• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mam-3200
KPNA5

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit alpha
Gene Name: KPNA5
Ensembl Gene: ENSMMUG00000048955.1
Ensembl Protein: ENSMMUP00000052071.1
Organism: Macaca mulatta
Taxa ID: 9544
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMMUT00000057312.1ENSMMUP00000052071.1
UniProtA0A1D5QVJ1, A0A1D5QVJ1_MACMU
GeneBankJSUE03032385

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASPGKDNYR  MKSYKNKALN  PQEMRRRREE  EGIQLRKQKR  EEQLFKRRNV  SLPRNDESML  60
61    ESPIQDPDIS  STVPIPEEEV  VTTDMVQMIF  SNNADQQLTA  TQKFRKLLSK  EPNPPIDQVI  120
121   QKPGVVQRFV  KFLERNENCT  LQFEAAWALT  NIASGTFLHT  KVVIETGAVP  IFIKLLNSEH  180
181   EDVQEQAVWA  LGNIAGDNAE  CRDFVLNCEI  LPPLLELLTN  SNRLTTTRNA  VWALSNLCRG  240
241   KNPPPNFSKV  SPCLNVLSRL  LFSSDPDVLA  DVCWALSYLS  DGPNDKIQAV  IDSGVCRRLV  300
301   ELLMHNDYKV  VSPALRAVGN  IVTGDDIQTQ  VILNCSALPC  LLHLLSSPKE  SIRKEACWTV  360
361   SNITAGNRAQ  IQAVIDANIF  PVLIEILQKA  EFRTRKEAAW  AITNATSGGT  PEQIRYLVAL  420
421   GCIKPLCDLL  TVMDSKIVQV  ALNGLENILR  LGEQESKQNG  IGVNPYCALI  EEAYGLDKIE  480
481   FLQSHENQEI  YQKAFDLIEH  YFGVEEDDPS  IVPQVDENQQ  QFIFQQQEAP  MDGFQL  536
Nucleotide CDS Sequence (FASTA)
1     ATGGCTAGTC  CAGGGAAAGA  TAACTATAGA  ATGAAAAGTT  ACAAGAATAA  AGCCCTAAAT  60
61    CCTCAAGAGA  TGCGTAGACG  AAGAGAAGAA  GAGGGAATAC  AGCTTAGAAA  ACAAAAAAGG  120
121   GAAGAACAGT  TGTTCAAACG  CAGAAATGTC  TCTTTGCCCA  GAAATGATGA  ATCTATGCTT  180
181   GAAAGTCCTA  TACAGGATCC  AGATATTAGT  TCCACTGTAC  CCATTCCAGA  GGAAGAAGTT  240
241   GTTACTACAG  ATATGGTTCA  GATGATTTTT  TCTAATAATG  CTGATCAACA  GCTAACAGCA  300
301   ACACAGAAAT  TTAGAAAGCT  GCTTTCTAAA  GAACCTAATC  CACCAATAGA  TCAAGTTATA  360
361   CAGAAACCAG  GAGTTGTACA  GAGATTTGTG  AAATTTCTTG  AAAGAAATGA  AAATTGCACT  420
421   TTACAATTTG  AAGCTGCATG  GGCATTAACT  AATATAGCAT  CTGGAACTTT  TCTGCATACC  480
481   AAGGTAGTGA  TTGAAACTGG  GGCTGTTCCA  ATTTTTATCA  AACTTCTTAA  TTCTGAACAT  540
541   GAAGATGTTC  AAGAGCAGGC  TGTTTGGGCA  CTTGGCAATA  TTGCTGGTGA  CAATGCAGAA  600
601   TGCAGAGATT  TTGTTTTGAA  TTGTGAAATA  CTTCCACCTC  TTTTAGAGTT  ATTAACAAAT  660
661   TCAAACAGAC  TCACAACAAC  AAGAAATGCT  GTGTGGGCCC  TCTCAAATTT  ATGTAGAGGC  720
721   AAAAACCCTC  CTCCAAACTT  TAGTAAGGTT  TCACCTTGCT  TAAATGTCCT  GTCACGACTG  780
781   TTGTTTAGCA  GTGACCCAGA  TGTGTTAGCA  GACGTGTGTT  GGGCCCTTTC  TTATCTCTCT  840
841   GATGGACCCA  ATGATAAAAT  TCAAGCAGTC  ATTGATTCTG  GAGTCTGTCG  AAGATTGGTG  900
901   GAACTTTTGA  TGCACAATGA  TTATAAAGTT  GTATCACCTG  CATTAAGGGC  AGTTGGTAAT  960
961   ATTGTGACTG  GTGATGATAT  TCAAACACAG  GTAATTTTGA  ATTGTTCTGC  ATTACCCTGT  1020
1021  CTCTTACATT  TATTGAGTAG  CCCAAAGGAG  TCAATTAGAA  AAGAAGCCTG  CTGGACTGTT  1080
1081  TCTAACATCA  CTGCTGGAAA  TAGAGCTCAG  ATTCAGGCTG  TTATAGATGC  AAATATTTTT  1140
1141  CCTGTTTTGA  TTGAGATTCT  TCAGAAAGCA  GAGTTTCGTA  CCAGAAAAGA  AGCAGCTTGG  1200
1201  GCTATAACTA  ATGCGACATC  AGGAGGTACT  CCAGAGCAAA  TAAGGTATTT  GGTAGCCTTA  1260
1261  GGCTGCATTA  AACCACTTTG  TGATCTTTTG  ACTGTTATGG  ACTCCAAAAT  AGTCCAAGTG  1320
1321  GCTTTAAATG  GACTTGAAAA  TATTTTACGT  CTTGGAGAAC  AAGAATCTAA  GCAGAATGGA  1380
1381  ATCGGCGTTA  ATCCATACTG  TGCTCTCATT  GAAGAAGCAT  ATGGTCTGGA  TAAAATTGAG  1440
1441  TTTTTGCAAA  GCCATGAAAA  TCAGGAAATT  TACCAGAAGG  CATTTGATCT  GATTGAACAT  1500
1501  TACTTTGGTG  TAGAAGAAGA  TGACCCCAGC  ATTGTACCTC  AGGTGGATGA  AAACCAACAA  1560
1561  CAGTTTATAT  TTCAGCAGCA  GGAAGCACCA  ATGGATGGAT  TTCAACTTTA  A  1611

▼ KEYWORD

ID
Family
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear pore
Cellular Component
Nucleoplasm
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Nuclear localization sequence binding
Molecular Function
Protein transporter activity
Biological Process
NLS-bearing protein import into nucleus

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cea-1352Cercocebus atys100.00.01010
LLPS-Chs-0532Chlorocebus sabaeus100.00.01011
LLPS-Maf-1483Macaca fascicularis100.00.01011
LLPS-Mal-0958Mandrillus leucophaeus100.00.01011
LLPS-Man-2885Macaca nemestrina100.00.01011
LLPS-Gog-0449Gorilla gorilla99.810.01010
LLPS-Aon-0781Aotus nancymaae99.810.01010
LLPS-Caj-0851Callithrix jacchus99.630.01008
LLPS-Hos-2834Homo sapiens99.630.01008
LLPS-Pat-3837Pan troglodytes99.630.01010
LLPS-Poa-2170Pongo abelii99.440.01002
LLPS-Paa-2611Papio anubis99.070.0 995
LLPS-Fec-2528Felis catus99.070.01008
LLPS-Cas-2783Carlito syrichta99.070.01008
LLPS-Aim-2129Ailuropoda melanoleuca98.880.01006
LLPS-Otg-4390Otolemur garnettii98.880.01006
LLPS-Bot-3694Bos taurus98.320.0 999
LLPS-Pap-2266Pan paniscus98.320.0 990
LLPS-Urm-1804Ursus maritimus98.150.01000
LLPS-Orc-2553Oryctolagus cuniculus98.130.0 998
LLPS-Caf-2487Canis familiaris97.960.0 993
LLPS-Ova-0586Ovis aries97.950.0 998
LLPS-Sus-1515Sus scrofa97.760.0 995
LLPS-Eqc-3148Equus caballus97.760.01009
LLPS-Tut-1224Tursiops truncatus97.390.0 983
LLPS-Myl-3704Myotis lucifugus96.080.0 979
LLPS-Rhb-3359Rhinopithecus bieti95.910.0 978
LLPS-Sah-1405Sarcophilus harrisii95.90.0 988
LLPS-Mea-3152Mesocricetus auratus95.90.0 980
LLPS-Ran-1491Rattus norvegicus94.760.0 952
LLPS-Mod-2630Monodelphis domestica94.590.0 969
LLPS-Pes-2513Pelodiscus sinensis94.40.0 990
LLPS-Tag-0575Taeniopygia guttata94.40.0 972
LLPS-Anp-2248Anas platyrhynchos94.220.0 972
LLPS-Gaga-0927Gallus gallus94.220.0 970
LLPS-Cap-3633Cavia porcellus94.030.0 986
LLPS-Anc-2101Anolis carolinensis91.420.0 941
LLPS-Dio-3218Dipodomys ordii91.290.0 917
LLPS-Loa-4296Loxodonta africana90.860.0 912
LLPS-Leo-0867Lepisosteus oculatus90.670.0 931
LLPS-Asm-4163Astyanax mexicanus89.740.0 935
LLPS-Icp-3416Ictalurus punctatus89.550.0 932
LLPS-Scf-3347Scleropages formosus88.250.0 922
LLPS-Orn-3501Oreochromis niloticus88.250.0 921
LLPS-Fia-0569Ficedula albicollis86.50.0 758
LLPS-Mum-4601Mus musculus84.70.0 872
LLPS-Ict-3964Ictidomys tridecemlineatus84.330.0 866
LLPS-Fud-4196Fukomys damarensis84.140.0 866
LLPS-Meg-1227Meleagris gallopavo84.140.0 860
LLPS-Ora-3345Ornithorhynchus anatinus84.110.0 833
LLPS-Orl-0830Oryzias latipes83.430.0 848
LLPS-Xet-0948Xenopus tropicalis83.020.0 857
LLPS-Scm-3715Scophthalmus maximus82.870.0 849
LLPS-Ten-1239Tetraodon nigroviridis82.870.0 853
LLPS-Tar-2551Takifugu rubripes82.680.0 851
LLPS-Xim-2775Xiphophorus maculatus82.680.0 838
LLPS-Dar-4244Danio rerio82.430.0 847
LLPS-Gaa-3659Gasterosteus aculeatus82.310.0 843
LLPS-Pof-1605Poecilia formosa82.220.0 832
LLPS-Mup-2014Mustela putorius furo79.590.0 800
LLPS-Nol-3937Nomascus leucogenys79.410.0 797
LLPS-Lac-0124Latimeria chalumnae77.080.0 769
LLPS-Cii-1094Ciona intestinalis65.090.0 635
LLPS-Drm-1601Drosophila melanogaster62.760.0 619
LLPS-Crn-0453Cryptococcus neoformans60.040.0 537
LLPS-Beb-0176Beauveria bassiana59.530.0 540
LLPS-Nec-0625Neurospora crassa59.250.0 551
LLPS-Coo-1424Colletotrichum orbiculare59.060.0 538
LLPS-Mao-1285Magnaporthe oryzae58.960.0 544
LLPS-Fuv-1029Fusarium verticillioides58.940.0 537
LLPS-Fuo-0668Fusarium oxysporum58.940.0 537
LLPS-Cogr-0059Colletotrichum graminicola58.860.0 535
LLPS-Trr-0178Trichoderma reesei58.740.0 554
LLPS-Cog-0318Colletotrichum gloeosporioides58.710.0 535
LLPS-Ved-1391Verticillium dahliae58.710.0 531
LLPS-Tum-0208Tuber melanosporum58.650.0 548
LLPS-Miv-0546Microbotryum violaceum58.610.0 543
LLPS-Trv-1149Trichoderma virens58.550.0 551
LLPS-Gag-1206Gaeumannomyces graminis58.460.0 564
LLPS-Mua-0005Musa acuminata58.370.0 530
LLPS-Ori-0779Oryza indica58.289e-178 518
LLPS-Lem-0538Leptosphaeria maculans58.150.0 540
LLPS-Orbr-0801Oryza brachyantha58.135e-180 525
LLPS-Sol-0417Solanum lycopersicum58.090.0 534
LLPS-Map-0249Magnaporthe poae58.070.0 562
LLPS-Orp-1406Oryza punctata58.01e-179 525
LLPS-Sob-0362Sorghum bicolor57.740.0 540
LLPS-Orb-0437Oryza barthii57.60.0 532
LLPS-Orgl-1316Oryza glumaepatula57.60.0 532
LLPS-Ors-1730Oryza sativa57.60.0 531
LLPS-Org-0778Oryza glaberrima57.60.0 532
LLPS-Orm-0572Oryza meridionalis57.60.0 532
LLPS-Orr-0629Oryza rufipogon57.60.0 531
LLPS-Asf-0705Aspergillus flavus57.590.0 540
LLPS-Aso-0120Aspergillus oryzae57.590.0 540
LLPS-Gor-1489Gossypium raimondii57.591e-178 521
LLPS-Sei-0627Setaria italica57.540.0 538
LLPS-Nef-0967Neosartorya fischeri57.510.0 537
LLPS-Asfu-0373Aspergillus fumigatus57.510.0 538
LLPS-Zem-0534Zea mays57.340.0 533
LLPS-Usm-0637Ustilago maydis57.220.0 540
LLPS-Cus-0336Cucumis sativus57.172e-180 526
LLPS-Ast-0980Aspergillus terreus57.110.0 536
LLPS-Pytr-0295Pyrenophora triticirepentis57.096e-180 525
LLPS-Fus-1103Fusarium solani57.040.0 538
LLPS-Asn-0636Aspergillus nidulans57.030.0 540
LLPS-Prp-0443Prunus persica57.032e-179 523
LLPS-Mel-0289Melampsora laricipopulina56.960.0 555
LLPS-Asc-0429Aspergillus clavatus56.890.0 540
LLPS-Via-2184Vigna angularis56.842e-177 518
LLPS-Gas-0099Galdieria sulphuraria56.830.0 540
LLPS-Dos-0786Dothistroma septosporum56.810.0 534
LLPS-Hea-1740Helianthus annuus56.751e-178 521
LLPS-Sem-1193Selaginella moellendorffii56.690.0 530
LLPS-Pug-0310Puccinia graminis56.610.0 540
LLPS-Zyt-0523Zymoseptoria tritici56.590.0 531
LLPS-Brd-2377Brachypodium distachyon56.460.0 527
LLPS-Met-1230Medicago truncatula56.452e-177 518
LLPS-Glm-1206Glycine max56.365e-178 520
LLPS-Amt-1823Amborella trichopoda56.330.0 538
LLPS-Coc-0830Corchorus capsularis56.11e-177 519
LLPS-Orni-2330Oryza nivara56.091e-179 525
LLPS-Nia-2496Nicotiana attenuata56.044e-178 520
LLPS-Sot-1448Solanum tuberosum55.970.0 534
LLPS-Brn-2320Brassica napus55.797e-178 520
LLPS-Bro-0021Brassica oleracea55.797e-178 520
LLPS-Viv-0579Vitis vinifera55.770.0 529
LLPS-Lep-1207Leersia perrieri55.684e-180 525
LLPS-Brr-0552Brassica rapa55.585e-178 520
LLPS-Php-1721Physcomitrella patens55.470.0 535
LLPS-Chr-1314Chlamydomonas reinhardtii55.470.0 541
LLPS-Pyt-0403Pyrenophora teres55.450.0 531
LLPS-Spr-0381Sporisorium reilianum55.390.0 533
LLPS-Mae-1182Manihot esculenta55.149e-179 521
LLPS-Tra-0265Triticum aestivum54.721e-177 518
LLPS-Yal-0529Yarrowia lipolytica54.470.0 537
LLPS-Abg-1031Absidia glauca54.346e-179 522
LLPS-Scj-0572Schizosaccharomyces japonicus54.08e-178 520
LLPS-Chc-0767Chondrus crispus53.530.0 534