• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-1273

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin alpha chain
Ensembl Gene: ENSMODG00000000689.3
Ensembl Protein: ENSMODP00000000825.3
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMODT00000000843.3ENSMODP00000000825.3
UniProtF6WM29, F6WM29_MONDO

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEPELQTNEL  VSAEGRNRKA  VLCQRCGSRV  LQPGAALFSR  RQRECISIHV  GQAGVQMGNA  60
61    CWELYCLEHG  IQPNGTMSSD  RTLGGGDDSF  NTFFSETGAG  KHVPRAVFVD  LEPAVIDEVR  120
121   TSIYKQLFHP  EQLISGKEDA  ANNYARGHYT  VGKEIIDLVL  ERIRKLSDQC  TGLQGFLIFH  180
181   SFGGGTGSGF  TSLLMERLSV  DYGKKSKLEF  AIYPAPQVST  AVVEPYNSIL  TTHTTLEHSD  240
241   CAFMVDNEAI  YDICRRNLDI  ERPTYTNLNR  LIGQIVSSIT  ASLRFDGALN  VDLTEFQTNL  300
301   VPYPRIHFPL  VTYSPIVSAE  KAYHEQLSVA  EISNACFDPS  NQMVKCDPRH  GKYMACCMLY  360
361   RGDVVPKDVN  AAIATIKTKR  TIQFVDWCPT  GFKVGINYQP  PTVVPGGDLA  EVQRAVCMLS  420
421   NTTAIAEAWA  RLDHKFDLMY  AKRAFVHWYV  GEGMEEGEFS  EAREDLAALE  KDYEEVGTDS  480
481   IEGEDESEEF  490
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCCGG  AGTTGCAGAC  GAACGAACTA  GTGTCAGCTG  AGGGCCGAAA  CAGAAAAGCT  60
61    GTGCTGTGTC  AGCGCTGTGG  ATCCCGGGTG  CTGCAGCCCG  GGGCCGCTCT  CTTCTCCCGC  120
121   AGACAGCGTG  AGTGTATCTC  TATCCATGTT  GGCCAGGCTG  GAGTGCAGAT  GGGCAATGCC  180
181   TGCTGGGAAT  TGTATTGCTT  AGAGCATGGT  ATCCAACCCA  ATGGTACCAT  GTCCAGTGAC  240
241   AGGACCTTGG  GGGGTGGTGA  TGACTCCTTC  AATACCTTCT  TCAGTGAGAC  TGGGGCTGGC  300
301   AAGCATGTCC  CCAGAGCAGT  CTTTGTAGAC  TTGGAGCCTG  CTGTAATAGA  TGAGGTTCGG  360
361   ACCAGCATCT  ATAAACAGCT  GTTTCATCCA  GAGCAGCTGA  TCTCTGGCAA  GGAAGATGCT  420
421   GCTAATAACT  ATGCCCGGGG  CCATTATACT  GTAGGGAAGG  AAATAATTGA  TCTTGTATTA  480
481   GAGCGCATCC  GAAAACTGTC  GGACCAATGC  ACAGGACTGC  AGGGATTTCT  GATATTTCAC  540
541   AGCTTTGGGG  GCGGTACAGG  TTCAGGCTTC  ACCTCTCTCC  TGATGGAGAG  ACTCTCTGTT  600
601   GACTATGGCA  AGAAGTCCAA  GCTGGAATTT  GCCATCTACC  CAGCCCCACA  GGTATCCACA  660
661   GCTGTGGTAG  AACCTTATAA  CTCCATCCTA  ACCACTCACA  CCACACTGGA  GCACTCAGAC  720
721   TGTGCCTTCA  TGGTGGACAA  TGAAGCCATC  TATGACATCT  GCCGCCGGAA  CTTGGACATC  780
781   GAGCGCCCTA  CCTACACCAA  TCTCAACCGC  CTCATCGGCC  AGATAGTCTC  TTCCATCACT  840
841   GCCTCCCTAC  GCTTTGATGG  TGCCCTCAAT  GTAGACCTCA  CTGAGTTCCA  GACCAATCTG  900
901   GTGCCTTATC  CTCGAATCCA  CTTCCCCCTT  GTCACCTACT  CGCCCATTGT  CTCTGCTGAA  960
961   AAGGCCTATC  ATGAGCAGCT  TTCTGTAGCG  GAGATCTCCA  ATGCCTGCTT  TGACCCCTCC  1020
1021  AACCAGATGG  TGAAGTGCGA  CCCTCGTCAT  GGCAAGTACA  TGGCTTGCTG  CATGCTCTAC  1080
1081  AGAGGTGACG  TGGTACCTAA  GGATGTCAAT  GCCGCCATTG  CCACAATCAA  GACCAAGAGA  1140
1141  ACCATTCAGT  TTGTAGACTG  GTGTCCCACT  GGCTTCAAGG  TTGGCATCAA  TTACCAGCCC  1200
1201  CCAACTGTGG  TGCCGGGTGG  AGACCTGGCA  GAAGTGCAGC  GGGCAGTTTG  CATGCTAAGT  1260
1261  AACACGACTG  CCATTGCTGA  GGCATGGGCC  CGCCTGGATC  ACAAGTTTGA  CCTTATGTAT  1320
1321  GCAAAGCGGG  CATTTGTACA  CTGGTACGTG  GGTGAAGGCA  TGGAGGAGGG  AGAATTCTCT  1380
1381  GAGGCCCGGG  AAGATTTGGC  TGCCCTGGAG  AAGGATTACG  AGGAAGTAGG  CACAGACTCT  1440
1441  ATCGAAGGAG  AAGATGAAAG  TGAAGAATTC  TAG  1473

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule-based process
Biological Process
Mitotic cell cycle

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Meg-2451Meleagris gallopavo95.780.0 888
LLPS-Lac-3490Latimeria chalumnae95.150.0 890
LLPS-Tag-0253Taeniopygia guttata94.650.0 877
LLPS-Drm-0758Drosophila melanogaster94.520.0 859
LLPS-Dar-2532Danio rerio93.850.0 858
LLPS-Gaga-2553Gallus gallus93.850.0 858
LLPS-Cii-2287Ciona intestinalis93.850.0 858
LLPS-Mea-1952Mesocricetus auratus93.850.0 859
LLPS-Fud-3765Fukomys damarensis93.850.0 858
LLPS-Asm-0010Astyanax mexicanus93.850.0 858
LLPS-Loa-3072Loxodonta africana93.640.0 859
LLPS-Aon-0811Aotus nancymaae93.640.0 859
LLPS-Bot-1794Bos taurus93.640.0 858
LLPS-Myl-0897Myotis lucifugus93.640.0 859
LLPS-Aim-0544Ailuropoda melanoleuca93.640.0 859
LLPS-Paa-3203Papio anubis93.640.0 858
LLPS-Man-3545Macaca nemestrina93.620.0 857
LLPS-Hos-3547Homo sapiens93.620.0 857
LLPS-Pap-3963Pan paniscus93.620.0 857
LLPS-Pat-4380Pan troglodytes93.620.0 857
LLPS-Orc-2690Oryctolagus cuniculus93.620.0 857
LLPS-Mam-0274Macaca mulatta93.620.0 857
LLPS-Cap-0921Cavia porcellus93.620.0 857
LLPS-Eqc-0069Equus caballus93.620.0 857
LLPS-Caf-1913Canis familiaris93.620.0 857
LLPS-Poa-2507Pongo abelii93.620.0 857
LLPS-Nol-2673Nomascus leucogenys93.620.0 857
LLPS-Anc-2036Anolis carolinensis93.620.0 857
LLPS-Sus-3651Sus scrofa93.620.0 857
LLPS-Cea-1318Cercocebus atys93.620.0 857
LLPS-Chs-1766Chlorocebus sabaeus93.620.0 857
LLPS-Mum-2576Mus musculus93.620.0 857
LLPS-Maf-1902Macaca fascicularis93.620.0 857
LLPS-Icp-1141Ictalurus punctatus93.620.0 855
LLPS-Gog-1557Gorilla gorilla93.620.0 857
LLPS-Scf-2328Scleropages formosus93.620.0 855
LLPS-Dio-2559Dipodomys ordii93.620.0 857
LLPS-Xim-1672Xiphophorus maculatus93.620.0 855
LLPS-Mup-0654Mustela putorius furo93.620.0 857
LLPS-Mal-0207Mandrillus leucophaeus93.620.0 857
LLPS-Ere-0436Erinaceus europaeus93.620.0 857
LLPS-Ran-0481Rattus norvegicus93.620.0 857
LLPS-Caj-2133Callithrix jacchus93.530.0 845
LLPS-Leo-1381Lepisosteus oculatus93.510.0 866
LLPS-Fia-1806Ficedula albicollis93.410.0 856
LLPS-Cis-1254Ciona savignyi93.410.0 863
LLPS-Fec-4788Felis catus93.390.0 855
LLPS-Scm-0904Scophthalmus maximus93.390.0 854
LLPS-Ict-2926Ictidomys tridecemlineatus93.390.0 856
LLPS-Ova-0174Ovis aries93.390.0 856
LLPS-Pes-3386Pelodiscus sinensis93.20.0 852
LLPS-Ora-0959Ornithorhynchus anatinus93.180.0 856
LLPS-Urm-3000Ursus maritimus93.170.0 853
LLPS-Pof-3465Poecilia formosa93.170.0 852
LLPS-Gaa-2011Gasterosteus aculeatus93.170.0 855
LLPS-Tut-0018Tursiops truncatus93.170.0 853
LLPS-Otg-3152Otolemur garnettii92.950.0 855
LLPS-Cas-1839Carlito syrichta92.740.0 853
LLPS-Sah-0275Sarcophilus harrisii92.740.0 855
LLPS-Orl-0238Oryzias latipes92.710.0 851
LLPS-Anp-1080Anas platyrhynchos92.670.0 866
LLPS-Tar-3942Takifugu rubripes92.620.0 855
LLPS-Ten-2970Tetraodon nigroviridis92.60.0 858
LLPS-Xet-0393Xenopus tropicalis92.240.0 843
LLPS-Orn-1753Oreochromis niloticus92.030.0 842
LLPS-Cae-0112Caenorhabditis elegans88.590.0 824