• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-2487
KPNA5

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit alpha
Gene Name: KPNA5
Ensembl Gene: ENSCAFG00000000905.4
Ensembl Protein: ENSCAFP00000001291.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     LSVYLSHAMA  SPGKDNYRMK  SYKNKALNPQ  EMRRRREEEG  IQLRKQKREE  QLFKRRNVSL  60
61    PRNDESMLES  PIQDPDISST  VPIPEEEVIT  TDMVQMIFSN  NADQQLTATQ  KFRKLLSKEP  120
121   NPPIDQVIQK  PGVVQRFVKF  LERNENCTLQ  FEAAWALTNI  ASGTFLHTKV  VIETGAVPIF  180
181   IKLLNSEHED  VQEQAVWALG  NIAGDNAECR  DFVLNCEILP  PLLELLTNSN  RLTTTRNAVW  240
241   ALSNLCRGKN  PPPNFSKVSP  CLNVLSRLLF  SSDPDVLADV  CWALSYLSDG  PNDKIQAVID  300
301   SGVCRRLVEL  LIKEVKNLYK  VVSPALRAVG  NIVTGDDIQT  QVILNCSALP  CLLHLLSSPK  360
361   ESIRKEACWT  VSNITAGNRA  QIQAVIDANI  FPVLIEILQK  AEFRTRKEAA  WAITNATSGG  420
421   TPEQIRYLVA  LGCIKPLCDL  LTVMDSKIVQ  VALNGLENIL  RLGEQESKQN  GIGINPYCAL  480
481   IEEAYGLDKI  EFLQSHENQE  IYQKAFDLIE  HYFGVEEDDP  SIVPQVDESQ  QQFVFQQQEA  540
541   PMEGFQL  547
Nucleotide CDS Sequence (FASTA)
1     TTGTCTGTCT  ATTTAAGCCA  TGCCATGGCT  AGTCCAGGGA  AAGATAACTA  TAGGATGAAA  60
61    AGTTATAAGA  ATAAAGCCCT  AAATCCCCAA  GAGATGCGTA  GACGAAGAGA  AGAAGAAGGA  120
121   ATACAACTTC  GAAAACAAAA  AAGGGAAGAG  CAGTTGTTCA  AACGAAGAAA  TGTCTCTCTG  180
181   CCCAGAAATG  ATGAATCTAT  GCTAGAAAGT  CCTATCCAGG  ATCCAGATAT  CAGTTCCACT  240
241   GTACCCATTC  CAGAGGAAGA  AGTTATCACC  ACAGATATGG  TTCAGATGAT  ATTTTCTAAC  300
301   AATGCTGATC  AACAGCTAAC  AGCAACTCAG  AAATTTAGAA  AGCTACTTTC  TAAAGAACCT  360
361   AACCCACCAA  TAGATCAGGT  TATACAGAAA  CCGGGAGTTG  TACAGAGATT  TGTGAAATTT  420
421   CTTGAAAGAA  ATGAAAATTG  TACTTTACAG  TTTGAAGCTG  CATGGGCATT  AACTAATATA  480
481   GCATCTGGAA  CTTTTCTGCA  TACCAAGGTA  GTGATTGAAA  CTGGGGCTGT  TCCAATATTT  540
541   ATTAAACTTC  TTAATTCAGA  GCATGAAGAT  GTGCAAGAGC  AGGCTGTTTG  GGCACTTGGT  600
601   AATATTGCTG  GTGACAATGC  AGAATGTAGA  GATTTTGTTT  TGAATTGTGA  AATACTTCCA  660
661   CCTCTTTTAG  AGTTATTAAC  AAATTCAAAC  AGACTTACAA  CAACCAGAAA  TGCTGTATGG  720
721   GCCCTCTCAA  ATTTATGTAG  AGGCAAAAAC  CCTCCTCCAA  ACTTTAGTAA  GGTTTCACCT  780
781   TGCTTAAATG  TCTTGTCACG  ATTGTTGTTT  AGCAGCGACC  CAGATGTATT  AGCAGATGTG  840
841   TGCTGGGCCC  TTTCTTATCT  CTCTGATGGA  CCCAATGATA  AAATTCAAGC  AGTCATTGAT  900
901   TCTGGAGTCT  GTCGAAGATT  GGTGGAACTT  TTGATAAAAG  AAGTTAAAAA  CCTTTATAAA  960
961   GTTGTATCAC  CTGCATTAAG  AGCAGTTGGT  AATATTGTGA  CTGGTGATGA  TATTCAAACA  1020
1021  CAGGTAATCT  TGAATTGTTC  TGCATTACCA  TGTCTCTTAC  ATTTGTTGAG  TAGCCCTAAG  1080
1081  GAATCAATAA  GAAAAGAAGC  CTGCTGGACT  GTTTCTAATA  TCACTGCTGG  AAATAGAGCT  1140
1141  CAGATTCAGG  CTGTTATAGA  TGCAAATATT  TTTCCTGTTT  TGATTGAGAT  TCTTCAGAAA  1200
1201  GCAGAGTTTC  GCACCAGAAA  AGAAGCAGCT  TGGGCTATAA  CTAATGCAAC  ATCAGGAGGC  1260
1261  ACTCCAGAAC  AAATAAGGTA  TTTGGTAGCT  TTAGGTTGCA  TTAAACCACT  TTGTGACCTG  1320
1321  TTGACTGTTA  TGGACTCTAA  AATAGTCCAA  GTGGCTTTAA  ATGGACTTGA  AAATATTTTA  1380
1381  CGTCTTGGAG  AACAAGAATC  TAAGCAGAAT  GGGATAGGTA  TTAATCCATA  CTGTGCTCTC  1440
1441  ATTGAAGAAG  CATATGGTCT  GGATAAAATC  GAATTTTTGC  AAAGCCATGA  AAATCAGGAA  1500
1501  ATTTACCAAA  AGGCTTTTGA  TTTGATTGAA  CATTACTTTG  GTGTAGAGGA  AGATGACCCA  1560
1561  AGCATTGTAC  CTCAGGTGGA  TGAAAGTCAA  CAGCAGTTTG  TTTTTCAGCA  GCAGGAAGCA  1620
1621  CCAATGGAAG  GGTTTCAACT  TTAA  1644

▼ KEYWORD

ID
Family
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear pore
Cellular Component
Nucleoplasm
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Nuclear localization sequence binding
Molecular Function
Protein transporter activity
Biological Process
NLS-bearing protein import into nucleus

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-2129Ailuropoda melanoleuca98.70.0 984
LLPS-Cas-2783Carlito syrichta98.520.0 983
LLPS-Fec-2528Felis catus98.520.0 984
LLPS-Pat-3837Pan troglodytes98.150.0 983
LLPS-Gog-0449Gorilla gorilla98.150.0 983
LLPS-Aon-0781Aotus nancymaae98.150.0 983
LLPS-Urm-1804Ursus maritimus97.980.0 978
LLPS-Mam-3200Macaca mulatta97.960.0 981
LLPS-Otg-4390Otolemur garnettii97.960.0 980
LLPS-Man-2885Macaca nemestrina97.960.0 982
LLPS-Hos-2834Homo sapiens97.960.0 981
LLPS-Mal-0958Mandrillus leucophaeus97.960.0 982
LLPS-Caj-0851Callithrix jacchus97.960.0 981
LLPS-Cea-1352Cercocebus atys97.960.0 981
LLPS-Chs-0532Chlorocebus sabaeus97.960.0 982
LLPS-Maf-1483Macaca fascicularis97.960.0 982
LLPS-Bot-3694Bos taurus97.780.0 976
LLPS-Poa-2170Pongo abelii97.420.0 976
LLPS-Ova-0586Ovis aries97.410.0 974
LLPS-Eqc-3148Equus caballus97.220.0 986
LLPS-Orc-2553Oryctolagus cuniculus97.220.0 973
LLPS-Paa-2611Papio anubis97.040.0 966
LLPS-Pap-2266Pan paniscus96.850.0 961
LLPS-Sus-1515Sus scrofa96.850.0 971
LLPS-Tut-1224Tursiops truncatus96.150.0 962
LLPS-Myl-3704Myotis lucifugus95.550.0 956
LLPS-Sah-1405Sarcophilus harrisii95.040.0 965
LLPS-Mea-3152Mesocricetus auratus94.990.0 954
LLPS-Tag-0575Taeniopygia guttata94.250.0 949
LLPS-Mod-2630Monodelphis domestica94.070.0 947
LLPS-Gaga-0927Gallus gallus94.060.0 947
LLPS-Cap-3633Cavia porcellus94.060.0 966
LLPS-Ran-1491Rattus norvegicus94.00.0 938
LLPS-Pes-2513Pelodiscus sinensis93.550.0 969
LLPS-Rhb-3359Rhinopithecus bieti93.530.0 949
LLPS-Anp-2248Anas platyrhynchos93.220.0 950
LLPS-Dio-3218Dipodomys ordii90.770.0 892
LLPS-Anc-2101Anolis carolinensis90.190.0 917
LLPS-Loa-4296Loxodonta africana90.190.0 887
LLPS-Leo-0867Lepisosteus oculatus89.810.0 907
LLPS-Asm-4163Astyanax mexicanus88.870.0 910
LLPS-Icp-3416Ictalurus punctatus87.850.0 909
LLPS-Orn-3501Oreochromis niloticus87.450.0 899
LLPS-Scf-3347Scleropages formosus87.20.0 896
LLPS-Fia-0569Ficedula albicollis85.270.0 732
LLPS-Ora-3345Ornithorhynchus anatinus84.120.0 818
LLPS-Mum-4601Mus musculus83.360.0 848
LLPS-Fud-4196Fukomys damarensis83.120.0 843
LLPS-Ict-3964Ictidomys tridecemlineatus82.990.0 842
LLPS-Orl-0830Oryzias latipes82.780.0 827
LLPS-Xet-0948Xenopus tropicalis82.410.0 837
LLPS-Meg-1227Meleagris gallopavo82.270.0 837
LLPS-Ten-1239Tetraodon nigroviridis82.040.0 830
LLPS-Scm-3715Scophthalmus maximus82.040.0 826
LLPS-Xim-2775Xiphophorus maculatus81.850.0 816
LLPS-Dar-4244Danio rerio81.60.0 820
LLPS-Gaa-3659Gasterosteus aculeatus81.480.0 822
LLPS-Pof-1605Poecilia formosa81.40.0 811
LLPS-Tar-2551Takifugu rubripes81.10.0 830
LLPS-Mup-2014Mustela putorius furo79.150.0 780
LLPS-Nol-3937Nomascus leucogenys78.60.0 775
LLPS-Lac-2517Latimeria chalumnae76.380.0 768
LLPS-Cii-1094Ciona intestinalis64.50.0 622
LLPS-Drm-1601Drosophila melanogaster62.60.0 613
LLPS-Miv-0546Microbotryum violaceum59.332e-180 526
LLPS-Crn-0453Cryptococcus neoformans59.090.0 527
LLPS-Beb-0176Beauveria bassiana58.980.0 531
LLPS-Nec-0625Neurospora crassa58.710.0 542
LLPS-Fus-1103Fusarium solani58.590.0 528
LLPS-Fuo-0668Fusarium oxysporum58.41e-180 527
LLPS-Trr-0178Trichoderma reesei58.40.0 546
LLPS-Fuv-1029Fusarium verticillioides58.41e-180 527
LLPS-Coo-1424Colletotrichum orbiculare58.370.0 528
LLPS-Usm-0637Ustilago maydis58.331e-178 522
LLPS-Mao-1285Magnaporthe oryzae58.270.0 535
LLPS-Trv-1149Trichoderma virens58.20.0 543
LLPS-Cogr-0059Colletotrichum graminicola58.179e-180 525
LLPS-Ved-1391Verticillium dahliae58.172e-178 522
LLPS-Cog-0318Colletotrichum gloeosporioides58.177e-180 526
LLPS-Tum-0208Tuber melanosporum57.910.0 538
LLPS-Gag-1206Gaeumannomyces graminis57.780.0 554
LLPS-Sol-0417Solanum lycopersicum57.750.0 527
LLPS-Lem-0538Leptosphaeria maculans57.620.0 530
LLPS-Mua-0005Musa acuminata57.624e-178 520
LLPS-Pytr-0295Pyrenophora triticirepentis57.427e-176 515
LLPS-Pyt-0403Pyrenophora teres57.428e-178 520
LLPS-Map-0249Magnaporthe poae57.390.0 553
LLPS-Mel-0289Melampsora laricipopulina57.280.0 537
LLPS-Gor-1489Gossypium raimondii57.252e-176 516
LLPS-Orbr-0801Oryza brachyantha57.178e-176 514
LLPS-Orp-1406Oryza punctata57.062e-175 515
LLPS-Php-1721Physcomitrella patens56.971e-180 527
LLPS-Sob-0362Sorghum bicolor56.80.0 530
LLPS-Asf-0705Aspergillus flavus56.670.0 530
LLPS-Aso-0120Aspergillus oryzae56.670.0 530
LLPS-Asc-0429Aspergillus clavatus56.670.0 528
LLPS-Org-0778Oryza glaberrima56.662e-178 521
LLPS-Orm-0572Oryza meridionalis56.662e-178 521
LLPS-Orr-0629Oryza rufipogon56.661e-177 521
LLPS-Ors-1730Oryza sativa56.662e-178 521
LLPS-Orgl-1316Oryza glumaepatula56.661e-177 521
LLPS-Orb-0437Oryza barthii56.661e-177 521
LLPS-Sei-0627Setaria italica56.610.0 528
LLPS-Asfu-0373Aspergillus fumigatus56.583e-180 526
LLPS-Nef-0967Neosartorya fischeri56.585e-180 526
LLPS-Sem-1193Selaginella moellendorffii56.585e-180 525
LLPS-Lep-1207Leersia perrieri56.467e-176 514
LLPS-Zem-0534Zea mays56.414e-179 523
LLPS-Cus-0336Cucumis sativus56.44e-176 515
LLPS-Prp-0443Prunus persica56.328e-176 514
LLPS-Coc-1121Corchorus capsularis56.275e-174 509
LLPS-Ast-0980Aspergillus terreus56.191e-179 525
LLPS-Asn-0636Aspergillus nidulans56.190.0 529
LLPS-Glm-2696Glycine max56.166e-174 509
LLPS-Gas-0099Galdieria sulphuraria56.10.0 531
LLPS-Hea-1740Helianthus annuus56.033e-175 513
LLPS-Viv-0579Vitis vinifera55.954e-178 521
LLPS-Dos-0786Dothistroma septosporum55.94e-179 524
LLPS-Vir-0910Vigna radiata55.813e-174 510
LLPS-Pug-0310Puccinia graminis55.749e-180 525
LLPS-Met-1230Medicago truncatula55.738e-174 509
LLPS-Nia-2496Nicotiana attenuata55.713e-175 513
LLPS-Zyt-0523Zymoseptoria tritici55.682e-178 522
LLPS-Mae-1182Manihot esculenta55.672e-174 511
LLPS-Sot-1448Solanum tuberosum55.661e-180 526
LLPS-Brd-2377Brachypodium distachyon55.533e-176 516
LLPS-Amt-1823Amborella trichopoda55.450.0 527
LLPS-Via-2184Vigna angularis55.261e-173 509
LLPS-Orni-2330Oryza nivara55.193e-175 515
LLPS-Spr-0381Sporisorium reilianum55.086e-176 515
LLPS-Brr-0552Brassica rapa54.938e-174 509
LLPS-Chr-1314Chlamydomonas reinhardtii54.780.0 530
LLPS-Yal-0529Yarrowia lipolytica54.091e-180 527
LLPS-Chc-0767Chondrus crispus53.862e-178 523
LLPS-Abg-1031Absidia glauca53.661e-175 514