.736e-62 215
LLPS-Bro-0619Brassica oleracea27.692e-63 219
LLPS-Brr-1494Brassica rapa27.663e-63 218
LLPS-Brn-2205Brassica napus27.663e-63 218
LLPS-Pot-1875Populus trichocarpa27.441e-58 206
LLPS-Glm-0787Glycine max27.294e-60 210
LLPS-Amt-1066Amborella trichopoda27.162e-62 216
LLPS-Art-0388Arabidopsis thaliana27.137e-61 212
LLPS-Vir-0672Vigna radiata27.131e-61 214
LLPS-Arl-1192Arabidopsis lyrata27.091e-55 197
LLPS-Asfu-1578Aspergillus fumigatus27.071e-32 133
LLPS-Nef-0697Neosartorya fischeri26.861e-31 130
LLPS-Scj-0603Schizosaccharomyces japonicus26.842e-49 181
LLPS-Yal-0642Yarrowia lipolytica26.643e-45 169
LLPS-Viv-2070Vitis vinifera26.625e-61 213
LLPS-Met-0628Medicago truncatula26.374e-59 208
LLPS-Coc-0591Corchorus capsularis26.033e-49 179
LLPS-Dac-0982Daucus carota25.898e-57 202
LLPS-Tum-0593Tuber melanosporum25.844e-33 135
LLPS-Ast-1095Aspergillus terreus25.361e-28 121
LLPS-Dos-1381Dothistroma septosporum25.32e-33 136
LLPS-Fus-1397Fusarium solani25.02e-29 124
LLPS-Lem-1311Leptosphaeria maculans25.02e-24 109
LLPS-Map-0715Magnaporthe poae25.04e-30 125
LLPS-Asn-0707Aspergillus nidulans25.03e-28 120
LLPS-Coo-1273Colletotrichum orbiculare24.93e-30 126
LLPS-Fuv-0867Fusarium verticillioides24.65e-30 125
LLPS-Gag-1273Gaeumannomyces graminis24.591e-33 136
LLPS-Beb-1074Beauveria bassiana24.396e-25 111
LLPS-Phn-0075Phaeosphaeria nodorum22.833e-27 117
LLPS-Via-1152Vigna angularis22.379e-1887.4