• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-1827
TUBB5

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta-5 chain
Gene Name: TUBB5
Ensembl Gene: ENSBTAG00000006969.5
Ensembl Protein: ENSBTAP00000009158.4
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHIQAG  QCGNQIGAKF  WEVISDEHGI  DPTGTYHGDS  DLQLDRISVY  YNEATGGKYV  60
61    PRAILVDLEP  GTMDSVRSGP  FGQIFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDSVLDVV  120
121   RKEAESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEYP  DRIMNTFSVV  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  CIDNEALYDI  CFRTLKLTTP  TYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRALTVPELT  QQVFDAKNMM  300
301   AACDPRHGRY  LTVAAVFRGR  MSMKEVDEQM  LNVQNKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMAVTFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  EEEEDFGEEA  EEEA  444
Nucleotide CDS Sequence (FASTA)
1     ATGAGGGAAA  TCGTGCACAT  CCAGGCCGGT  CAGTGTGGCA  ATCAGATCGG  TGCCAAGTTC  60
61    TGGGAGGTGA  TCAGTGATGA  ACATGGCATC  GACCCCACCG  GCACCTATCA  TGGGGACAGC  120
121   GACCTACAAC  TGGACCGCAT  CTCCGTGTAC  TACAATGAAG  CCACAGGTGG  CAAATATGTC  180
181   CCTCGTGCTA  TCTTGGTGGA  TCTAGAACCC  GGAACCATGG  ACTCTGTTCG  CTCAGGTCCT  240
241   TTTGGTCAGA  TCTTCAGACC  AGACAACTTT  GTTTTTGGTC  AGTCCGGGGC  AGGCAACAAC  300
301   TGGGCCAAGG  GCCACTATAC  AGAGGGAGCC  GAGCTGGTTG  ACTCGGTCCT  GGATGTGGTT  360
361   CGGAAGGAGG  CCGAGAGCTG  TGACTGCCTG  CAGGGCTTCC  AGCTGACCCA  CTCGCTGGGT  420
421   GGGGGCACTG  GCTCCGGAAT  GGGCACCTTG  CTCATCAGCA  AGATCCGTGA  AGAGTATCCC  480
481   GACCGCATCA  TGAACACCTT  CAGCGTGGTG  CCCTCACCCA  AAGTTTCCGA  CACTGTGGTT  540
541   GAGCCCTACA  ACGCCACCCT  CTCTGTCCAT  CAGCTGGTGG  AGAACACTGA  TGAAACCTAC  600
601   TGCATTGACA  ACGAGGCCCT  TTACGACATA  TGTTTCCGCA  CCCTCAAGCT  GACCACACCA  660
661   ACCTATGGAG  ACCTGAACCA  CCTCGTCTCG  GCCACCATGA  GTGGAGTCAC  CACTTGCCTC  720
721   CGCTTTCCTG  GCCAGCTCAA  TGCTGACCTC  CGCAAGCTGG  CCGTCAACAT  GGTGCCCTTC  780
781   CCACGCCTCC  ACTTCTTCAT  GCCTGGCTTT  GCCCCTCTTA  CCAGCCGTGG  CAGCCAGCAG  840
841   TATCGGGCCC  TCACTGTCCC  TGAGCTCACC  CAGCAGGTCT  TCGATGCCAA  GAACATGATG  900
901   GCTGCCTGTG  ACCCCCGCCA  TGGCCGGTAC  CTCACCGTGG  CTGCTGTGTT  CCGTGGGCGG  960
961   ATGTCCATGA  AGGAGGTAGA  TGAGCAGATG  CTCAACGTGC  AGAATAAGAA  CAGCAGCTAC  1020
1021  TTCGTGGAAT  GGATCCCCAA  CAACGTCAAG  ACAGCTGTTT  GCGACATCCC  ACCCCGTGGT  1080
1081  CTGAAGATGG  CAGTCACCTT  CATTGGCAAC  AGCACAGCCA  TCCAGGAGCT  GTTCAAGCGC  1140
1141  ATCTCGGAGC  AGTTCACGGC  CATGTTCCGC  CGGAAGGCCT  TCCTCCACTG  GTACACAGGT  1200
1201  GAGGGCATGG  ACGAGATGGA  GTTCACCGAG  GCTGAGAGCA  ACATGAACGA  CCTCGTCTCC  1260
1261  GAGTACCAGC  AGTACCAGGA  TGCCACCGCA  GAAGAGGAAG  AGGATTTCGG  TGAGGAGGCC  1320
1321  GAAGAGGAGG  CCTAA  1335

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell body
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic ribonucleoprotein granule
Cellular Component
Microtubule
Cellular Component
Nuclear envelope lumen
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
MHC class I protein binding
Molecular Function
Structural constituent of cytoskeleton
Molecular Function
Ubiquitin protein ligase binding
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule-based process
Biological Process
Mitotic cell cycle
Biological Process
Regulation of synapse organization
Biological Process
Spindle assembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cas-0144Carlito syrichta100.00.0 856
LLPS-Xet-2638Xenopus tropicalis100.00.0 856
LLPS-Gaga-0956Gallus gallus100.00.0 856
LLPS-Nol-3585Nomascus leucogenys100.00.0 856
LLPS-Ict-0371Ictidomys tridecemlineatus100.00.0 856
LLPS-Cap-2266Cavia porcellus100.00.0 856
LLPS-Caf-1898Canis familiaris100.00.0 856
LLPS-Poa-2450Pongo abelii100.00.0 856
LLPS-Mam-1384Macaca mulatta100.00.0 856
LLPS-Rhb-0035Rhinopithecus bieti100.00.0 856
LLPS-Fec-0714Felis catus100.00.0 856
LLPS-Mod-1514Monodelphis domestica100.00.0 856
LLPS-Hos-2586Homo sapiens100.00.0 856
LLPS-Urm-3705Ursus maritimus100.00.0 856
LLPS-Pat-3341Pan troglodytes100.00.0 856
LLPS-Man-2333Macaca nemestrina100.00.0 856
LLPS-Ran-0387Rattus norvegicus100.00.0 856
LLPS-Ova-2492Ovis aries100.00.0 856
LLPS-Paa-2063Papio anubis100.00.0 815
LLPS-Mal-0435Mandrillus leucophaeus100.00.0 856
LLPS-Dio-3081Dipodomys ordii100.00.0 856
LLPS-Gog-0740Gorilla gorilla100.00.0 856
LLPS-Caj-4022Callithrix jacchus100.00.0 856
LLPS-Chs-2404Chlorocebus sabaeus100.00.0 856
LLPS-Mum-2220Mus musculus100.00.0 856
LLPS-Maf-1203Macaca fascicularis100.00.0 856
LLPS-Mea-0977Mesocricetus auratus100.00.0 856
LLPS-Aon-0745Aotus nancymaae100.00.0 856
LLPS-Cea-2760Cercocebus atys100.00.0 856
LLPS-Sah-2303Sarcophilus harrisii100.00.0 856
LLPS-Ten-2857Tetraodon nigroviridis99.770.0 854
LLPS-Orn-1311Oreochromis niloticus99.770.0 854
LLPS-Scm-0346Scophthalmus maximus99.770.0 854
LLPS-Dar-0751Danio rerio99.770.0 854
LLPS-Pof-2149Poecilia formosa99.770.0 854
LLPS-Xim-3736Xiphophorus maculatus99.770.0 853
LLPS-Scf-1527Scleropages formosus99.770.0 854
LLPS-Gaa-1416Gasterosteus aculeatus99.770.0 854
LLPS-Icp-3812Ictalurus punctatus99.770.0 854
LLPS-Orl-3812Oryzias latipes99.770.0 854
LLPS-Orc-2133Oryctolagus cuniculus99.530.0 851
LLPS-Lac-1301Latimeria chalumnae99.530.0 853
LLPS-Mup-3390Mustela putorius furo99.530.0 851
LLPS-Eqc-1937Equus caballus99.510.0 813
LLPS-Fud-1632Fukomys damarensis99.30.0 850
LLPS-Anc-3698Anolis carolinensis98.360.0 845
LLPS-Tar-2601Takifugu rubripes98.130.0 847
LLPS-Asm-3759Astyanax mexicanus98.130.0 846
LLPS-Cii-2095Ciona intestinalis98.130.0 846
LLPS-Leo-2361Lepisosteus oculatus98.130.0 845
LLPS-Cis-0796Ciona savignyi98.130.0 846
LLPS-Anp-3174Anas platyrhynchos98.00.0 784
LLPS-Sus-0286Sus scrofa97.820.0 803
LLPS-Otg-1654Otolemur garnettii97.420.0 839
LLPS-Fia-0318Ficedula albicollis97.420.0 842
LLPS-Pap-1145Pan paniscus97.420.0 839
LLPS-Myl-2541Myotis lucifugus97.420.0 839
LLPS-Aim-3912Ailuropoda melanoleuca97.420.0 842
LLPS-Tut-2274Tursiops truncatus97.420.0 842
LLPS-Pes-0306Pelodiscus sinensis97.190.0 840
LLPS-Tag-2634Taeniopygia guttata96.960.0 838
LLPS-Ere-0293Erinaceus europaeus96.960.0 833
LLPS-Ora-3257Ornithorhynchus anatinus96.960.0 837
LLPS-Drm-0325Drosophila melanogaster96.320.0 793
LLPS-Cae-1271Caenorhabditis elegans95.320.0 825
LLPS-Loa-2963Loxodonta africana94.850.0 815
LLPS-Chr-0860Chlamydomonas reinhardtii89.930.0 790
LLPS-Php-1447Physcomitrella patens89.460.0 791
LLPS-Orbr-1685Oryza brachyantha88.290.0 773
LLPS-Sem-1389Selaginella moellendorffii88.060.0 782