• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Kop-0100
ALA1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Alanine--tRNA ligase; Alanyl-tRNA synthetase; AlaRS
Gene Name: ALA1, PAS_chr3_0462
Ensembl Gene: PAS_chr3_0462
Ensembl Protein: CAY70511
Organism: Komagataella pastoris
Taxa ID: 644223
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblCAY70511CAY70511
UniProtC4R4M5, C4R4M5_KOMPG
GeneBankFN392321CAY70511.1
RefSeqXM_002492645.1XP_002492690.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MLKFPHKGIS  SIKSKPRIGI  IAMSTLASKE  WTANKVRSTF  FDFFKSKDHT  YVPSSSVIPY  60
61    DDPTLLFTNA  GMNQYKPIFL  GTVDPSSDFA  TLKRATNSQK  CIRAGGKHND  LEDVGRDSYH  120
121   HTFFEMLGNW  SFGDYFKKEA  IGYGWELLTK  VYGLEKERLY  VSYFGGDAGL  GLEPDLEAKE  180
181   YWKALGVAED  HILPGSVEDN  FWEMGDQGPC  GPCSEIHYDR  IGGRNAASLV  NQDDPDVLEI  240
241   WNIVFIQFNR  EADGSLKPLP  SKHIDTGMGF  ERLVSILQNV  RSNYDTDVFD  PLFTKIQEIT  300
301   GVRPYSGHFG  KEDMDGIDTA  YRVLADHVRT  LTFSLADGGV  PNNEGRGYVL  RRILRRGARY  360
361   ARKYMNYPIG  KFFSQLAPAL  IEQVKETFPE  VDKNFDTIAE  ILDEEEASFS  RTLDRGERLF  420
421   EQYAIIASKT  PEQTLAGRDV  WRLYDTYGFP  VDLTRLMAEE  TGLKIDDEGF  EIAKEASREA  480
481   SKGNGKTQGK  ELVKLDVHVL  GELEKNSEVP  KTDDSYKYGT  KNIEASIVAI  YNGKELIQST  540
541   SEVADDQQLG  ILLDKTPFYA  EQGGQIYDTG  KIVIDGVAEF  NVENVQSYAG  YVLHTGYVEE  600
601   GVLSVSDKII  AGYDELRRWP  IKNNHTGTHI  LNFALRDVLG  DDVEQKGSLV  APEKLRFDFS  660
661   HKKALTLSEL  QKVEDISNEV  IKKNVPVFAS  DVTLAVGKEI  NGLRAVFGET  YPDPVRVVSI  720
721   GVPVEELVKN  PSNAEWHNAS  IEFCGGTHVA  KTGDIKDFVI  IEESGIAKGI  RRIVAVTSTE  780
781   AHTVQRIARE  KNDQLDAIAK  MSFGEAKEKK  LKEFNVALGK  LQISVLAKND  LKTKFTNIEK  840
841   VVKDELKVRQ  KAESKKTLDT  VKDYFNEHED  SPFFVAHVPV  SSNAKLLTEA  FSYIKKEIPD  900
901   KSLYLIVGNE  SEPKIAQGCY  VSDNALSKGV  VASEVTNVAS  EFIGGKAGGK  GNICQGVGTN  960
961   PEGINKAIEA  VTKILKEKLS  I  981
Nucleotide CDS Sequence (FASTA)
1     ATGCTAAAGT  TCCCCCACAA  AGGAATTTCA  TCAATCAAGA  GTAAACCCCG  AATTGGAATA  60
61    ATTGCAATGA  GTACCCTAGC  ATCTAAGGAA  TGGACTGCCA  ACAAGGTGCG  TTCCACGTTT  120
121   TTCGATTTCT  TTAAAAGCAA  AGACCATACC  TATGTCCCAT  CATCCTCTGT  GATTCCATAC  180
181   GATGACCCCA  CCTTATTGTT  TACAAATGCC  GGTATGAACC  AGTATAAGCC  CATTTTTTTG  240
241   GGAACTGTTG  ACCCTTCGTC  TGACTTTGCC  ACTTTGAAAA  GAGCCACCAA  CTCTCAAAAG  300
301   TGTATCCGAG  CTGGAGGGAA  GCACAACGAC  CTGGAGGATG  TTGGAAGAGA  TTCTTACCAT  360
361   CACACATTCT  TCGAAATGCT  TGGTAATTGG  TCGTTTGGTG  ACTATTTCAA  GAAGGAAGCC  420
421   ATTGGGTACG  GCTGGGAACT  GTTAACTAAA  GTCTATGGCT  TAGAAAAGGA  AAGACTTTAC  480
481   GTCAGTTACT  TCGGCGGCGA  TGCAGGCCTC  GGACTGGAAC  CTGATTTAGA  AGCCAAAGAA  540
541   TACTGGAAGG  CCCTAGGTGT  CGCTGAAGAT  CACATTTTGC  CTGGGTCTGT  TGAAGACAAC  600
601   TTCTGGGAAA  TGGGTGACCA  AGGCCCCTGT  GGTCCATGTT  CAGAGATACA  TTACGACAGA  660
661   ATCGGCGGAA  GAAATGCAGC  TTCTTTGGTG  AACCAAGATG  ATCCTGATGT  ATTAGAAATT  720
721   TGGAACATTG  TGTTTATTCA  GTTCAACCGT  GAAGCAGACG  GCTCCTTGAA  GCCTCTCCCC  780
781   TCTAAGCACA  TTGACACAGG  TATGGGATTT  GAGAGATTGG  TTTCTATTCT  TCAAAATGTA  840
841   AGATCAAACT  ATGACACCGA  TGTTTTCGAT  CCTCTGTTCA  CGAAGATTCA  AGAAATTACT  900
901   GGTGTAAGGC  CCTACTCTGG  CCATTTTGGA  AAGGAAGATA  TGGACGGTAT  TGACACTGCG  960
961   TATCGTGTTT  TGGCTGACCA  CGTTCGTACC  CTGACCTTTT  CCTTGGCCGA  TGGTGGTGTT  1020
1021  CCAAACAATG  AGGGTAGAGG  CTACGTTTTG  CGTCGTATTT  TACGTCGTGG  TGCTCGTTAT  1080
1081  GCTAGAAAAT  ATATGAACTA  CCCAATTGGA  AAGTTCTTTT  CTCAACTGGC  TCCAGCTTTA  1140
1141  ATTGAACAAG  TAAAAGAGAC  CTTCCCAGAA  GTTGATAAGA  ACTTTGACAC  CATTGCTGAG  1200
1201  ATTTTAGATG  AGGAAGAAGC  TTCTTTTTCT  AGAACATTAG  ACCGTGGTGA  GAGATTGTTC  1260
1261  GAACAGTATG  CCATCATTGC  ATCCAAGACA  CCAGAACAAA  CATTGGCTGG  AAGAGACGTA  1320
1321  TGGAGGTTGT  ATGACACATA  CGGATTTCCT  GTTGATTTGA  CTAGATTGAT  GGCTGAAGAA  1380
1381  ACAGGTCTCA  AGATTGATGA  CGAAGGCTTT  GAGATTGCAA  AAGAAGCTTC  AAGAGAAGCA  1440
1441  TCTAAAGGTA  ACGGAAAGAC  CCAAGGCAAA  GAATTGGTTA  AACTTGACGT  CCATGTTTTG  1500
1501  GGCGAGCTGG  AAAAAAATTC  TGAAGTTCCA  AAGACTGATG  ACTCTTACAA  GTATGGAACC  1560
1561  AAGAACATTG  AGGCTTCTAT  CGTTGCCATT  TACAACGGTA  AGGAACTGAT  TCAGTCGACT  1620
1621  TCTGAAGTTG  CCGACGACCA  ACAGTTAGGA  ATTCTACTCG  ACAAGACCCC  CTTCTATGCT  1680
1681  GAACAAGGTG  GTCAGATATA  CGATACGGGT  AAGATTGTCA  TTGATGGCGT  TGCTGAATTC  1740
1741  AACGTTGAGA  ACGTACAATC  CTATGCGGGC  TATGTATTGC  ATACCGGTTA  TGTTGAAGAA  1800
1801  GGTGTTCTAT  CAGTTTCTGA  CAAAATCATT  GCTGGCTATG  ATGAACTGCG  CCGCTGGCCC  1860
1861  ATCAAGAATA  ACCATACTGG  TACACATATT  TTGAATTTTG  CTCTAAGAGA  CGTCTTAGGT  1920
1921  GATGATGTTG  AACAAAAGGG  TTCCCTTGTT  GCTCCAGAGA  AGCTCCGTTT  TGACTTTTCT  1980
1981  CACAAAAAAG  CTTTGACCCT  TAGTGAATTG  CAAAAAGTAG  AAGACATCTC  CAACGAAGTG  2040
2041  ATCAAGAAGA  ATGTACCAGT  ATTTGCCAGC  GACGTCACGT  TAGCCGTCGG  TAAGGAGATC  2100
2101  AATGGTCTGA  GAGCTGTTTT  TGGTGAAACG  TATCCAGATC  CGGTCCGTGT  CGTCTCCATC  2160
2161  GGAGTTCCAG  TTGAAGAGCT  GGTGAAGAAT  CCTTCGAACG  CTGAATGGCA  CAATGCTTCT  2220
2221  ATTGAGTTTT  GTGGAGGTAC  ACATGTAGCT  AAGACTGGTG  ATATCAAGGA  CTTTGTTATC  2280
2281  ATTGAAGAGA  GTGGTATTGC  CAAAGGAATA  AGGCGTATCG  TTGCAGTCAC  CAGCACTGAG  2340
2341  GCTCATACCG  TGCAGCGCAT  TGCCAGGGAA  AAGAATGATC  AATTGGATGC  CATTGCAAAG  2400
2401  ATGAGCTTTG  GCGAGGCTAA  GGAGAAGAAA  CTCAAAGAAT  TCAACGTTGC  ACTGGGTAAA  2460
2461  TTGCAAATTT  CCGTTCTTGC  CAAGAACGAC  CTAAAGACCA  AGTTTACCAA  CATTGAGAAG  2520
2521  GTTGTCAAGG  ATGAGCTGAA  GGTTAGACAA  AAGGCTGAGA  GCAAGAAAAC  TCTGGACACT  2580
2581  GTTAAGGACT  ATTTCAATGA  GCATGAAGAC  TCGCCCTTTT  TTGTCGCTCA  CGTTCCAGTC  2640
2641  TCCAGCAATG  CCAAACTATT  AACTGAAGCA  TTCAGTTATA  TCAAGAAAGA  AATTCCAGAT  2700
2701  AAATCGTTGT  ATTTAATTGT  CGGTAATGAA  TCTGAACCCA  AGATTGCCCA  AGGATGTTAT  2760
2761  GTCTCGGACA  ATGCTCTCTC  GAAGGGGGTC  GTTGCCTCTG  AGGTAACTAA  CGTTGCCTCG  2820
2821  GAATTTATCG  GAGGAAAAGC  TGGTGGAAAA  GGTAACATCT  GTCAAGGAGT  GGGAACCAAC  2880
2881  CCTGAAGGAA  TCAACAAGGC  CATTGAAGCA  GTAACGAAGA  TCTTAAAGGA  GAAACTCAGC  2940
2941  ATCTAG  2946

▼ KEYWORD


ID
Family
Aminoacyl-tRNA synthetase
ATP-binding
Complete proteome
Cytoplasm
Ligase
Metal-binding
Mitochondrion
Nucleotide-binding
Protein biosynthesis
Reference proteome
RNA-binding
tRNA-binding
Zinc

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Alanine-tRNA ligase activity
Molecular Function
ATP binding
Molecular Function
TRNA binding
Molecular Function
Zinc ion binding
Biological Process
Mitochondrial alanyl-tRNA aminoacylation

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sot-0672Solanum tuberosum77.271e-1887.4
LLPS-Sol-1203Solanum lycopersicum74.382e-55 213
LLPS-Sac-0067Saccharomyces cerevisiae68.990.01323
LLPS-Asg-0906Ashbya gossypii66.460.01292
LLPS-Yal-0824Yarrowia lipolytica64.530.01218
LLPS-Nef-0054Neosartorya fischeri62.30.01153
LLPS-Pytr-0900Pyrenophora triticirepentis62.290.01140
LLPS-Scj-0101Schizosaccharomyces japonicus62.270.01217
LLPS-Pyt-0410Pyrenophora teres62.190.01140
LLPS-Asfu-0461Aspergillus fumigatus61.990.01145
LLPS-Tum-0014Tuber melanosporum61.680.01204
LLPS-Ast-0610Aspergillus terreus61.610.01181
LLPS-Asni-0048Aspergillus niger61.60.01176
LLPS-Zyt-0836Zymoseptoria tritici61.580.01172
LLPS-Asc-0836Aspergillus clavatus61.430.01153
LLPS-Asn-0989Aspergillus nidulans61.130.01176
LLPS-Aso-0189Aspergillus oryzae61.060.01062
LLPS-Scc-0666Schizosaccharomyces cryophilus60.880.01199
LLPS-Lem-0450Leptosphaeria maculans60.770.01141
LLPS-Phn-0342Phaeosphaeria nodorum60.770.01140
LLPS-Scp-0847Schizosaccharomyces pombe60.340.01186
LLPS-Cog-0542Colletotrichum gloeosporioides60.250.01144
LLPS-Cogr-0200Colletotrichum graminicola59.520.01132
LLPS-Trv-0940Trichoderma virens59.410.01150
LLPS-Dos-0024Dothistroma septosporum59.380.01137
LLPS-Mao-0144Magnaporthe oryzae59.350.01130
LLPS-Fus-0818Fusarium solani59.240.01139
LLPS-Fuv-1133Fusarium verticillioides59.120.01139
LLPS-Miv-0017Microbotryum violaceum59.060.01117
LLPS-Coo-0717Colletotrichum orbiculare59.040.01123
LLPS-Nec-0783Neurospora crassa58.970.01138
LLPS-Fuo-0625Fusarium oxysporum58.810.01136
LLPS-Gag-0620Gaeumannomyces graminis58.730.01137
LLPS-Trr-1044Trichoderma reesei58.680.01138
LLPS-Beb-0062Beauveria bassiana58.660.01125
LLPS-Crn-0224Cryptococcus neoformans57.860.01104
LLPS-Ved-0598Verticillium dahliae57.380.01083
LLPS-Put-0572Puccinia triticina57.290.01056
LLPS-Abg-0127Absidia glauca57.040.01082
LLPS-Mel-0168Melampsora laricipopulina56.990.01044
LLPS-Usm-0629Ustilago maydis56.940.01110
LLPS-Pug-0247Puccinia graminis56.860.01063
LLPS-Scs-0802Sclerotinia sclerotiorum56.540.01051
LLPS-Coc-0120Corchorus capsularis56.460.0 610
LLPS-Spr-0851Sporisorium reilianum56.310.01098
LLPS-Map-1138Magnaporthe poae55.930.01069
LLPS-Blg-0863Blumeria graminis55.830.01097
LLPS-Chr-0450Chlamydomonas reinhardtii54.760.0 818
LLPS-Via-0835Vigna angularis53.690.0 818
LLPS-Lep-0017Leersia perrieri52.850.0 810
LLPS-Nia-0742Nicotiana attenuata52.680.0 854
LLPS-Hea-0544Helianthus annuus52.240.0 858
LLPS-Lac-0962Latimeria chalumnae51.80.0 900
LLPS-Bro-0598Brassica oleracea51.330.0 723
LLPS-Gaga-0622Gallus gallus50.720.0 913
LLPS-Tar-0625Takifugu rubripes50.630.0 847
LLPS-Tag-3534Taeniopygia guttata50.520.0 912
LLPS-Eqc-1169Equus caballus50.490.0 887
LLPS-Caj-0770Callithrix jacchus50.420.0 884
LLPS-Paa-1738Papio anubis50.410.0 919
LLPS-Meg-2102Meleagris gallopavo50.410.0 916
LLPS-Fia-0048Ficedula albicollis50.410.0 913
LLPS-Otg-1877Otolemur garnettii50.360.0 912
LLPS-Chs-3950Chlorocebus sabaeus50.310.0 919
LLPS-Cea-2862Cercocebus atys50.310.0 918
LLPS-Ora-0783Ornithorhynchus anatinus50.260.0 915
LLPS-Viv-0416Vitis vinifera50.220.0 852
LLPS-Maf-0334Macaca fascicularis50.10.0 915
LLPS-Anc-0581Anolis carolinensis50.10.0 917
LLPS-Pat-2405Pan troglodytes50.10.0 912
LLPS-Pap-1422Pan paniscus50.10.0 912
LLPS-Hos-3128Homo sapiens50.10.0 912
LLPS-Mam-1544Macaca mulatta50.00.0 913
LLPS-Cap-3200Cavia porcellus49.950.0 921
LLPS-Cas-0627Carlito syrichta49.850.0 912
LLPS-Mup-0750Mustela putorius furo49.840.0 917
LLPS-Php-1056Physcomitrella patens49.840.0 882
LLPS-Glm-1580Glycine max49.790.0 844
LLPS-Rhb-2350Rhinopithecus bieti49.790.0 911
LLPS-Ran-2479Rattus norvegicus49.740.0 905
LLPS-Caf-0714Canis familiaris49.740.0 912
LLPS-Ict-1477Ictidomys tridecemlineatus49.740.0 916
LLPS-Urm-0749Ursus maritimus49.740.0 905
LLPS-Fud-1956Fukomys damarensis49.690.0 909
LLPS-Osl-1438Ostreococcus lucimarinus49.650.0 801
LLPS-Dio-0198Dipodomys ordii49.640.0 914
LLPS-Met-1418Medicago truncatula49.640.0 857
LLPS-Bot-1977Bos taurus49.530.0 913
LLPS-Aim-0392Ailuropoda melanoleuca49.530.0 905
LLPS-Ova-1220Ovis aries49.530.0 915
LLPS-Orl-0860Oryzias latipes49.430.0 907
LLPS-Mua-0080Musa acuminata49.430.0 842
LLPS-Drm-1478Drosophila melanogaster49.380.0 913
LLPS-Pes-1241Pelodiscus sinensis49.380.0 889
LLPS-Mea-3215Mesocricetus auratus49.330.0 901
LLPS-Fec-1091Felis catus49.330.0 909
LLPS-Arl-1919Arabidopsis lyrata49.30.0 842
LLPS-Mum-3399Mus musculus49.220.0 901
LLPS-Amt-0605Amborella trichopoda49.170.0 870
LLPS-Orn-3366Oreochromis niloticus49.170.0 906
LLPS-Man-2577Macaca nemestrina49.060.0 870
LLPS-Scf-1225Scleropages formosus48.960.0 895
LLPS-Pof-0993Poecilia formosa48.920.0 900
LLPS-Brn-2553Brassica napus48.910.0 868
LLPS-Sus-0472Sus scrofa48.910.0 888
LLPS-Brr-0701Brassica rapa48.910.0 868
LLPS-Art-0465Arabidopsis thaliana48.890.0 853
LLPS-Cae-0190Caenorhabditis elegans48.870.0 866
LLPS-Thc-0252Theobroma cacao48.860.0 850
LLPS-Asm-3138Astyanax mexicanus48.860.0 900
LLPS-Pot-0469Populus trichocarpa48.850.0 867
LLPS-Icp-1636Ictalurus punctatus48.650.0 895
LLPS-Mae-1991Manihot esculenta48.640.0 865
LLPS-Dar-0838Danio rerio48.610.0 896
LLPS-Chc-0849Chondrus crispus48.520.0 815
LLPS-Ten-1360Tetraodon nigroviridis48.510.0 872
LLPS-Orr-1853Oryza rufipogon48.440.0 863
LLPS-Org-0669Oryza glaberrima48.440.0 872
LLPS-Loa-1372Loxodonta africana48.440.0 898
LLPS-Myl-1393Myotis lucifugus48.430.0 893
LLPS-Xim-0023Xiphophorus maculatus48.40.0 894
LLPS-Ori-0772Oryza indica48.390.0 872
LLPS-Prp-0502Prunus persica48.360.0 838
LLPS-Ors-0683Oryza sativa48.330.0 870
LLPS-Mod-2332Monodelphis domestica48.320.0 883
LLPS-Phv-0674Phaseolus vulgaris48.320.0 852
LLPS-Brd-0505Brachypodium distachyon48.240.0 863
LLPS-Hov-1575Hordeum vulgare48.230.0 852
LLPS-Orm-0464Oryza meridionalis48.180.0 859
LLPS-Scm-2298Scophthalmus maximus48.090.0 884
LLPS-Xet-0132Xenopus tropicalis48.080.0 885
LLPS-Sob-0249Sorghum bicolor48.030.0 843
LLPS-Cus-0524Cucumis sativus48.020.0 853
LLPS-Cis-0505Ciona savignyi48.010.0 860
LLPS-Gor-0697Gossypium raimondii47.860.0 858
LLPS-Cii-1898Ciona intestinalis47.840.0 853
LLPS-Nol-1605Nomascus leucogenys47.848e-140 447
LLPS-Tra-1590Triticum aestivum47.810.0 844
LLPS-Sah-2161Sarcophilus harrisii47.740.0 876
LLPS-Mal-1171Mandrillus leucophaeus47.680.0 828
LLPS-Sei-0670Setaria italica47.670.0 854
LLPS-Gas-1073Galdieria sulphuraria47.390.0 848
LLPS-Tru-1152Triticum urartu47.30.0 803
LLPS-Zem-1642Zea mays46.890.0 823
LLPS-Gaa-1530Gasterosteus aculeatus46.620.0 827
LLPS-Dac-1307Daucus carota46.520.0 792
LLPS-Aon-0681Aotus nancymaae46.450.0 809
LLPS-Orbr-0609Oryza brachyantha46.30.0 717
LLPS-Orb-1231Oryza barthii46.280.0 847
LLPS-Orgl-1321Oryza glumaepatula46.180.0 842
LLPS-Orni-0214Oryza nivara46.180.0 842
LLPS-Orp-0548Oryza punctata44.780.0 787
LLPS-Cym-0463Cyanidioschyzon merolae44.440.0 806
LLPS-Tut-0727Tursiops truncatus40.230.0 665
LLPS-Gog-1243Gorilla gorilla39.870.0 654
LLPS-Leo-1799Lepisosteus oculatus39.620.0 625
LLPS-Orc-0009Oryctolagus cuniculus39.440.0 605
LLPS-Poa-0953Pongo abelii39.140.0 614
LLPS-Sem-1587Selaginella moellendorffii38.477e-141 452
LLPS-Vir-0127Vigna radiata34.523e-134 435