LLPS-Cap-2946
PDGFRB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Platelet-derived growth factor receptor beta |
| Gene Name: | PDGFRB |
| Ensembl Gene: | ENSCPOG00000005994.4 |
| Ensembl Protein: | ENSCPOP00000005411.3 |
| Organism: | Cavia porcellus |
| Taxa ID: | 10141 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCPOT00000006057.3 | ENSCPOP00000005411.3 |
| UniProt | H0V6S9, H0V6S9_CAVPO | |
| GeneBank | AAKN02010066 | |
| RefSeq | XM_003477350.3, XM_013141037.1 | XP_003477398.1, XP_012996491.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQPPGVMPAP VLQGQLLLLS LLLLLGPQIS QGLVMVPAGP ELVLNLSSTF VLTCLGSAPV 60 61 LWERMSQVPQ QEVVMTQDGT FTSKLTLTNV TGGDTGEYFC TYNSSLELES SERRRLYIFV 120 121 PDPSMGFLPI DPEDVFVFVT EITETTIPCR VTDPRLVVTL HEKKEDVPLP IPYDHQRGFI 180 181 GTFEDKTYIC KTTIGDREVE SDAYYVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN 240 241 EVVNFEWMYP RKESGRQVEA VTDFLPDMPN HIRSILHIHD AELGDSGTYI CNVSESVNEH 300 301 RDEKAINVTV VERGYVRLLQ GLDTVEIAEL HQSRTLQVLI EAYPPPTVLW FKDNRTLGDT 360 361 SVGEIALATR NVSETRYVSE LTLVRVKVAE AGSYTMRAFH EDDEDQLSFR LQVNVPVRVL 420 421 ELSESHPANG DQTVRCRGRG MPQPHVSWFL CRDLKRCPHE LLPTPLGNSS EEESQLETNV 480 481 TYWAEEQEYE VASTLRLRHV DQQLSVLCMV HNLLGQDVQE VTVVPHSLPF KVVVISAILA 540 541 LVVLTIVSLI ILIILWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600 601 VLGRTLGSGA FGQVVEATAH GLGHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660 661 HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKHRP PSIELYSNTL 720 721 PVGLPLPSPV SLSGESDGGY MDMSKDESVD YVPMLDMKGD IKYADIESSN YMAPYDNYVP 780 781 SAPERTYRAT LINESPVLSY TDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840 841 KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900 901 GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960 961 LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDTSSVLYT AVQPNEGDND 1020 1021 YIIPLPDPKP EVAEEGPLEG SPSLASSTLN EANTSSTISC DSPLDPQEEP DPEPPAEPEP 1080 1081 ELEQPPDSGC PRPQVEVEDS FL 1102 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAGCCTC CAGGTGTGAT GCCAGCTCCG GTCCTCCAAG GCCAGTTGCT GTTACTGTCA 60 61 CTGCTGTTGC TGCTGGGACC ACAGATCTCC CAAGGCCTGG TCATGGTGCC TGCAGGCCCA 120 121 GAGCTGGTTC TCAATCTCTC TAGCACCTTT GTTCTGACCT GCTTGGGTTC AGCTCCAGTG 180 181 CTGTGGGAAC GAATGTCCCA GGTACCCCAA CAGGAAGTGG TCATGACCCA GGATGGCACC 240 241 TTCACCAGCA AACTGACACT GACCAACGTC ACTGGGGGAG ACACAGGAGA ATACTTCTGC 300 301 ACCTACAACA GCTCCCTTGA GCTGGAGTCC AGTGAGCGGA GGCGGCTGTA CATCTTTGTG 360 361 CCAGATCCCA GTATGGGCTT CCTCCCCATA GACCCTGAGG ATGTATTTGT CTTTGTCACG 420 421 GAAATCACTG AGACCACCAT CCCATGCCGA GTCACAGACC CCCGGCTGGT GGTGACGCTG 480 481 CACGAGAAGA AAGAGGATGT TCCTCTGCCT ATCCCCTATG ATCACCAACG AGGTTTCATT 540 541 GGTACTTTTG AGGACAAGAC CTACATTTGC AAAACCACCA TTGGGGACAG GGAAGTGGAA 600 601 TCCGATGCCT ACTATGTCTA CAGCCTACAG GTGTCATCCA TCAATGTCTC TGTGAATGCA 660 661 GTGCAGACTG TGGTACGCCA GGGTGAGAAC ATCACCATCA TGTGCATCGT GACGGGGAAT 720 721 GAGGTGGTCA ACTTTGAGTG GATGTACCCC CGAAAGGAGA GTGGGCGGCA GGTAGAGGCA 780 781 GTGACGGACT TCCTCCCTGA CATGCCAAAC CACATTCGCT CCATCCTGCA CATCCACGAC 840 841 GCTGAGCTGG GTGACTCAGG GACCTACATT TGCAATGTGT CAGAGAGTGT GAACGAGCAC 900 901 CGAGACGAGA AGGCCATCAA CGTCACTGTG GTCGAGAGAG GCTATGTGAG GCTGCTGCAA 960 961 GGGCTGGACA CTGTGGAAAT CGCTGAGCTG CACCAGAGCC GGACACTGCA GGTGCTGATC 1020 1021 GAAGCTTACC CTCCGCCCAC TGTCCTGTGG TTCAAAGACA ACCGCACCCT TGGTGACACC 1080 1081 AGTGTCGGCG AGATAGCCCT GGCCACACGC AATGTGTCCG AGACCCGGTA TGTGTCGGAG 1140 1141 CTGACACTGG TGCGGGTGAA GGTGGCAGAG GCTGGCAGTT ACACCATGCG GGCCTTCCAT 1200 1201 GAGGATGACG AGGACCAGCT GTCTTTCCGG CTGCAGGTCA ATGTCCCTGT CCGTGTGCTG 1260 1261 GAGCTGAGCG AGAGCCACCC TGCCAATGGG GACCAGACAG TCCGCTGTCG CGGCCGAGGC 1320 1321 ATGCCCCAGC CACATGTCAG CTGGTTTCTC TGCAGAGACC TCAAAAGGTG TCCGCACGAG 1380 1381 CTGTTGCCCA CGCCTCTGGG GAACAGTTCT GAAGAGGAGA GCCAGCTGGA GACCAACGTG 1440 1441 ACATACTGGG CTGAGGAGCA GGAGTACGAG GTGGCGAGCA CGTTGCGCCT GCGCCATGTG 1500 1501 GATCAGCAGC TGTCGGTGCT CTGCATGGTG CACAACCTGC TGGGCCAGGA CGTGCAGGAG 1560 1561 GTCACCGTGG TGCCACACTC CCTGCCCTTC AAGGTGGTAG TGATCTCAGC CATCCTGGCC 1620 1621 TTGGTGGTTC TCACCATTGT CTCTCTCATC ATCCTCATCA TACTTTGGCA GAAGAAACCA 1680 1681 CGCTATGAGA TCCGGTGGAA GGTGATTGAG TCTGTGAGCT CCGACGGCCA TGAGTACATC 1740 1741 TATGTGGACC CCATGCAGCT TCCCTATGAC TCCACGTGGG AGCTGCCAAG GGACCAGCTT 1800 1801 GTGCTTGGAC GCACCCTCGG CTCCGGGGCC TTCGGGCAGG TGGTGGAGGC CACAGCTCAC 1860 1861 GGGCTGGGTC ACTCACAGGC CACCATGAAA GTGGCTGTCA AGATGCTGAA ATCCACGGCC 1920 1921 CGTAGCAGTG AGAAGCAAGC CCTCATGTCA GAGCTGAAGA TCATGAGTCA CCTAGGGCCC 1980 1981 CACCTGAACG TGGTCAACCT GCTGGGGGCC TGCACCAAAG GAGGACCCAT CTACATCATC 2040 2041 ACTGAGTACT GCCGCTACGG CGACCTGGTG GACTACCTGC ACCGCAACAA GCACACCTTC 2100 2101 CTGCAGCACC ACTCGGACAA GCACCGCCCT CCCAGCATCG AGCTCTATAG CAACACCTTA 2160 2161 CCTGTGGGGC TGCCCTTGCC CAGCCCCGTG TCCCTGAGTG GGGAGAGTGA CGGTGGCTAC 2220 2221 ATGGACATGA GCAAGGATGA GTCAGTGGAC TACGTGCCCA TGCTGGACAT GAAGGGAGAC 2280 2281 ATCAAATACG CAGACATCGA GTCCTCCAAC TACATGGCCC CGTACGATAA CTACGTCCCC 2340 2341 TCCGCCCCTG AGAGGACCTA CCGGGCAACT CTGATCAATG AGTCCCCCGT GCTCAGCTAC 2400 2401 ACAGACCTCG TGGGCTTCAG CTACCAGGTG GCAAATGGCA TGGAGTTCTT GGCCTCCAAG 2460 2461 AATTGTGTCC ACCGAGACCT GGCAGCCAGG AACGTGCTCA TCTGCGAAGG CAAGCTAGTC 2520 2521 AAGATCTGTG ACTTCGGCCT GGCTCGAGAC ATCATGCGAG ACTCGAACTA CATCTCTAAA 2580 2581 GGCAGCACCT TCCTGCCCCT GAAGTGGATG GCCCCGGAGA GCATCTTCAA CAGCCTTTAC 2640 2641 ACCACTTTGA GCGACGTGTG GTCCTTTGGG ATCCTCCTCT GGGAGATCTT CACCTTGGGT 2700 2701 GGCACCCCTT ACCCAGAGCT GCCCATGAAT GAGCAGTTCT ACAATGCCAT CAAGCGGGGC 2760 2761 TACCGCATGG CGCAGCCCGC TCATGCCTCC GATGAGATCT ATGAGATCAT GCAGAAGTGC 2820 2821 TGGGAAGAGA AGTTTGAGAT CCGGCCTCCC TTCTCCCAGC TGGTGCTGCT TCTGGAGAGA 2880 2881 CTGCTGGGTG AGGGGTACAA AAAGAAGTAC CAGCAGGTGG ATGAGGAGTT TCTGAGGAGC 2940 2941 GACCACCCAG CCATCCTTCG GTCCCAAGCC CGCTTGCCTG GGTTCCATGG CCTCCGGTCT 3000 3001 CCCCTGGACA CCAGCTCTGT CCTCTACACT GCCGTACAGC CCAATGAGGG TGACAATGAC 3060 3061 TATATCATCC CCCTGCCTGA CCCCAAACCT GAGGTTGCTG AGGAGGGCCC ACTGGAGGGC 3120 3121 TCCCCCAGCC TTGCCAGCTC CACCCTGAAT GAAGCCAACA CTTCCTCTAC CATCTCCTGT 3180 3181 GACAGCCCCC TGGACCCTCA AGAGGAGCCA GACCCAGAGC CCCCGGCAGA GCCAGAGCCG 3240 3241 GAGTTGGAGC AACCTCCGGA TTCAGGCTGT CCCAGGCCCC AGGTCGAAGT GGAGGACAGC 3300 3301 TTCCTGTAG 3309 |
▼ KEYWORD
ID | Family |
ATP-binding | |
Cell membrane | |
Chemotaxis | |
Complete proteome | |
Cytoplasmic vesicle | |
Developmental protein | |
Disulfide bond | |
Immunoglobulin domain | |
Kinase | |
Lysosome | |
Membrane | |
Nucleotide-binding | |
Receptor | |
Reference proteome | |
Repeat | |
Signal | |
Transferase | |
Transmembrane | |
Transmembrane helix | |
Tyrosine-protein kinase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Golgi apparatus | |
Cellular Component | Integral component of membrane | |
Cellular Component | Intrinsic component of plasma membrane | |
Cellular Component | Lysosomal lumen | |
Molecular Function | ATP binding | |
Molecular Function | Platelet-derived growth factor beta-receptor activity | |
Molecular Function | Platelet-derived growth factor binding | |
Molecular Function | Platelet-derived growth factor receptor binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | Vascular endothelial growth factor binding | |
Biological Process | Cell chemotaxis | |
Biological Process | Multicellular organism development | |
Biological Process | Phosphatidylinositol metabolic process | |
Biological Process | Phosphatidylinositol-mediated signaling | |
Biological Process | Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | |
Biological Process | Positive regulation of ERK1 and ERK2 cascade | |
Biological Process | Positive regulation of phosphatidylinositol 3-kinase activity | |
Biological Process | Positive regulation of phospholipase C activity | |
Biological Process | Positive regulation of phosphoprotein phosphatase activity | |
Biological Process | Positive regulation of smooth muscle cell migration | |
Biological Process | Positive regulation of smooth muscle cell proliferation | |
Biological Process | Protein autophosphorylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fud-4386 | Fukomys damarensis | 92.13 | 0.0 | 1869 |
| LLPS-Mea-2263 | Mesocricetus auratus | 90.52 | 0.0 | 1190 |
| LLPS-Bot-1738 | Bos taurus | 89.35 | 0.0 | 1768 |
| LLPS-Ova-0490 | Ovis aries | 89.26 | 0.0 | 1768 |
| LLPS-Ict-3094 | Ictidomys tridecemlineatus | 89.24 | 0.0 | 1808 |
| LLPS-Mup-3155 | Mustela putorius furo | 88.42 | 0.0 | 1754 |
| LLPS-Eqc-1925 | Equus caballus | 88.26 | 0.0 | 1774 |
| LLPS-Poa-2094 | Pongo abelii | 87.79 | 0.0 | 1755 |
| LLPS-Pap-4507 | Pan paniscus | 87.79 | 0.0 | 1755 |
| LLPS-Hos-1287 | Homo sapiens | 87.43 | 0.0 | 1758 |
| LLPS-Mam-3014 | Macaca mulatta | 87.42 | 0.0 | 1749 |
| LLPS-Gog-3635 | Gorilla gorilla | 87.25 | 0.0 | 1761 |
| LLPS-Fec-0650 | Felis catus | 87.19 | 0.0 | 1760 |
| LLPS-Pat-3562 | Pan troglodytes | 87.16 | 0.0 | 1756 |
| LLPS-Orc-4299 | Oryctolagus cuniculus | 87.07 | 0.0 | 1768 |
| LLPS-Caf-1686 | Canis familiaris | 87.05 | 0.0 | 1769 |
| LLPS-Otg-3291 | Otolemur garnettii | 87.04 | 0.0 | 1759 |
| LLPS-Nol-2454 | Nomascus leucogenys | 86.98 | 0.0 | 1751 |
| LLPS-Caj-4518 | Callithrix jacchus | 86.91 | 0.0 | 1739 |
| LLPS-Maf-4331 | Macaca fascicularis | 86.89 | 0.0 | 1751 |
| LLPS-Man-4541 | Macaca nemestrina | 86.8 | 0.0 | 1747 |
| LLPS-Mal-3860 | Mandrillus leucophaeus | 86.8 | 0.0 | 1748 |
| LLPS-Chs-0509 | Chlorocebus sabaeus | 86.8 | 0.0 | 1749 |
| LLPS-Paa-4449 | Papio anubis | 86.71 | 0.0 | 1748 |
| LLPS-Cea-2438 | Cercocebus atys | 86.62 | 0.0 | 1745 |
| LLPS-Aon-3511 | Aotus nancymaae | 86.58 | 0.0 | 1750 |
| LLPS-Sus-3796 | Sus scrofa | 86.53 | 0.0 | 1741 |
| LLPS-Loa-4578 | Loxodonta africana | 85.86 | 0.0 | 1723 |
| LLPS-Ran-2077 | Rattus norvegicus | 85.69 | 0.0 | 1727 |
| LLPS-Aim-0494 | Ailuropoda melanoleuca | 85.43 | 0.0 | 1731 |
| LLPS-Rhb-2400 | Rhinopithecus bieti | 85.26 | 0.0 | 1709 |
| LLPS-Dio-3702 | Dipodomys ordii | 85.22 | 0.0 | 1712 |
| LLPS-Myl-1384 | Myotis lucifugus | 85.21 | 0.0 | 1714 |
| LLPS-Mum-3340 | Mus musculus | 84.95 | 0.0 | 1712 |
| LLPS-Cas-0326 | Carlito syrichta | 84.28 | 0.0 | 1696 |
| LLPS-Sah-3570 | Sarcophilus harrisii | 76.86 | 0.0 | 1549 |
| LLPS-Mod-0052 | Monodelphis domestica | 72.81 | 0.0 | 1439 |
| LLPS-Meg-0799 | Meleagris gallopavo | 68.45 | 0.0 | 1336 |
| LLPS-Anp-2130 | Anas platyrhynchos | 68.27 | 0.0 | 1325 |
| LLPS-Tag-2484 | Taeniopygia guttata | 67.54 | 0.0 | 1318 |
| LLPS-Fia-0991 | Ficedula albicollis | 67.45 | 0.0 | 1296 |
| LLPS-Pes-2892 | Pelodiscus sinensis | 66.47 | 0.0 | 1321 |
| LLPS-Gaga-3484 | Gallus gallus | 64.44 | 0.0 | 1285 |
| LLPS-Anc-2545 | Anolis carolinensis | 61.31 | 0.0 | 1199 |
| LLPS-Pof-1513 | Poecilia formosa | 58.97 | 9e-54 | 208 |
| LLPS-Scf-1471 | Scleropages formosus | 58.1 | 5e-56 | 215 |
| LLPS-Xet-0772 | Xenopus tropicalis | 57.23 | 0.0 | 1109 |
| LLPS-Lac-3884 | Latimeria chalumnae | 56.76 | 0.0 | 1105 |
| LLPS-Ora-0847 | Ornithorhynchus anatinus | 54.32 | 0.0 | 957 |
| LLPS-Leo-0588 | Lepisosteus oculatus | 53.67 | 0.0 | 1005 |
| LLPS-Dar-0526 | Danio rerio | 52.82 | 0.0 | 898 |
| LLPS-Ten-3586 | Tetraodon nigroviridis | 52.56 | 2e-48 | 190 |
| LLPS-Asm-3327 | Astyanax mexicanus | 50.84 | 0.0 | 911 |
| LLPS-Icp-3572 | Ictalurus punctatus | 50.0 | 3e-49 | 193 |
| LLPS-Gaa-0134 | Gasterosteus aculeatus | 49.95 | 0.0 | 859 |
| LLPS-Orl-3976 | Oryzias latipes | 49.95 | 0.0 | 877 |
| LLPS-Orn-1029 | Oreochromis niloticus | 49.42 | 0.0 | 873 |
| LLPS-Scm-1708 | Scophthalmus maximus | 48.5 | 0.0 | 880 |
| LLPS-Tar-2460 | Takifugu rubripes | 47.8 | 0.0 | 853 |
| LLPS-Xim-3937 | Xiphophorus maculatus | 47.45 | 0.0 | 843 |