DrLLPS - Data resource of LLPS

LLPS-Dar-0017
rrs1

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Ribosome biogenesis regulatory protein
Gene Name:	rrs1
Ensembl Gene:	ENSDARG00000003941.9
Ensembl Protein:	ENSDARP00000111034.2
Organism:	Danio rerio
Taxa ID:	7955
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0027	Q9XVT0	Regulator	P-body	46.39	5e-42	155
Bos taurus	LLPS-Bot-0191	F1MPT7	Client	Nucleolus	66.33	9e-126	372
Mus musculus	LLPS-Mum-1927	Q9CYH6	Client	Nucleolus	67.51	4e-114	343
Arabidopsis thaliana	LLPS-Art-0249	Q9SH88	Client	Nucleolus	39.44	6e-28	115
Homo sapiens	LLPS-Hos-0590	Q15050	Client	Nucleolus	66.67	1e-118	355

▼ FUNCTION

Involved in ribosomal large subunit assembly.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSDART00000125190.3	ENSDARP00000111034.2
UniProt		Q7SX91, Q7SX91_DANRE
GeneBank	BX470095, BC164156, BC055615	, AAI64156.1, AAH55615.1
RefSeq	NM_200062.1	NP_956356.1
Entrez	337399

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASCSIEDVL AKAERDEAEK LKSITVLKEL DLEFDPGLLL AFDKNRLDTR DFKGNKREDC 60 61 LRSLARDNTQ LLINEIWKLP TERVDEVIVA KLPEPTTKLP REKPAPKPKP PTKWEQFAKL 120 121 KGIQKKKKTN LVWDEVHKEW KRRWGYKRAK DDTKEWLIEV PATADPNEDQ FAKRNKAKKE 180 181 RVARNEYNRL KNIARAQKVK VPGTGLLPTS QQTKAELAQA VSLAKISTAS VGKFQEKLPK 240 241 EKPARNTGKK RKFQPLIGDF SSEKQKQLDL LKVMDSKKPR LDITKAVNKQ MREEDSESAR 300 301 NNKKGFGKKG RKGGMPGKGK GKGKPGGKGK APKGKGRKPQ MKQGKR 346
Nucleotide CDS Sequence (FASTA)
1 ATGGCTTCGT GCAGTATTGA AGACGTGCTC GCTAAAGCTG AAAGAGACGA GGCTGAGAAG 60 61 CTCAAAAGTA TTACGGTGCT CAAAGAGTTG GATCTTGAAT TCGACCCGGG ACTTTTGCTG 120 121 GCGTTTGACA AGAACCGACT TGACACACGG GACTTTAAAG GCAACAAACG GGAGGACTGT 180 181 CTTCGCTCTT TAGCGCGAGA CAACACACAA CTTCTCATCA ACGAGATATG GAAACTACCC 240 241 ACAGAGAGAG TCGACGAAGT GATCGTCGCC AAGCTGCCAG AACCGACCAC TAAACTACCC 300 301 AGAGAAAAAC CAGCACCGAA ACCTAAGCCT CCTACTAAAT GGGAACAGTT TGCCAAGCTG 360 361 AAAGGCATTC AGAAGAAAAA GAAGACCAAC TTGGTCTGGG ATGAAGTTCA CAAGGAGTGG 420 421 AAGAGGAGAT GGGGGTATAA ACGTGCCAAA GATGACACCA AAGAGTGGTT GATTGAGGTC 480 481 CCGGCGACTG CAGATCCAAA CGAAGACCAG TTCGCCAAAA GGAATAAAGC CAAAAAGGAA 540 541 AGAGTGGCCA GAAACGAGTA CAACAGACTC AAAAACATCG CCAGAGCTCA GAAGGTCAAG 600 601 GTTCCTGGAA CAGGACTCCT GCCTACATCC CAGCAGACCA AAGCGGAGCT GGCACAAGCG 660 661 GTCAGTCTGG CCAAAATATC CACCGCATCG GTTGGCAAAT TCCAGGAGAA GCTGCCCAAG 720 721 GAAAAACCAG CCAGAAACAC TGGGAAGAAG AGGAAATTCC AGCCTCTTAT TGGGGACTTC 780 781 AGTAGCGAGA AGCAAAAACA GCTGGATTTA TTGAAGGTGA TGGACAGTAA GAAGCCCCGT 840 841 CTCGATATCA CTAAAGCTGT GAATAAGCAG ATGAGGGAAG AGGACTCGGA GTCTGCTCGG 900 901 AATAATAAGA AAGGGTTTGG AAAGAAGGGA CGCAAGGGAG GCATGCCTGG TAAAGGAAAA 960 961 GGCAAAGGAA AACCTGGAGG AAAGGGAAAA GCTCCTAAAG GCAAAGGGCG CAAACCTCAG 1020 1021 ATGAAGCAAG GAAAGCGCTA A 1041

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0539	Nucleus
KW-1267	Proteomics identification
KW-1185	Reference proteome
KW-0690	Ribosome biogenesis

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005730	Cellular Component	Nucleolus
GO:0030687	Cellular Component	Preribosome, large subunit precursor
GO:0000447	Biological Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042273	Biological Process	Ribosomal large subunit biogenesis
GO:0000055	Biological Process	Ribosomal large subunit export from nucleus

▼ KEGG

dre:337399

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD

Interaction
RAIN	MIST

Physicochemical
AAindex

Function
CGDB

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Leo-0555	Lepisosteus oculatus	82.61	5e-156	449
LLPS-Pof-0870	Poecilia formosa	80.81	3e-149	431
LLPS-Icp-0880	Ictalurus punctatus	80.6	2e-153	442
LLPS-Tar-0838	Takifugu rubripes	79.36	3e-137	400
LLPS-Ten-0488	Tetraodon nigroviridis	79.12	3e-139	406
LLPS-Scm-1799	Scophthalmus maximus	78.42	2e-142	415
LLPS-Orn-0781	Oreochromis niloticus	76.77	2e-138	404
LLPS-Lac-0864	Latimeria chalumnae	76.59	3e-142	413
LLPS-Asm-1791	Astyanax mexicanus	76.33	3e-143	418
LLPS-Gaa-0457	Gasterosteus aculeatus	74.92	2e-149	432
LLPS-Nol-1247	Nomascus leucogenys	69.82	1e-98	301
LLPS-Loa-1644	Loxodonta africana	67.67	3e-131	387
LLPS-Orc-0124	Oryctolagus cuniculus	67.67	3e-131	387
LLPS-Aon-0927	Aotus nancymaae	67.67	5e-131	386
LLPS-Dio-1154	Dipodomys ordii	67.38	2e-86	268
LLPS-Man-1024	Macaca nemestrina	67.33	8e-131	385
LLPS-Mam-1935	Macaca mulatta	67.33	8e-131	385
LLPS-Ict-1859	Ictidomys tridecemlineatus	67.33	3e-130	384
LLPS-Cea-2451	Cercocebus atys	67.33	2e-130	384
LLPS-Maf-2003	Macaca fascicularis	67.33	8e-131	385
LLPS-Caj-1613	Callithrix jacchus	67.33	5e-130	383
LLPS-Gog-1039	Gorilla gorilla	67.33	2e-130	385
LLPS-Mal-1213	Mandrillus leucophaeus	67.33	2e-130	384
LLPS-Poa-1495	Pongo abelii	67.23	4e-128	376
LLPS-Pap-1800	Pan paniscus	67.0	5e-130	384
LLPS-Rhb-0740	Rhinopithecus bieti	67.0	8e-130	383
LLPS-Cap-0149	Cavia porcellus	67.0	8e-130	383
LLPS-Eqc-0087	Equus caballus	67.0	2e-131	386
LLPS-Mea-0020	Mesocricetus auratus	67.0	6e-131	386
LLPS-Chs-0258	Chlorocebus sabaeus	67.0	4e-130	384
LLPS-Mup-1877	Mustela putorius furo	67.0	8e-131	385
LLPS-Hos-0590	Homo sapiens	66.67	5e-129	381
LLPS-Pat-0191	Pan troglodytes	66.67	1e-129	382
LLPS-Sus-1221	Sus scrofa	66.67	7e-132	388
LLPS-Fec-0755	Felis catus	66.33	1e-129	382
LLPS-Caf-0070	Canis familiaris	66.33	2e-129	382
LLPS-Mum-1927	Mus musculus	66.33	2e-130	385
LLPS-Bot-0191	Bos taurus	66.33	5e-132	389
LLPS-Ere-0415	Erinaceus europaeus	66.33	6e-129	380
LLPS-Otg-0007	Otolemur garnettii	66.0	7e-128	378
LLPS-Ran-1208	Rattus norvegicus	66.0	1e-129	382
LLPS-Mod-0291	Monodelphis domestica	65.45	4e-127	376
LLPS-Cas-1215	Carlito syrichta	62.14	8e-36	132
LLPS-Ora-1429	Ornithorhynchus anatinus	61.79	3e-110	333
LLPS-Scf-0153	Scleropages formosus	57.73	6e-92	283
LLPS-Gaga-0379	Gallus gallus	55.15	3e-91	284
LLPS-Cii-0127	Ciona intestinalis	55.02	4e-85	267
LLPS-Cis-0900	Ciona savignyi	53.98	7e-84	264
LLPS-Drm-1025	Drosophila melanogaster	49.83	3e-67	222
LLPS-Tum-0693	Tuber melanosporum	49.61	5e-18	84.7
LLPS-Scj-0021	Schizosaccharomyces japonicus	48.92	5e-19	87.0
LLPS-Paa-1878	Papio anubis	48.49	3e-73	236
LLPS-Lem-0236	Leptosphaeria maculans	47.22	2e-15	78.6
LLPS-Scc-0565	Schizosaccharomyces cryophilus	47.18	4e-22	95.9
LLPS-Scp-0873	Schizosaccharomyces pombe	45.32	6e-21	92.4
LLPS-Cae-0027	Caenorhabditis elegans	45.02	7e-52	181
LLPS-Nec-0704	Neurospora crassa	44.62	8e-13	70.5
LLPS-Tru-0043	Triticum urartu	44.03	5e-26	114
LLPS-Sem-0198	Selaginella moellendorffii	43.97	2e-37	140
LLPS-Gor-0408	Gossypium raimondii	43.53	1e-34	135
LLPS-Coc-0389	Corchorus capsularis	43.53	6e-32	127
LLPS-Pot-0934	Populus trichocarpa	43.01	1e-38	146
LLPS-Cogr-0371	Colletotrichum graminicola	42.86	3e-15	77.4
LLPS-Viv-2302	Vitis vinifera	42.81	4e-32	128
LLPS-Ved-0251	Verticillium dahliae	42.57	4e-10	62.8
LLPS-Phv-1274	Phaseolus vulgaris	42.46	1e-36	140
LLPS-Thc-0571	Theobroma cacao	42.29	4e-33	130
LLPS-Fuo-0425	Fusarium oxysporum	42.25	1e-12	70.1
LLPS-Fuv-0539	Fusarium verticillioides	42.25	1e-12	70.1
LLPS-Mae-0115	Manihot esculenta	42.11	9e-31	124
LLPS-Glm-2118	Glycine max	42.11	5e-30	122
LLPS-Via-0187	Vigna angularis	42.11	9e-37	141
LLPS-Abg-0603	Absidia glauca	42.09	9e-46	164
LLPS-Zyt-0150	Zymoseptoria tritici	41.98	1e-07	57.8
LLPS-Beb-0004	Beauveria bassiana	41.78	4e-14	74.3
LLPS-Kop-0469	Komagataella pastoris	41.72	7e-17	82.0
LLPS-Phn-0106	Phaeosphaeria nodorum	41.67	1e-11	67.4
LLPS-Asg-0559	Ashbya gossypii	41.67	1e-21	95.5
LLPS-Nia-0695	Nicotiana attenuata	41.5	2e-26	112
LLPS-Mao-0345	Magnaporthe oryzae	41.04	1e-15	78.2
LLPS-Pytr-0248	Pyrenophora triticirepentis	41.01	1e-08	58.2
LLPS-Pyt-0387	Pyrenophora teres	41.01	2e-08	58.5
LLPS-Fus-0548	Fusarium solani	40.88	6e-16	79.3
LLPS-Mua-0953	Musa acuminata	40.79	9e-37	140
LLPS-Orbr-0240	Oryza brachyantha	40.62	5e-35	135
LLPS-Trr-0929	Trichoderma reesei	40.54	7e-15	76.3
LLPS-Gag-0811	Gaeumannomyces graminis	40.45	2e-15	77.4
LLPS-Tra-0563	Triticum aestivum	40.36	1e-35	138
LLPS-Brr-0877	Brassica rapa	40.34	1e-34	134
LLPS-Sol-0774	Solanum lycopersicum	40.32	2e-26	111
LLPS-Cus-0172	Cucumis sativus	40.0	3e-34	134
LLPS-Coo-0763	Colletotrichum orbiculare	39.89	3e-17	82.8
LLPS-Prp-0746	Prunus persica	39.86	1e-36	140
LLPS-Arl-0694	Arabidopsis lyrata	39.8	1e-39	148
LLPS-Sob-0453	Sorghum bicolor	39.79	1e-34	135
LLPS-Dac-0007	Daucus carota	39.78	4e-29	119
LLPS-Map-0448	Magnaporthe poae	39.66	3e-15	77.0
LLPS-Bro-0465	Brassica oleracea	39.43	1e-35	137
LLPS-Orb-0851	Oryza barthii	39.35	1e-36	140
LLPS-Orni-0203	Oryza nivara	39.35	1e-36	140
LLPS-Pug-0231	Puccinia graminis	39.34	5e-31	125
LLPS-Miv-0059	Microbotryum violaceum	39.29	2e-34	134
LLPS-Trv-0094	Trichoderma virens	39.15	2e-13	72.4
LLPS-Hov-2013	Hordeum vulgare	39.08	1e-33	132
LLPS-Zem-0267	Zea mays	39.01	1e-29	120
LLPS-Lep-0807	Leersia perrieri	39.01	3e-36	139
LLPS-Orr-0127	Oryza rufipogon	38.99	2e-35	137
LLPS-Orgl-0111	Oryza glumaepatula	38.99	6e-36	139
LLPS-Vir-0170	Vigna radiata	38.93	3e-23	102
LLPS-Brn-1249	Brassica napus	38.73	7e-35	135
LLPS-Cog-0355	Colletotrichum gloeosporioides	38.67	4e-16	79.7
LLPS-Php-0323	Physcomitrella patens	38.67	7e-36	139
LLPS-Hea-1074	Helianthus annuus	38.66	9e-30	121
LLPS-Sac-1299	Saccharomyces cerevisiae	38.66	3e-20	91.3
LLPS-Amt-1110	Amborella trichopoda	38.6	1e-34	134
LLPS-Sot-0378	Solanum tuberosum	38.57	2e-26	112
LLPS-Art-0249	Arabidopsis thaliana	38.46	6e-38	143
LLPS-Spr-0396	Sporisorium reilianum	38.31	1e-21	97.4
LLPS-Sei-0198	Setaria italica	38.3	2e-32	129
LLPS-Crn-0932	Cryptococcus neoformans	38.17	2e-25	108
LLPS-Asn-0599	Aspergillus nidulans	38.04	1e-12	70.1
LLPS-Usm-0006	Ustilago maydis	38.02	1e-21	97.4
LLPS-Met-1162	Medicago truncatula	37.86	2e-33	131
LLPS-Orp-0029	Oryza punctata	37.7	6e-37	141
LLPS-Asc-0537	Aspergillus clavatus	37.62	4e-15	77.4
LLPS-Yal-0663	Yarrowia lipolytica	37.58	9e-14	73.2
LLPS-Aso-0569	Aspergillus oryzae	37.5	2e-13	72.8
LLPS-Asf-0463	Aspergillus flavus	37.5	2e-13	72.8
LLPS-Ors-0506	Oryza sativa	37.38	4e-37	141
LLPS-Brd-0630	Brachypodium distachyon	37.38	8e-31	124
LLPS-Org-0205	Oryza glaberrima	37.25	6e-38	144
LLPS-Asni-0122	Aspergillus niger	36.7	3e-13	72.0
LLPS-Chr-0150	Chlamydomonas reinhardtii	36.67	2e-31	127
LLPS-Asfu-0504	Aspergillus fumigatus	36.55	5e-12	68.6
LLPS-Mel-0285	Melampsora laricipopulina	36.42	2e-31	126
LLPS-Ast-0106	Aspergillus terreus	36.07	1e-15	79.0
LLPS-Put-0136	Puccinia triticina	35.76	4e-28	117
LLPS-Nef-0729	Neosartorya fischeri	35.35	1e-12	70.5
LLPS-Ori-0357	Oryza indica	34.27	5e-25	107
LLPS-Blg-0744	Blumeria graminis	33.49	8e-17	82.0
LLPS-Osl-0642	Ostreococcus lucimarinus	32.75	7e-23	100
LLPS-Gas-0345	Galdieria sulphuraria	32.16	4e-15	77.8
LLPS-Chc-0195	Chondrus crispus	31.54	2e-15	79.0
LLPS-Cym-0300	Cyanidioschyzon merolae	29.27	4e-13	72.4

LLPS-Dar-0017rrs1

Protein Sequence

Nucleotide Sequence

LLPS-Dar-0017
rrs1