• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Icp-1636
aars

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: alanine--tRNA ligase, cytoplasmic
Gene Name: aars, AARS
Ensembl Gene: ENSIPUG00000020538.1
Ensembl Protein: ENSIPUP00000030485.1
Organism: Ictalurus punctatus
Taxa ID: 7998
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSASIGVLRC  RHLIHMALHL  TFFCAKAFTC  WQSSLNNPAS  MDTSLTAAQI  REKFIDFFRR  60
61    YEHEYVHSSS  TIPLDDPTLL  FANAGMNQFK  PIFLNTIDPS  HPMARLKRAA  NTQKCIRAGG  120
121   KHNDLDDVGK  DVYHHTFFEM  LGSWSFGDYF  KQLACKMALE  LLTQEFGIPL  ERLYFTYFGG  180
181   HAEAGLECDN  ECKQIWLDLG  VAEERILPGN  MKDNFWEMGD  TGPCGPCSEI  HYDRIGGRDA  240
241   SHLVNMDDPN  VLEIWNLVFI  QFNRESETEL  KPLPKKSIDT  GMGLERLVSV  LQNTMSNYDT  300
301   DLFIPYFEAI  QKGTGARLYT  GKVGSEDQDG  IDMAYRVLAA  HARTITIALS  DGGRPDNTGR  360
361   GYVLRRILRR  AVRYAHEKLG  AQKGFFASLV  DVVVQSLGDA  FPELKKDPDS  VKDVINEEEM  420
421   QFLKTLSRGR  RILDRKIQNL  GDSKTIPGDT  AWLLYDTYGF  PLDLTVLIAE  EKGMGIDLGA  480
481   FEEEKKAAQL  KSQGKGAGGE  DHIMLDIYAI  EELRNKGVPA  TDDTLKYSYT  SDDNGNYEFE  540
541   QAVGTVLALR  RERAFVDEVS  TGQECGVVLD  KTSFYAEQGG  QTFDEGYMLR  ENDSTEDRME  600
601   FTVKNTQVRG  GYVLHVGTVY  GTLKVGDRLT  LHVDEARRRP  IMSNHTSTHI  LNFALRSVLG  660
661   EADQRGSLVA  PDRLRFDFTA  KGAMSTEEVR  RTEEIASAMI  KDAKPVYAKE  ASLAAAKAIQ  720
721   GLRAVFDETY  PDPVRVVSIG  IPVEDLLADP  NSTAGALTSV  EFCGGTHLQN  SGHAAQFVIV  780
781   SEEAIAKGIR  RIVAVTGVPA  QKAQRKADAL  RQSLSAMAEK  VKAQTAPNKD  VQKEIADLTE  840
841   TLGTAVISQW  QKDEMRETLK  GLKKIMDDLD  RSSKADVQKR  VLEKTKEIIE  SNPNQPLLVM  900
901   EMESGASAKA  LNESLKLLKS  QSPQTAAMLF  AVDNEAGKII  CLCQVPQELS  NQGLKANEWV  960
961   QEVCPLLDGK  GGGKDMSAQA  TGRNTQCVQE  ALKLANKFAQ  LKLGQN  1006
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGCCT  CCATAGGAGT  GTTACGGTGT  CGTCATCTCA  TCCACATGGC  TCTCCATCTC  60
61    ACTTTTTTCT  GTGCCAAAGC  ATTTACATGC  TGGCAGTCCT  CTTTGAACAA  CCCAGCCAGC  120
121   ATGGACACTT  CACTGACTGC  TGCTCAGATC  CGTGAGAAGT  TTATTGACTT  CTTCCGTCGC  180
181   TATGAGCATG  AGTATGTGCA  CTCGTCCTCC  ACCATTCCCC  TGGATGACCC  AACCCTACTC  240
241   TTTGCTAATG  CTGGCATGAA  CCAGTTCAAA  CCCATTTTCC  TAAACACCAT  CGACCCATCC  300
301   CACCCCATGG  CTAGACTGAA  GCGTGCTGCC  AACACCCAGA  AGTGCATCCG  TGCTGGTGGT  360
361   AAACATAATG  ACCTGGATGA  CGTGGGAAAG  GATGTGTACC  ACCACACCTT  CTTTGAGATG  420
421   TTGGGCTCCT  GGTCCTTTGG  AGATTACTTT  AAACAATTGG  CCTGTAAGAT  GGCTCTGGAA  480
481   CTGTTGACCC  AGGAGTTTGG  CATCCCTCTC  GAGCGCTTGT  ATTTCACCTA  CTTTGGAGGA  540
541   CATGCTGAAG  CAGGTCTTGA  GTGTGACAAT  GAGTGCAAGC  AGATCTGGCT  TGACCTAGGG  600
601   GTGGCAGAGG  AGCGTATCCT  GCCAGGTAAC  ATGAAGGACA  ATTTCTGGGA  GATGGGAGAC  660
661   ACTGGTCCCT  GTGGGCCCTG  TAGTGAAATC  CACTACGACC  GCATCGGAGG  CAGAGACGCT  720
721   TCACACCTTG  TCAACATGGA  CGACCCTAAT  GTGCTGGAGA  TCTGGAATCT  GGTGTTTATC  780
781   CAGTTCAATA  GAGAGTCCGA  GACAGAGCTG  AAGCCTCTAC  CTAAGAAGAG  CATTGATACT  840
841   GGAATGGGGC  TGGAGCGACT  GGTCTCTGTC  CTGCAGAACA  CGATGTCTAA  CTACGACACA  900
901   GACCTCTTCA  TTCCTTACTT  TGAAGCTATC  CAGAAGGGCA  CAGGAGCCAG  GCTTTACACT  960
961   GGAAAAGTTG  GATCAGAAGA  CCAAGATGGC  ATTGACATGG  CATATCGTGT  TCTAGCTGCC  1020
1021  CACGCCCGCA  CCATCACTAT  AGCTCTGTCT  GACGGTGGTC  GACCTGACAA  CACTGGAAGG  1080
1081  GGATACGTGT  TGAGAAGGAT  CCTGCGACGC  GCTGTACGGT  ATGCTCATGA  GAAGCTGGGG  1140
1141  GCTCAGAAGG  GCTTCTTCGC  CTCTCTGGTG  GACGTGGTGG  TGCAGTCACT  GGGAGATGCT  1200
1201  TTCCCAGAGC  TGAAGAAAGA  CCCAGACTCC  GTGAAGGATG  TCATTAATGA  AGAGGAAATG  1260
1261  CAGTTTCTTA  AGACTCTTAG  CAGGGGGCGA  CGCATCCTGG  ACAGGAAGAT  CCAAAACCTT  1320
1321  GGAGACAGCA  AAACTATTCC  AGGGGACACT  GCCTGGCTGC  TATACGATAC  CTATGGCTTC  1380
1381  CCTCTGGACC  TGACTGTCCT  CATTGCAGAG  GAGAAAGGAA  TGGGAATAGA  CCTAGGTGCG  1440
1441  TTTGAGGAGG  AGAAGAAAGC  AGCACAGCTG  AAGTCCCAAG  GCAAAGGTGC  TGGAGGTGAG  1500
1501  GACCACATCA  TGCTGGACAT  CTATGCCATT  GAGGAGCTGA  GAAACAAAGG  AGTCCCTGCC  1560
1561  ACCGACGACA  CACTGAAATA  CAGCTACACC  TCTGATGACA  ACGGCAACTA  CGAGTTTGAG  1620
1621  CAGGCTGTTG  GCACGGTGCT  TGCTCTGAGG  CGGGAGCGTG  CGTTCGTGGA  TGAGGTGAGC  1680
1681  ACAGGACAGG  AATGTGGTGT  GGTGCTCGAT  AAGACATCTT  TCTATGCTGA  GCAGGGAGGT  1740
1741  CAGACCTTCG  ACGAGGGATA  CATGCTGCGT  GAGAACGACT  CCACAGAGGA  CAGGATGGAG  1800
1801  TTCACGGTGA  AGAACACTCA  GGTGCGTGGA  GGCTACGTGC  TGCATGTTGG  AACTGTATAT  1860
1861  GGCACGCTGA  AGGTTGGAGA  CCGTCTCACT  CTGCATGTTG  ATGAGGCTCG  CCGCAGGCCC  1920
1921  ATCATGAGTA  ACCACACTTC  CACCCACATC  CTGAACTTTG  CTTTGAGGTC  AGTGCTTGGT  1980
1981  GAAGCTGATC  AGCGCGGTTC  CCTTGTGGCA  CCAGACCGCC  TGCGCTTTGA  CTTTACTGCC  2040
2041  AAGGGAGCTA  TGAGCACAGA  GGAGGTGCGC  CGAACTGAGG  AAATCGCCAG  CGCCATGATA  2100
2101  AAGGATGCCA  AGCCAGTGTA  CGCCAAGGAG  GCCTCACTTG  CAGCTGCCAA  GGCTATCCAG  2160
2161  GGCCTGCGTG  CTGTCTTTGA  CGAGACGTAT  CCAGACCCTG  TGAGGGTTGT  GTCCATCGGC  2220
2221  ATCCCTGTGG  AGGATCTACT  GGCTGACCCG  AACAGCACTG  CAGGCGCTCT  CACCTCCGTT  2280
2281  GAGTTCTGTG  GTGGAACGCA  CCTGCAGAAC  TCTGGTCATG  CTGCCCAGTT  TGTGATTGTG  2340
2341  TCCGAGGAGG  CCATCGCTAA  GGGCATCAGG  CGAATCGTGG  CTGTGACTGG  AGTACCGGCT  2400
2401  CAGAAGGCCC  AAAGGAAAGC  TGATGCTCTG  CGTCAGTCCC  TGTCTGCCAT  GGCCGAGAAG  2460
2461  GTGAAAGCTC  AGACTGCTCC  CAATAAAGAC  GTCCAGAAGG  AAATAGCAGA  CCTGACTGAG  2520
2521  ACCTTAGGAA  CTGCTGTGAT  CTCCCAGTGG  CAGAAAGATG  AGATGAGGGA  GACTCTGAAG  2580
2581  GGCTTGAAAA  AGATCATGGA  TGACCTGGAC  CGTAGCAGCA  AAGCTGATGT  GCAGAAGAGG  2640
2641  GTTCTGGAGA  AGACAAAAGA  GATCATCGAA  AGCAACCCAA  ACCAGCCTCT  TCTCGTCATG  2700
2701  GAGATGGAAA  GTGGAGCTAG  TGCAAAGGCT  CTGAATGAGT  CCTTGAAGCT  GCTGAAGTCT  2760
2761  CAGTCCCCTC  AGACTGCTGC  CATGCTATTT  GCTGTGGATA  ATGAAGCTGG  CAAGATTATC  2820
2821  TGCCTCTGCC  AAGTGCCACA  GGAACTTTCA  AATCAGGGTT  TGAAAGCCAA  CGAGTGGGTT  2880
2881  CAGGAAGTGT  GCCCTCTGCT  GGATGGAAAA  GGAGGCGGGA  AAGACATGTC  TGCTCAGGCC  2940
2941  ACAGGCAGAA  ACACGCAGTG  TGTCCAGGAG  GCCCTGAAGC  TGGCCAACAA  ATTTGCCCAA  3000
3001  CTCAAACTGG  GACAAAACTA  G  3021

▼ KEYWORD


ID
Family
Aminoacyl-tRNA synthetase
ATP-binding
Coiled coil
Complete proteome
Ligase
Metal-binding
Nucleotide-binding
Protein biosynthesis
Reference proteome
RNA-binding
tRNA-binding
Zinc

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Alanine-tRNA ligase activity
Molecular Function
ATP binding
Molecular Function
TRNA binding
Molecular Function
Zinc ion binding
Biological Process
Alanyl-tRNA aminoacylation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-3138Astyanax mexicanus89.480.01850
LLPS-Dar-0838Danio rerio89.20.01849
LLPS-Orn-3366Oreochromis niloticus88.720.01791
LLPS-Pof-0993Poecilia formosa87.580.01772
LLPS-Xim-0023Xiphophorus maculatus87.060.01761
LLPS-Orl-0860Oryzias latipes86.850.01755
LLPS-Scm-2298Scophthalmus maximus86.540.01751
LLPS-Scf-1225Scleropages formosus85.880.01729
LLPS-Tar-0625Takifugu rubripes85.450.01564
LLPS-Ten-1360Tetraodon nigroviridis82.730.01668
LLPS-Ova-1220Ovis aries81.330.01656
LLPS-Eqc-1169Equus caballus81.260.01566
LLPS-Ict-1477Ictidomys tridecemlineatus81.220.01651
LLPS-Urm-0749Ursus maritimus81.220.01649
LLPS-Mum-3399Mus musculus81.120.01645
LLPS-Mea-3215Mesocricetus auratus81.120.01645
LLPS-Cap-3200Cavia porcellus81.020.01649
LLPS-Paa-1738Papio anubis81.020.01646
LLPS-Ran-2479Rattus norvegicus81.020.01649
LLPS-Dio-0198Dipodomys ordii81.020.01644
LLPS-Cea-2862Cercocebus atys81.020.01647
LLPS-Fec-1091Felis catus80.910.01649
LLPS-Mup-0750Mustela putorius furo80.910.01648
LLPS-Bot-1977Bos taurus80.910.01649
LLPS-Caj-0770Callithrix jacchus80.910.01617
LLPS-Fud-1956Fukomys damarensis80.910.01646
LLPS-Chs-3950Chlorocebus sabaeus80.910.01648
LLPS-Caf-0714Canis familiaris80.810.01646
LLPS-Rhb-2350Rhinopithecus bieti80.810.01643
LLPS-Lac-0962Latimeria chalumnae80.810.01605
LLPS-Hos-3128Homo sapiens80.810.01642
LLPS-Aim-0392Ailuropoda melanoleuca80.810.01643
LLPS-Maf-0334Macaca fascicularis80.810.01643
LLPS-Pat-2405Pan troglodytes80.710.01640
LLPS-Pap-1422Pan paniscus80.710.01640
LLPS-Mam-1544Macaca mulatta80.60.01642
LLPS-Otg-1877Otolemur garnettii80.60.01645
LLPS-Ora-0783Ornithorhynchus anatinus80.60.01640
LLPS-Fia-0048Ficedula albicollis80.520.01633
LLPS-Cas-0627Carlito syrichta80.50.01642
LLPS-Tag-3534Taeniopygia guttata80.210.01628
LLPS-Gaga-0622Gallus gallus80.10.01613
LLPS-Sus-0472Sus scrofa80.060.01623
LLPS-Meg-2102Meleagris gallopavo79.790.01627
LLPS-Gaa-1530Gasterosteus aculeatus79.760.01590
LLPS-Myl-1393Myotis lucifugus79.610.01642
LLPS-Sot-0672Solanum tuberosum79.553e-1989.0
LLPS-Loa-1372Loxodonta africana79.250.01636
LLPS-Pes-1241Pelodiscus sinensis79.110.01602
LLPS-Anc-0581Anolis carolinensis78.990.01613
LLPS-Mod-2332Monodelphis domestica78.960.01625
LLPS-Sah-2161Sarcophilus harrisii77.570.01593
LLPS-Xet-0132Xenopus tropicalis77.510.01596
LLPS-Mal-1171Mandrillus leucophaeus77.510.01476
LLPS-Man-2577Macaca nemestrina77.180.01536
LLPS-Aon-0681Aotus nancymaae73.340.01447
LLPS-Drm-1478Drosophila melanogaster60.410.01187
LLPS-Sol-1203Solanum lycopersicum60.142e-47 188
LLPS-Cis-0505Ciona savignyi59.570.01187
LLPS-Cii-1898Ciona intestinalis59.480.01198
LLPS-Cae-0190Caenorhabditis elegans57.440.01118
LLPS-Coc-0120Corchorus capsularis56.560.0 626
LLPS-Lep-0017Leersia perrieri51.680.0 782
LLPS-Abg-0127Absidia glauca50.920.0 934
LLPS-Sac-0067Saccharomyces cerevisiae50.110.0 903
LLPS-Nol-1605Nomascus leucogenys49.81e-151 479
LLPS-Yal-0824Yarrowia lipolytica49.640.0 879
LLPS-Dos-0024Dothistroma septosporum49.590.0 883
LLPS-Chr-0450Chlamydomonas reinhardtii49.220.0 824
LLPS-Crn-0224Cryptococcus neoformans49.170.0 860
LLPS-Via-0835Vigna angularis49.130.0 817
LLPS-Asc-0836Aspergillus clavatus48.760.0 853
LLPS-Php-1056Physcomitrella patens48.720.0 889
LLPS-Kop-0100Komagataella pastoris48.650.0 908
LLPS-Miv-0017Microbotryum violaceum48.60.0 874
LLPS-Tum-0014Tuber melanosporum48.450.0 868
LLPS-Scj-0101Schizosaccharomyces japonicus48.450.0 890
LLPS-Mua-0080Musa acuminata48.450.0 848
LLPS-Art-0465Arabidopsis thaliana48.340.0 854
LLPS-Nef-0054Neosartorya fischeri48.30.0 834
LLPS-Lem-0450Leptosphaeria maculans48.270.0 851
LLPS-Asfu-0461Aspergillus fumigatus48.20.0 833
LLPS-Gor-0697Gossypium raimondii48.20.0 864
LLPS-Zyt-0836Zymoseptoria tritici48.050.0 870
LLPS-Brn-2535Brassica napus48.00.0 857
LLPS-Pot-0469Populus trichocarpa47.930.0 877
LLPS-Scp-0847Schizosaccharomyces pombe47.880.0 875
LLPS-Mel-0168Melampsora laricipopulina47.870.0 860
LLPS-Put-0572Puccinia triticina47.860.0 830
LLPS-Glm-1580Glycine max47.850.0 832
LLPS-Mae-2058Manihot esculenta47.830.0 852
LLPS-Pyt-0410Pyrenophora teres47.790.0 835
LLPS-Phn-0342Phaeosphaeria nodorum47.760.0 843
LLPS-Pytr-0900Pyrenophora triticirepentis47.750.0 833
LLPS-Gas-1073Galdieria sulphuraria47.740.0 851
LLPS-Prp-0502Prunus persica47.720.0 841
LLPS-Asni-0048Aspergillus niger47.670.0 850
LLPS-Brr-0701Brassica rapa47.660.0 857
LLPS-Phv-0674Phaseolus vulgaris47.640.0 848
LLPS-Chc-0849Chondrus crispus47.640.0 812
LLPS-Cus-0524Cucumis sativus47.540.0 849
LLPS-Asg-0906Ashbya gossypii47.490.0 854
LLPS-Amt-0605Amborella trichopoda47.360.0 861
LLPS-Org-0669Oryza glaberrima47.190.0 852
LLPS-Met-1418Medicago truncatula47.190.0 838
LLPS-Ors-0683Oryza sativa47.080.0 850
LLPS-Ori-0772Oryza indica47.080.0 850
LLPS-Tra-1590Triticum aestivum47.060.0 836
LLPS-Arl-1919Arabidopsis lyrata47.030.0 841
LLPS-Pug-0247Puccinia graminis47.010.0 835
LLPS-Hov-1307Hordeum vulgare46.980.0 825
LLPS-Orr-1853Oryza rufipogon46.970.0 843
LLPS-Viv-0416Vitis vinifera46.970.0 836
LLPS-Asn-0989Aspergillus nidulans46.970.0 838
LLPS-Thc-0252Theobroma cacao46.930.0 856
LLPS-Orm-0464Oryza meridionalis46.870.0 837
LLPS-Nia-0742Nicotiana attenuata46.860.0 850
LLPS-Usm-0629Ustilago maydis46.590.0 855
LLPS-Hea-0544Helianthus annuus46.590.0 833
LLPS-Trr-1044Trichoderma reesei46.420.0 842
LLPS-Gag-0620Gaeumannomyces graminis46.40.0 790
LLPS-Trv-0940Trichoderma virens46.310.0 847
LLPS-Sob-0249Sorghum bicolor46.260.0 823
LLPS-Scc-0666Schizosaccharomyces cryophilus46.240.0 885
LLPS-Spr-0851Sporisorium reilianum46.140.0 832
LLPS-Coo-0717Colletotrichum orbiculare46.090.0 782
LLPS-Ast-0610Aspergillus terreus46.080.0 843
LLPS-Aso-0189Aspergillus oryzae46.020.0 748
LLPS-Cog-0542Colletotrichum gloeosporioides45.920.0 779
LLPS-Zem-1642Zea mays45.730.0 810
LLPS-Brd-0505Brachypodium distachyon45.660.0 827
LLPS-Blg-0863Blumeria graminis45.60.0 808
LLPS-Cogr-0200Colletotrichum graminicola45.510.0 764
LLPS-Tru-1183Triticum urartu45.480.0 811
LLPS-Orb-1231Oryza barthii45.210.0 832
LLPS-Sei-0670Setaria italica45.20.0 820
LLPS-Beb-0062Beauveria bassiana45.160.0 798
LLPS-Orgl-1321Oryza glumaepatula44.910.0 823
LLPS-Nec-0783Neurospora crassa44.860.0 781
LLPS-Orni-0214Oryza nivara44.810.0 821
LLPS-Leo-1799Lepisosteus oculatus44.790.0 758
LLPS-Orbr-0609Oryza brachyantha44.710.0 699
LLPS-Osl-1438Ostreococcus lucimarinus44.690.0 725
LLPS-Gog-1243Gorilla gorilla44.690.0 780
LLPS-Tut-0727Tursiops truncatus44.670.0 756
LLPS-Fus-0818Fusarium solani44.620.0 781
LLPS-Poa-0953Pongo abelii44.550.0 748
LLPS-Fuv-1133Fusarium verticillioides44.470.0 780
LLPS-Fuo-0625Fusarium oxysporum44.410.0 781
LLPS-Ved-0598Verticillium dahliae44.320.0 757
LLPS-Mao-0144Magnaporthe oryzae44.230.0 779
LLPS-Orc-0009Oryctolagus cuniculus44.020.0 742
LLPS-Bro-0598Brassica oleracea43.650.0 743
LLPS-Orp-0548Oryza punctata43.310.0 754
LLPS-Scs-0802Sclerotinia sclerotiorum42.890.0 751
LLPS-Dac-1307Daucus carota42.790.0 751
LLPS-Map-1138Magnaporthe poae42.30.0 725
LLPS-Cym-0463Cyanidioschyzon merolae42.210.0 718
LLPS-Sem-1587Selaginella moellendorffii34.344e-129 421
LLPS-Vir-0127Vigna radiata33.164e-121 400