LLPS-Asni-0116
An07g09370
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
| Gene Name: | An07g09370 |
| Ensembl Gene: | An07g09370 |
| Ensembl Protein: | CAK39703 |
| Organism: | Aspergillus niger |
| Taxa ID: | 425011 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CAK39703 | CAK39703 |
| UniProt | A2QPG6, A2QPG6_ASPNC | |
| GeneBank | AM270149 | CAK39703.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGADMEAAPV LSTPDDRILE ATDPVPNRSP VSDEEIAITY DIERTLKEIR QARYKRIALQ 60 61 FPDDMLPDAP RVFQLLKSVA QLKVDEAEPA PRLYILADTS YGTCCVDEVA AEHVDADVVV 120 121 HYGRSCLSPT ARLPVIYVFT HKELALEKVV RAFKETYPEL DTKVILAADV TYCDHVPAVY 180 181 EALVKEGYTN LFATEVLHDP SSAIPNRTVP ETVRESPESL AEWQLFHISD PPTALLLTLA 240 241 SRVAAIYIYP TDKPGQDVKP LPASTAAALR RRYAILTSLN TAPIFGILVN TLSVKNYLHI 300 301 VDHVRERIAA AGKKSYLFVV GKLNAAKVAN FSEIGGWVVI GCWESSLVDS RDFWKPVITP 360 361 FELELTLKGD TERVWTGAWQ SDFQTVLDQS AAEAENGDAS TNGAVPGEDE DEMSEPESAP 420 421 PEFDLRTGRY VSHSRPMRNP APRVSASGEE GAASSASAGG PSAARALARR AKGDLAMIGG 480 481 TISPGAEFLR SQRTWKGLGS DFDIQYEEEE DAKDSTLVVE GRKGIARGYT VGETIERH 538 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGCGCCG ATATGGAGGC CGCCCCGGTC CTCTCCACCC CGGACGACCG CATCCTCGAA 60 61 GCCACCGACC CCGTCCCGAA CCGCAGTCCC GTCTCCGACG AAGAAATCGC CATCACCTAT 120 121 GACATTGAAC GCACGCTCAA GGAGATCCGC CAGGCGCGGT ATAAGCGCAT TGCGCTGCAG 180 181 TTTCCGGATG ATATGCTCCC GGATGCGCCG AGGGTGTTCC AGCTTCTTAA GTCGGTGGCT 240 241 CAGTTGAAGG TGGACGAGGC TGAGCCTGCG CCCAGGTTGT ATATCCTGGC AGATACTTCC 300 301 TACGGAACTT GTTGCGTGGA TGAGGTGGCG GCTGAGCATG TGGATGCCGA TGTGGTCGTG 360 361 CATTACGGCC GGTCGTGTTT GTCGCCGACG GCCAGACTCC CTGTGATTTA TGTGTTTACG 420 421 CATAAGGAGT TGGCGCTGGA GAAGGTCGTG CGTGCGTTCA AGGAGACGTA TCCGGAGCTG 480 481 GATACGAAGG TTATTCTGGC GGCTGATGTG ACTTACTGTG ATCATGTCCC CGCAGTGTAT 540 541 GAGGCTCTGG TGAAGGAGGG GTATACGAAT CTGTTTGCGA CGGAGGTGCT TCATGACCCT 600 601 TCGTCTGCTA TTCCGAACCG GACGGTGCCG GAGACGGTGC GCGAGAGTCC CGAGTCTCTG 660 661 GCTGAGTGGC AGCTTTTTCA CATCTCTGAT CCGCCTACTG CGCTGCTTCT CACCCTTGCT 720 721 TCTCGCGTGG CGGCTATCTA CATCTATCCT ACGGATAAGC CGGGCCAGGA TGTTAAGCCC 780 781 CTGCCCGCGT CCACGGCCGC CGCCTTGCGC CGTCGCTATG CTATCCTGAC GTCCTTGAAT 840 841 ACCGCCCCGA TCTTTGGTAT CCTGGTCAAC ACGTTGAGTG TGAAGAATTA CCTGCATATT 900 901 GTGGATCATG TTCGGGAACG GATCGCGGCG GCCGGGAAGA AGAGTTATTT GTTTGTGGTG 960 961 GGCAAGCTGA ACGCGGCTAA GGTGGCTAAC TTCAGCGAGA TCGGCGGCTG GGTGGTCATC 1020 1021 GGATGCTGGG AAAGCTCCCT CGTTGATAGT CGGGATTTCT GGAAACCGGT TATCACGCCG 1080 1081 TTTGAGTTGG AGCTTACCCT GAAGGGGGAT ACGGAGCGGG TCTGGACGGG AGCCTGGCAG 1140 1141 AGTGATTTCC AGACTGTCCT GGATCAGTCC GCTGCTGAGG CAGAGAATGG AGATGCGTCG 1200 1201 ACGAACGGTG CTGTGCCCGG GGAGGATGAG GATGAGATGT CCGAGCCCGA GTCGGCTCCG 1260 1261 CCAGAATTCG ACTTGCGCAC TGGCCGGTAT GTCTCGCATT CCCGGCCCAT GCGAAACCCT 1320 1321 GCACCCCGCG TTTCTGCCTC AGGAGAAGAG GGTGCTGCCT CGTCAGCATC AGCTGGAGGT 1380 1381 CCATCGGCAG CGCGAGCCCT GGCCAGACGA GCCAAAGGGG ATCTCGCGAT GATCGGCGGG 1440 1441 ACCATCTCCC CTGGAGCGGA ATTCCTTCGG TCGCAACGGA CGTGGAAGGG GCTGGGCAGT 1500 1501 GATTTCGATA TCCAGTACGA GGAAGAGGAG GACGCGAAGG ATAGCACACT GGTGGTGGAA 1560 1561 GGGCGCAAGG GTATTGCAAG GGGATATACG GTAGGAGAAA CAATAGAGCG ACACTAG 1617 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Molecular Function | Transferase activity | |
Biological Process | Peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asc-0946 | Aspergillus clavatus | 75.56 | 0.0 | 794 |
| LLPS-Nef-0599 | Neosartorya fischeri | 74.78 | 0.0 | 785 |
| LLPS-Asfu-1063 | Aspergillus fumigatus | 73.47 | 0.0 | 783 |
| LLPS-Asn-0368 | Aspergillus nidulans | 72.99 | 0.0 | 754 |
| LLPS-Aso-1385 | Aspergillus oryzae | 72.88 | 0.0 | 754 |
| LLPS-Asf-0877 | Aspergillus flavus | 72.88 | 0.0 | 754 |
| LLPS-Ast-0364 | Aspergillus terreus | 68.6 | 2e-55 | 199 |
| LLPS-Phn-0827 | Phaeosphaeria nodorum | 55.48 | 0.0 | 577 |
| LLPS-Pyt-1139 | Pyrenophora teres | 54.88 | 0.0 | 536 |
| LLPS-Lem-1576 | Leptosphaeria maculans | 54.69 | 0.0 | 556 |
| LLPS-Pytr-0924 | Pyrenophora triticirepentis | 54.19 | 0.0 | 541 |
| LLPS-Scs-0187 | Sclerotinia sclerotiorum | 50.35 | 1e-158 | 471 |
| LLPS-Dos-1553 | Dothistroma septosporum | 49.83 | 1e-163 | 484 |
| LLPS-Blg-1343 | Blumeria graminis | 49.57 | 5e-125 | 389 |
| LLPS-Zyt-0637 | Zymoseptoria tritici | 49.19 | 5e-154 | 459 |
| LLPS-Cogr-1487 | Colletotrichum graminicola | 48.9 | 9e-141 | 424 |
| LLPS-Trr-0186 | Trichoderma reesei | 48.74 | 5e-147 | 441 |
| LLPS-Coo-0080 | Colletotrichum orbiculare | 48.42 | 2e-139 | 420 |
| LLPS-Fus-1606 | Fusarium solani | 48.02 | 1e-143 | 432 |
| LLPS-Php-1706 | Physcomitrella patens | 48.0 | 3e-11 | 69.7 |
| LLPS-Trv-1062 | Trichoderma virens | 47.7 | 2e-148 | 444 |
| LLPS-Nec-0330 | Neurospora crassa | 47.55 | 3e-148 | 446 |
| LLPS-Spr-0685 | Sporisorium reilianum | 47.4 | 3e-17 | 89.4 |
| LLPS-Osl-0801 | Ostreococcus lucimarinus | 47.32 | 9e-18 | 90.5 |
| LLPS-Fuo-1118 | Fusarium oxysporum | 47.27 | 4e-141 | 426 |
| LLPS-Fuv-0696 | Fusarium verticillioides | 47.09 | 1e-140 | 424 |
| LLPS-Beb-1538 | Beauveria bassiana | 47.05 | 1e-131 | 399 |
| LLPS-Mua-0698 | Musa acuminata | 46.67 | 1e-16 | 87.0 |
| LLPS-Ved-0269 | Verticillium dahliae | 46.66 | 3e-134 | 409 |
| LLPS-Gag-1099 | Gaeumannomyces graminis | 45.75 | 6e-137 | 416 |
| LLPS-Mao-1631 | Magnaporthe oryzae | 44.24 | 4e-133 | 407 |
| LLPS-Sol-1792 | Solanum lycopersicum | 43.75 | 1e-12 | 74.7 |
| LLPS-Usm-1450 | Ustilago maydis | 40.83 | 1e-18 | 93.6 |
| LLPS-Tum-1244 | Tuber melanosporum | 40.21 | 1e-96 | 312 |
| LLPS-Ten-0773 | Tetraodon nigroviridis | 38.71 | 5e-61 | 214 |
| LLPS-Cis-0954 | Ciona savignyi | 38.58 | 7e-24 | 105 |
| LLPS-Miv-0461 | Microbotryum violaceum | 38.55 | 2e-20 | 99.4 |
| LLPS-Brn-1708 | Brassica napus | 38.36 | 7e-17 | 84.3 |
| LLPS-Pug-0683 | Puccinia graminis | 37.95 | 1e-12 | 74.7 |
| LLPS-Zem-2444 | Zea mays | 37.68 | 2e-14 | 79.7 |
| LLPS-Xet-1269 | Xenopus tropicalis | 37.4 | 2e-55 | 199 |
| LLPS-Sah-3930 | Sarcophilus harrisii | 37.39 | 1e-10 | 67.8 |
| LLPS-Icp-0832 | Ictalurus punctatus | 36.9 | 3e-61 | 216 |
| LLPS-Leo-2643 | Lepisosteus oculatus | 36.32 | 5e-60 | 213 |
| LLPS-Scf-3766 | Scleropages formosus | 36.32 | 2e-58 | 208 |
| LLPS-Asg-1200 | Ashbya gossypii | 36.31 | 7e-71 | 244 |
| LLPS-Scj-1418 | Schizosaccharomyces japonicus | 36.28 | 9e-62 | 217 |
| LLPS-Hov-1546 | Hordeum vulgare | 36.11 | 3e-14 | 79.3 |
| LLPS-Dar-0561 | Danio rerio | 35.68 | 4e-58 | 207 |
| LLPS-Scc-1609 | Schizosaccharomyces cryophilus | 35.67 | 5e-71 | 242 |
| LLPS-Vir-0115 | Vigna radiata | 35.06 | 9e-15 | 80.9 |
| LLPS-Asm-2796 | Astyanax mexicanus | 34.68 | 7e-60 | 212 |
| LLPS-Scp-1309 | Schizosaccharomyces pombe | 34.44 | 5e-71 | 242 |
| LLPS-Xim-2984 | Xiphophorus maculatus | 34.44 | 8e-58 | 206 |
| LLPS-Lac-0294 | Latimeria chalumnae | 34.12 | 3e-54 | 197 |
| LLPS-Pof-1351 | Poecilia formosa | 34.04 | 3e-57 | 204 |
| LLPS-Sac-0075 | Saccharomyces cerevisiae | 33.92 | 1e-68 | 236 |
| LLPS-Orl-1427 | Oryzias latipes | 33.83 | 5e-56 | 201 |
| LLPS-Art-2774 | Arabidopsis thaliana | 33.76 | 2e-49 | 183 |
| LLPS-Arl-1705 | Arabidopsis lyrata | 33.67 | 3e-49 | 182 |
| LLPS-Orn-3416 | Oreochromis niloticus | 33.56 | 1e-56 | 203 |
| LLPS-Kop-0345 | Komagataella pastoris | 33.08 | 6e-59 | 211 |
| LLPS-Brr-2179 | Brassica rapa | 32.95 | 3e-50 | 185 |
| LLPS-Bro-2350 | Brassica oleracea | 32.57 | 3e-53 | 194 |
| LLPS-Mel-0675 | Melampsora laricipopulina | 32.35 | 2e-38 | 152 |
| LLPS-Bot-3778 | Bos taurus | 32.29 | 1e-30 | 128 |
| LLPS-Anc-0850 | Anolis carolinensis | 32.26 | 4e-53 | 193 |
| LLPS-Dio-3973 | Dipodomys ordii | 32.17 | 2e-30 | 127 |
| LLPS-Viv-2303 | Vitis vinifera | 32.01 | 1e-40 | 158 |
| LLPS-Gaga-2757 | Gallus gallus | 31.98 | 3e-41 | 160 |
| LLPS-Drm-1318 | Drosophila melanogaster | 31.96 | 5e-35 | 141 |
| LLPS-Fia-0245 | Ficedula albicollis | 31.95 | 1e-55 | 200 |
| LLPS-Mea-3913 | Mesocricetus auratus | 31.93 | 2e-32 | 133 |
| LLPS-Orm-1943 | Oryza meridionalis | 31.89 | 5e-39 | 154 |
| LLPS-Ova-1333 | Ovis aries | 31.86 | 4e-30 | 127 |
| LLPS-Cus-1352 | Cucumis sativus | 31.83 | 2e-44 | 169 |
| LLPS-Eqc-3547 | Equus caballus | 31.82 | 2e-31 | 130 |
| LLPS-Crn-1196 | Cryptococcus neoformans | 31.74 | 5e-44 | 168 |
| LLPS-Hea-2105 | Helianthus annuus | 31.72 | 2e-40 | 157 |
| LLPS-Ict-1602 | Ictidomys tridecemlineatus | 31.5 | 1e-31 | 131 |
| LLPS-Brd-0002 | Brachypodium distachyon | 31.5 | 2e-40 | 157 |
| LLPS-Ran-1178 | Rattus norvegicus | 31.5 | 1e-33 | 137 |
| LLPS-Urm-3757 | Ursus maritimus | 31.44 | 1e-29 | 125 |
| LLPS-Nia-1497 | Nicotiana attenuata | 31.44 | 1e-42 | 164 |
| LLPS-Poa-1848 | Pongo abelii | 31.44 | 2e-23 | 107 |
| LLPS-Cap-0221 | Cavia porcellus | 31.43 | 2e-31 | 130 |
| LLPS-Loa-0721 | Loxodonta africana | 31.41 | 2e-30 | 128 |
| LLPS-Gas-1322 | Galdieria sulphuraria | 31.22 | 2e-32 | 133 |
| LLPS-Scm-1688 | Scophthalmus maximus | 31.12 | 5e-58 | 207 |
| LLPS-Gaa-2826 | Gasterosteus aculeatus | 31.11 | 8e-53 | 192 |
| LLPS-Nol-4502 | Nomascus leucogenys | 31.05 | 3e-28 | 121 |
| LLPS-Chs-1280 | Chlorocebus sabaeus | 31.05 | 5e-28 | 120 |
| LLPS-Sem-0619 | Selaginella moellendorffii | 31.03 | 7e-33 | 133 |
| LLPS-Fud-1009 | Fukomys damarensis | 31.03 | 5e-32 | 132 |
| LLPS-Meg-1473 | Meleagris gallopavo | 31.0 | 2e-54 | 197 |
| LLPS-Sot-2068 | Solanum tuberosum | 31.0 | 3e-41 | 160 |
| LLPS-Fec-4522 | Felis catus | 30.97 | 4e-30 | 127 |
| LLPS-Pot-1118 | Populus trichocarpa | 30.89 | 2e-43 | 166 |
| LLPS-Aim-0972 | Ailuropoda melanoleuca | 30.88 | 2e-30 | 127 |
| LLPS-Mae-0311 | Manihot esculenta | 30.85 | 2e-38 | 152 |
| LLPS-Sob-1805 | Sorghum bicolor | 30.79 | 3e-43 | 166 |
| LLPS-Met-2521 | Medicago truncatula | 30.79 | 2e-43 | 167 |
| LLPS-Tar-2626 | Takifugu rubripes | 30.72 | 1e-51 | 190 |
| LLPS-Via-2088 | Vigna angularis | 30.65 | 5e-25 | 109 |
| LLPS-Orc-3570 | Oryctolagus cuniculus | 30.64 | 1e-28 | 122 |
| LLPS-Mum-4880 | Mus musculus | 30.63 | 7e-31 | 129 |
| LLPS-Coc-1734 | Corchorus capsularis | 30.53 | 1e-39 | 155 |
| LLPS-Mup-0808 | Mustela putorius furo | 30.53 | 2e-30 | 127 |
| LLPS-Cas-0090 | Carlito syrichta | 30.39 | 2e-29 | 124 |
| LLPS-Pap-3878 | Pan paniscus | 30.18 | 8e-29 | 123 |
| LLPS-Pat-4479 | Pan troglodytes | 30.18 | 5e-29 | 123 |
| LLPS-Gog-1212 | Gorilla gorilla | 30.18 | 9e-29 | 123 |
| LLPS-Caf-4085 | Canis familiaris | 30.14 | 2e-29 | 124 |
| LLPS-Otg-2153 | Otolemur garnettii | 30.05 | 7e-30 | 126 |
| LLPS-Gor-1434 | Gossypium raimondii | 30.0 | 5e-38 | 150 |
| LLPS-Hos-3998 | Homo sapiens | 29.97 | 5e-29 | 123 |
| LLPS-Aon-4212 | Aotus nancymaae | 29.89 | 8e-29 | 123 |
| LLPS-Thc-1828 | Theobroma cacao | 29.87 | 4e-37 | 150 |
| LLPS-Dac-1362 | Daucus carota | 29.8 | 9e-39 | 153 |
| LLPS-Orni-1639 | Oryza nivara | 29.74 | 1e-47 | 178 |
| LLPS-Yal-0186 | Yarrowia lipolytica | 29.65 | 4e-47 | 176 |
| LLPS-Orr-2081 | Oryza rufipogon | 29.56 | 9e-48 | 179 |
| LLPS-Orgl-2338 | Oryza glumaepatula | 29.56 | 3e-47 | 177 |
| LLPS-Man-4283 | Macaca nemestrina | 29.46 | 1e-28 | 122 |
| LLPS-Mam-0937 | Macaca mulatta | 29.46 | 1e-28 | 122 |
| LLPS-Maf-2172 | Macaca fascicularis | 29.46 | 4e-28 | 121 |
| LLPS-Paa-1927 | Papio anubis | 29.46 | 3e-28 | 121 |
| LLPS-Mal-4161 | Mandrillus leucophaeus | 29.46 | 3e-28 | 121 |
| LLPS-Ors-2217 | Oryza sativa | 29.38 | 2e-47 | 177 |
| LLPS-Org-1287 | Oryza glaberrima | 29.38 | 3e-47 | 177 |
| LLPS-Cii-1999 | Ciona intestinalis | 29.28 | 1e-42 | 164 |
| LLPS-Lep-0056 | Leersia perrieri | 29.27 | 2e-41 | 160 |
| LLPS-Ori-0422 | Oryza indica | 29.25 | 7e-28 | 119 |
| LLPS-Orb-1611 | Oryza barthii | 29.25 | 8e-28 | 119 |
| LLPS-Glm-0398 | Glycine max | 29.23 | 3e-38 | 152 |
| LLPS-Caj-0475 | Callithrix jacchus | 29.1 | 4e-27 | 118 |
| LLPS-Orp-1942 | Oryza punctata | 29.06 | 2e-41 | 160 |
| LLPS-Phv-2437 | Phaseolus vulgaris | 28.92 | 3e-43 | 166 |
| LLPS-Mod-3331 | Monodelphis domestica | 28.91 | 1e-27 | 119 |
| LLPS-Sei-1497 | Setaria italica | 28.83 | 2e-44 | 169 |
| LLPS-Rhb-1024 | Rhinopithecus bieti | 28.36 | 5e-15 | 81.3 |
| LLPS-Tru-1737 | Triticum urartu | 28.26 | 8e-40 | 157 |
| LLPS-Prp-0629 | Prunus persica | 28.2 | 7e-41 | 159 |