LLPS-Mal-3860
PDGFRB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Platelet-derived growth factor receptor beta |
| Gene Name: | PDGFRB |
| Ensembl Gene: | ENSMLEG00000019760.1 |
| Ensembl Protein: | ENSMLEP00000004382.1 |
| Organism: | Mandrillus leucophaeus |
| Taxa ID: | 9568 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLET00000021589.1 | ENSMLEP00000004382.1 |
| Ensembl | ENSMLET00000021578.1 | ENSMLEP00000004380.1 |
| UniProt | A0A2K5XM61, A0A2K5XM61_MANLE | |
| RefSeq | XM_011985365.1, XM_011985367.1 | XP_011840755.1, XP_011840757.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRLPGAMPAL ALKGQLLLLP LLLLLKPQVS QGLVITPPGP ELILNVSSTF VLTCSGSAPV 60 61 MWERMSQELP QEMAKAQDNT FSSVLTLTNL TGLDTGEYFC TYNDSRGLEP DERKRLYIFV 120 121 PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDIALP VPYDHQRGFS 180 181 GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN 240 241 EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH 300 301 QDEKAINITV VESGYVRLLG EVGALQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS 360 361 SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL 420 421 ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPMLLGNSS EEESQLETNV 480 481 TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDMQE VIVVPHSLPF KAVVISAILA 540 541 LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600 601 VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660 661 HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL 720 721 PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP 780 781 SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840 841 KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900 901 GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960 961 LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDSSSVLYT AVQPNEGDND 1020 1021 YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQEEP EPEPQLERQV 1080 1081 EPEPELEQLP DSGCPAPRAE AEDSFL 1106 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGGCTTC CGGGTGCGAT GCCAGCTCTG GCCCTCAAAG GCCAGCTGCT GTTGCTGCCC 60 61 CTGCTGTTAC TGCTGAAACC GCAGGTCTCT CAGGGCCTGG TCATCACACC CCCGGGGCCA 120 121 GAGCTTATCC TCAATGTCTC CAGCACCTTT GTTCTGACCT GCTCGGGTTC AGCTCCCGTG 180 181 ATGTGGGAGC GGATGTCCCA GGAGCTCCCA CAGGAAATGG CCAAAGCCCA GGACAATACC 240 241 TTCTCCAGCG TGCTGACACT GACCAACCTC ACTGGGCTAG ACACGGGAGA ATACTTTTGC 300 301 ACCTACAATG ACTCCCGTGG ACTGGAGCCT GATGAGCGGA AACGGCTCTA CATCTTTGTG 360 361 CCAGATCCCA CCGTGGGCTT CCTCCCTAAT GACGCCGAGG AACTATTCAT CTTTCTTACG 420 421 GAAATAACTG AGATCACCAT TCCATGCCGA GTAACAGACC CACAACTGGT GGTGACACTG 480 481 CACGAGAAGA AAGGGGACAT TGCACTGCCT GTCCCCTACG ATCACCAGCG TGGCTTTTCT 540 541 GGTATCTTTG AGGACAGAAG CTACATCTGC AAAACCACCA TTGGGGACAG GGAGGTGGAT 600 601 TCCGACGCCT ACTATGTCTA CAGACTCCAG GTGTCATCCA TCAACGTCTC CGTGAATGCA 660 661 GTGCAGACGG TGGTCCGCCA GGGTGAGAAC ATTACCCTCA TGTGCATTGT GATCGGGAAT 720 721 GAGGTGGTCA ACTTCGAGTG GACGTACCCC CGCAAAGAAA GTGGGCGGCT GGTGGAGCCG 780 781 GTGACCGACT TCCTCTTGGA TATGCCTTAC CACATCCGCT CCATCCTGCA CATCCCCAGT 840 841 GCCGAGTTAG AAGACTCGGG GACCTACACC TGCAATGTGA CAGAGAGTGT GAACGACCAT 900 901 CAGGATGAAA AGGTTTCCTC CTCAACCACC AGCTGCCCCA TCCCTGAGGC AGCACTCCGT 960 961 GGGGGTATGG TTTTGTCACT GCCCAGACCT AGCAGTGACA TCTCATTATC CCCAGCCCAG 1020 1021 TGA 1023 |
▼ KEYWORD
ID | Family |
ATP-binding | |
Cell membrane | |
Chemotaxis | |
Complete proteome | |
Cytoplasmic vesicle | |
Developmental protein | |
Disulfide bond | |
Immunoglobulin domain | |
Kinase | |
Lysosome | |
Membrane | |
Nucleotide-binding | |
Receptor | |
Reference proteome | |
Repeat | |
Signal | |
Transferase | |
Transmembrane | |
Transmembrane helix | |
Tyrosine-protein kinase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Golgi apparatus | |
Cellular Component | Integral component of membrane | |
Cellular Component | Intrinsic component of plasma membrane | |
Cellular Component | Lysosomal lumen | |
Molecular Function | ATP binding | |
Molecular Function | Platelet-derived growth factor beta-receptor activity | |
Molecular Function | Platelet-derived growth factor binding | |
Molecular Function | Platelet-derived growth factor receptor binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | Vascular endothelial growth factor binding | |
Biological Process | Cell chemotaxis | |
Biological Process | Multicellular organism development | |
Biological Process | Phosphatidylinositol metabolic process | |
Biological Process | Phosphatidylinositol-mediated signaling | |
Biological Process | Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | |
Biological Process | Positive regulation of ERK1 and ERK2 cascade | |
Biological Process | Positive regulation of phosphatidylinositol 3-kinase activity | |
Biological Process | Positive regulation of phospholipase C activity | |
Biological Process | Positive regulation of phosphoprotein phosphatase activity | |
Biological Process | Positive regulation of smooth muscle cell migration | |
Biological Process | Positive regulation of smooth muscle cell proliferation | |
Biological Process | Protein autophosphorylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-4541 | Macaca nemestrina | 99.82 | 0.0 | 2027 |
| LLPS-Maf-4331 | Macaca fascicularis | 99.73 | 0.0 | 2025 |
| LLPS-Mam-3014 | Macaca mulatta | 99.72 | 0.0 | 2014 |
| LLPS-Cea-2438 | Cercocebus atys | 99.55 | 0.0 | 2022 |
| LLPS-Chs-0509 | Chlorocebus sabaeus | 99.55 | 0.0 | 2021 |
| LLPS-Paa-4449 | Papio anubis | 99.46 | 0.0 | 2022 |
| LLPS-Nol-2454 | Nomascus leucogenys | 98.73 | 0.0 | 2008 |
| LLPS-Poa-2094 | Pongo abelii | 98.64 | 0.0 | 2004 |
| LLPS-Pap-4507 | Pan paniscus | 98.28 | 0.0 | 2001 |
| LLPS-Hos-1287 | Homo sapiens | 98.28 | 0.0 | 2006 |
| LLPS-Pat-3562 | Pan troglodytes | 98.19 | 0.0 | 2004 |
| LLPS-Gog-3635 | Gorilla gorilla | 98.01 | 0.0 | 2008 |
| LLPS-Rhb-2400 | Rhinopithecus bieti | 97.29 | 0.0 | 1960 |
| LLPS-Aon-3511 | Aotus nancymaae | 96.22 | 0.0 | 1976 |
| LLPS-Caj-4518 | Callithrix jacchus | 96.21 | 0.0 | 1966 |
| LLPS-Otg-3291 | Otolemur garnettii | 93.41 | 0.0 | 1895 |
| LLPS-Mup-3155 | Mustela putorius furo | 91.77 | 0.0 | 1843 |
| LLPS-Eqc-1925 | Equus caballus | 91.64 | 0.0 | 1867 |
| LLPS-Mea-2263 | Mesocricetus auratus | 90.15 | 0.0 | 1236 |
| LLPS-Caf-1686 | Canis familiaris | 89.51 | 0.0 | 1846 |
| LLPS-Bot-1738 | Bos taurus | 89.42 | 0.0 | 1837 |
| LLPS-Ova-0490 | Ovis aries | 89.33 | 0.0 | 1837 |
| LLPS-Ict-3094 | Ictidomys tridecemlineatus | 89.33 | 0.0 | 1853 |
| LLPS-Sus-3796 | Sus scrofa | 89.15 | 0.0 | 1833 |
| LLPS-Orc-4299 | Oryctolagus cuniculus | 89.15 | 0.0 | 1834 |
| LLPS-Fec-0650 | Felis catus | 88.78 | 0.0 | 1831 |
| LLPS-Cas-0326 | Carlito syrichta | 88.72 | 0.0 | 1837 |
| LLPS-Loa-4578 | Loxodonta africana | 88.53 | 0.0 | 1837 |
| LLPS-Myl-1384 | Myotis lucifugus | 87.93 | 0.0 | 1782 |
| LLPS-Aim-0494 | Ailuropoda melanoleuca | 87.92 | 0.0 | 1809 |
| LLPS-Cap-2946 | Cavia porcellus | 86.44 | 0.0 | 1780 |
| LLPS-Ran-2077 | Rattus norvegicus | 85.9 | 0.0 | 1772 |
| LLPS-Mum-3340 | Mus musculus | 85.34 | 0.0 | 1762 |
| LLPS-Fud-4386 | Fukomys damarensis | 85.12 | 0.0 | 1777 |
| LLPS-Dio-3702 | Dipodomys ordii | 84.87 | 0.0 | 1751 |
| LLPS-Sah-3570 | Sarcophilus harrisii | 78.31 | 0.0 | 1566 |
| LLPS-Mod-0052 | Monodelphis domestica | 73.94 | 0.0 | 1464 |
| LLPS-Meg-0799 | Meleagris gallopavo | 68.31 | 0.0 | 1326 |
| LLPS-Anp-2130 | Anas platyrhynchos | 68.23 | 0.0 | 1336 |
| LLPS-Tag-2484 | Taeniopygia guttata | 67.96 | 0.0 | 1322 |
| LLPS-Fia-0991 | Ficedula albicollis | 67.47 | 0.0 | 1292 |
| LLPS-Pes-2892 | Pelodiscus sinensis | 65.93 | 0.0 | 1299 |
| LLPS-Gaga-3484 | Gallus gallus | 65.73 | 0.0 | 1285 |
| LLPS-Anc-2545 | Anolis carolinensis | 61.91 | 0.0 | 1204 |
| LLPS-Xet-0772 | Xenopus tropicalis | 57.07 | 0.0 | 1100 |
| LLPS-Ora-0847 | Ornithorhynchus anatinus | 57.03 | 0.0 | 974 |
| LLPS-Lac-3884 | Latimeria chalumnae | 56.29 | 0.0 | 1097 |
| LLPS-Scf-1394 | Scleropages formosus | 55.13 | 6e-49 | 192 |
| LLPS-Leo-0588 | Lepisosteus oculatus | 54.83 | 0.0 | 1025 |
| LLPS-Orl-2092 | Oryzias latipes | 53.21 | 1e-48 | 191 |
| LLPS-Dar-1263 | Danio rerio | 52.98 | 1e-48 | 191 |
| LLPS-Ten-3586 | Tetraodon nigroviridis | 52.56 | 2e-48 | 190 |
| LLPS-Gaa-3445 | Gasterosteus aculeatus | 52.11 | 4e-52 | 203 |
| LLPS-Asm-3327 | Astyanax mexicanus | 51.24 | 0.0 | 915 |
| LLPS-Orn-1029 | Oreochromis niloticus | 49.66 | 0.0 | 884 |
| LLPS-Icp-2665 | Ictalurus punctatus | 49.38 | 0.0 | 902 |
| LLPS-Scm-1708 | Scophthalmus maximus | 48.59 | 0.0 | 884 |
| LLPS-Tar-2460 | Takifugu rubripes | 48.04 | 0.0 | 871 |
| LLPS-Xim-3937 | Xiphophorus maculatus | 47.47 | 0.0 | 849 |
| LLPS-Pof-0451 | Poecilia formosa | 47.18 | 0.0 | 851 |