• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Mam-1079
AARS2

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Uncharacterized protein
Gene Name: AARS2, AARS
Ensembl Gene: ENSMMUG00000014387.3
Ensembl Protein: ENSMMUP00000056715.1
Organism: Macaca mulatta
Taxa ID: 9544
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Mitochondrial RNA granulePredicted from orthologs(View)

▼ FUNCTION


Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MAALVAAAAR  RLRRAIRRSL  AWRGPSHRLL  SSEPPAAKAS  AVRAAFLNFF  RDRHGHRLVP  60
61    SASVRPRGDP  SLLFVNAGMN  QFKPIFLGTV  DPRSEMAGFR  RVANSQKCVR  AGGRHNDLED  120
121   VGRDLSHHTF  FEMLGNWAFG  GEYFKEEACS  MAWELLTQVY  GIPTERLWVS  YFDGDPKAGL  180
181   EPDLETRDIW  LSLGVPATRV  LSFGPQENFW  EMGNTGPCGP  CTEIHYDLAG  GVGAPQLVEL  240
241   WNLVFMQHNR  EADGSLQPLP  QWHVDTGMGL  ERLVAVLQGK  HSTYDTDLFS  PLLHAIQQGC  300
301   RAPPYLGRVG  VADEGRTDTA  YRVVADHIRT  LSVCISDGVF  PGMSGPPLVL  RRILRRAVRF  360
361   SMEILKAPPG  FLGSLVPVVV  ETLRPSFQGD  LAPLLLCLVQ  ISNLVLEDEA  AFLASLERGR  420
421   RIIDRTLRTL  GPSDMFPAEV  AWSLSLSGDL  GLPLDMVELM  LEEKGVQLDS  TGLERLAQEA  480
481   AQHQARQAEP  VQKQGLWLDV  HALGELQHQG  VPPTDSSPKY  NYSLRPNGSY  EFGTCEAQVL  540
541   QLYTEDGTAV  ASVGKGQRCG  LLLDRTNFYA  EQGGQASDRG  YLVRVGQEDV  LFPVARAQVC  600
601   GGFILHEAVA  PECLQIGDQV  QLHVDKAWRL  ACMAKHTATH  LLNWALRQTL  GPGTEQQGSH  660
661   LNPEQLRLDV  TTQTALTPER  LRAVENTVQE  AVQQDKPVYM  EEVPLALTAQ  VPGLRCLDEV  720
721   YPDPVRVVSV  GVPVAHALDP  ASQAALQTSV  ELCCGTHLLR  TGAVGDLVII  GDRQLSKGTT  780
781   RLLAITGEQA  QQARELGQNL  AQEVKAATER  LSQGSRDVAE  ALRLSKDIGR  LIEAVETSVM  840
841   PQWQRRELLA  TLKMLQRRAN  TAIRKLQMGQ  AAKKTQELLE  RHSKGPLIVD  TVSAESLSVL  900
901   VKVVRQLCEQ  APSTSVLLLS  PQSMGKVLCA  CQVAQGAMPT  FTAEAWALAV  CSHMGGKAWG  960
961   SRVVAQGTGS  TTDLEAALST  ARAYALSQL  989
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGCGT  TGGTGGCAGC  TGCAGCCCGG  CGGCTGCGGC  GGGCCATTCG  AAGGTCGCTC  60
61    GCATGGCGGG  GCCCCAGCCA  TCGGCTGCTC  TCATCGGAGC  CCCCTGCAGC  CAAGGCCTCG  120
121   GCCGTGAGGG  CCGCCTTTCT  GAACTTCTTT  CGGGACCGCC  ATGGCCACCG  GCTGGTGCCC  180
181   TCCGCCTCCG  TGCGGCCCCG  CGGCGACCCC  AGTTTGCTTT  TTGTCAACGC  GGGCATGAAC  240
241   CAGTTCAAGC  CAATCTTTCT  GGGCACCGTG  GATCCACGAA  GCGAAATGGC  AGGCTTCCGA  300
301   CGTGTGGCCA  ACAGCCAGAA  ATGTGTGAGA  GCTGGAGGAC  GCCATAACGA  CCTGGAAGAT  360
361   GTGGGTCGAG  ACCTTTCCCA  TCATACCTTC  TTTGAAATGC  TTGGCAATTG  GGCCTTTGGG  420
421   GGTGAATATT  TTAAGGAGGA  GGCATGTAGC  ATGGCCTGGG  AACTGCTGAC  TCAGGTCTAT  480
481   GGGATCCCTA  CGGAAAGGCT  CTGGGTCTCC  TACTTTGATG  GTGACCCTAA  GGCAGGGTTG  540
541   GAGCCAGACT  TGGAGACCAG  GGACATTTGG  CTGAGCTTAG  GGGTGCCTGC  TACTCGTGTG  600
601   CTTTCCTTTG  GACCACAAGA  GAACTTCTGG  GAGATGGGGA  ATACCGGCCC  TTGTGGACCC  660
661   TGTACCGAGA  TCCACTATGA  CCTTGCTGGT  GGGGTGGGAG  CCCCCCAGCT  GGTAGAACTT  720
721   TGGAACCTGG  TCTTCATGCA  ACACAACAGA  GAGGCAGATG  GAAGCCTGCA  GCCCTTGCCC  780
781   CAGTGGCATG  TGGACACAGG  AATGGGCCTG  GAAAGGCTGG  TGGCTGTGCT  GCAAGGCAAA  840
841   CACTCCACCT  ATGACACTGA  CCTCTTTTCC  CCGCTGCTCC  ACGCCATACA  GCAGGGCTGC  900
901   AGGGCACCCC  CTTACTTGGG  CCGGGTAGGG  GTGGCAGACG  AGGGGCGCAC  AGACACAGCG  960
961   TACCGCGTGG  TGGCTGACCA  CATCCGCACA  CTCAGTGTCT  GCATCTCTGA  TGGCGTCTTC  1020
1021  CCTGGGATGT  CAGGTCCCCC  GCTGGTTCTT  CGTCGGATCC  TCCGTCGAGC  TGTACGTTTC  1080
1081  TCCATGGAGA  TCTTAAAGGC  ACCACCTGGC  TTCCTAGGCA  GCCTGGTGCC  TGTAGTGGTG  1140
1141  GAGACATTGA  GACCCTCCTT  TCAAGGAGAC  CTAGCTCCAC  TTCTGCTCTG  TCTGGTTCAG  1200
1201  ATCTCCAACC  TGGTGTTAGA  GGACGAGGCA  GCCTTCCTGG  CCTCCCTGGA  GCGGGGTCGG  1260
1261  CGGATCATTG  ATCGGACTCT  GAGGACCCTG  GGGCCTTCAG  ATATGTTCCC  TGCTGAAGTG  1320
1321  GCCTGGTCCT  TGTCACTGTC  TGGAGACCTG  GGGCTCCCCT  TGGACATGGT  AGAGCTGATG  1380
1381  CTGGAGGAGA  AAGGGGTCCA  GCTGGACTCC  ACTGGACTGG  AGCGGTTGGC  CCAGGAGGCG  1440
1441  GCCCAGCACC  AGGCACGGCA  GGCTGAGCCA  GTTCAGAAGC  AGGGATTGTG  GCTTGATGTC  1500
1501  CATGCACTGG  GGGAGCTGCA  GCACCAAGGA  GTGCCCCCAA  CTGACAGCAG  CCCCAAGTAC  1560
1561  AACTACTCCC  TGCGACCCAA  CGGAAGTTAT  GAGTTCGGCA  CCTGTGAGGC  CCAGGTGTTG  1620
1621  CAACTGTATA  CAGAGGACGG  GACAGCAGTG  GCCTCTGTGG  GGAAAGGCCA  GCGTTGTGGC  1680
1681  CTCCTCTTGG  ACAGGACCAA  CTTCTACGCA  GAACAGGGGG  GCCAGGCTTC  AGACCGTGGC  1740
1741  TACCTGGTGC  GGGTAGGGCA  AGAGGACGTG  CTGTTCCCAG  TAGCCCGGGC  CCAGGTCTGT  1800
1801  GGGGGTTTCA  TCCTGCATGA  GGCAGTAGCC  CCTGAGTGCC  TACAGATCGG  GGACCAGGTG  1860
1861  CAGCTGCATG  TGGATAAGGC  CTGGCGTCTA  GCCTGCATGG  CGAAGCACAC  GGCCACCCAC  1920
1921  CTGCTGAACT  GGGCACTGCG  GCAGACCCTG  GGCCCTGGCA  CAGAGCAGCA  GGGCTCCCAT  1980
1981  CTCAATCCTG  AGCAGCTGCG  CTTGGATGTG  ACCACCCAGA  CCGCATTGAC  CCCAGAGCGG  2040
2041  CTCCGGGCAG  TGGAGAACAC  TGTGCAGGAG  GCCGTGCAGC  AGGATAAGCC  TGTGTACATG  2100
2101  GAGGAGGTGC  CCCTGGCGCT  CACTGCCCAG  GTCCCTGGCC  TGCGCTGTCT  GGATGAAGTT  2160
2161  TACCCAGACC  CTGTACGGGT  GGTGTCAGTG  GGGGTACCCG  TGGCCCATGC  ATTGGACCCA  2220
2221  GCCTCCCAAG  CCGCACTGCA  GACCTCTGTG  GAGCTGTGCT  GTGGGACGCA  CCTGTTACGT  2280
2281  ACAGGGGCTG  TAGGGGACCT  GGTTATCATC  GGGGACCGCC  AGCTTTCCAA  GGGCACTACC  2340
2341  CGCCTGCTGG  CCATCACTGG  GGAGCAGGCC  CAGCAGGCCC  GAGAGCTAGG  CCAGAACCTG  2400
2401  GCTCAGGAAG  TGAAAGCAGC  CACTGAGCGA  CTGAGTCAGG  GGAGCCGGGA  TGTGGCAGAG  2460
2461  GCACTGAGGC  TGTCCAAGGA  CATAGGACGA  CTCATTGAAG  CTGTGGAAAC  TTCTGTGATG  2520
2521  CCCCAGTGGC  AGCGGCGGGA  GCTGCTGGCC  ACACTGAAGA  TGCTGCAGCG  GCGTGCCAAC  2580
2581  ACTGCCATCC  GTAAGCTGCA  GATGGGGCAG  GCTGCAAAGA  AAACTCAGGA  GCTGCTGGAG  2640
2641  CGGCACTCGA  AGGGGCCTCT  GATTGTGGAC  ACGGTCTCTG  CTGAGTCTCT  CTCAGTGCTG  2700
2701  GTGAAGGTGG  TACGGCAGCT  GTGTGAGCAG  GCCCCCAGCA  CATCTGTGCT  CCTACTCAGC  2760
2761  CCCCAGTCCA  TGGGGAAGGT  GCTGTGTGCC  TGTCAGGTGG  CCCAGGGTGC  CATGCCCACT  2820
2821  TTCACAGCAG  AGGCCTGGGC  ACTGGCAGTG  TGCAGCCACA  TGGGGGGCAA  GGCCTGGGGC  2880
2881  TCGCGAGTGG  TGGCCCAAGG  CACCGGAAGC  ACTACTGACC  TGGAAGCTGC  CCTCAGTACA  2940
2941  GCCCGAGCCT  ATGCCCTCAG  CCAGCTCTGA  2970

▼ KEYWORD


ID
Family
Aminoacyl-tRNA synthetase
ATP-binding
Coiled coil
Complete proteome
Ligase
Metal-binding
Nucleotide-binding
Protein biosynthesis
Reference proteome
RNA-binding
tRNA-binding
Ubl conjugation
Zinc

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Alanine-tRNA ligase activity
Molecular Function
Amino acid binding
Molecular Function
ATP binding
Molecular Function
TRNA binding
Molecular Function
Zinc ion binding
Biological Process
Alanyl-tRNA aminoacylation
Biological Process
Mitochondrial alanyl-tRNA aminoacylation
Biological Process
Mitochondrial respiratory chain complex assembly
Biological Process
TRNA modification

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-2808Macaca fascicularis98.450.01772
LLPS-Man-4331Macaca nemestrina98.240.01769
LLPS-Paa-1354Papio anubis98.040.01765
LLPS-Chs-2910Chlorocebus sabaeus97.720.01758
LLPS-Cea-2561Cercocebus atys97.720.01757
LLPS-Rhb-0526Rhinopithecus bieti97.00.01747
LLPS-Nol-1605Nomascus leucogenys95.820.0 584
LLPS-Pat-2278Pan troglodytes94.620.01701
LLPS-Gog-1243Gorilla gorilla94.520.01701
LLPS-Pap-0759Pan paniscus94.520.01699
LLPS-Hos-0559Homo sapiens94.420.01698
LLPS-Poa-0953Pongo abelii94.30.01611
LLPS-Mal-4666Mandrillus leucophaeus93.060.01650
LLPS-Aon-4231Aotus nancymaae91.560.01568
LLPS-Caj-1676Callithrix jacchus88.480.01624
LLPS-Myl-3202Myotis lucifugus86.250.01564
LLPS-Loa-3214Loxodonta africana86.250.01558
LLPS-Cas-2552Carlito syrichta86.140.01555
LLPS-Eqc-4145Equus caballus86.040.01556
LLPS-Otg-1191Otolemur garnettii86.020.01556
LLPS-Fec-4717Felis catus85.830.01541
LLPS-Mea-1109Mesocricetus auratus85.170.01514
LLPS-Bot-1965Bos taurus84.940.01509
LLPS-Tut-0727Tursiops truncatus84.930.01543
LLPS-Caf-3115Canis familiaris84.90.01536
LLPS-Ict-2566Ictidomys tridecemlineatus84.520.01543
LLPS-Sus-0710Sus scrofa84.140.01504
LLPS-Mup-3729Mustela putorius furo83.850.01515
LLPS-Aim-4037Ailuropoda melanoleuca83.510.01480
LLPS-Ran-3874Rattus norvegicus83.210.01427
LLPS-Fud-1609Fukomys damarensis82.940.01498
LLPS-Orc-0009Oryctolagus cuniculus82.880.01452
LLPS-Mum-4122Mus musculus82.710.01489
LLPS-Ova-1431Ovis aries82.660.01431
LLPS-Cap-4632Cavia porcellus82.010.01471
LLPS-Dio-1902Dipodomys ordii79.590.01394
LLPS-Urm-3082Ursus maritimus76.620.01244
LLPS-Mod-3825Monodelphis domestica75.310.01365
LLPS-Sah-1240Sarcophilus harrisii74.640.01357
LLPS-Sol-1203Solanum lycopersicum62.832e-39 163
LLPS-Pes-1803Pelodiscus sinensis61.890.01070
LLPS-Tag-3102Taeniopygia guttata60.150.01079
LLPS-Fia-2700Ficedula albicollis59.480.01010
LLPS-Meg-2914Meleagris gallopavo58.480.0 951
LLPS-Orb-1231Oryza barthii58.312e-116 389
LLPS-Gaga-2585Gallus gallus58.140.01023
LLPS-Orni-0214Oryza nivara57.982e-114 384
LLPS-Anc-1253Anolis carolinensis57.860.01043
LLPS-Icp-1645Ictalurus punctatus57.850.0 994
LLPS-Asm-0609Astyanax mexicanus57.490.0 988
LLPS-Dar-2299Danio rerio57.380.0 840
LLPS-Pof-0150Poecilia formosa56.740.0 940
LLPS-Scf-3215Scleropages formosus56.270.0 988
LLPS-Scm-0013Scophthalmus maximus55.780.0 961
LLPS-Xim-0746Xiphophorus maculatus55.670.0 917
LLPS-Orn-2016Oreochromis niloticus55.590.0 939
LLPS-Gaa-1530Gasterosteus aculeatus55.245e-126 413
LLPS-Orl-1600Oryzias latipes55.170.0 884
LLPS-Sot-0672Solanum tuberosum54.552e-0857.8
LLPS-Leo-1799Lepisosteus oculatus54.50.0 905
LLPS-Tar-2625Takifugu rubripes52.140.0 893
LLPS-Coc-0120Corchorus capsularis48.633e-146 454
LLPS-Chr-0450Chlamydomonas reinhardtii46.571e-173 545
LLPS-Ora-0783Ornithorhynchus anatinus45.10.0 720
LLPS-Ten-1360Tetraodon nigroviridis44.570.0 687
LLPS-Via-0835Vigna angularis43.30.0 561
LLPS-Art-0465Arabidopsis thaliana43.090.0 564
LLPS-Sem-1587Selaginella moellendorffii42.643e-65 241
LLPS-Xet-0132Xenopus tropicalis42.50.0 684
LLPS-Cae-0190Caenorhabditis elegans42.150.0 686
LLPS-Sob-0249Sorghum bicolor42.134e-176 547
LLPS-Lac-0962Latimeria chalumnae42.120.0 675
LLPS-Brn-2553Brassica napus41.850.0 588
LLPS-Brr-0701Brassica rapa41.850.0 589
LLPS-Drm-1478Drosophila melanogaster41.630.0 704
LLPS-Tra-1584Triticum aestivum41.332e-179 556
LLPS-Gor-0697Gossypium raimondii41.280.0 574
LLPS-Lep-0017Leersia perrieri41.152e-174 539
LLPS-Cym-0463Cyanidioschyzon merolae41.095e-166 522
LLPS-Prp-0502Prunus persica41.070.0 562
LLPS-Amt-0605Amborella trichopoda41.040.0 575
LLPS-Arl-1919Arabidopsis lyrata40.950.0 559
LLPS-Thc-0252Theobroma cacao40.880.0 565
LLPS-Mae-1991Manihot esculenta40.650.0 570
LLPS-Cii-1898Ciona intestinalis40.640.0 682
LLPS-Crn-0224Cryptococcus neoformans40.611e-175 546
LLPS-Mua-0080Musa acuminata40.61e-176 546
LLPS-Bro-0598Brassica oleracea40.581e-160 502
LLPS-Nia-0742Nicotiana attenuata40.520.0 569
LLPS-Cus-0524Cucumis sativus40.460.0 582
LLPS-Orr-1853Oryza rufipogon40.450.0 563
LLPS-Org-0669Oryza glaberrima40.310.0 563
LLPS-Orm-0464Oryza meridionalis40.211e-179 556
LLPS-Php-1056Physcomitrella patens40.191e-180 558
LLPS-Ori-0772Oryza indica40.190.0 558
LLPS-Ors-0683Oryza sativa40.192e-180 558
LLPS-Hov-1307Hordeum vulgare40.090.0 561
LLPS-Hea-0544Helianthus annuus39.960.0 573
LLPS-Sei-0670Setaria italica39.799e-174 541
LLPS-Cis-0505Ciona savignyi39.770.0 665
LLPS-Tru-1183Triticum urartu39.71e-172 536
LLPS-Osl-1438Ostreococcus lucimarinus39.541e-169 528
LLPS-Met-1418Medicago truncatula39.520.0 567
LLPS-Brd-0505Brachypodium distachyon39.52e-178 553
LLPS-Scc-0666Schizosaccharomyces cryophilus39.480.0 619
LLPS-Pot-0469Populus trichocarpa39.410.0 564
LLPS-Scj-0101Schizosaccharomyces japonicus39.40.0 619
LLPS-Viv-0416Vitis vinifera39.170.0 578
LLPS-Asfu-0461Aspergillus fumigatus39.110.0 570
LLPS-Glm-1580Glycine max39.092e-180 558
LLPS-Phv-0674Phaseolus vulgaris39.00.0 572
LLPS-Scp-0847Schizosaccharomyces pombe38.980.0 604
LLPS-Nef-0054Neosartorya fischeri38.750.0 574
LLPS-Asc-0836Aspergillus clavatus38.740.0 583
LLPS-Pytr-0900Pyrenophora triticirepentis38.70.0 578
LLPS-Fuv-1133Fusarium verticillioides38.441e-180 557
LLPS-Fuo-0625Fusarium oxysporum38.440.0 560
LLPS-Orbr-0609Oryza brachyantha38.442e-141 451
LLPS-Orgl-1321Oryza glumaepatula38.429e-175 545
LLPS-Put-0572Puccinia triticina38.410.0 565
LLPS-Pyt-0410Pyrenophora teres38.270.0 573
LLPS-Fus-0818Fusarium solani38.262e-178 551
LLPS-Asg-0906Ashbya gossypii38.150.0 570
LLPS-Lem-0450Leptosphaeria maculans38.140.0 560
LLPS-Asn-0989Aspergillus nidulans38.090.0 563
LLPS-Kop-0100Komagataella pastoris38.080.0 608
LLPS-Gag-0620Gaeumannomyces graminis38.080.0 565
LLPS-Pug-0247Puccinia graminis38.070.0 570
LLPS-Sac-0067Saccharomyces cerevisiae38.00.0 596
LLPS-Orp-0548Oryza punctata37.992e-164 514
LLPS-Yal-0824Yarrowia lipolytica37.840.0 578
LLPS-Phn-0342Phaeosphaeria nodorum37.841e-177 550
LLPS-Abg-0127Absidia glauca37.820.0 582
LLPS-Ast-0610Aspergillus terreus37.780.0 562
LLPS-Gas-1073Galdieria sulphuraria37.761e-175 545
LLPS-Zem-1642Zea mays37.63e-172 536
LLPS-Miv-0017Microbotryum violaceum37.586e-180 555
LLPS-Tum-0014Tuber melanosporum37.370.0 598
LLPS-Mao-0144Magnaporthe oryzae37.312e-175 548
LLPS-Asni-0048Aspergillus niger37.290.0 562
LLPS-Trv-0940Trichoderma virens37.230.0 566
LLPS-Chc-0849Chondrus crispus37.224e-176 545
LLPS-Usm-0629Ustilago maydis37.010.0 576
LLPS-Cog-0542Colletotrichum gloeosporioides36.982e-177 548
LLPS-Trr-1044Trichoderma reesei36.94e-180 556
LLPS-Spr-0851Sporisorium reilianum36.780.0 570
LLPS-Dos-0024Dothistroma septosporum36.730.0 560
LLPS-Zyt-0836Zymoseptoria tritici36.710.0 572
LLPS-Mel-0168Melampsora laricipopulina36.630.0 587
LLPS-Map-1138Magnaporthe poae36.61e-167 526
LLPS-Dac-1307Daucus carota36.577e-173 537
LLPS-Cogr-0200Colletotrichum graminicola36.417e-174 540
LLPS-Aso-0189Aspergillus oryzae36.332e-156 493
LLPS-Coo-0717Colletotrichum orbiculare36.284e-176 545
LLPS-Nec-0783Neurospora crassa36.194e-172 539
LLPS-Beb-0062Beauveria bassiana35.984e-171 532
LLPS-Blg-0863Blumeria graminis35.314e-173 539
LLPS-Ved-0598Verticillium dahliae35.181e-163 513
LLPS-Scs-0802Sclerotinia sclerotiorum33.545e-149 474
LLPS-Vir-0127Vigna radiata30.941e-81 291