DrLLPS - Data resource of LLPS

LLPS-Drm-0884
SNRPG

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Probable small nuclear ribonucleoprotein G
Gene Name:	SNRPG, SmG, CG9742
Ensembl Gene:	FBgn0261791
Ensembl Protein:	FBpp0111906
Organism:	Drosophila melanogaster
Taxa ID:	7227
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Nuclear speckle, Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-0608	O82221	Client	Nucleolus	63.64	8e-25	94.0
Homo sapiens	LLPS-Hos-0273	P62308	Client	Cajal body	60.53	1e-24	94.7
Mus musculus	LLPS-Mum-0702	P62309	Client	Nuclear speckle, Nucleolus	72.37	6e-35	120

▼ FUNCTION

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly (PubMed:18621711). Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	FBtr0112993	FBpp0111906
Ensembl	FBtr0074377	FBpp0074151
UniProt		Q9VXE0, RUXG_DROME, B7Z0Y9, Q8MYW8
GeneBank	AE014298, AY113538, AY070698	AAM29543.1, AAL48169.1, ACL82939.1
RefSeq	NM_001144737.2, NM_132911.3	NP_001138209.1, NP_573139.1
Entrez	32636

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSKAHPPEVK KYMDKRMMLK LNGGRAVTGI LRGFDPFMNV VLDDTVEECK DNTKNNIGMV 60 61 VIRGNSIVMV EALDRV 76
Nucleotide CDS Sequence (FASTA)
1 ATGTCGAAGG CCCATCCCCC AGAGGTGAAA AAATACATGG ACAAGCGCAT GATGCTGAAA 60 61 CTGAACGGCG GACGCGCGGT GACCGGTATT TTGCGAGGCT TCGATCCCTT CATGAACGTG 120 121 GTCCTGGACG ACACGGTGGA GGAGTGCAAG GACAACACGA AGAACAACAT CGGCATGGTG 180 181 GTTATCCGCG GCAACAGCAT CGTCATGGTG GAGGCCCTGG ACAGGGTC 228

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0071013	Cellular Component	Catalytic step 2 spliceosome
GO:0005829	Cellular Component	Cytosol
GO:0005634	Cellular Component	Nucleus
GO:0043186	Cellular Component	P granule
GO:0071011	Cellular Component	Precatalytic spliceosome
GO:0030532	Cellular Component	Small nuclear ribonucleoprotein complex
GO:0034719	Cellular Component	SMN-Sm protein complex
GO:0005681	Cellular Component	Spliceosomal complex
GO:0005685	Cellular Component	U1 snRNP
GO:0005689	Cellular Component	U12-type spliceosomal complex
GO:0005686	Cellular Component	U2 snRNP
GO:0071004	Cellular Component	U2-type prespliceosome
GO:0005687	Cellular Component	U4 snRNP
GO:0005682	Cellular Component	U5 snRNP
GO:0003723	Molecular Function	RNA binding
GO:0000398	Biological Process	MRNA splicing, via spliceosome
GO:0000387	Biological Process	Spliceosomal snRNP assembly

▼ KEGG

dme:Dmel_CG9742

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	Gene3D

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Physicochemical
AAindex

Localization
COMPARTMENTS

Expression
ArrayExpress

Element
RAID

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gaa-0947	Gasterosteus aculeatus	76.74	3e-18	76.3
LLPS-Mod-2014	Monodelphis domestica	72.37	2e-34	119
LLPS-Fec-2213	Felis catus	72.37	6e-35	120
LLPS-Scm-0992	Scophthalmus maximus	72.37	2e-35	120
LLPS-Pap-0361	Pan paniscus	72.37	4e-32	112
LLPS-Dar-0747	Danio rerio	72.37	2e-34	118
LLPS-Loa-1168	Loxodonta africana	72.37	6e-35	120
LLPS-Rhb-0470	Rhinopithecus bieti	72.37	6e-35	120
LLPS-Orc-0726	Oryctolagus cuniculus	72.37	7e-35	119
LLPS-Cap-0541	Cavia porcellus	72.37	6e-35	120
LLPS-Poa-1730	Pongo abelii	72.37	6e-35	120
LLPS-Caf-0065	Canis familiaris	72.37	6e-35	120
LLPS-Gaga-1851	Gallus gallus	72.37	2e-34	119
LLPS-Ict-1868	Ictidomys tridecemlineatus	72.37	6e-35	120
LLPS-Chs-2425	Chlorocebus sabaeus	72.37	6e-35	120
LLPS-Mea-2587	Mesocricetus auratus	72.37	6e-35	120
LLPS-Mum-0702	Mus musculus	72.37	6e-35	120
LLPS-Sah-3646	Sarcophilus harrisii	72.37	2e-34	119
LLPS-Sus-3174	Sus scrofa	72.37	6e-35	120
LLPS-Leo-2152	Lepisosteus oculatus	72.37	1e-34	119
LLPS-Caj-1645	Callithrix jacchus	72.37	6e-35	120
LLPS-Fud-2550	Fukomys damarensis	72.37	6e-35	120
LLPS-Bot-3737	Bos taurus	72.37	5e-35	120
LLPS-Dio-1221	Dipodomys ordii	72.37	6e-35	120
LLPS-Ran-1864	Rattus norvegicus	72.37	6e-35	120
LLPS-Mup-1179	Mustela putorius furo	72.37	6e-35	120
LLPS-Myl-1708	Myotis lucifugus	72.37	1e-34	119
LLPS-Ova-4370	Ovis aries	72.37	6e-35	120
LLPS-Lac-0761	Latimeria chalumnae	71.05	2e-34	118
LLPS-Pof-0529	Poecilia formosa	71.05	2e-33	116
LLPS-Pat-1019	Pan troglodytes	71.05	2e-31	110
LLPS-Mam-2005	Macaca mulatta	71.05	4e-34	117
LLPS-Maf-3151	Macaca fascicularis	71.05	2e-34	118
LLPS-Xim-0978	Xiphophorus maculatus	71.05	2e-33	116
LLPS-Ere-0219	Erinaceus europaeus	70.27	3e-32	113
LLPS-Aim-1012	Ailuropoda melanoleuca	70.0	8e-25	94.4
LLPS-Cea-0058	Cercocebus atys	69.86	2e-32	113
LLPS-Mal-3916	Mandrillus leucophaeus	69.86	2e-32	113
LLPS-Cas-0699	Carlito syrichta	69.84	8e-26	96.7
LLPS-Ten-2547	Tetraodon nigroviridis	69.74	1e-33	116
LLPS-Xet-1977	Xenopus tropicalis	69.74	6e-33	114
LLPS-Aon-0938	Aotus nancymaae	69.74	3e-33	115
LLPS-Gog-3918	Gorilla gorilla	69.74	4e-30	107
LLPS-Scf-0591	Scleropages formosus	69.74	5e-33	115
LLPS-Paa-2903	Papio anubis	69.74	3e-33	115
LLPS-Tut-2081	Tursiops truncatus	69.23	4e-26	97.1
LLPS-Asm-0036	Astyanax mexicanus	68.85	4e-24	92.0
LLPS-Icp-2284	Ictalurus punctatus	68.42	3e-29	105
LLPS-Orl-0980	Oryzias latipes	68.33	1e-23	91.7
LLPS-Man-1397	Macaca nemestrina	67.12	9e-31	109
LLPS-Tag-1223	Taeniopygia guttata	67.11	3e-29	105
LLPS-Otg-0623	Otolemur garnettii	66.22	8e-28	101
LLPS-Urm-2747	Ursus maritimus	66.18	1e-26	98.6
LLPS-Cae-0605	Caenorhabditis elegans	65.79	1e-29	106
LLPS-Anp-1481	Anas platyrhynchos	65.71	1e-26	98.6
LLPS-Fia-0269	Ficedula albicollis	65.71	1e-26	98.6
LLPS-Art-0608	Arabidopsis thaliana	63.64	8e-25	94.0
LLPS-Php-0089	Physcomitrella patens	63.64	4e-26	97.4
LLPS-Mua-2308	Musa acuminata	63.64	1e-26	98.6
LLPS-Arl-0301	Arabidopsis lyrata	63.64	8e-25	94.0
LLPS-Nol-3941	Nomascus leucogenys	63.49	1e-22	88.2
LLPS-Nef-0293	Neosartorya fischeri	62.86	8e-25	94.0
LLPS-Fuo-1053	Fusarium oxysporum	62.86	1e-25	96.3
LLPS-Asc-1014	Aspergillus clavatus	62.86	8e-25	94.0
LLPS-Tar-1588	Takifugu rubripes	62.5	5e-26	97.1
LLPS-Brr-0566	Brassica rapa	62.34	5e-24	92.0
LLPS-Ors-1675	Oryza sativa	62.34	2e-25	95.5
LLPS-Orbr-0992	Oryza brachyantha	62.34	2e-25	95.5
LLPS-Sob-2118	Sorghum bicolor	62.34	1e-25	96.3
LLPS-Amt-0535	Amborella trichopoda	62.34	2e-25	95.9
LLPS-Mae-0655	Manihot esculenta	62.34	5e-24	92.0
LLPS-Orr-0533	Oryza rufipogon	62.34	2e-25	95.5
LLPS-Prp-0016	Prunus persica	62.34	1e-24	93.6
LLPS-Bro-0493	Brassica oleracea	62.34	1e-23	90.9
LLPS-Org-2066	Oryza glaberrima	62.34	2e-25	95.5
LLPS-Glm-1784	Glycine max	62.34	1e-24	93.6
LLPS-Sol-0172	Solanum lycopersicum	62.34	2e-25	95.5
LLPS-Ori-0995	Oryza indica	62.34	2e-25	95.5
LLPS-Brn-1027	Brassica napus	62.34	1e-23	90.9
LLPS-Orni-0866	Oryza nivara	62.34	2e-25	95.5
LLPS-Orgl-1473	Oryza glumaepatula	62.34	2e-25	95.5
LLPS-Sot-0108	Solanum tuberosum	62.34	3e-25	95.5
LLPS-Lep-0600	Leersia perrieri	62.34	2e-25	95.5
LLPS-Sei-1369	Setaria italica	62.34	2e-25	95.9
LLPS-Anc-0147	Anolis carolinensis	61.84	5e-29	104
LLPS-Blg-1581	Blumeria graminis	61.84	1e-25	96.7
LLPS-Ast-1460	Aspergillus terreus	61.43	2e-24	93.2
LLPS-Asfu-1175	Aspergillus fumigatus	61.43	1e-24	93.6
LLPS-Ved-1346	Verticillium dahliae	61.43	2e-25	95.9
LLPS-Gor-0552	Gossypium raimondii	61.04	9e-24	91.3
LLPS-Viv-0029	Vitis vinifera	61.04	7e-24	91.7
LLPS-Zem-1460	Zea mays	61.04	8e-25	94.0
LLPS-Hea-0632	Helianthus annuus	61.04	4e-23	92.0
LLPS-Cus-0858	Cucumis sativus	61.04	8e-24	91.7
LLPS-Met-0712	Medicago truncatula	61.04	1e-24	93.6
LLPS-Aso-0990	Aspergillus oryzae	61.02	4e-17	75.1
LLPS-Eqc-2670	Equus caballus	60.94	9e-20	82.0
LLPS-Hos-0273	Homo sapiens	60.53	8e-25	94.7
LLPS-Scs-0548	Sclerotinia sclerotiorum	60.53	7e-26	97.1
LLPS-Asf-0442	Aspergillus flavus	60.53	1e-24	94.0
LLPS-Trr-1345	Trichoderma reesei	60.0	2e-24	93.6
LLPS-Trv-0766	Trichoderma virens	60.0	2e-24	93.6
LLPS-Cogr-0050	Colletotrichum graminicola	60.0	6e-25	94.7
LLPS-Coo-1229	Colletotrichum orbiculare	60.0	6e-25	94.7
LLPS-Nec-1140	Neurospora crassa	60.0	2e-24	93.2
LLPS-Pot-1905	Populus trichocarpa	59.74	9e-23	89.0
LLPS-Phv-0758	Phaseolus vulgaris	59.74	1e-23	91.3
LLPS-Coc-0987	Corchorus capsularis	59.74	2e-23	90.5
LLPS-Sem-1971	Selaginella moellendorffii	59.74	2e-24	92.8
LLPS-Dac-1405	Daucus carota	59.74	2e-23	90.5
LLPS-Thc-0041	Theobroma cacao	59.74	2e-23	90.5
LLPS-Vir-0696	Vigna radiata	59.74	3e-23	91.7
LLPS-Cog-0643	Colletotrichum gloeosporioides	59.68	1e-20	84.0
LLPS-Tum-0931	Tuber melanosporum	59.21	4e-25	94.7
LLPS-Beb-0954	Beauveria bassiana	58.57	2e-25	95.5
LLPS-Orp-0729	Oryza punctata	58.44	4e-24	92.4
LLPS-Orm-1156	Oryza meridionalis	58.44	4e-24	92.8
LLPS-Orb-1806	Oryza barthii	58.44	4e-24	92.4
LLPS-Brd-0483	Brachypodium distachyon	58.44	2e-24	93.2
LLPS-Pytr-1112	Pyrenophora triticirepentis	57.89	4e-25	94.7
LLPS-Asn-0186	Aspergillus nidulans	57.89	9e-24	91.3
LLPS-Lem-0748	Leptosphaeria maculans	57.89	1e-24	94.0
LLPS-Pyt-0110	Pyrenophora teres	57.89	4e-25	94.7
LLPS-Dos-0742	Dothistroma septosporum	57.14	2e-22	88.2
LLPS-Phn-0789	Phaeosphaeria nodorum	56.58	1e-24	94.0
LLPS-Chr-0419	Chlamydomonas reinhardtii	56.58	1e-21	85.5
LLPS-Chc-0632	Chondrus crispus	56.34	5e-21	84.0
LLPS-Sac-1057	Saccharomyces cerevisiae	56.16	5e-20	81.6
LLPS-Put-0596	Puccinia triticina	55.84	3e-23	89.7
LLPS-Tra-0731	Triticum aestivum	55.84	1e-19	80.5
LLPS-Map-0419	Magnaporthe poae	55.71	3e-23	90.1
LLPS-Zyt-1160	Zymoseptoria tritici	55.26	4e-22	87.0
LLPS-Mel-0972	Melampsora laricipopulina	54.55	2e-22	88.2
LLPS-Mao-0602	Magnaporthe oryzae	54.29	1e-21	86.3
LLPS-Hov-1928	Hordeum vulgare	54.22	7e-21	84.0
LLPS-Scc-1001	Schizosaccharomyces cryophilus	53.95	2e-25	95.9
LLPS-Miv-0936	Microbotryum violaceum	53.52	9e-18	75.9
LLPS-Scp-0638	Schizosaccharomyces pombe	53.33	2e-24	93.2
LLPS-Pug-1293	Puccinia graminis	53.25	1e-22	88.2
LLPS-Osl-1122	Ostreococcus lucimarinus	53.12	9e-16	70.5
LLPS-Gag-0693	Gaeumannomyces graminis	52.86	1e-21	86.3
LLPS-Asni-1169	Aspergillus niger	52.86	6e-19	79.3
LLPS-Asg-0102	Ashbya gossypii	51.39	4e-19	79.3
LLPS-Crn-0053	Cryptococcus neoformans	51.35	4e-22	87.0
LLPS-Scj-0662	Schizosaccharomyces japonicus	51.32	5e-24	92.0
LLPS-Gas-0396	Galdieria sulphuraria	46.48	6e-15	69.3
LLPS-Fus-0326	Fusarium solani	45.07	6e-14	67.0
LLPS-Fuv-0841	Fusarium verticillioides	45.07	7e-14	66.6
LLPS-Spr-0316	Sporisorium reilianum	42.86	3e-18	77.0
LLPS-Kop-0447	Komagataella pastoris	42.86	6e-15	68.6
LLPS-Usm-0207	Ustilago maydis	40.48	8e-17	73.6
LLPS-Abg-1600	Absidia glauca	39.19	2e-13	65.9

LLPS-Drm-0884SNRPG

Protein Sequence

Nucleotide Sequence

LLPS-Drm-0884
SNRPG