• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-1154
PABPC1L

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Polyadenylate-binding protein
Gene Name: PABPC1L
Ensembl Gene: ENSMODG00000016198.3
Ensembl Protein: ENSMODP00000029058.2
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Binds the poly(A) tail of mRNA.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMODT00000030636.2ENSMODP00000029058.2
UniProtF6TY24, F6TY24_MONDO

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNASGPGYPL  ASLYVGDLHP  DVTEAMLYEK  FSAAGPIMSI  RVCRDVATRR  SLGYAYINFQ  60
61    QPADAERALD  TMNFEVIKGR  PIRIMWSQRD  PGLRKSGIGN  IFIKNLDDSI  DNKALYDTFS  120
121   TFGNILSCKV  VCDENGSRGF  GFVHFETHEA  ANQAINTMNG  MLLNDRKVFV  GHFKSRQERE  180
181   AELGARALEF  TNIYVKNFEG  DMDDECLQEL  FSQFGKTLSV  KVMVDENGQS  RGFGFVNFEK  240
241   HEEAQKAVSN  MNGKELGGRV  LYVGRAQKRS  ERQSELKRRF  EQMKQERVNR  YQGVNLYVKN  300
301   LDDIIDDEKL  RKEFSPYGVI  TSAKVMTEGG  HSKGFGFVCF  SSPEEATKAV  TEMNGRIVST  360
361   KPLYVALAQR  KEERKAILTS  QYMQRLSTLR  GLNGPLFPQP  TNYFLPAIPQ  VAAIFQPPAR  420
421   ATFYSPSTVA  PVRPAPRWTS  YSPRSSSTPR  RTVSNISTVR  QASTQVPRAG  PHMQRVANIG  480
481   TQTMGTGCPG  SPGRAVAQYK  YSSAVRNTHQ  VMEPAVHIQG  QEPLTASMLA  SAPVQEQKQM  540
541   LGDRLYPLIY  GIHAQLAGKI  TGMLLEIDNS  ELLLLLESPE  SLHSKVGT  588
Nucleotide CDS Sequence (FASTA)
1     ATGAACGCCA  GCGGCCCCGG  CTACCCTCTC  GCGTCCCTCT  ATGTGGGCGA  CCTGCACCCC  60
61    GACGTGACGG  AGGCCATGCT  GTATGAGAAG  TTCTCGGCCG  CGGGACCCAT  CATGTCCATC  120
121   CGCGTCTGCC  GCGACGTAGC  CACGCGCCGC  TCTCTGGGCT  ATGCCTACAT  CAACTTCCAG  180
181   CAGCCTGCAG  ACGCCGAACG  GGCCCTGGAC  ACCATGAACT  TTGAGGTGAT  CAAAGGCAGG  240
241   CCCATCCGTA  TCATGTGGTC  GCAGCGGGAC  CCAGGGCTCC  GGAAATCCGG  CATTGGCAAC  300
301   ATCTTCATCA  AGAACCTGGA  TGACTCCATT  GACAACAAGG  CCTTGTACGA  CACCTTCTCC  360
361   ACCTTTGGGA  ACATCCTCTC  TTGCAAGGTG  GTATGTGATG  AGAATGGCTC  CCGGGGATTT  420
421   GGCTTCGTCC  ACTTTGAGAC  TCATGAGGCT  GCAAACCAAG  CCATCAACAC  CATGAATGGA  480
481   ATGCTGCTAA  ATGACCGGAA  AGTCTTCGTG  GGCCACTTCA  AGTCTCGGCA  GGAAAGGGAG  540
541   GCAGAGCTGG  GGGCGCGAGC  GCTGGAGTTC  ACCAACATCT  ACGTCAAGAA  CTTCGAGGGA  600
601   GACATGGATG  ACGAGTGCCT  GCAGGAGCTC  TTCTCCCAGT  TCGGAAAGAC  TCTGAGCGTG  660
661   AAGGTGATGG  TCGACGAGAA  TGGCCAGTCC  CGAGGCTTCG  GCTTTGTCAA  CTTTGAGAAG  720
721   CACGAGGAAG  CCCAGAAGGC  TGTGAGTAAC  ATGAATGGGA  AAGAGCTCGG  CGGTCGGGTT  780
781   CTGTACGTCG  GACGGGCCCA  GAAGAGGTCC  GAGAGGCAGA  GTGAGCTGAA  GCGGAGATTT  840
841   GAGCAGATGA  AGCAGGAGAG  AGTGAACCGC  TACCAGGGTG  TGAACCTGTA  TGTGAAGAAT  900
901   CTGGATGATA  TCATTGATGA  CGAGAAGCTG  AGGAAGGAAT  TCTCGCCCTA  CGGCGTGATC  960
961   ACCAGTGCTA  AAGTGATGAC  AGAGGGTGGC  CACAGCAAGG  GGTTTGGCTT  TGTGTGTTTT  1020
1021  TCCTCCCCAG  AAGAGGCTAC  GAAGGCCGTG  ACAGAGATGA  ACGGGCGAAT  TGTCAGCACC  1080
1081  AAGCCCCTCT  ACGTGGCCCT  GGCCCAACGC  AAGGAAGAGC  GGAAGGCCAT  CCTCACCAGC  1140
1141  CAGTACATGC  AGCGCCTCTC  CACCCTCCGG  GGCTTAAATG  GCCCCCTCTT  TCCCCAACCC  1200
1201  ACCAATTATT  TCCTACCTGC  TATCCCCCAG  GTGGCCGCGA  TCTTCCAGCC  TCCTGCCCGG  1260
1261  GCGACCTTCT  ACAGTCCCAG  CACTGTGGCC  CCCGTGCGTC  CGGCTCCCCG  GTGGACCAGC  1320
1321  TATTCCCCGA  GGTCTTCATC  CACCCCCCGG  CGCACCGTCT  CCAATATCAG  TACCGTCCGG  1380
1381  CAGGCCTCTA  CTCAGGTGCC  CCGGGCAGGG  CCCCACATGC  AGAGAGTGGC  CAATATCGGG  1440
1441  ACCCAGACTA  TGGGAACTGG  ATGTCCAGGC  TCCCCAGGCC  GAGCTGTCGC  CCAATACAAG  1500
1501  TATTCCTCAG  CTGTACGTAA  TACACATCAG  GTCATGGAGC  CAGCGGTGCA  TATCCAAGGG  1560
1561  CAGGAGCCCT  TAACTGCATC  CATGTTGGCC  TCAGCCCCAG  TGCAGGAACA  GAAGCAGATG  1620
1621  CTTGGTGACA  GACTGTACCC  ACTCATCTAT  GGGATACATG  CTCAGCTGGC  TGGCAAGATC  1680
1681  ACCGGCATGC  TGCTGGAGAT  CGACAACTCT  GAGCTGCTGC  TGCTGCTCGA  GTCTCCAGAG  1740
1741  TCCCTTCACT  CCAAGGTAGG  TACTTGA  1767

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Reference proteome
Repeat
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic stress granule
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Ribonucleoprotein complex
Molecular Function
MRNA 3'-UTR binding
Molecular Function
Poly(A) binding
Molecular Function
Poly(U) RNA binding
Molecular Function
RNA binding
Biological Process
Chromatin remodeling
Biological Process
Chromatin-mediated maintenance of transcription
Biological Process
MRNA polyadenylation
Biological Process
Nucleus localization
Biological Process
Oocyte maturation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-2020Pelodiscus sinensis87.410.0 739
LLPS-Sah-0442Sarcophilus harrisii86.470.0 736
LLPS-Urm-0107Ursus maritimus82.670.0 614
LLPS-Maf-4216Macaca fascicularis79.510.0 883
LLPS-Cea-1044Cercocebus atys79.170.0 882
LLPS-Mal-3525Mandrillus leucophaeus79.170.0 882
LLPS-Hos-2049Homo sapiens79.030.0 878
LLPS-Poa-1096Pongo abelii79.030.0 880
LLPS-Gog-4698Gorilla gorilla79.030.0 878
LLPS-Chs-3821Chlorocebus sabaeus78.990.0 879
LLPS-Rhb-1116Rhinopithecus bieti78.860.0 879
LLPS-Fia-1569Ficedula albicollis78.440.0 812
LLPS-Fec-4418Felis catus78.40.0 874
LLPS-Paa-2310Papio anubis78.080.0 875
LLPS-Caj-2482Callithrix jacchus77.990.0 873
LLPS-Aon-3891Aotus nancymaae77.820.0 868
LLPS-Meg-0711Meleagris gallopavo77.440.0 874
LLPS-Man-2602Macaca nemestrina77.370.0 848
LLPS-Anc-0689Anolis carolinensis76.860.0 880
LLPS-Ict-4169Ictidomys tridecemlineatus76.60.0 853
LLPS-Mup-4223Mustela putorius furo76.50.0 863
LLPS-Tag-0263Taeniopygia guttata76.420.0 883
LLPS-Sus-1489Sus scrofa76.180.0 852
LLPS-Cas-0443Carlito syrichta76.080.0 857
LLPS-Ova-2725Ovis aries75.780.0 860
LLPS-Otg-2429Otolemur garnettii75.590.0 857
LLPS-Dio-3521Dipodomys ordii75.220.0 852
LLPS-Loa-2808Loxodonta africana75.130.0 850
LLPS-Ere-0730Erinaceus europaeus73.480.0 824
LLPS-Cap-3822Cavia porcellus73.280.0 807
LLPS-Fud-2226Fukomys damarensis73.080.0 791
LLPS-Leo-2262Lepisosteus oculatus72.680.0 837
LLPS-Aim-4325Ailuropoda melanoleuca71.850.0 819
LLPS-Myl-2889Myotis lucifugus71.040.0 804
LLPS-Ran-4419Rattus norvegicus70.380.0 757
LLPS-Orc-1045Oryctolagus cuniculus70.10.0 803
LLPS-Mum-4469Mus musculus70.020.0 763
LLPS-Caf-4154Canis familiaris69.390.0 790
LLPS-Tut-0106Tursiops truncatus69.360.0 778
LLPS-Ora-0485Ornithorhynchus anatinus69.20.0 792
LLPS-Pof-2411Poecilia formosa69.140.0 788
LLPS-Gaga-1755Gallus gallus69.110.0 786
LLPS-Pat-0096Pan troglodytes69.040.0 795
LLPS-Bot-0676Bos taurus69.040.0 795
LLPS-Orn-1234Oreochromis niloticus68.180.0 781
LLPS-Scf-1757Scleropages formosus68.030.0 769
LLPS-Asm-0389Astyanax mexicanus67.960.0 797
LLPS-Icp-1763Ictalurus punctatus67.750.0 771
LLPS-Mam-1121Macaca mulatta67.660.0 785
LLPS-Xim-0002Xiphophorus maculatus67.410.0 756
LLPS-Tar-1585Takifugu rubripes67.390.0 770
LLPS-Scm-0124Scophthalmus maximus67.340.0 778
LLPS-Dar-0605Danio rerio67.120.0 768
LLPS-Anp-0205Anas platyrhynchos67.050.0 665
LLPS-Orl-1335Oryzias latipes67.00.0 769
LLPS-Gaa-0140Gasterosteus aculeatus66.890.0 780
LLPS-Eqc-0520Equus caballus66.230.0 780
LLPS-Xet-1894Xenopus tropicalis65.970.0 773
LLPS-Ten-0752Tetraodon nigroviridis65.930.0 758
LLPS-Nol-4396Nomascus leucogenys65.416e-176 510
LLPS-Lac-0490Latimeria chalumnae65.330.0 771
LLPS-Mea-0928Mesocricetus auratus64.70.0 725
LLPS-Cae-0017Caenorhabditis elegans64.632e-173 514
LLPS-Pap-3693Pan paniscus63.615e-148 438
LLPS-Abg-0396Absidia glauca62.868e-169 501
LLPS-Pug-0751Puccinia graminis61.142e-155 473
LLPS-Scj-1180Schizosaccharomyces japonicus61.018e-161 481
LLPS-Miv-0375Microbotryum violaceum60.982e-151 460
LLPS-Sac-0254Saccharomyces cerevisiae59.154e-150 452
LLPS-Php-2380Physcomitrella patens56.751e-148 450
LLPS-Gas-0605Galdieria sulphuraria56.642e-151 462
LLPS-Hea-1746Helianthus annuus56.271e-146 446
LLPS-Cis-0525Ciona savignyi56.210.0 620
LLPS-Scs-0002Sclerotinia sclerotiorum55.51e-150 460
LLPS-Nec-1339Neurospora crassa55.59e-153 465
LLPS-Gag-0588Gaeumannomyces graminis55.342e-150 459
LLPS-Mel-0295Melampsora laricipopulina54.939e-157 473
LLPS-Asn-0437Aspergillus nidulans54.911e-153 466
LLPS-Map-0652Magnaporthe poae54.631e-149 454
LLPS-Asg-0826Ashbya gossypii54.463e-147 445
LLPS-Trr-0204Trichoderma reesei54.428e-150 457
LLPS-Trv-1365Trichoderma virens54.422e-149 456
LLPS-Drm-0098Drosophila melanogaster54.210.0 583
LLPS-Mao-0122Magnaporthe oryzae54.191e-146 449
LLPS-Blg-0163Blumeria graminis54.053e-148 454
LLPS-Nef-0595Neosartorya fischeri54.022e-155 471
LLPS-Asfu-0098Aspergillus fumigatus53.784e-155 471
LLPS-Cogr-0927Colletotrichum graminicola53.277e-149 455
LLPS-Osl-0062Ostreococcus lucimarinus53.17e-147 443
LLPS-Ved-0859Verticillium dahliae52.911e-149 456
LLPS-Lem-0308Leptosphaeria maculans52.892e-147 451
LLPS-Pytr-0128Pyrenophora triticirepentis52.88e-148 450
LLPS-Zyt-0584Zymoseptoria tritici52.093e-147 450
LLPS-Coo-0169Colletotrichum orbiculare51.894e-150 458
LLPS-Crn-0202Cryptococcus neoformans49.043e-165 494
LLPS-Scp-0021Schizosaccharomyces pombe48.031e-170 507
LLPS-Scc-0164Schizosaccharomyces cryophilus47.231e-157 474
LLPS-Sem-1324Selaginella moellendorffii46.821e-153 462
LLPS-Vir-0236Vigna radiata45.693e-147 447
LLPS-Glm-1402Glycine max45.336e-151 456
LLPS-Prp-0551Prunus persica45.267e-147 446
LLPS-Zem-1330Zea mays45.141e-146 446
LLPS-Chc-0157Chondrus crispus45.143e-156 471
LLPS-Yal-0100Yarrowia lipolytica45.082e-153 462
LLPS-Cus-0370Cucumis sativus44.188e-149 451
LLPS-Brr-0886Brassica rapa43.932e-148 449