LLPS-Drm-1478
AlaRS

▼ OVERVIEW


Status: Unreviewed
Protein Name: Alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; AlaRS
Gene Name: AlaRS, Aats-ala, alaS, CG13391
Ensembl Gene: FBgn0027094
Ensembl Protein: FBpp0089366
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MKLLTAKEVR  NAYLDFFKEQ  KHIYVHSSST  IPLDDPTLLF  ANAGMNQFKP  IFLGTADPNS  60
61    EMSKWVRVAN  TQKCIRAGGK  HNDLDDVGKD  VYHHTFFEML  GNWSFGDYFK  KEICSWAWEF  120
121   LTQRLALPKD  RLYVTYFGGD  AASGLEPDLE  CKQMWLDLGL  KPEHILPGSM  KDNFWEMGET  180
181   GPCGPCSELH  FDRIGGRSVP  ELVNMDDPDV  LEIWNLVFIQ  YNRESDGSLK  QLPKKHIDCG  240
241   MGFERLVSVI  QNKRSNYDTD  LFVPLFDAIQ  AGTGAPPYQG  RVGADDVDGI  DMAYRVLADH  300
301   ARTITIALAD  GGTPDNTGRG  YVLRRILRRA  VRYATEKLNA  KPGFFATLVN  TVVDLLGDAF  360
361   PEVKKDPQHI  IDIINEEELQ  FLKTLTRGRN  LLNRTIEKLG  NQTTIPGDVA  WRLYDTYGFP  420
421   VDLTQLMAEE  KSLKIDMDGY  EAAKHNSYVL  SQGKGASKIE  EINLDVHAIS  QLQEQGVPPT  480
481   NDTFKYKYEA  VSDERDSAYN  YGVCNSKIVA  LRFENQFVNE  ITSGQKAGIV  LDKTNFYAES  540
541   GGQIYDQGAL  VKVNDEANEF  LVDRVYNRGG  YILHIGVVEG  TLKVGDELEL  HIDVERRWLT  600
601   MKNHSATHAL  NHCLLQVLGK  DTEQKGSLVV  PEKLRFDFNS  KAAMTIEQVS  KTEQLTKEMV  660
661   YKNVPIYAKE  SKLALAKKIR  GLRSVFDEVY  PDPVRVISFG  VPVDELEQNP  DSEAGEQTSV  720
721   EFCGGTHLRR  SGHIMDFVIS  SEEAIAKGIR  RIVALTGPEA  LKALKKSEAF  EQEIVRLKAT  780
781   IDNDKSGKDS  KSHVKEIVEL  TEQISHATIP  YVKKDEMRNL  LKGLKKTLDD  KERALRAAVS  840
841   VTVVERAKTL  CEANPNATVL  VEQLEAFNNT  KALDAALKQV  RSQLPDAAAM  FLSVDADSKK  900
901   IFCLSSVPKS  AVEKGLKANE  WVQHVSATLG  GKGGGKPESA  QASGTNYEKV  DEIVQLASKF  960
961   AQSKLS  966
Nucleotide CDS Sequence (FASTA)
1     ATGAAGTTAC  TCACAGCAAA  GGAGGTGCGC  AACGCCTATC  TGGACTTCTT  CAAGGAGCAG  60
61    AAGCACATCT  ATGTTCACTC  GTCCAGCACG  ATTCCATTGG  ACGATCCCAC  GCTGTTGTTC  120
121   GCCAACGCCG  GCATGAATCA  GTTCAAGCCC  ATTTTTCTGG  GCACCGCTGA  TCCCAACAGC  180
181   GAAATGTCCA  AGTGGGTGCG  CGTGGCCAAC  ACGCAGAAGT  GCATTCGCGC  CGGTGGCAAG  240
241   CACAACGATC  TGGACGACGT  GGGCAAGGAT  GTCTATCATC  ACACCTTCTT  TGAAATGCTG  300
301   GGAAACTGGT  CCTTCGGTGA  CTACTTTAAG  AAGGAGATCT  GCTCCTGGGC  CTGGGAGTTT  360
361   CTCACGCAGC  GACTCGCCCT  ACCCAAGGAT  CGTCTGTATG  TGACTTACTT  TGGTGGTGAC  420
421   GCGGCCAGCG  GTCTGGAGCC  CGATCTGGAG  TGCAAGCAAA  TGTGGCTGGA  CTTGGGCCTG  480
481   AAACCGGAAC  ACATCCTGCC  GGGCAGCATG  AAGGACAACT  TCTGGGAGAT  GGGCGAGACT  540
541   GGGCCCTGCG  GACCATGCTC  TGAGCTGCAC  TTCGACCGGA  TCGGCGGGCG  CAGCGTTCCG  600
601   GAGCTGGTCA  ACATGGACGA  TCCCGATGTC  CTGGAGATCT  GGAATCTCGT  GTTCATCCAG  660
661   TACAACCGTG  AATCTGATGG  CAGCTTGAAG  CAACTTCCCA  AGAAGCACAT  TGATTGCGGC  720
721   ATGGGTTTCG  AGCGGCTGGT  GTCCGTCATC  CAGAATAAGC  GATCTAACTA  CGATACCGAT  780
781   CTGTTTGTGC  CACTTTTCGA  TGCCATCCAG  GCGGGCACTG  GTGCCCCACC  TTACCAGGGT  840
841   CGTGTGGGTG  CCGACGATGT  GGACGGCATT  GACATGGCCT  ACCGCGTGCT  TGCCGATCAC  900
901   GCCCGCACCA  TCACCATTGC  TTTGGCTGAT  GGCGGCACTC  CGGACAACAC  TGGCCGAGGC  960
961   TATGTGCTGC  GACGCATCCT  TCGTCGCGCT  GTGCGTTATG  CCACTGAGAA  GTTGAATGCC  1020
1021  AAGCCCGGTT  TCTTCGCCAC  CCTGGTGAAC  ACAGTGGTTG  ATCTGCTTGG  TGATGCCTTC  1080
1081  CCGGAGGTGA  AAAAAGATCC  CCAACACATC  ATTGATATTA  TCAACGAGGA  AGAGTTGCAG  1140
1141  TTCCTTAAGA  CGTTAACGCG  CGGGCGCAAC  TTGCTGAACC  GCACAATCGA  AAAGTTGGGT  1200
1201  AACCAGACTA  CCATTCCCGG  AGATGTTGCT  TGGCGGCTGT  ACGACACCTA  CGGCTTCCCA  1260
1261  GTCGATCTAA  CCCAGCTTAT  GGCAGAGGAG  AAATCCTTGA  AAATCGATAT  GGATGGCTAT  1320
1321  GAGGCAGCCA  AGCATAATTC  ATATGTGCTT  TCGCAGGGCA  AAGGTGCTAG  CAAAATCGAG  1380
1381  GAGATCAATC  TGGATGTGCA  CGCCATTTCG  CAGCTGCAGG  AGCAAGGTGT  GCCACCAACC  1440
1441  AACGACACCT  TCAAGTACAA  GTACGAGGCT  GTGTCTGACG  AACGTGACTC  CGCCTACAAC  1500
1501  TACGGTGTGT  GCAATAGTAA  AATTGTTGCC  CTGCGCTTCG  AAAACCAGTT  TGTGAACGAG  1560
1561  ATCACCAGCG  GACAGAAGGC  GGGCATCGTT  CTGGACAAAA  CAAATTTCTA  TGCAGAGAGC  1620
1621  GGTGGTCAAA  TCTACGACCA  AGGTGCACTG  GTTAAAGTCA  ATGACGAGGC  GAACGAGTTC  1680
1681  CTTGTGGACC  GTGTCTACAA  CCGCGGAGGC  TACATTCTTC  ACATTGGCGT  TGTAGAGGGC  1740
1741  ACCCTTAAGG  TGGGTGATGA  GTTGGAACTG  CACATCGACG  TGGAGCGTCG  CTGGTTGACC  1800
1801  ATGAAAAACC  ACTCGGCCAC  CCATGCCCTC  AACCATTGCT  TGCTGCAAGT  ATTGGGTAAG  1860
1861  GACACCGAAC  AGAAAGGCTC  TCTGGTAGTG  CCAGAGAAGC  TACGCTTTGA  CTTCAACAGC  1920
1921  AAGGCGGCAA  TGACCATCGA  GCAGGTGTCC  AAGACGGAGC  AGCTGACTAA  GGAGATGGTG  1980
1981  TACAAGAATG  TGCCGATCTA  CGCAAAGGAG  TCGAAATTGG  CCCTGGCCAA  GAAGATCCGA  2040
2041  GGCCTGCGAT  CGGTCTTCGA  CGAAGTGTAC  CCGGATCCCG  TTAGGGTAAT  CTCCTTCGGA  2100
2101  GTGCCCGTAG  ATGAACTGGA  GCAGAATCCC  GATTCTGAAG  CCGGCGAACA  AACCTCCGTC  2160
2161  GAGTTTTGCG  GCGGCACCCA  TTTGAGGCGC  TCGGGTCACA  TAATGGACTT  TGTTATCAGC  2220
2221  AGCGAAGAGG  CCATTGCCAA  GGGTATCCGA  AGAATTGTGG  CTCTTACAGG  ACCCGAAGCT  2280
2281  CTGAAGGCAC  TGAAGAAATC  TGAAGCATTT  GAACAAGAAA  TCGTCCGGCT  TAAGGCCACC  2340
2341  ATTGATAACG  ATAAGTCCGG  TAAGGACTCC  AAGTCGCATG  TGAAGGAGAT  TGTTGAGCTG  2400
2401  ACTGAACAGA  TCTCGCATGC  TACGATTCCC  TACGTGAAAA  AGGACGAGAT  GCGCAATCTG  2460
2461  CTGAAGGGCT  TGAAGAAAAC  ATTGGACGAT  AAGGAACGTG  CCCTGCGTGC  CGCTGTCTCG  2520
2521  GTCACTGTTG  TGGAGCGCGC  CAAGACTCTG  TGCGAAGCCA  ATCCCAATGC  CACCGTGCTG  2580
2581  GTCGAGCAGT  TGGAAGCCTT  TAACAACACC  AAGGCGCTGG  ATGCCGCACT  GAAGCAAGTG  2640
2641  CGCAGCCAGC  TGCCCGACGC  TGCCGCCATG  TTTCTGTCAG  TGGATGCGGA  CTCCAAGAAG  2700
2701  ATCTTCTGTC  TCAGCTCGGT  GCCGAAAAGT  GCCGTGGAAA  AGGGTCTGAA  GGCCAACGAG  2760
2761  TGGGTGCAGC  ATGTTTCCGC  CACGCTGGGA  GGCAAGGGAG  GTGGCAAACC  GGAATCCGCC  2820
2821  CAGGCATCGG  GCACAAATTA  CGAAAAGGTG  GACGAAATTG  TCCAATTGGC  CAGCAAATTC  2880
2881  GCTCAGTCGA  AACTGTCT  2898

▼ KEYWORD


ID
Family
Aminoacyl-tRNA synthetase
ATP-binding
Complete proteome
Cytoplasm
Ligase
Metal-binding
Nucleotide-binding
Protein biosynthesis
Reference proteome
RNA-binding
tRNA-binding
Zinc

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Alanine-tRNA ligase activity
Molecular Function
Amino acid binding
Molecular Function
ATP binding
Molecular Function
TRNA binding
Molecular Function
Zinc ion binding
Biological Process
Alanyl-tRNA aminoacylation
Biological Process
TRNA modification

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sot-0672Solanum tuberosum72.737e-1782.4
LLPS-Sol-1203Solanum lycopersicum72.037e-50 195
LLPS-Cas-0627Carlito syrichta61.430.01197
LLPS-Ora-0783Ornithorhynchus anatinus61.350.01199
LLPS-Chs-3950Chlorocebus sabaeus61.240.01200
LLPS-Caj-0770Callithrix jacchus61.220.01169
LLPS-Cea-2862Cercocebus atys61.140.01197
LLPS-Paa-1738Papio anubis61.140.01197
LLPS-Maf-0334Macaca fascicularis61.040.01196
LLPS-Mup-0750Mustela putorius furo61.040.01199
LLPS-Ran-2479Rattus norvegicus61.040.01197
LLPS-Cap-3200Cavia porcellus61.040.01203
LLPS-Caf-0714Canis familiaris61.040.01197
LLPS-Ict-1477Ictidomys tridecemlineatus61.040.01198
LLPS-Eqc-1169Equus caballus61.030.01137
LLPS-Pat-2405Pan troglodytes60.930.01187
LLPS-Urm-0749Ursus maritimus60.930.01192
LLPS-Pap-1422Pan paniscus60.930.01187
LLPS-Hos-3128Homo sapiens60.930.01189
LLPS-Otg-1877Otolemur garnettii60.930.01193
LLPS-Aim-0392Ailuropoda melanoleuca60.830.01193
LLPS-Rhb-2350Rhinopithecus bieti60.830.01192
LLPS-Mam-1544Macaca mulatta60.830.01196
LLPS-Mea-3215Mesocricetus auratus60.730.01192
LLPS-Mum-3399Mus musculus60.730.01196
LLPS-Bot-1977Bos taurus60.730.01192
LLPS-Fec-1091Felis catus60.730.01193
LLPS-Fud-1956Fukomys damarensis60.620.01192
LLPS-Dio-0198Dipodomys ordii60.620.01194
LLPS-Sus-0472Sus scrofa60.520.01181
LLPS-Ova-1220Ovis aries60.520.01193
LLPS-Icp-1636Ictalurus punctatus60.410.01184
LLPS-Dar-0838Danio rerio60.140.01177
LLPS-Orl-0860Oryzias latipes60.00.01180
LLPS-Asm-3138Astyanax mexicanus59.90.01184
LLPS-Scf-1225Scleropages formosus59.90.01174
LLPS-Lac-0962Latimeria chalumnae59.830.01167
LLPS-Pof-0993Poecilia formosa59.790.01179
LLPS-Anc-0581Anolis carolinensis59.730.01183
LLPS-Myl-1393Myotis lucifugus59.680.01181
LLPS-Orn-3366Oreochromis niloticus59.630.01174
LLPS-Tar-0625Takifugu rubripes59.50.01080
LLPS-Gaga-0622Gallus gallus59.480.01167
LLPS-Loa-1372Loxodonta africana59.450.01178
LLPS-Meg-2102Meleagris gallopavo59.380.01180
LLPS-Xim-0023Xiphophorus maculatus59.270.01171
LLPS-Mod-2332Monodelphis domestica59.160.01165
LLPS-Man-2577Macaca nemestrina59.150.01127
LLPS-Tag-3534Taeniopygia guttata59.070.01169
LLPS-Fia-0048Ficedula albicollis58.860.01168
LLPS-Pes-1241Pelodiscus sinensis58.570.01155
LLPS-Scm-2298Scophthalmus maximus58.240.01155
LLPS-Xet-0132Xenopus tropicalis58.240.01153
LLPS-Sah-2161Sarcophilus harrisii58.090.01134
LLPS-Ten-1360Tetraodon nigroviridis58.070.01138
LLPS-Mal-1171Mandrillus leucophaeus57.220.01049
LLPS-Coc-0120Corchorus capsularis57.220.0 640
LLPS-Gaa-1530Gasterosteus aculeatus56.250.01064
LLPS-Cii-1898Ciona intestinalis56.040.01106
LLPS-Aon-0681Aotus nancymaae55.90.01053
LLPS-Cae-0190Caenorhabditis elegans55.460.01122
LLPS-Cis-0505Ciona savignyi55.220.01087
LLPS-Nol-1605Nomascus leucogenys50.529e-158 494
LLPS-Sac-0067Saccharomyces cerevisiae50.160.0 904
LLPS-Crn-0224Cryptococcus neoformans49.640.0 894
LLPS-Miv-0017Microbotryum violaceum49.480.0 884
LLPS-Yal-0824Yarrowia lipolytica49.380.0 887
LLPS-Kop-0100Komagataella pastoris49.380.0 930
LLPS-Abg-0127Absidia glauca49.280.0 914
LLPS-Lep-0017Leersia perrieri49.160.0 767
LLPS-Osl-1438Ostreococcus lucimarinus49.070.0 713
LLPS-Scj-0101Schizosaccharomyces japonicus49.020.0 927
LLPS-Bro-0598Brassica oleracea48.450.0 718
LLPS-Scc-0666Schizosaccharomyces cryophilus48.250.0 900
LLPS-Pug-0247Puccinia graminis48.140.0 865
LLPS-Scp-0847Schizosaccharomyces pombe48.090.0 890
LLPS-Asn-0989Aspergillus nidulans47.930.0 874
LLPS-Asg-0906Ashbya gossypii47.80.0 863
LLPS-Php-1056Physcomitrella patens47.670.0 858
LLPS-Chr-0450Chlamydomonas reinhardtii47.630.0 805
LLPS-Ast-0610Aspergillus terreus47.60.0 859
LLPS-Tum-0014Tuber melanosporum47.420.0 850
LLPS-Nia-0742Nicotiana attenuata47.290.0 851
LLPS-Glm-1580Glycine max47.280.0 843
LLPS-Mae-2058Manihot esculenta47.270.0 870
LLPS-Pot-0469Populus trichocarpa47.230.0 874
LLPS-Trv-0940Trichoderma virens47.160.0 853
LLPS-Dos-0024Dothistroma septosporum47.110.0 847
LLPS-Via-0835Vigna angularis47.10.0 827
LLPS-Gor-0697Gossypium raimondii47.090.0 855
LLPS-Hea-0544Helianthus annuus47.060.0 843
LLPS-Prp-0502Prunus persica47.040.0 836
LLPS-Spr-0851Sporisorium reilianum46.930.0 865
LLPS-Viv-0416Vitis vinifera46.920.0 860
LLPS-Asfu-0461Aspergillus fumigatus46.850.0 831
LLPS-Nef-0054Neosartorya fischeri46.750.0 832
LLPS-Brn-2535Brassica napus46.730.0 845
LLPS-Put-0572Puccinia triticina46.710.0 826
LLPS-Usm-0629Ustilago maydis46.680.0 860
LLPS-Asc-0836Aspergillus clavatus46.650.0 843
LLPS-Asni-0048Aspergillus niger46.630.0 851
LLPS-Zyt-0836Zymoseptoria tritici46.60.0 843
LLPS-Amt-0605Amborella trichopoda46.60.0 844
LLPS-Phv-0674Phaseolus vulgaris46.590.0 857
LLPS-Cogr-0200Colletotrichum graminicola46.590.0 783
LLPS-Met-1418Medicago truncatula46.540.0 853
LLPS-Pyt-0410Pyrenophora teres46.510.0 818
LLPS-Thc-0252Theobroma cacao46.480.0 848
LLPS-Phn-0342Phaeosphaeria nodorum46.460.0 832
LLPS-Mua-0080Musa acuminata46.450.0 828
LLPS-Mel-0168Melampsora laricipopulina46.420.0 837
LLPS-Aso-0189Aspergillus oryzae46.340.0 764
LLPS-Coo-0717Colletotrichum orbiculare46.270.0 781
LLPS-Brr-0701Brassica rapa46.210.0 854
LLPS-Trr-1044Trichoderma reesei46.170.0 837
LLPS-Pytr-0900Pyrenophora triticirepentis46.10.0 817
LLPS-Fuv-1133Fusarium verticillioides46.080.0 807
LLPS-Lem-0450Leptosphaeria maculans46.080.0 811
LLPS-Fuo-0625Fusarium oxysporum46.080.0 808
LLPS-Cog-0542Colletotrichum gloeosporioides46.070.0 785
LLPS-Chc-0849Chondrus crispus45.980.0 790
LLPS-Cus-0524Cucumis sativus45.840.0 851
LLPS-Ved-0598Verticillium dahliae45.780.0 778
LLPS-Fus-0818Fusarium solani45.680.0 798
LLPS-Art-0465Arabidopsis thaliana45.490.0 828
LLPS-Tra-1584Triticum aestivum45.450.0 809
LLPS-Hov-1575Hordeum vulgare45.40.0 820
LLPS-Arl-1919Arabidopsis lyrata45.180.0 813
LLPS-Gag-0620Gaeumannomyces graminis45.170.0 781
LLPS-Beb-0062Beauveria bassiana45.150.0 784
LLPS-Mao-0144Magnaporthe oryzae45.060.0 771
LLPS-Nec-0783Neurospora crassa45.060.0 788
LLPS-Sob-0249Sorghum bicolor44.920.0 795
LLPS-Org-0669Oryza glaberrima44.910.0 814
LLPS-Ors-0683Oryza sativa44.810.0 808
LLPS-Sei-0670Setaria italica44.80.0 786
LLPS-Ori-0772Oryza indica44.70.0 809
LLPS-Blg-0863Blumeria graminis44.70.0 803
LLPS-Orm-0464Oryza meridionalis44.550.0 800
LLPS-Orr-1853Oryza rufipogon44.490.0 799
LLPS-Brd-0505Brachypodium distachyon44.350.0 814
LLPS-Tru-1183Triticum urartu44.210.0 789
LLPS-Tut-0727Tursiops truncatus44.160.0 766
LLPS-Gas-1073Galdieria sulphuraria43.680.0 810
LLPS-Zem-1642Zea mays43.670.0 773
LLPS-Dac-1307Daucus carota43.510.0 798
LLPS-Gog-1243Gorilla gorilla43.260.0 775
LLPS-Poa-0953Pongo abelii43.180.0 747
LLPS-Orb-1231Oryza barthii42.840.0 790
LLPS-Leo-1799Lepisosteus oculatus42.680.0 758
LLPS-Cym-0463Cyanidioschyzon merolae42.670.0 754
LLPS-Scs-0802Sclerotinia sclerotiorum42.640.0 738
LLPS-Orgl-1321Oryza glumaepatula42.510.0 781
LLPS-Orbr-0609Oryza brachyantha42.410.0 669
LLPS-Orni-0214Oryza nivara42.360.0 777
LLPS-Orp-0548Oryza punctata42.020.0 737
LLPS-Orc-0009Oryctolagus cuniculus41.980.0 729
LLPS-Map-1138Magnaporthe poae40.910.0 710
LLPS-Sem-1587Selaginella moellendorffii32.595e-135 436
LLPS-Vir-0127Vigna radiata32.492e-122 402