• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaga-2424
PFKP

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent 6-phosphofructokinase
Gene Name: PFKP
Ensembl Gene: ENSGALG00000006939.6
Ensembl Protein: ENSGALP00000011232.3
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MFTASLPPRA  PAARGEGQHG  TSRSHLQPLP  RRSPASRTPP  TCPLPHKRNR  PPVARDNSAP  60
61    SYWLLETTVN  RRSRRGVGGR  SREGCQQERS  EETAVVAGGQ  ILDRAAFVLP  GDAQGMNAAV  120
121   RAVVRMGIYV  KAKVYFVYEG  YQGMVDGGDN  IVEVSWESVS  SILQVGGTVI  GSARCKSFRT  180
181   REGRLQAAYN  LVRRGITNLC  VIGGDGSLTG  ANLFREEWSG  LLEELAQKGK  IDEEAVKKYA  240
241   YLNIVGMVGS  IDNDFCGTDM  TIGTDSALHR  IIEVVDAIMT  TAQSHQRTFV  LEVMGRHCGY  300
301   LALVSALACG  ADWVFIPEYP  PEEGWEDSMC  VKLSENRARK  KRLNIIIVAE  GAIDCHNKPI  360
361   TSEKVKDLVV  QRLGFDTRVT  ILGHVQRGGT  PSAFDRILAS  RMGVEAVLAL  LEATPDTPAC  420
421   VVSLSGNQAV  RLPLMECVQM  TQEVQKAMDE  GRFVEAVRLR  GRSFENNLNT  YKLLSQKKPD  480
481   AELPKSNFNV  AVLNVGAPAA  GMNAAVRAAV  RVGITEGHKM  FAVIDGFEGF  ARGKIKEISW  540
541   GDVGGWTGQG  GSILGTKRTL  PAKYLEKIAD  QMRTNNINAL  MVIGGFEAYL  GLLELSAARE  600
601   KYDEFCVPMV  MVPATVSNNV  PGSDFSIGAD  TALNTITDTC  DRIFEEQFDI  RELQANVEHL  660
661   TEKMKTSIQR  GLVLRNENCN  ENYTTDFIYQ  LYSEEGKGVF  DCRKNVLGHM  QQGGAPSPFD  720
721   RNFGTKISAK  AMQWISKKLK  ETYRKGKVFA  NTDDSVCLLG  MRRRNLVFQP  VAELKNETDF  780
781   VHRIPMEQWW  LKLRPLMKIL  AKYKTSYDVS  DSGQLEHVAM  HSPKEAETGA  I  831
Nucleotide CDS Sequence (FASTA)
1     ATGGATCACC  AGCCCAAGTT  CTTCGAGAAC  CTCTCCGGCA  CCGGGAAAGC  CATCGGGGTG  60
61    CTGACCAGCG  GCGGCGATGC  CCAAGGTATG  AATGCTGCTG  TGCGTGCAGT  AGTACGCATG  120
121   GGAATATATG  TGAAAGCCAA  AGTCTATTTC  GTTTATGAGG  GTTACCAAGG  AATGGTTGAT  180
181   GGCGGTGATA  ATATTGTTGA  AGTTTCTTGG  GAAAGTGTAT  CCAGTATCCT  GCAAGTGGGA  240
241   GGTACGGTCA  TTGGTAGTGC  ACGCTGCAAA  TCTTTTCGTA  CCCGGGAGGG  TCGCCTGCAG  300
301   GCAGCCTACA  ACTTGGTTCG  GAGGGGAATC  ACTAATCTTT  GTGTGATTGG  TGGAGATGGT  360
361   AGCTTAACTG  GTGCCAATCT  GTTCCGTGAA  GAATGGAGTG  GACTTCTAGA  AGAACTAGCG  420
421   CAGAAAGGAA  AGATTGATGA  AGAAGCTGTT  AAGAAATATG  CTTACCTTAA  CATTGTGGGA  480
481   ATGGTTGGAT  CCATAGACAA  TGACTTCTGT  GGCACTGATA  TGACCATAGG  TACTGACTCA  540
541   GCCTTGCACA  GAATCATTGA  AGTTGTGGAT  GCCATCATGA  CCACTGCACA  AAGCCATCAG  600
601   AGGACATTTG  TTCTGGAGGT  TATGGGGAGA  CACTGTGGGT  ATTTAGCTCT  TGTCAGTGCC  660
661   TTAGCTTGTG  GTGCAGATTG  GGTATTTATT  CCTGAATACC  CACCAGAAGA  AGGATGGGAG  720
721   GATTCAATGT  GTGTTAAGCT  TTCAGAGAAC  CGTGCACGAA  AGAAAAGGCT  GAATATTATT  780
781   ATTGTAGCTG  AAGGAGCTAT  TGATTGCCAC  AACAAACCTA  TAACATCAGA  GAAGGTTAAG  840
841   GATCTTGTGG  TTCAGCGGCT  TGGATTTGAC  ACCCGAGTAA  CTATCTTGGG  TCATGTGCAG  900
901   AGAGGTGGAA  CTCCTTCAGC  TTTTGATAGA  ATTTTGGCAA  GCCGAATGGG  TGTAGAAGCT  960
961   GTGCTTGCAC  TTCTAGAAGC  TACTCCAGAC  ACTCCTGCTT  GTGTTGTGTC  CCTCTCTGGA  1020
1021  AACCAGGCTG  TTCGTCTGCC  TTTGATGGAG  TGTGTGCAGA  TGACTCAAGA  AGTACAGAAA  1080
1081  GCCATGGATG  AAGGAAGATT  TGTTGAGGCT  GTGAGGCTTC  GTGGGAGGAG  CTTTGAAAAC  1140
1141  AACCTTAACA  CCTACAAATT  GCTGTCACAA  AAAAAGCCAG  ATGCCGAGCT  TCCAAAGTCC  1200
1201  AATTTTAATG  TGGCAGTCTT  AAATGTTGGT  GCGCCTGCAG  CTGGAATGAA  TGCTGCAGTG  1260
1261  AGGGCTGCAG  TGAGAGTTGG  CATAACGGAA  GGCCATAAAA  TGTTTGCTGT  CATTGATGGA  1320
1321  TTTGAAGGTT  TTGCTAGAGG  GAAGATCAAG  GAAATCAGCT  GGGGAGATGT  TGGAGGCTGG  1380
1381  ACTGGTCAAG  GAGGATCAAT  TCTTGGTACC  AAACGTACTC  TTCCTGCAAA  ATATTTGGAG  1440
1441  AAGATTGCTG  ACCAGATGCG  CACTAACAAC  ATTAATGCTC  TTATGGTTAT  TGGTGGATTT  1500
1501  GAGGCATACC  TCGGACTTTT  GGAATTGTCA  GCTGCCCGAG  AGAAATATGA  TGAATTCTGT  1560
1561  GTTCCAATGG  TTATGGTTCC  TGCAACAGTA  TCCAACAATG  TACCGGGTTC  AGATTTCAGC  1620
1621  ATTGGTGCAG  ATACTGCTCT  GAACACTATA  ACTGATCTAC  AGAACATGGG  GAAAAACGTG  1680
1681  GAGAAGATGA  AAATTTAA  1698

▼ KEYWORD

ID
Family
Allosteric enzyme
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
6-phosphofructokinase complex
Molecular Function
6-phosphofructokinase activity
Molecular Function
AMP binding
Molecular Function
ATP binding
Molecular Function
Fructose-6-phosphate binding
Molecular Function
Metal ion binding
Molecular Function
Monosaccharide binding
Biological Process
Canonical glycolysis
Biological Process
Fructose 1,6-bisphosphate metabolic process
Biological Process
Fructose 6-phosphate metabolic process
Biological Process
Glucose catabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-2933Pelodiscus sinensis87.570.01225
LLPS-Xet-2537Xenopus tropicalis83.150.01124
LLPS-Pap-2887Pan paniscus81.390.01178
LLPS-Pat-3613Pan troglodytes81.260.01176
LLPS-Hos-3107Homo sapiens81.260.01179
LLPS-Paa-4204Papio anubis81.120.01176
LLPS-Caj-3275Callithrix jacchus80.990.01173
LLPS-Chs-4099Chlorocebus sabaeus80.70.01165
LLPS-Dio-4205Dipodomys ordii80.110.01158
LLPS-Gaa-2758Gasterosteus aculeatus79.550.01161
LLPS-Ten-2750Tetraodon nigroviridis78.770.01154
LLPS-Tar-3767Takifugu rubripes78.420.01159
LLPS-Mam-0948Macaca mulatta77.380.01105
LLPS-Tag-2200Taeniopygia guttata77.161e-99 314
LLPS-Scf-2914Scleropages formosus76.940.01176
LLPS-Scm-2597Scophthalmus maximus76.280.01117
LLPS-Man-4011Macaca nemestrina75.10.01091
LLPS-Bot-3173Bos taurus74.660.01125
LLPS-Urm-1637Ursus maritimus73.750.01025
LLPS-Leo-1200Lepisosteus oculatus69.080.01018
LLPS-Orl-3989Oryzias latipes68.780.01015
LLPS-Otg-4170Otolemur garnettii68.570.01003
LLPS-Maf-1952Macaca fascicularis68.390.01002
LLPS-Cea-1426Cercocebus atys68.390.01002
LLPS-Orc-3475Oryctolagus cuniculus68.370.01011
LLPS-Aim-0056Ailuropoda melanoleuca68.340.01002
LLPS-Mup-0465Mustela putorius furo68.080.01003
LLPS-Sus-4399Sus scrofa68.070.01006
LLPS-Cap-2401Cavia porcellus68.070.01006
LLPS-Ict-3662Ictidomys tridecemlineatus68.070.01006
LLPS-Mum-4455Mus musculus67.980.01004
LLPS-Ran-2738Rattus norvegicus67.980.01005
LLPS-Fec-2644Felis catus67.980.01004
LLPS-Eqc-3401Equus caballus67.870.01010
LLPS-Mea-3354Mesocricetus auratus67.850.01001
LLPS-Rhb-4328Rhinopithecus bieti67.810.01002
LLPS-Nol-1703Nomascus leucogenys67.720.01004
LLPS-Caf-1672Canis familiaris67.680.0 999
LLPS-Anc-2842Anolis carolinensis67.190.01004
LLPS-Ora-0863Ornithorhynchus anatinus66.580.0 985
LLPS-Myl-3619Myotis lucifugus66.490.0 988
LLPS-Meg-1133Meleagris gallopavo66.090.0 917
LLPS-Mal-2659Mandrillus leucophaeus66.080.0 983
LLPS-Fia-1639Ficedula albicollis65.830.0 981
LLPS-Sah-2879Sarcophilus harrisii65.790.0 992
LLPS-Ova-1289Ovis aries65.710.0 993
LLPS-Cas-1179Carlito syrichta65.690.0 946
LLPS-Aon-4656Aotus nancymaae65.240.0 959
LLPS-Pof-3822Poecilia formosa65.00.0 965
LLPS-Fud-4456Fukomys damarensis64.980.0 910
LLPS-Xim-4111Xiphophorus maculatus64.740.0 966
LLPS-Icp-2024Ictalurus punctatus64.460.0 965
LLPS-Asm-2203Astyanax mexicanus64.070.0 947
LLPS-Dar-1019Danio rerio64.010.0 971
LLPS-Orn-2342Oreochromis niloticus63.730.0 951
LLPS-Poa-3391Pongo abelii63.210.0 874
LLPS-Gog-2307Gorilla gorilla63.010.0 924
LLPS-Loa-1417Loxodonta africana61.420.0 849
LLPS-Lac-2556Latimeria chalumnae55.30.0 749
LLPS-Mod-4084Monodelphis domestica50.259e-53 187
LLPS-Asf-1112Aspergillus flavus48.981e-151 466
LLPS-Abg-0238Absidia glauca46.640.0 609
LLPS-Aso-0853Aspergillus oryzae45.070.0 568
LLPS-Asn-1372Aspergillus nidulans44.120.0 567
LLPS-Nef-1245Neosartorya fischeri43.980.0 560
LLPS-Asfu-1419Aspergillus fumigatus43.980.0 558
LLPS-Asni-0090Aspergillus niger43.730.0 564
LLPS-Scc-0468Schizosaccharomyces cryophilus43.711e-169 523
LLPS-Pytr-1140Pyrenophora triticirepentis43.70.0 550
LLPS-Lem-1131Leptosphaeria maculans43.680.0 551
LLPS-Cog-0759Colletotrichum gloeosporioides43.457e-173 526
LLPS-Ast-0349Aspergillus terreus43.40.0 560
LLPS-Asc-0084Aspergillus clavatus43.350.0 548
LLPS-Phn-1026Phaeosphaeria nodorum43.031e-175 533
LLPS-Dos-0945Dothistroma septosporum42.973e-172 525
LLPS-Kop-1480Komagataella pastoris41.684e-172 531
LLPS-Map-0973Magnaporthe poae41.622e-164 504
LLPS-Asg-0716Ashbya gossypii41.614e-166 514
LLPS-Spr-0794Sporisorium reilianum41.613e-167 512
LLPS-Usm-1259Ustilago maydis41.536e-153 477
LLPS-Sac-0201Saccharomyces cerevisiae40.551e-160 500
LLPS-Ori-2089Oryza indica38.267e-49 179
LLPS-Mel-1375Melampsora laricipopulina36.743e-150 469
LLPS-Cae-0984Caenorhabditis elegans36.663e-137 432
LLPS-Put-0611Puccinia triticina34.582e-127 407
LLPS-Tra-0062Triticum aestivum29.347e-1273.2
LLPS-Hov-0252Hordeum vulgare29.274e-1273.6
LLPS-Sem-0561Selaginella moellendorffii29.027e-1376.3
LLPS-Glm-1540Glycine max28.962e-1068.6
LLPS-Met-1419Medicago truncatula28.964e-1067.4
LLPS-Gor-2670Gossypium raimondii28.961e-1068.9
LLPS-Brd-1915Brachypodium distachyon28.813e-1274.7
LLPS-Phv-2182Phaseolus vulgaris28.511e-0965.9
LLPS-Coc-0112Corchorus capsularis28.511e-0965.9
LLPS-Brr-2891Brassica rapa28.464e-1170.5
LLPS-Sol-1883Solanum lycopersicum28.45e-1376.3
LLPS-Tru-1652Triticum urartu28.48e-1273.2
LLPS-Nia-1787Nicotiana attenuata28.241e-1275.5
LLPS-Vir-2113Vigna radiata28.177e-1067.0
LLPS-Mae-2393Manihot esculenta28.062e-1068.6
LLPS-Orb-1034Oryza barthii28.059e-1169.3
LLPS-Thc-1815Theobroma cacao28.059e-1066.2
LLPS-Orni-0591Oryza nivara28.059e-1169.3
LLPS-Orgl-0692Oryza glumaepatula28.051e-1069.3
LLPS-Sei-2427Setaria italica28.051e-1068.6
LLPS-Ors-1378Oryza sativa28.059e-1169.3
LLPS-Pot-1922Populus trichocarpa28.059e-1066.2
LLPS-Sob-1961Sorghum bicolor28.051e-1172.4
LLPS-Orr-0831Oryza rufipogon28.059e-1169.3
LLPS-Org-1039Oryza glaberrima28.059e-1169.3
LLPS-Zem-2480Zea mays28.052e-1172.0
LLPS-Via-2288Vigna angularis27.76e-0963.9
LLPS-Orp-1193Oryza punctata27.692e-1172.0
LLPS-Orbr-2118Oryza brachyantha27.692e-1171.2
LLPS-Lep-1767Leersia perrieri27.643e-1171.2
LLPS-Orm-1308Oryza meridionalis27.641e-1172.8
LLPS-Art-3039Arabidopsis thaliana27.351e-0965.9
LLPS-Hea-1248Helianthus annuus27.249e-1169.3
LLPS-Amt-2312Amborella trichopoda27.242e-0965.1
LLPS-Brn-2698Brassica napus27.231e-0966.2
LLPS-Bro-0453Brassica oleracea27.236e-1067.0
LLPS-Sot-0352Solanum tuberosum27.175e-1170.1
LLPS-Php-0343Physcomitrella patens26.982e-1172.0
LLPS-Arl-2328Arabidopsis lyrata26.944e-0964.3
LLPS-Cym-0836Cyanidioschyzon merolae26.855e-1273.2
LLPS-Chc-1089Chondrus crispus26.831e-0965.9
LLPS-Gas-1104Galdieria sulphuraria26.675e-0860.8
LLPS-Cus-1362Cucumis sativus26.456e-1169.7
LLPS-Dac-2369Daucus carota26.424e-1067.4
LLPS-Osl-1292Ostreococcus lucimarinus26.113e-0758.2
LLPS-Mua-1967Musa acuminata26.021e-1068.9
LLPS-Viv-0705Vitis vinifera25.26e-0963.5
LLPS-Prp-2523Prunus persica23.331e-0655.8