• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Man-1838
TUBA1C

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin alpha chain
Gene Name: TUBA1C
Ensembl Gene: ENSMNEG00000000827.1
Ensembl Protein: ENSMNEP00000000391.1
Organism: Macaca nemestrina
Taxa ID: 9545
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ SEQUENCE

Protein Sequence (FASTA)
1     SLFNGVEELG  RDECFVTLQL  PTPFNTCTFS  QSRGEPGCDS  KRECISIHVG  QAGVQIGNAC  60
61    WELYCLEHGI  QPDGQMPSDK  TIGGGDDSFN  TFFSETGAGK  HVPRAVFVDL  EPTVIDEVRT  120
121   GTYRQLFHPE  QLITGKEDAA  NNYARGHYTI  GKEIIDLVLD  RIRKLADQCT  GLQGFLVFHS  180
181   FGGGTGSGFT  SLLMERLSVD  YGKKSKLEFS  IYPAPQVSTA  VVEPYNSILT  THTTLEHSDC  240
241   AFMVDNEAIY  DICRRNLDIE  RPTYTNLNRL  ISQIVSSITA  SLRFDGALNV  DLTEFQTNLV  300
301   PYPRIHFPLA  TYAPVISAEK  AYHEQLTVAE  ITNACFEPAN  QMVKCDPRHG  KYMACCLLYR  360
361   GDVVPKDVNA  AIATIKTKRT  IQFVDWCPTG  FKVGINYQPP  TVVPGGDLAK  VQRAVCMLSN  420
421   TTAIAEAWAR  LDHKFDLMYA  KRAFVHWYVG  EGMEEGEFSE  AREDMAALEK  DYEEVGADSA  480
481   DGEDEGEEY  489
Nucleotide CDS Sequence (FASTA)
1     CGTGAGTGCA  TCTCCATCCA  TGTTGGCCAG  GCTGGTGTCC  AGATTGGCAA  TGCCTGCTGG  60
61    GAGCTCTACT  GCCTGGAACA  TGGCATCCAG  CCTGATGGCC  AGATGCCAAG  TGACAAGACC  120
121   ATTGGGGGAG  GAGATGATTC  CTTCAACACC  TTCTTCAGTG  AGACGGGCGC  TGGCAAGCAT  180
181   GTGCCCCGGG  CCGTGTTTGG  CTTCTTGGTT  TTCCACAGCT  TTGGTGGGGG  AACTGGTTCT  240
241   GGGTTCACCT  CCCTGCTCAT  GGAACGTCTC  TCAGTTGATT  ATGGCAAGAA  ATCCAAGCTG  300
301   GAGTTCTCCA  TTTACCCAGC  GCCCCAGGTT  TCCACAGCTG  TAGTTGAGCC  CTACAACTCC  360
361   ATCCTCACCA  CCCACACCAC  CCTGGAGCAC  TCTGATTGTG  CCTTCATGGT  AGACAATGAG  420
421   GCCATCTATG  ACATCTGTCG  TAGAAACCTC  GATATTGAGC  GCCCAACCTA  CACTAACCTT  480
481   AACCGCCTTA  TTAGCCAGAT  TGTGTCCTCC  ATCACTGCTT  CCCTGAGATT  TGATGGAGCC  540
541   CTGAATGTTG  ACCTGACAGA  ATTCCAGACC  AACCTGGTGC  CCTACCCCCG  CATCCACTTC  600
601   CCTCTGGCCA  CATACGCCCC  TGTCATCTCT  GCTGAGAAAG  CCTACCATGA  ACAGCTTACT  660
661   GTAGCAGAGA  TCACCAATGC  TTGCTTTGAG  CCAGCCAACC  AGATGGTGAA  ATGTGACCCT  720
721   CGCCATGGTA  AATACATGGC  TTGCTGCCTG  TTGTACCGTG  GTGATGTGGT  TCCCAAAGAT  780
781   GTCAATGCTG  CCATTGCCAC  CATCAAGACC  AAGCGTACCA  TCCAGTTTGT  GGATTGGTGC  840
841   CCCACTGGCT  TCAAGGTTGG  CATCAACTAC  CAGCCTCCCA  CTGTGGTGCC  TGGTGGAGAC  900
901   CTGGCCAAGG  TTCAGAGAGC  TGTGTGCATG  CTGAGCAACA  CCACAGCCAT  TGCCGAGGCC  960
961   TGGGCTCGCC  TGGACCACAA  GTTTGACCTG  ATGTATGCCA  AGCGTGCCTT  TGTTCACTGG  1020
1021  TATGTGGGTG  AGGGGATGGA  GGAAGGCGAG  TTTTCAGAGG  CCCGTGAGGA  CATGGCTGCC  1080
1081  CTTGAGAAGG  ATTATGAGGA  GGTTGGAGCA  GATAGTGCTG  ATGGAGAGGA  TGAGGGTGAA  1140
1141  GAGTATTAA  1149

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-2445Pelodiscus sinensis100.02e-79 265
LLPS-Mum-3577Mus musculus100.00.0 875
LLPS-Maf-0209Macaca fascicularis99.790.0 950
LLPS-Mal-2039Mandrillus leucophaeus99.790.0 960
LLPS-Paa-2748Papio anubis99.790.0 950
LLPS-Fia-2663Ficedula albicollis99.770.0 874
LLPS-Dar-3733Danio rerio99.770.0 873
LLPS-Anc-1966Anolis carolinensis99.770.0 874
LLPS-Asm-0148Astyanax mexicanus99.770.0 873
LLPS-Fud-2337Fukomys damarensis99.770.0 874
LLPS-Icp-1141Ictalurus punctatus99.770.0 873
LLPS-Chs-1539Chlorocebus sabaeus99.770.0 874
LLPS-Ran-3631Rattus norvegicus99.770.0 874
LLPS-Scf-2328Scleropages formosus99.770.0 873
LLPS-Mam-0805Macaca mulatta99.570.0 945
LLPS-Orc-2690Oryctolagus cuniculus99.540.0 871
LLPS-Pat-2764Pan troglodytes99.540.0 874
LLPS-Urm-3000Ursus maritimus99.540.0 872
LLPS-Pap-4472Pan paniscus99.540.0 872
LLPS-Hos-0454Homo sapiens99.540.0 871
LLPS-Mod-1950Monodelphis domestica99.540.0 872
LLPS-Fec-0466Felis catus99.540.0 872
LLPS-Ict-1665Ictidomys tridecemlineatus99.540.0 870
LLPS-Gaga-2212Gallus gallus99.540.0 871
LLPS-Cas-1839Carlito syrichta99.540.0 873
LLPS-Poa-2507Pongo abelii99.540.0 871
LLPS-Ten-2970Tetraodon nigroviridis99.540.0 873
LLPS-Cap-3401Cavia porcellus99.540.0 872
LLPS-Caj-2133Callithrix jacchus99.540.0 874
LLPS-Gog-1557Gorilla gorilla99.540.0 871
LLPS-Sus-3651Sus scrofa99.540.0 871
LLPS-Myl-1343Myotis lucifugus99.540.0 872
LLPS-Dio-2079Dipodomys ordii99.540.0 871
LLPS-Bot-1689Bos taurus99.540.0 871
LLPS-Tut-0018Tursiops truncatus99.540.0 872
LLPS-Caf-1216Canis familiaris99.310.0 873
LLPS-Aon-0811Aotus nancymaae99.310.0 872
LLPS-Leo-3078Lepisosteus oculatus99.310.0 874
LLPS-Ora-0959Ornithorhynchus anatinus99.310.0 873
LLPS-Pof-3465Poecilia formosa99.30.0 870
LLPS-Xet-0144Xenopus tropicalis99.30.0 872
LLPS-Xim-1672Xiphophorus maculatus99.30.0 870
LLPS-Loa-1707Loxodonta africana99.080.0 870
LLPS-Lac-1000Latimeria chalumnae99.080.0 878
LLPS-Aim-3885Ailuropoda melanoleuca99.080.0 874
LLPS-Scm-0904Scophthalmus maximus99.070.0 870
LLPS-Orl-0238Oryzias latipes98.840.0 869
LLPS-Ova-0174Ovis aries98.840.0 869
LLPS-Otg-3152Otolemur garnettii98.610.0 868
LLPS-Sah-0275Sarcophilus harrisii98.610.0 870
LLPS-Ere-0754Erinaceus europaeus98.610.0 864
LLPS-Tar-3942Takifugu rubripes98.610.0 865
LLPS-Meg-1613Meleagris gallopavo98.40.0 874
LLPS-Cea-1125Cercocebus atys98.310.0 936
LLPS-Eqc-0975Equus caballus98.140.0 866
LLPS-Gaa-2776Gasterosteus aculeatus98.140.0 865
LLPS-Cii-2287Ciona intestinalis97.910.0 865
LLPS-Mup-4254Mustela putorius furo97.910.0 853
LLPS-Orn-1753Oreochromis niloticus97.680.0 856
LLPS-Nol-2673Nomascus leucogenys97.680.0 865
LLPS-Drm-0758Drosophila melanogaster97.680.0 864
LLPS-Mea-1952Mesocricetus auratus97.450.0 863
LLPS-Anp-1080Anas platyrhynchos97.220.0 864
LLPS-Cis-1540Ciona savignyi96.750.0 860
LLPS-Tag-0253Taeniopygia guttata94.680.0 848
LLPS-Cae-0112Caenorhabditis elegans93.50.0 831
LLPS-Rhb-1604Rhinopithecus bieti90.950.0 808