LLPS-Hos-a957
ADCY5
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5 |
| Gene Name: | ADCY5 |
| Ensembl Gene: | ENSG00000173175.14 |
| Ensembl Protein: | ENSP00000420252.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000483566.1 | ENSP00000420252.1 |
| Ensembl | ENST00000466617.5 | ENSP00000420082.1 |
| Ensembl | ENST00000491190.5 | ENSP00000418537.1 |
| Ensembl | ENST00000309879.9 | ENSP00000308685.5 |
| Ensembl | ENST00000476455.1 | ENSP00000417789.1 |
| Ensembl | ENST00000462833.5 | ENSP00000419361.1 |
| UniProt | O95622, ADCY5_HUMAN, B7Z8A6, Q7RTV7, Q8NFM3 | |
| GeneBank | AF497517, BK000371, AC025571, AK303070, U65473, AC112503 | AAM94374.1, AAD00121.1, DAA00057.1, BAH13892.1 |
| RefSeq | NM_001199642.1, NM_183357.2 | NP_001186571.1, NP_899200.1 |
| Entrez | 111 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA 60 61 VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK SAWQERGGDD CGRGSRRQRR 120 121 GAASGGSTRA PPAGGGGGSA AAAASAGGTE VRPRSVEVGL EERRGKGRAA DELEAGAVEG 180 181 GEGSGDGGSS ADSGSGAGPG AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS 240 241 SLTMLMAVLV LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL 300 301 ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA VLSGVLLSAL 360 361 HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA EVSQRQAFQE TRECIQARLH 420 421 SQRENQQQER LLLSVLPRHV AMEMKADINA KQEDMMFHKI YIQKHDNVSI LFADIEGFTS 480 481 LASQCTAQEL VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM 540 541 GMDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK 600 601 AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK EEKAMIAKMN 660 661 RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED PKDKNAQESA NPEDEVDEFL 720 721 GRAIDARSID RLRSEHVRKF LLTFREPDLE KKYSKQVDDR FGAYVACASL VFLFICFVQI 780 781 TIVPHSIFML SFYLTCSLLL TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF 840 841 TITLVFLAAF VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP 900 901 WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP GVTLFDNADL 960 961 LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA LYLHAQQVES TARLDFLWKL 1020 1021 QATEEKEEME ELQAYNRRLL HNILPKDVAA HFLARERRND ELYYQSCECV AVMFASIANF 1080 1081 SEFYVELEAN NEGVECLRLL NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY 1140 1141 DKVGKTHIKA LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG 1200 1201 NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM TYFLNGGPPL 1260 1261 S 1261 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGTCTC AGAAAGAGGG CTGTTGCAGC AGAGGTGACC TGTCCATTCA GACAGGTCCT 60 61 GGAGGAGAAT GGGCCCCACG GAGGCTTGTC TCCAATGTTC TCATTTTCTC CTGCACCAAC 120 121 ATCGTGGGTG TCTGCACCCA CTATCCGGCT GAGGTCTCCC AGAGACAGGC TTTCCAGGAG 180 181 ACCCGAGAGT GCATCCAGGC GCGGCTCCAC TCGCAGCGGG AGAACCAGCA GCAGGAACGG 240 241 CTCCTGCTGT CTGTCCTTCC CCGTCATGTT GCCATGGAGA TGAAAGCAGA CATCAACGCC 300 301 AAGCAGGAGG ATATGATGTT CCATAAGATT TACATCCAGA AACATGACAA CGTGAGCATC 360 361 CTGTTTGCTG ACATCGAGGG CTTCACCAGC CTGGCGTCCC AGTGCACTGC ACAGGAACTG 420 421 GTCATGACCC TCAACGAGCT CTTCGCCCGC TTTGACAAGC TGGCCGCAGA GAATCACTGT 480 481 TTACGTATTA AGATCCTTGG GGATTGTTAT TACTGCGTCT CGGGGCTGCC TGAAGCAAGG 540 541 GCTGACCACG CCCACTGCTG TGTGGAGATG GGCATGGACA TGATCGAGGC CATCTCGTTG 600 601 GTCCGGGAGG TGACAGGGGT GAACGTGAAC ATGCGTGTGG GAATTCACAG CGGGCGAGTA 660 661 CACTGCGGTG TCCTTGGTCT CAGGAAGTGG CAGTTCGACG TCTGGTCTAA CGATGTCACG 720 721 CTAGCCAACC ACATGGAGGC TGGCGGCAAG GCAGGACGCA TCCACATCAC CAAGGCTACA 780 781 CTCAACTACC TGAATGGGGA CTACGAGGTG GAGCCAGGCT GTGGGGGCGA GCGCAACGCC 840 841 TACCTCAAGG AGCACAGTAT CGAGACCTTC CTCATCCTGC GCTGCACCCA GAAGCGGAAA 900 901 GAAGAGAAGG CCATGATCGC CAAGATGAAC CGCCAGAGAA CCAACTCCAT CGGGCACAAC 960 961 CCACCACACT GGGGGGCTGA GCGCCCCTTC TACAACCACC TGGGTGGCAA CCAGGTGTCC 1020 1021 AAGGAGATGA AGCGGATGGG CTTTGAAGAC CCCAAGGACA AGAACGCCCA GGAGAGTGCG 1080 1081 AACCCTGAGG ATGAAGTGGA TGAGTTTCTG GGCCGTGCCA TTGACGCCAG GAGCATTGAT 1140 1141 AGGCTTCGGT CTGAGCACGT CCGCAAGTTC CTCCTGACCT TCAGGGAGCC TGACTTAGAG 1200 1201 AAGAAGTACT CCAAGCAGGT AGACGACCGA TTTGGTGCCT ATGTGGCGTG TGCCTCGCTC 1260 1261 GTCTTCCTCT TCATCTGCTT TGTCCAGATC ACCATCGTGC CCCACTCCAT ATTCATGCTC 1320 1321 AGCTTCTACC TGACCTGTTC CCTGCTGCTG ACCTTGGTGG TGTTTGTGTC TGTGATCTAC 1380 1381 TCCTGCGTAA AGCTCTTCCC CTCCCCACTG CAGACCCTCT CCAGGAAGAT CGTGCGGTCC 1440 1441 AAGATGAACA GCACCCTGGT TGGGGTGTTC ACCATCACCC TGGTGTTCCT GGCGGCTTTT 1500 1501 GTCAACATGT TCACGTGCAA CTCCAGGGAC CTGCTGGGCT GCTTGGCACA GGAGCACAAC 1560 1561 ATCAGCGCGA GCCAGGTCAA CGCGTGTCAC GTGGCGGAGT CGGCCGTCAA CTACAGCCTG 1620 1621 GGCGATGAGC AGGGCTTCTG TGGCAGCCCC TGGCCCAACT GCAACTTCCC CGAGTACTTC 1680 1681 ACCTACAGCG TGCTGCTCAG CCTGCTGGCC TGCTCCGTGT TCCTGCAGAT CAGCTGCATC 1740 1741 GGGAAGCTGG TGCTCATGCT GGCCATCGAG CTCATCTACG TGCTCATCGT GGAGGTGCCA 1800 1801 GGTGTCACGC TCTTCGACAA CGCCGACCTG CTGGTCACCG CCAACGCCAT AGACTTCTTC 1860 1861 AACAACGGGA CCTCCCAGTG CCCTGAGCAT GCAACCAAGG TGGCATTGAA GGTGGTGACG 1920 1921 CCCATCATCA TCTCAGTCTT TGTGCTGGCC CTGTACCTGC ACGCCCAGCA GGTGGAGTCC 1980 1981 ACTGCCCGCC TCGACTTCCT CTGGAAACTG CAGGCCACAG AGGAGAAAGA GGAGATGGAG 2040 2041 GAGCTGCAGG CCTACAACCG GCGGCTGCTG CACAACATCC TGCCCAAGGA CGTGGCCGCT 2100 2101 CACTTCCTGG CCCGCGAGCG GCGCAATGAT GAGCTCTACT ATCAGTCCTG TGAGTGTGTG 2160 2161 GCGGTCATGT TCGCCTCCAT CGCCAACTTC TCCGAGTTCT ACGTTGAGCT GGAGGCCAAC 2220 2221 AACGAGGGTG TCGAGTGCCT GCGGCTACTC AATGAGATCA TCGCTGACTT TGATGAGATC 2280 2281 ATCAGCGAGG ATCGGTTCCG GCAGCTGGAG AAGATCAAGA CCATCGGCAG CACCTACATG 2340 2341 GCTGCCTCCG GCCTCAACGA CTCTACCTAC GACAAGGTGG GCAAGACCCA CATCAAGGCA 2400 2401 CTGGCCGACT TTGCCATGAA GCTGATGGAC CAGATGAAGT ACATCAATGA GCACTCCTTC 2460 2461 AACAACTTCC AGATGAAGAT CGGGCTCAAC ATCGGCCCCG TGGTGGCCGG GGTGATAGGG 2520 2521 GCACGAAAGC CTCAGTACGA CATCTGGGGC AATACCGTGA ACGTGGCCAG CCGCATGGAC 2580 2581 AGCACCGGTG TACCCGACCG CATCCAGGTC ACCACAGACA TGTACCAGGT GCTGGCTGCC 2640 2641 AACACGTACC AGCTGGAGTG CCGGGGCGTG GTCAAGGTCA AGGGCAAAGG CGAGATGATG 2700 2701 ACCTACTTCC TCAATGGAGG GCCCCCGCTC AGTTAG 2736 |
▼ KEYWORD
ID | Family |
Alternative splicing | |
ATP-binding | |
cAMP biosynthesis | |
Cell membrane | |
Cell projection | |
Cilium | |
Complete proteome | |
Disease mutation | |
Glycoprotein | |
Lyase | |
Magnesium | |
Membrane | |
Metal-binding | |
Methylation | |
Nucleotide-binding | |
Phosphoprotein | |
Reference proteome | |
Repeat | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cilium | |
Cellular Component | Integral component of membrane | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Intermediate filament cytoskeleton | |
Cellular Component | Plasma membrane | |
Molecular Function | Adenylate cyclase activity | |
Molecular Function | Adenylate cyclase binding | |
Molecular Function | ATP binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Scaffold protein binding | |
Biological Process | Activation of adenylate cyclase activity | |
Biological Process | Activation of protein kinase A activity | |
Biological Process | Adenosine receptor signaling pathway | |
Biological Process | Adenylate cyclase-activating dopamine receptor signaling pathway | |
Biological Process | Adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | Adenylate cyclase-inhibiting dopamine receptor signaling pathway | |
Biological Process | Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | CAMP biosynthetic process | |
Biological Process | Cellular response to forskolin | |
Biological Process | Cellular response to glucagon stimulus | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | Locomotory behavior | |
Biological Process | Neuromuscular process controlling balance | |
Biological Process | Positive regulation of cytosolic calcium ion concentration | |
Biological Process | Regulation of insulin secretion involved in cellular response to glucose stimulus | |
Biological Process | Renal water homeostasis |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-a922 | Pan paniscus | 99.91 | 0.0 | 2199 |
| LLPS-Chs-a932 | Chlorocebus sabaeus | 99.55 | 0.0 | 1846 |
| LLPS-Nol-a922 | Nomascus leucogenys | 99.45 | 0.0 | 2610 |
| LLPS-Mal-a929 | Mandrillus leucophaeus | 99.34 | 0.0 | 2202 |
| LLPS-Cea-a942 | Cercocebus atys | 99.13 | 0.0 | 2602 |
| LLPS-Mam-a925 | Macaca mulatta | 99.13 | 0.0 | 2602 |
| LLPS-Caj-a934 | Callithrix jacchus | 98.65 | 0.0 | 2593 |
| LLPS-Mup-a904 | Mustela putorius furo | 98.04 | 0.0 | 2078 |
| LLPS-Aim-a896 | Ailuropoda melanoleuca | 97.79 | 0.0 | 2207 |
| LLPS-Pat-a944 | Pan troglodytes | 97.78 | 0.0 | 2549 |
| LLPS-Ict-a927 | Ictidomys tridecemlineatus | 97.69 | 0.0 | 2200 |
| LLPS-Caf-a919 | Canis familiaris | 97.6 | 0.0 | 2114 |
| LLPS-Bot-a942 | Bos taurus | 97.46 | 0.0 | 2556 |
| LLPS-Man-a945 | Macaca nemestrina | 97.15 | 0.0 | 2528 |
| LLPS-Eqc-a937 | Equus caballus | 97.11 | 0.0 | 2374 |
| LLPS-Fec-a941 | Felis catus | 96.99 | 0.0 | 2540 |
| LLPS-Maf-a941 | Macaca fascicularis | 96.83 | 0.0 | 2526 |
| LLPS-Rhb-a930 | Rhinopithecus bieti | 96.79 | 0.0 | 2179 |
| LLPS-Paa-a944 | Papio anubis | 96.75 | 0.0 | 2512 |
| LLPS-Sus-a941 | Sus scrofa | 96.35 | 0.0 | 2533 |
| LLPS-Aon-a946 | Aotus nancymaae | 96.04 | 0.0 | 2510 |
| LLPS-Urm-a845 | Ursus maritimus | 95.86 | 0.0 | 1912 |
| LLPS-Ran-a937 | Rattus norvegicus | 95.41 | 0.0 | 2354 |
| LLPS-Mum-a942 | Mus musculus | 95.33 | 0.0 | 2335 |
| LLPS-Mea-a898 | Mesocricetus auratus | 95.24 | 0.0 | 2375 |
| LLPS-Loa-a907 | Loxodonta africana | 95.02 | 0.0 | 2375 |
| LLPS-Cas-a812 | Carlito syrichta | 94.75 | 0.0 | 1790 |
| LLPS-Fud-a902 | Fukomys damarensis | 94.64 | 0.0 | 2124 |
| LLPS-Cap-a938 | Cavia porcellus | 94.38 | 0.0 | 1972 |
| LLPS-Poa-a917 | Pongo abelii | 93.43 | 0.0 | 2211 |
| LLPS-Dio-a907 | Dipodomys ordii | 92.43 | 0.0 | 2017 |
| LLPS-Myl-a871 | Myotis lucifugus | 90.5 | 0.0 | 2123 |
| LLPS-Tag-a808 | Taeniopygia guttata | 86.75 | 0.0 | 998 |
| LLPS-Sah-a846 | Sarcophilus harrisii | 86.4 | 0.0 | 1587 |
| LLPS-Mod-a900 | Monodelphis domestica | 84.43 | 0.0 | 2103 |
| LLPS-Fia-a825 | Ficedula albicollis | 79.48 | 0.0 | 1992 |
| LLPS-Pes-a802 | Pelodiscus sinensis | 79.45 | 0.0 | 1967 |
| LLPS-Gaga-a843 | Gallus gallus | 79.18 | 0.0 | 1989 |
| LLPS-Meg-a753 | Meleagris gallopavo | 78.66 | 0.0 | 1981 |
| LLPS-Scf-a792 | Scleropages formosus | 75.46 | 0.0 | 1857 |
| LLPS-Leo-a805 | Lepisosteus oculatus | 74.74 | 0.0 | 1896 |
| LLPS-Dar-a821 | Danio rerio | 74.58 | 0.0 | 1874 |
| LLPS-Xet-a804 | Xenopus tropicalis | 73.08 | 0.0 | 1655 |
| LLPS-Icp-a819 | Ictalurus punctatus | 73.01 | 0.0 | 1852 |
| LLPS-Orn-a816 | Oreochromis niloticus | 72.48 | 0.0 | 1829 |
| LLPS-Pof-a813 | Poecilia formosa | 71.96 | 0.0 | 1792 |
| LLPS-Orl-a807 | Oryzias latipes | 71.68 | 0.0 | 1791 |
| LLPS-Xim-a823 | Xiphophorus maculatus | 71.42 | 0.0 | 1804 |
| LLPS-Ten-a774 | Tetraodon nigroviridis | 71.34 | 0.0 | 1778 |
| LLPS-Orc-a880 | Oryctolagus cuniculus | 71.33 | 0.0 | 1499 |
| LLPS-Anc-a851 | Anolis carolinensis | 70.75 | 0.0 | 1506 |
| LLPS-Tar-a775 | Takifugu rubripes | 70.64 | 0.0 | 1748 |
| LLPS-Ora-a773 | Ornithorhynchus anatinus | 69.89 | 0.0 | 763 |
| LLPS-Otg-a928 | Otolemur garnettii | 67.78 | 0.0 | 1502 |
| LLPS-Gog-a934 | Gorilla gorilla | 67.64 | 0.0 | 1528 |
| LLPS-Ova-a906 | Ovis aries | 67.01 | 0.0 | 1504 |
| LLPS-Gaa-a794 | Gasterosteus aculeatus | 66.89 | 0.0 | 1568 |
| LLPS-Lac-a826 | Latimeria chalumnae | 66.38 | 0.0 | 1044 |
| LLPS-Scm-a783 | Scophthalmus maximus | 65.92 | 0.0 | 1617 |