LLPS-Dar-0561
dph2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2 |
| Gene Name: | dph2, zgc:162269 |
| Ensembl Gene: | ENSDARG00000078077.6 |
| Ensembl Protein: | ENSDARP00000122763.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000139093.2 | ENSDARP00000122763.1 |
| Ensembl | ENSDART00000114076.6 | ENSDARP00000097722.3 |
| UniProt | A4QN59, DPH2_DANRE | |
| GeneBank | BC134939 | AAI34940.1 |
| RefSeq | NM_001089397.1 | NP_001082866.1 |
| Entrez | 562538 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTDAFSSSSE AVLQRSVTST HSFHPSGDLL LLYQTPETCR FITSNHFKKV ALQFPDELLP 60 61 DAVRVSAEIE DKTKAKTYIL GDTSYGSCCV DEVAAEHVGA DCIVHYGSSC LSPCRRLPLL 120 121 YVFGKRPIDV HQCASSFKEL YPNLQSHIIV LFDVTYSHAI DDLRTLLCDV YPNVVVSRLK 180 181 TDHSCGAELI QDSCVDLQSN DDGVIFKFGR QFRIKEGQTV NDYSIFYIGQ EGLTLTNFMM 240 241 SWNNCVFSSF NPETSTGRVE SVQINKALMK RYYAIERAKD ASVVGILVGT LGVANYLIII 300 301 EQLKDTIQRA GKKSYMFAMG KINVPKLANF LEIDIYVLVA CPENSLLDSS EFYRPVVTPF 360 361 EMELACNKHR EWTGEYVTDF RELLPGGSSH VGFPEPSQSA TEEETTDVSL ITGALRSCST 420 421 NSSEMMHNSE TSSLVLRNQT LTVANTNAAA SFLAGRSWQG LEPKLGQTPV VKAVKGQRGI 480 481 AIAYEEEGNE DASTQQKL 498 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACGGACG CGTTCAGCAG CAGCAGTGAG GCGGTTCTCC AGCGCTCGGT CACTTCAACA 60 61 CACAGTTTCC ACCCTTCTGG AGACCTTCTG CTGCTCTACC AGACACCCGA GACCTGTCGT 120 121 TTCATCACTA GCAATCACTT CAAGAAGGTG GCCTTACAGT TTCCAGATGA ACTGCTGCCT 180 181 GATGCCGTCC GGGTATCTGC TGAAATAGAG GATAAAACCA AAGCCAAGAC TTACATTTTA 240 241 GGGGATACAT CCTATGGCAG CTGTTGTGTG GATGAAGTAG CAGCAGAACA TGTGGGAGCA 300 301 GACTGTATAG TGCATTATGG GTCATCTTGT CTCAGCCCAT GCAGACGACT ACCGCTTCTG 360 361 TACGTGTTTG GGAAAAGACC CATTGATGTC CATCAGTGTG CGTCATCCTT TAAAGAGCTT 420 421 TACCCGAATC TCCAAAGCCA TATCATAGTA CTGTTTGACG TCACTTACTC ACATGCTATA 480 481 GATGATCTCA GAACACTTTT GTGTGACGTC TACCCTAATG TTGTGGTGTC TCGTCTGAAA 540 541 ACGGATCATT CCTGTGGTGC TGAACTCATA CAGGACAGCT GTGTGGACTT GCAGTCAAAC 600 601 GATGATGGAG TCATTTTTAA ATTTGGCAGA CAATTCAGAA TAAAAGAAGG ACAAACTGTT 660 661 AATGATTACA GCATCTTTTA CATTGGCCAG GAAGGCCTGA CGCTTACAAA CTTCATGATG 720 721 AGCTGGAACA ATTGTGTCTT TAGCTCATTC AACCCAGAGA CAAGCACGGG TCGAGTGGAA 780 781 TCGGTTCAAA TCAACAAAGC ACTGATGAAG CGCTATTATG CCATTGAGCG GGCCAAAGAT 840 841 GCCAGTGTGG TGGGCATTTT GGTGGGCACC CTGGGTGTTG CCAACTATCT GATTATCATC 900 901 GAACAGCTGA AAGACACTAT TCAAAGAGCA GGCAAGAAGA GCTATATGTT TGCCATGGGA 960 961 AAGATCAATG TTCCCAAGCT TGCGAACTTC CTGGAAATTG ATATTTACGT GTTAGTTGCG 1020 1021 TGTCCAGAAA ACTCCCTGCT GGACTCAAGT GAATTCTACA GGCCTGTGGT GACTCCGTTT 1080 1081 GAGATGGAGC TGGCTTGTAA TAAGCACAGA GAGTGGACTG GAGAATATGT CACAGACTTC 1140 1141 AGAGAGTTAC TGCCTGGTGG AAGCAGTCAT GTGGGCTTTC CTGAACCCAG TCAGTCTGCC 1200 1201 ACTGAGGAGG AGACCACAGA CGTGTCTCTC ATCACAGGAG CTCTACGAAG CTGTTCCACC 1260 1261 AACTCATCTG AGATGATGCA TAACTCAGAG ACATCTTCGC TTGTCCTCAG GAATCAGACT 1320 1321 CTCACTGTGG CCAATACTAA CGCTGCGGCA TCTTTTCTGG CAGGCCGCAG CTGGCAGGGA 1380 1381 CTGGAGCCAA AATTAGGGCA GACCCCGGTG GTTAAAGCTG TAAAGGGACA GAGAGGCATT 1440 1441 GCAATCGCTT ACGAAGAGGA GGGTAATGAG GACGCTTCAA CACAACAAAA ATTATAA 1497 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Molecular Function | Transferase activity | |
Biological Process | Peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asm-2796 | Astyanax mexicanus | 73.59 | 0.0 | 733 |
| LLPS-Icp-0832 | Ictalurus punctatus | 72.67 | 0.0 | 721 |
| LLPS-Orn-3416 | Oreochromis niloticus | 68.02 | 0.0 | 673 |
| LLPS-Scm-1688 | Scophthalmus maximus | 66.53 | 0.0 | 664 |
| LLPS-Orl-1427 | Oryzias latipes | 66.33 | 0.0 | 672 |
| LLPS-Xim-2984 | Xiphophorus maculatus | 65.79 | 0.0 | 660 |
| LLPS-Ten-0773 | Tetraodon nigroviridis | 64.83 | 0.0 | 636 |
| LLPS-Pof-1351 | Poecilia formosa | 64.3 | 0.0 | 641 |
| LLPS-Leo-2643 | Lepisosteus oculatus | 63.2 | 0.0 | 644 |
| LLPS-Gaa-2826 | Gasterosteus aculeatus | 62.73 | 0.0 | 613 |
| LLPS-Scf-3766 | Scleropages formosus | 61.29 | 0.0 | 609 |
| LLPS-Tar-2626 | Takifugu rubripes | 61.14 | 0.0 | 627 |
| LLPS-Lac-0294 | Latimeria chalumnae | 58.32 | 0.0 | 588 |
| LLPS-Ast-0364 | Aspergillus terreus | 57.78 | 6e-26 | 114 |
| LLPS-Fia-0245 | Ficedula albicollis | 54.97 | 0.0 | 561 |
| LLPS-Xet-1269 | Xenopus tropicalis | 54.0 | 0.0 | 530 |
| LLPS-Gaga-2757 | Gallus gallus | 53.56 | 1e-153 | 456 |
| LLPS-Anc-0850 | Anolis carolinensis | 53.37 | 0.0 | 539 |
| LLPS-Meg-1473 | Meleagris gallopavo | 51.93 | 2e-178 | 517 |
| LLPS-Cis-0954 | Ciona savignyi | 45.96 | 7e-59 | 201 |
| LLPS-Via-2088 | Vigna angularis | 42.26 | 3e-49 | 177 |
| LLPS-Fud-1009 | Fukomys damarensis | 40.76 | 8e-117 | 360 |
| LLPS-Fec-4522 | Felis catus | 40.56 | 7e-119 | 365 |
| LLPS-Dio-3973 | Dipodomys ordii | 40.44 | 7e-113 | 350 |
| LLPS-Scc-1609 | Schizosaccharomyces cryophilus | 40.43 | 7e-108 | 337 |
| LLPS-Ova-1333 | Ovis aries | 40.4 | 2e-113 | 351 |
| LLPS-Ran-1178 | Rattus norvegicus | 40.36 | 2e-120 | 369 |
| LLPS-Mup-0808 | Mustela putorius furo | 40.16 | 1e-117 | 362 |
| LLPS-Poa-1848 | Pongo abelii | 40.08 | 3e-103 | 325 |
| LLPS-Bot-3778 | Bos taurus | 39.96 | 1e-111 | 347 |
| LLPS-Caf-4085 | Canis familiaris | 39.92 | 9e-117 | 360 |
| LLPS-Cap-0221 | Cavia porcellus | 39.76 | 5e-114 | 352 |
| LLPS-Loa-0721 | Loxodonta africana | 39.76 | 3e-115 | 356 |
| LLPS-Mum-4880 | Mus musculus | 39.76 | 1e-118 | 364 |
| LLPS-Mea-3913 | Mesocricetus auratus | 39.76 | 8e-116 | 357 |
| LLPS-Aon-4212 | Aotus nancymaae | 39.76 | 1e-113 | 352 |
| LLPS-Eqc-3547 | Equus caballus | 39.56 | 1e-113 | 351 |
| LLPS-Mam-0937 | Macaca mulatta | 39.56 | 1e-112 | 349 |
| LLPS-Nol-4502 | Nomascus leucogenys | 39.56 | 3e-113 | 350 |
| LLPS-Hos-3998 | Homo sapiens | 39.56 | 3e-113 | 350 |
| LLPS-Pat-4479 | Pan troglodytes | 39.56 | 2e-112 | 348 |
| LLPS-Pap-3878 | Pan paniscus | 39.56 | 2e-112 | 348 |
| LLPS-Urm-3757 | Ursus maritimus | 39.56 | 3e-117 | 361 |
| LLPS-Man-4283 | Macaca nemestrina | 39.56 | 4e-113 | 350 |
| LLPS-Mal-4161 | Mandrillus leucophaeus | 39.56 | 5e-112 | 347 |
| LLPS-Paa-1927 | Papio anubis | 39.56 | 4e-112 | 348 |
| LLPS-Aim-0972 | Ailuropoda melanoleuca | 39.56 | 3e-116 | 358 |
| LLPS-Gog-1212 | Gorilla gorilla | 39.56 | 9e-113 | 349 |
| LLPS-Cas-0090 | Carlito syrichta | 39.52 | 3e-114 | 353 |
| LLPS-Otg-2153 | Otolemur garnettii | 39.41 | 6e-112 | 347 |
| LLPS-Scp-1309 | Schizosaccharomyces pombe | 39.41 | 2e-100 | 318 |
| LLPS-Orc-3570 | Oryctolagus cuniculus | 39.36 | 1e-109 | 341 |
| LLPS-Maf-2172 | Macaca fascicularis | 39.36 | 5e-111 | 345 |
| LLPS-Chs-1280 | Chlorocebus sabaeus | 39.36 | 1e-111 | 346 |
| LLPS-Caj-0475 | Callithrix jacchus | 39.17 | 3e-111 | 345 |
| LLPS-Sah-3930 | Sarcophilus harrisii | 39.0 | 4e-99 | 313 |
| LLPS-Cii-1999 | Ciona intestinalis | 38.92 | 9e-108 | 337 |
| LLPS-Ict-1602 | Ictidomys tridecemlineatus | 38.77 | 4e-111 | 345 |
| LLPS-Nec-0330 | Neurospora crassa | 38.53 | 3e-60 | 214 |
| LLPS-Sem-0619 | Selaginella moellendorffii | 38.44 | 3e-80 | 261 |
| LLPS-Usm-1450 | Ustilago maydis | 37.68 | 4e-26 | 116 |
| LLPS-Rhb-1024 | Rhinopithecus bieti | 37.68 | 6e-85 | 274 |
| LLPS-Mao-1631 | Magnaporthe oryzae | 37.46 | 3e-53 | 195 |
| LLPS-Dac-1362 | Daucus carota | 37.38 | 1e-85 | 280 |
| LLPS-Blg-1343 | Blumeria graminis | 37.22 | 4e-50 | 187 |
| LLPS-Brn-1708 | Brassica napus | 36.81 | 1e-27 | 114 |
| LLPS-Brd-0002 | Brachypodium distachyon | 36.5 | 8e-92 | 295 |
| LLPS-Cogr-1487 | Colletotrichum graminicola | 36.29 | 1e-60 | 213 |
| LLPS-Coo-0080 | Colletotrichum orbiculare | 36.29 | 1e-58 | 208 |
| LLPS-Miv-0461 | Microbotryum violaceum | 36.26 | 7e-91 | 295 |
| LLPS-Mod-3331 | Monodelphis domestica | 36.17 | 5e-101 | 319 |
| LLPS-Spr-0685 | Sporisorium reilianum | 35.84 | 5e-40 | 157 |
| LLPS-Prp-0629 | Prunus persica | 35.77 | 1e-94 | 303 |
| LLPS-Asni-0116 | Aspergillus niger | 35.68 | 2e-70 | 240 |
| LLPS-Sei-1497 | Setaria italica | 35.4 | 8e-96 | 306 |
| LLPS-Lep-0056 | Leersia perrieri | 35.38 | 2e-91 | 295 |
| LLPS-Tru-1737 | Triticum urartu | 35.25 | 1e-87 | 288 |
| LLPS-Scj-1418 | Schizosaccharomyces japonicus | 35.25 | 4e-89 | 288 |
| LLPS-Asn-0368 | Aspergillus nidulans | 35.24 | 3e-71 | 243 |
| LLPS-Mua-0698 | Musa acuminata | 35.1 | 2e-92 | 297 |
| LLPS-Aso-1385 | Aspergillus oryzae | 35.09 | 1e-73 | 249 |
| LLPS-Asf-0877 | Aspergillus flavus | 35.09 | 1e-73 | 249 |
| LLPS-Sot-2068 | Solanum tuberosum | 34.97 | 4e-88 | 286 |
| LLPS-Pot-1118 | Populus trichocarpa | 34.92 | 2e-92 | 297 |
| LLPS-Orr-2081 | Oryza rufipogon | 34.84 | 4e-94 | 301 |
| LLPS-Hea-2105 | Helianthus annuus | 34.83 | 2e-92 | 296 |
| LLPS-Thc-1828 | Theobroma cacao | 34.79 | 2e-85 | 286 |
| LLPS-Org-1287 | Oryza glaberrima | 34.65 | 1e-93 | 300 |
| LLPS-Ors-2217 | Oryza sativa | 34.65 | 1e-93 | 300 |
| LLPS-Orgl-2338 | Oryza glumaepatula | 34.65 | 2e-93 | 300 |
| LLPS-Orni-1639 | Oryza nivara | 34.65 | 1e-93 | 300 |
| LLPS-Orp-1942 | Oryza punctata | 34.61 | 8e-89 | 288 |
| LLPS-Glm-0398 | Glycine max | 34.56 | 2e-92 | 299 |
| LLPS-Viv-2303 | Vitis vinifera | 34.33 | 7e-91 | 293 |
| LLPS-Hov-1546 | Hordeum vulgare | 34.32 | 9e-91 | 294 |
| LLPS-Phv-2437 | Phaseolus vulgaris | 34.25 | 2e-93 | 299 |
| LLPS-Sob-1805 | Sorghum bicolor | 34.23 | 4e-89 | 289 |
| LLPS-Orm-1943 | Oryza meridionalis | 34.21 | 6e-87 | 283 |
| LLPS-Asc-0946 | Aspergillus clavatus | 34.19 | 5e-69 | 237 |
| LLPS-Zem-2444 | Zea mays | 34.13 | 4e-89 | 290 |
| LLPS-Fus-1606 | Fusarium solani | 33.96 | 9e-54 | 195 |
| LLPS-Pyt-1139 | Pyrenophora teres | 33.75 | 6e-67 | 231 |
| LLPS-Cus-1352 | Cucumis sativus | 33.73 | 3e-91 | 294 |
| LLPS-Asfu-1063 | Aspergillus fumigatus | 33.71 | 4e-69 | 237 |
| LLPS-Brr-2179 | Brassica rapa | 33.67 | 2e-84 | 276 |
| LLPS-Nia-1497 | Nicotiana attenuata | 33.66 | 1e-86 | 282 |
| LLPS-Coc-1734 | Corchorus capsularis | 33.54 | 9e-90 | 290 |
| LLPS-Sol-1792 | Solanum lycopersicum | 33.52 | 3e-81 | 278 |
| LLPS-Pytr-0924 | Pyrenophora triticirepentis | 33.5 | 5e-68 | 234 |
| LLPS-Nef-0599 | Neosartorya fischeri | 33.26 | 1e-67 | 233 |
| LLPS-Bro-2350 | Brassica oleracea | 33.2 | 4e-84 | 275 |
| LLPS-Met-2521 | Medicago truncatula | 33.14 | 3e-89 | 292 |
| LLPS-Art-2774 | Arabidopsis thaliana | 33.13 | 2e-84 | 276 |
| LLPS-Arl-1705 | Arabidopsis lyrata | 33.13 | 1e-83 | 274 |
| LLPS-Php-1706 | Physcomitrella patens | 33.13 | 5e-78 | 260 |
| LLPS-Mae-0311 | Manihot esculenta | 33.07 | 4e-91 | 294 |
| LLPS-Tum-1244 | Tuber melanosporum | 33.01 | 1e-55 | 201 |
| LLPS-Gor-1434 | Gossypium raimondii | 33.0 | 8e-87 | 283 |
| LLPS-Beb-1538 | Beauveria bassiana | 33.0 | 2e-61 | 215 |
| LLPS-Dos-1553 | Dothistroma septosporum | 32.64 | 1e-63 | 223 |
| LLPS-Zyt-0637 | Zymoseptoria tritici | 32.4 | 2e-66 | 230 |
| LLPS-Orb-1611 | Oryza barthii | 32.38 | 3e-52 | 188 |
| LLPS-Ori-0422 | Oryza indica | 32.38 | 5e-52 | 187 |
| LLPS-Gas-1322 | Galdieria sulphuraria | 31.88 | 2e-53 | 193 |
| LLPS-Ved-0269 | Verticillium dahliae | 31.84 | 9e-50 | 184 |
| LLPS-Drm-1318 | Drosophila melanogaster | 31.58 | 7e-71 | 239 |
| LLPS-Lem-1576 | Leptosphaeria maculans | 31.54 | 4e-72 | 246 |
| LLPS-Scs-0187 | Sclerotinia sclerotiorum | 31.46 | 3e-68 | 235 |
| LLPS-Mel-0675 | Melampsora laricipopulina | 31.08 | 1e-64 | 224 |
| LLPS-Trr-0186 | Trichoderma reesei | 30.96 | 1e-57 | 206 |
| LLPS-Trv-1062 | Trichoderma virens | 30.86 | 2e-56 | 202 |
| LLPS-Fuo-1118 | Fusarium oxysporum | 30.57 | 8e-59 | 209 |
| LLPS-Gag-1099 | Gaeumannomyces graminis | 30.51 | 3e-53 | 194 |
| LLPS-Crn-1196 | Cryptococcus neoformans | 30.4 | 8e-72 | 243 |
| LLPS-Osl-0801 | Ostreococcus lucimarinus | 30.31 | 6e-65 | 225 |
| LLPS-Fuv-0696 | Fusarium verticillioides | 30.1 | 9e-59 | 209 |
| LLPS-Phn-0827 | Phaeosphaeria nodorum | 30.09 | 2e-66 | 230 |
| LLPS-Pug-0683 | Puccinia graminis | 30.02 | 6e-63 | 221 |
| LLPS-Vir-0115 | Vigna radiata | 29.86 | 2e-69 | 236 |
| LLPS-Asg-1200 | Ashbya gossypii | 29.72 | 2e-52 | 192 |
| LLPS-Sac-0075 | Saccharomyces cerevisiae | 29.64 | 1e-56 | 203 |
| LLPS-Yal-0186 | Yarrowia lipolytica | 28.54 | 1e-41 | 160 |
| LLPS-Kop-0345 | Komagataella pastoris | 28.14 | 2e-52 | 191 |